Canadian journal of physiology and pharmacology最新文献_第6页

Retraction: β-arrestin-1 mediates the endothelin-1-induced activation of Akt and integrin-linked kinase. 撤稿：β-arrestin-1 介导内皮素-1 诱导的 Akt 和整合素连接激酶活化。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-11-01 Epub Date: 2024-08-23 DOI: 10.1139/cjpp-2024-0265

引用次数: 0

Agonists, inverse agonists, and antagonists as therapeutic approaches to manipulate retinoic acid-related orphan receptors. 将激动剂、反向激动剂和拮抗剂作为操控维甲酸相关孤儿受体 (ROR) 的治疗方法。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-11-01 Epub Date: 2024-05-10 DOI: 10.1139/cjpp-2024-0099

Darya Nematisouldaragh, Huong Nguyen, Inna Rabinovich-Nikitin

{"title":"Agonists, inverse agonists, and antagonists as therapeutic approaches to manipulate retinoic acid-related orphan receptors.","authors":"Darya Nematisouldaragh, Huong Nguyen, Inna Rabinovich-Nikitin","doi":"10.1139/cjpp-2024-0099","DOIUrl":"10.1139/cjpp-2024-0099","url":null,"abstract":"Retinoic acid-related orphan receptors (RORs) serve as transcription factors that play a pivotal role in a myriad of physiological processes within the body. Their involvement extends to critical biological processes that confer protective effects in the heart, immune system, and nervous system, as well as contributing to the mitigation of several aggressive cancer types. These protective functions are attributed to ROR's regulation of key proteins and the management of various cellular processes, including autophagy, mitophagy, inflammation, oxidative stress, and glucose metabolism, highlighting the emerging need for pharmacological approaches to modulate ROR expression. Thus, the modulation of RORs is a rapidly growing area of research aimed not only at comprehending these receptors, but also at manipulating them to attain the desired physiological response. Despite the presence of natural ROR ligands, the development of synthetic agonists with high selectivity for these receptors holds substantial therapeutic potential. The exploration and advancement of such compounds can effectively target diseases associated with ROR dysregulation, thereby providing avenues for therapeutic interventions. Herein, we provide a comprehensive examination of the multifaceted role of ROR in diverse physiological and pathophysiological conditions, accompanied by an in-depth exploration of a spectrum of ROR agonists, inverse agonists, and antagonists.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"620-633"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140903907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Canadian Society of Pharmacology and Therapeutics. 加拿大药理学和治疗学学会。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-10-01 DOI: 10.1139/cjpp-2024-0260

引用次数: 0

Oral hormonal contraceptives and cardiovascular risks in females. 口服荷尔蒙避孕药与女性心血管风险。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-10-01 Epub Date: 2024-05-23 DOI: 10.1139/cjpp-2024-0041

Sukhwinder K Bhullar, Inna Rabinovich-Nikitin, Lorrie A Kirshenbaum

{"title":"Oral hormonal contraceptives and cardiovascular risks in females.","authors":"Sukhwinder K Bhullar, Inna Rabinovich-Nikitin, Lorrie A Kirshenbaum","doi":"10.1139/cjpp-2024-0041","DOIUrl":"10.1139/cjpp-2024-0041","url":null,"abstract":"Oral hormonal contraception (OHC) is a widely employed method in females for the prevention of unintended pregnancies, as well as for the treatment of menstrual disorders, endometriosis, and polycystic ovarian syndrome. However, it is believed that with OHCs use, some females may have higher risk of cardiovascular diseases, such as hypertension, diabetes, myocardial infarction, thrombosis, and heart failure. Although such risks are infrequently detected in healthy young females with the use of oral contraceptives, slightly elevated risks of cardiovascular diseases have been observed among reproductive-aged healthy females. However, prolonged use of OHC has also been claimed to have protective cardiac effects and may contribute to reduced risk of cardiovascular disease. In fact, the debate on whether OHC administration increases the risk of cardiovascular diseases has been ongoing with inconsistent and controversial viewpoints. Nevertheless, a great deal of work has been carried out to understand the relationship between OHC use and the occurrence of cardiovascular risk in females who use OHC for preventing the unwanted pregnancy or treatment of other disorders. Therefore, in this review we summarize the most recent available evidence regarding the association between the use of oral hormonal contraceptives and the risk for cardiovascular disease in females who are using OHC to prevent unintended pregnancy.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"572-584"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141086886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of biological sex on valvular heart disease, interventions, and outcomes. 生理性别对瓣膜性心脏病、干预措施和结果的影响。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-10-01 Epub Date: 2024-03-01 DOI: 10.1139/cjpp-2023-0390

