Cardiovascular Drugs and Therapy最新文献_第4页

Citrated Kaolin Reaction Time on Thromboelastography 6s Identifies Bleeding-Prone Phenotypes in Older Adults with Atrial Fibrillation Receiving Direct Oral Anticoagulant Therapy. 柠檬酸高岭土对血栓弹性成像的反应时间为6s，可识别接受直接口服抗凝治疗的老年房颤患者的易出血表型。

IF 3.5 3区医学

Cardiovascular Drugs and Therapy Pub Date : 2026-10-01 Epub Date: 2026-05-28 DOI: 10.1007/s10557-026-07895-2

Jin Kyung Hwang, Su Hyun Lee, Sung Joo Cha, Chee Hae Kim, Chang Hoon Lee

{"title":"Citrated Kaolin Reaction Time on Thromboelastography 6s Identifies Bleeding-Prone Phenotypes in Older Adults with Atrial Fibrillation Receiving Direct Oral Anticoagulant Therapy.","authors":"Jin Kyung Hwang, Su Hyun Lee, Sung Joo Cha, Chee Hae Kim, Chang Hoon Lee","doi":"10.1007/s10557-026-07895-2","DOIUrl":"10.1007/s10557-026-07895-2","url":null,"abstract":"Purpose: Older adults with atrial fibrillation (AF) receiving direct oral anticoagulants (DOACs) remain at increased bleeding risk, and conventional clinical scores offer limited predictive value. Thromboelastography (TEG6s) provides point-of-care assessment of global hemostasis; however, its clinical utility remains unclear. This study investigated the association between TEG6s parameters and bleeding events in older adults with AF receiving DOAC therapy.Methods: We prospectively enrolled 100 patients aged ≥ 75 years with non-valvular AF receiving DOAC therapy. Baseline TEG6s parameters, including citrated kaolin reaction time (CKR), were obtained. Bleeding events were classified per International Society on Thrombosis and Haemostasis criteria. Logistic regression and receiver operating characteristic (ROC) analyses identified predictors of clinically relevant bleeding, defined as major and clinically relevant non-major bleeding.Results: Clinically relevant bleeding occurred in 33 patients during a 1-year follow-up. Prolonged CKR was independently associated with increased bleeding risk in multivariate analysis (hazard ratio 1.36; 95% confidence interval: 1.10-1.70; p = 0.005). ROC analysis demonstrated fair discriminative performance for CKR (area under the curve = 0.712), suggesting a potential role as a biomarker for bleeding risk stratification. Other TEG parameters and conventional clinical risk scores were not significant predictors.Conclusion: Prolonged CKR was significantly associated with clinically relevant bleeding events in older adults with AF receiving DOAC therapy. CKR may reflect an underlying bleeding tendency and could serve as an investigational biomarker for bleeding risk stratification. However, its clinical utility requires confirmation in larger, multicenter studies.","PeriodicalId":9557,"journal":{"name":"Cardiovascular Drugs and Therapy","volume":" ","pages":"1839-1847"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148041263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to "DTX1 Regulates Aortic Dissection Progression by Modulating Vascular Smooth Muscle Cell Phenotypic Switching Via Ubiquitination of ITGA5". 致“DTX1通过ITGA5泛素化调节血管平滑肌细胞表型转换调节主动脉夹层进展”的信。

IF 3.5 3区医学

Cardiovascular Drugs and Therapy Pub Date : 2026-10-01 Epub Date: 2026-08-11 DOI: 10.1007/s10557-026-07932-0

Huanping Jin, Xiaomin Xu

引用次数: 0

MicroRNAs and Long Non-coding RNAs Associated With Sirtuin Pathways in Myocardial Ischemia/Reperfusion Injury. 心肌缺血/再灌注损伤中与Sirtuin通路相关的microrna和长链非编码rna。

IF 3.5 3区医学

Cardiovascular Drugs and Therapy Pub Date : 2026-10-01 Epub Date: 2026-03-18 DOI: 10.1007/s10557-026-07860-z

