Miles Marchand MD, Zayeeda Shahreen Labiba MA, Karleen Schulze MMath, Marie Pigeyre MD, PhD, Dipika Desai MSc, Jeffrey Brook PhD, James Irvine MD, Sylvia Abonyi PhD, Philip Joseph MD, Paul Poirier MD, PhD, Myriam Pettigrew MSc, Randy Littlechild, Lisa Mayotte RN, Matthias G. Friedrich MD, Sonia S. Anand MD, PhD
{"title":"Clinical and Community Factors’ Correlation With NT-proBNP in First Nations: A Cross-sectional Analysis of the CAHHM-FN Cohort","authors":"Miles Marchand MD, Zayeeda Shahreen Labiba MA, Karleen Schulze MMath, Marie Pigeyre MD, PhD, Dipika Desai MSc, Jeffrey Brook PhD, James Irvine MD, Sylvia Abonyi PhD, Philip Joseph MD, Paul Poirier MD, PhD, Myriam Pettigrew MSc, Randy Littlechild, Lisa Mayotte RN, Matthias G. Friedrich MD, Sonia S. Anand MD, PhD","doi":"10.1016/j.cjca.2026.03.056","DOIUrl":"10.1016/j.cjca.2026.03.056","url":null,"abstract":"<div><h3>Background</h3><div>In Canada, Indigenous populations face inequities in cardiovascular care, and have disparate heart failure (HF) outcomes. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a biomarker that has been reported to predict subclinical left ventricular (LV) dysfunction, clinical HF, and cardiovascular events. Because of disparities in HF outcomes and care between Indigenous and non-Indigenous people in Canada, in this study we sought to understand the unique sociocultural, clinical, and community factors that are associated with circulating NT-proBNP levels.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional analysis of 579 First Nations adults from the Canadian Alliance for Healthy Hearts and Minds First Nations (CAHHM-FN) study, who completed detailed questionnaires, physical measures, community audits, cardiac magnetic resonance imaging, and biomarker testing. We examined associations between NT-proBNP levels and clinical, sociocultural, and community factors, and subsequently evaluated the association between NT-proBNP and LV size, mass, and function on cardiac magnetic resonance imaging.</div></div><div><h3>Results</h3><div>Increased access to primary care and cardiovascular risk factor screening were associated with lower NT-proBNP levels. Higher NT-proBNP levels were associated with older age, female sex, cardiovascular disease, and secondhand smoke exposure. Participants in the highest NT-proBNP tertile were more likely to have increased LV dimensions and mass and reduced ejection fraction.</div></div><div><h3>Conclusions</h3><div>In this unique Indigenous cohort, several clinical, community, and sociocultural factors were associated with NT-proBNP elevation, which was also associated with subclinical LV abnormalities. These findings might explain some of the disparities in HF outcomes faced by Indigenous populations. Longitudinal follow-up is needed to assess these factors’ predictive value on the development of incident clinical HF.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages 2421-2430"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Finlay A. McAlister MD, Tracey Bushnik MBA, Alexander A. Leung MD
{"title":"Changes in Hypertension Prevalence and Control in Canada After the COVID-19 Pandemic: Insights From the Canadian Health Measures Survey Cycle 7","authors":"Finlay A. McAlister MD, Tracey Bushnik MBA, Alexander A. Leung MD","doi":"10.1016/j.cjca.2026.04.013","DOIUrl":"10.1016/j.cjca.2026.04.013","url":null,"abstract":"<div><h3>Background</h3><div>The impact of the COVID-19 pandemic on hypertension prevalence and control in Canada is unknown despite pandemic-associated changes in lifestyle behaviours, socioeconomic factors, and availability of medical care.</div></div><div><h3>Methods</h3><div>We compared data for non-pregnant adult participants from the 7 cycles of the nationally representative Canadian Health Measures Survey (CHMS) conducted between 2007-2009 and 2022-2024, including questionnaires and physical measurements.</div></div><div><h3>Results</h3><div>The prevalence of hypertension in CHMS adult participants remained relatively stable between 2007-2009 (20.3%, 95%CI 18.8%-21.8%) and 2018-2019 (22.0%, 95%CI 17.8%-27.0%), but increased to 27.7% (95%CI 24.8%-30.8%) in 2022-2024 (p=0.03 compared to 2018-2019). Prevalence was highest in men (31.8%, 95%CI 27.4%-36.5%) in 2022-2024. Although the absolute rates were lower, the relative increases in hypertension prevalence between 2018-2019 and 2022-2024 were greatest in younger adults: 207.7% in those aged 20-39 years (from 2.6% to 8.0%, p=0.007), 25.5% in those aged 40-59 years (from 20.0% to 25.1%, p=0.20), and 10.2% in those aged 60-79 years (from 50.9% to 56.1%, p=0.27). In 2022-2024, almost 3 out of 4 adults with hypertension were aware of their diagnosis and two-thirds were taking treatment but less than half were treated and controlled. This represented a 13% absolute decline in treated and controlled hypertension in 2022-2024 compared to 2018-2019 (42.7% [95%CI 36.9%-48.8%] versus 55.7% [95%CI 48.1%-63.1%], p=0.007). Control rates were lower in adults younger than 60 years (35.5%, 95%CI 25.8%-46.6%) and women (35.0%, 95%CI 26.6%-44.5%).