Evan J Wiens, Kristal Kawa, Malek Kass, Ashish H Shah

{"title":"Impact of biological sex on valvular heart disease, interventions, and outcomes.","authors":"Evan J Wiens, Kristal Kawa, Malek Kass, Ashish H Shah","doi":"10.1139/cjpp-2023-0390","DOIUrl":"10.1139/cjpp-2023-0390","url":null,"abstract":"Valvular heart disease (VHD) is common, affecting >14% of individuals aged >75, and is associated with morbidity, including heart failure and arrhythmia, and risk of early mortality. Increasingly, important sex differences are being found between males and females with VHD. These sex differences can involve the epidemiology, pathophysiology, presentation, diagnosis, and outcomes of the disease. Females are often disadvantaged, and female sex has been shown to be associated with delayed diagnosis and inferior outcomes in various forms of VHD. In addition, the unique pathophysiologic state of pregnancy is associated with increased risk for maternal and fetal morbidity and mortality in many forms of VHD. Therefore, understanding and recognizing these sex differences, and familiarity with the attendant risks of pregnancy and management of pregnant females with VHD, is of great importance for any primary care or cardiovascular medicine practitioner caring for the female patient. This review will outline sex differences in aortic, mitral, pulmonic, and tricuspid VHD, with particular focus on differences in pathophysiology, clinical presentation, and outcomes. In addition, the pathophysiology and management implications of pregnancy will be discussed.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"585-593"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140012214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac physiology and pathophysiology in pregnancy. 妊娠期心脏生理学和病理生理学。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-10-01 Epub Date: 2024-05-30 DOI: 10.1139/cjpp-2024-0010

Shekoofeh Saboktakin Rizi, Evan Wiens, Jennifer Hunt, Robin Ducas

引用次数: 0

Coronary microvascular disease in women: epidemiology, mechanisms, evaluation, and treatment. 女性冠状动脉微血管疾病：流行病学、机制、评估和治疗。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-10-01 Epub Date: 2024-05-10 DOI: 10.1139/cjpp-2023-0414

Rebecca S Steinberg, Anamaria Dragan, Puja K Mehta, Olga Toleva

{"title":"Coronary microvascular disease in women: epidemiology, mechanisms, evaluation, and treatment.","authors":"Rebecca S Steinberg, Anamaria Dragan, Puja K Mehta, Olga Toleva","doi":"10.1139/cjpp-2023-0414","DOIUrl":"10.1139/cjpp-2023-0414","url":null,"abstract":"Coronary microvascular dysfunction (CMD) involves functional or structural abnormalities of the coronary microvasculature resulting in dysregulation of coronary blood flow (CBF) in response to myocardial oxygen demand. This perfusion mismatch causes myocardial ischemia, which manifests in patients as microvascular angina (MVA). CMD can be diagnosed non-invasively via multiple imaging techniques or invasively using coronary function testing (CFT), which assists in determining the specific mechanisms involving endothelium-independent and dependent epicardial and microcirculation domains. Unlike traditional coronary artery disease (CAD), CMD can often occur in patients without obstructive atherosclerotic epicardial disease, which can make the diagnosis of CMD difficult. Moreover, MVA due to CMD is more prevalent in women and carries increased risk of future cardiovascular events. Successful treatment of symptomatic CMD is often patient-specific risk factor and endotype targeted. This article aims to review newly identified mechanisms and novel treatment strategies for managing CMD, and outline sex-specific differences in the presentation and pathophysiology of the disease.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"594-606"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140903910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardio-rheumatology: the cardiovascular, pharmacological, and surgical risks associated with rheumatological diseases in women. 心风湿病学：与女性风湿病相关的心血管、药物和手术风险。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-09-01 Epub Date: 2024-03-15 DOI: 10.1139/cjpp-2023-0420