Anna Nowak-Szwed, Ceren Eyileten, Zofia Wicik, Sara Ahmadova, Dirk von Lewinski, Harald Sourij, Marek Postula

引用次数: 0

Beyond Aspirin: Reevaluating Rivaroxaban-Clopidogrel Therapy in PCI Patients with Gastrointestinal Disease. 阿司匹林之外：重新评估利伐沙班-氯吡格雷治疗PCI患者胃肠道疾病。

IF 3.5 3区医学

Cardiovascular Drugs and Therapy Pub Date : 2026-10-01 Epub Date: 2026-01-13 DOI: 10.1007/s10557-026-07833-2

Talha Khan, Maheen Rizwan, Ali Raamiz Rizvi

引用次数: 0

Immortal Time Bias Compromises Conclusions Regarding SGLT2 Inhibitor Use in Diabetic Prostate Cancer Patients on Hormone Therapy. 不朽的时间偏差影响了SGLT2抑制剂用于激素治疗的糖尿病前列腺癌患者的结论

IF 3.5 3区医学

Cardiovascular Drugs and Therapy Pub Date : 2026-10-01 Epub Date: 2026-02-19 DOI: 10.1007/s10557-026-07853-y

Kuo-Wang Tsai, Joshua Wang

引用次数: 0

The Gut Microbiota-Metabolite-Host Axis in Cardiometabolic Diseases: Bridging Bench to Bedside. 心脏代谢疾病中的肠道微生物群-代谢物-宿主轴：从实验室到临床的桥梁。

IF 3.5 3区医学

Cardiovascular Drugs and Therapy Pub Date : 2026-10-01 Epub Date: 2026-04-16 DOI: 10.1007/s10557-026-07875-6

Lang Chen, Di Yang

引用次数: 0

Therapeutic Ultrasound in Cardiovascular Medicine: Applications of Low-intensity Pulsed Ultrasound and Ultrasound-targeted Microbubble Destruction. 超声治疗在心血管医学中的应用：低强度脉冲超声和超声靶向微泡破坏。

IF 3.5 3区医学

Cardiovascular Drugs and Therapy Pub Date : 2026-10-01 Epub Date: 2026-03-07 DOI: 10.1007/s10557-026-07864-9

Yucong Shi, Yongqing Ye, Shanshan Chang, Dongxu Lu, Yinzhu Chu

{"title":"Therapeutic Ultrasound in Cardiovascular Medicine: Applications of Low-intensity Pulsed Ultrasound and Ultrasound-targeted Microbubble Destruction.","authors":"Yucong Shi, Yongqing Ye, Shanshan Chang, Dongxu Lu, Yinzhu Chu","doi":"10.1007/s10557-026-07864-9","DOIUrl":"10.1007/s10557-026-07864-9","url":null,"abstract":"Cardiovascular disease (CVD) represents a significant global health challenge, with its high incidence and mortality rates placing a substantial burden on both patients and society. Although conventional therapies have achieved certain results, they continue to face considerable limitations. In recent years, therapeutic ultrasound has emerged as a promising medical technology, offering notable potential in the treatment of CVD owing to its non-invasiveness, safety, and targeting precision. Low-intensity pulsed ultrasound (LIPUS), a form of therapeutic ultrasound, uses pulsed, low-intensity, moderate-frequency acoustic waves to produce biological effects. This modality minimizes thermal impact while enhancing mechanical interactions. Another well-regarded technique is ultrasound-targeted microbubble destruction (UTMD), an innovative gene delivery system characterized by safety, reliable targeting, and high personalization. In clinical practice for CVD, both LIPUS and UTMD exhibit distinct advantages. This review examines the current landscape of CVD and discusses the potential and future applications of LIPUS and UTMD in their management.","PeriodicalId":9557,"journal":{"name":"Cardiovascular Drugs and Therapy","volume":" ","pages":"1899-1915"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147371998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DTX1 Regulates Aortic Dissection Progression by Modulating Vascular Smooth Muscle Cell Phenotypic Switching via Ubiquitination of ITGA5. DTX1通过ITGA5泛素化调控血管平滑肌细胞表型转换调控主动脉夹层进展。