</div></div><div><h3>Conclusions</h3><div>Hypertension prevalence has increased and control has declined in Canada between 2018-2019 and 2022-2024, particularly in younger adults and women.</div></div><div><h3>Trial Registration</h3><div>Not applicable.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages 2456-2463"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hazeema Haq BMSc, Lorne Gula MD, FRCPC, Ahmed T. Moustafa MB BCh, FRCPC, Allan Skanes MD, FRCPC, Pavel Antiperovitch MD, FRCPC, Anthony S.L. Tang MD, FRCPC, Habib R. Khan MBBS, FRCPUK, PhD
{"title":"Prolonged Loop Recorder Retention: Safety, Diagnostic Yield, and the Case for Community-Based Explantation","authors":"Hazeema Haq BMSc, Lorne Gula MD, FRCPC, Ahmed T. Moustafa MB BCh, FRCPC, Allan Skanes MD, FRCPC, Pavel Antiperovitch MD, FRCPC, Anthony S.L. Tang MD, FRCPC, Habib R. Khan MBBS, FRCPUK, PhD","doi":"10.1016/j.cjca.2026.06.030","DOIUrl":"10.1016/j.cjca.2026.06.030","url":null,"abstract":"<div><h3>Background</h3><div>Implantable loop recorders (ILRs) or insertable cardiac monitors (ICMs) are vital for long-term cardiac monitoring to diagnosed arrhythmias in patients with cryptogenic stroke, syncope, recurrent palpitations, and heart disease. Their increasing use raises demand on limited resources, worsened by the response to Covid-19, which led to deferring elective procedures such as ILR removal. We examined whether longer ILR dwell time was linked to more complications, assessed diagnostic yield, and compared explantation costs between a hospital and simulated community clinics.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed all ILR implantations at the London Health Sciences Centre from 2011 to 2025. We recorded patient characteristics, implantation and explantation dates, diagnostic findings, complications, and institutional cost data. We also modelled a simulated community-based explantation cost using local clinic resource estimates.</div></div><div><h3>Results</h3><div>Among 772 patients, the mean device dwell time was 3.4 years; in the 355 patients (46%) who retained devices beyond the 3.25-year recommended replacement time the mean duration was 5.5 ± 2.2 years. The overall complication rate was 8.0% (n = 62): patient-reported discomfort (3.9%), recording errors (1.8%), unsuitable device position (1.2%), excessive bleeding (0.5%), and infection (0.7%). On a time-to-event basis, the complication rate was highest in the first 180 days (4.13 per 100 device-years) and was not significantly higher beyond the recommended replacement time (incidence-rate ratio 1.36; <em>P</em> = 0.24). Symptom-rhythm correlation was established in 38.4% of patients. Explantation costs for ILR were approximately $490 per case in the hospital setting and $70 in the simulated community clinic, resulting in potential savings of 85.7%.</div></div><div><h3>Conclusions</h3><div>Prolonged ILR dwell time didn’t increase complication rates. Findings support deferred explantation and community removal to lower costs, but safety and feasibility need prospective studies.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages 2384-2392"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148381631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luca Zanella MD, Jennifer Chung MD, MSc, Maral Ouzounian MD, PhD, Michael A. Seidman MD, PhD
{"title":"Beyond Just Inflammation: An Immunophenotyping Compass to Define the Clinical Pathophysiology and Guide the Management of Takayasu Arteritis","authors":"Luca Zanella MD, Jennifer Chung MD, MSc, Maral Ouzounian MD, PhD, Michael A. Seidman MD, PhD","doi":"10.1016/j.cjca.2026.07.360","DOIUrl":"10.1016/j.cjca.2026.07.360","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages 2288-2289"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148547984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea Amabile MD, Manuel Giraldo-Grueso MD, Johannes Bonatti MD
{"title":"Population-Level Validation of Robotic Coronary Artery Bypass Surgery: Building the Case for Broader Adoption?","authors":"Andrea Amabile MD, Manuel Giraldo-Grueso MD, Johannes Bonatti MD","doi":"10.1016/j.cjca.2026.07.361","DOIUrl":"10.1016/j.cjca.2026.07.361","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages 2290-2292"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148560800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"P022 INTRA-INSTITUTIONAL USE OF POSITIVE DEVIANCY IN SURGICAL INFECTIONS IN ISOLATED CORONARY BYPASS","authors":"Y. Qiu","doi":"10.1016/j.cjca.2026.07.031","DOIUrl":"10.1016/j.cjca.2026.07.031","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages S18-S19"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}