Samantha Le Sommer, Maria I Kontaridis

{"title":"Cardio-rheumatology: the cardiovascular, pharmacological, and surgical risks associated with rheumatological diseases in women.","authors":"Samantha Le Sommer, Maria I Kontaridis","doi":"10.1139/cjpp-2023-0420","DOIUrl":"10.1139/cjpp-2023-0420","url":null,"abstract":"Cardiovascular disease (CVD) remains the number one cause of death worldwide. Women are at increased risk of death from CVD, but the mechanisms for how and why this occurs remain elusive. One subset of women who are exceptionally vulnerable to CVD are those with rheumatic diseases (RDs). Indeed, women account for 80% of all RDs, disorders that encompass a broad range of autoimmune and autoinflammatory diseases that lead to chronic inflammation and pathology. The clear association of increased CVD risk in women with RD is thought to be mediated by a number of factors, including RD pathology itself, pharmacological induction of CVD, and/or as yet unidentified mechanisms. As such, elucidation of the causes and treatments of these pathologies has given rise to a new subspecialty of cardiology: cardio-rheumatology. Here, we review and discuss the CVD risks in patients with RDs, the associated sex disparities in RD and CVD care, as well as the current therapeutic and interventional options available to specifically help women with RDs. We hope this discussion will provide guidance and support to patients, as well as to cardio-rheumatologists, as these groups are the most uniquely positioned to radically improve CVD care in these individuals. Moreover, we are hopeful this discussion may lead to better, more efficacious approaches to treating these disorders in women in the near future.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"511-522"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140136504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-specific considerations in cardiovascular drug therapy. 心血管药物治疗中的性别特异性考虑。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-09-01 Epub Date: 2024-05-23 DOI: 10.1139/cjpp-2024-0040

Inna Rabinovich-Nikitin, Shuangbo Liu, Lorrie A Kirshenbaum

引用次数: 0

Preventing broken hearts in women with breast cancer: a concise review on chemotherapy-mediated cardiotoxicity. 预防乳腺癌女性的心碎:化疗介导的心脏毒性的简明综述。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-09-01 Epub Date: 2023-12-01 DOI: 10.1139/cjpp-2023-0358

Hilary J Bews, Lana Mackic, Davinder S Jassal

{"title":"Preventing broken hearts in women with breast cancer: a concise review on chemotherapy-mediated cardiotoxicity.","authors":"Hilary J Bews, Lana Mackic, Davinder S Jassal","doi":"10.1139/cjpp-2023-0358","DOIUrl":"10.1139/cjpp-2023-0358","url":null,"abstract":"Cancer and cardiovascular disease are the leading causes of death for Canadian women. One in eight Canadian women will receive the life-changing diagnosis of breast cancer (BC) in their lifetime, with 1 in 34 dying from the disease. Although doxorubicin (DOX) and trastuzumab (TRZ) have significantly improved survival in women diagnosed with human epidermal growth factor receptor 2 (HER2)-positive BC, approximately one in four women who receive this treatment are at risk of developing chemotherapy-induced cardiotoxicity. Cardiotoxicity is defined as a decline in left ventricular ejection fraction (LVEF) of >10% to an absolute value of <53%. Current guidelines recommend the serial monitoring of LVEF in this patient population using non-invasive cardiac imaging modalities including transthoracic echocardiography or multi-gated acquisition scan; however, this will only allow for the detection of established cardiotoxicity. Recent studies have demonstrated that a reduction in global longitudinal strain by speckle tracking echocardiography can identify pre-clinical systolic dysfunction prior to a decline in overall LVEF. Implementation of early detection techniques would allow for the prompt initiation of cardioprotective strategies. In addition to the early detection of chemotherapy-mediated cardiotoxicity, the prophylactic use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, β-blockers, statins, exercise, and nutraceutical therapies have been studied in the setting of cardio-oncology.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"487-497"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138469965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0