IF 3.5 3区医学

Cardiovascular Drugs and Therapy Pub Date : 2026-10-01 Epub Date: 2026-05-06 DOI: 10.1007/s10557-026-07877-4

Dong Wang, Lingbo Yang, Junqing Zong

{"title":"DTX1 Regulates Aortic Dissection Progression by Modulating Vascular Smooth Muscle Cell Phenotypic Switching via Ubiquitination of ITGA5.","authors":"Dong Wang, Lingbo Yang, Junqing Zong","doi":"10.1007/s10557-026-07877-4","DOIUrl":"10.1007/s10557-026-07877-4","url":null,"abstract":"Background: Aortic dissection (AD) is a life-threatening vascular disorder characterized by medial degeneration and phenotypic switching of vascular smooth muscle cells (VSMCs). While integrin subunit alpha 5 (ITGA5) has been implicated in VSMC plasticity, the upstream molecular mechanisms governing its regulation remain poorly defined.Methods: Publicly available transcriptomic datasets were analyzed using differential expression analysis and WGCNA to identify hub genes associated with AD. The UbiBrowser database was employed to predict potential E3 ubiquitin ligases targeting ITGA5. In vitro, human aortic smooth muscle cells (HASMCs) were stimulated with Angiotensin II to mimic pathological conditions, and subjected to gain and loss-of-function assays, protein stability analysis, and co-immunoprecipitation in combination with HEK-293T cells. A BAPN-induced AD mouse model was utilized to evaluate the in vivo studies. Protein and gene expression were assessed by Western blotting, qPCR, and immunofluorescence.Results: ITGA5 promoted the phenotypic switch of HASMCs toward a synthetic/inflammatory state. Deltex E3 ubiquitin ligase 1 (DTX1) directly interacted with ITGA5 and promoted its ubiquitination at lysine 137, leading to proteasome-dependent degradation. DTX1 overexpression suppressed ITGA5 levels, maintained contractile marker expression, and inhibited the synthetic/inflammatory phenotype of HASMCs. In vivo, DTX1 expression was downregulated and ITGA5 upregulated in BAPN-treated aortas, whereas DTX1 overexpression reduced ITGA5 levels, preserved medial integrity, and attenuated AD progression.Conclusion: This study identifies DTX1 as a novel E3 ubiquitin ligase that promotes ITGA5 degradation, thereby maintaining the contractile phenotype of VSMCs and limiting AD progression. Targeting the DTX1-ITGA5 axis may offer a promising therapeutic approach for AD.","PeriodicalId":9557,"journal":{"name":"Cardiovascular Drugs and Therapy","volume":" ","pages":"1747-1762"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond Branch Patency: Timing, Bleeding Phenotype, and Organ Risk in Antithrombotic Therapy After Branched EVAR. 超出分支通畅：分支EVAR后抗血栓治疗的时机、出血表型和器官风险。

IF 3.5 3区医学

Cardiovascular Drugs and Therapy Pub Date : 2026-10-01 Epub Date: 2026-06-10 DOI: 10.1007/s10557-026-07899-y

Jiaqian Ying

引用次数: 0

Re: Effects of Dapagliflozin Combined with Sacubitril/Valsartan on Cardiac Electrophysiology and Quantitative Myocardial Motion Parameters in Patients with Atrial Fibrillation and Heart Failure with Preserved Ejection Fraction. 研究：达格列净联合沙比利/缬沙坦对房颤和心力衰竭患者心脏电生理和定量心肌运动参数的影响。

IF 3.5 3区医学

Cardiovascular Drugs and Therapy Pub Date : 2026-10-01 Epub Date: 2026-07-16 DOI: 10.1007/s10557-026-07917-z

Ying Zhao

引用次数: 0