Canadian journal of physiology and pharmacology最新文献_第5页

Lysophosphatidic acid metabolism and signaling in heart disease. 溶血磷脂酸代谢和信号在心脏病中的作用。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-12-01 Epub Date: 2024-07-05 DOI: 10.1139/cjpp-2024-0077

Anu Jose, Jeffy J Fernando, Petra C Kienesberger

引用次数: 0

Nebivolol prevents redox imbalance and attenuates bladder dysfunction induced by cyclophosphamide in mice. 奈必洛尔能防止环磷酰胺引起的小鼠氧化还原失衡并减轻膀胱功能障碍。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-12-01 Epub Date: 2024-09-13 DOI: 10.1139/cjpp-2024-0064

Carolina P S Jesus, Gustavo F Pimenta, Mariana G de Oliveira, Thales M H Dourado, Edson Antunes, Carlos R Tirapelli

{"title":"Nebivolol prevents redox imbalance and attenuates bladder dysfunction induced by cyclophosphamide in mice.","authors":"Carolina P S Jesus, Gustavo F Pimenta, Mariana G de Oliveira, Thales M H Dourado, Edson Antunes, Carlos R Tirapelli","doi":"10.1139/cjpp-2024-0064","DOIUrl":"10.1139/cjpp-2024-0064","url":null,"abstract":"Cyclophosphamide (CYP) is combined with cytoprotective agents to minimize its toxicity in the bladder, which is mediated by reactive oxygen species (ROS). Using multiple antioxidant mechanisms, nebivolol protects from oxidative stress in distinctive conditions. We hypothesized that nebivolol would attenuate both molecular and functional alterations induced by CYP in the bladder. Male C57BL/6 were pretreated or not with nebivolol (10 mg/kg/day, gavage), which was given 5 days before a single injection of CYP (300 mg/kg; i.p.). Molecular and functional parameters were assessed at 24 h in the bladder. Nebivolol prevented increases in ROS generation and lipoperoxidation as well as reduction of superoxide dismutase activity induced by CYP. Increased voiding frequency, decreased voiding interval, and reduced bladder capacity were found in CYP-treated mice. These responses were prevented by nebivolol. An augmented number of urinary spots and smaller urinary volumes were detected in CYP-injected mice, and nebivolol partially prevented these responses. The reduction of ROS levels is the primary mechanism by which nebivolol attenuates the deleterious effects of CYP in the bladder. The association of nebivolol with other cytoprotective agents could be an option to prevent CYP-associated oxidative damage to the bladder during chemotherapy.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"729-740"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular adverse events associated with triptans for treatment of migraine: a pharmacovigilance study of the FDA adverse event reporting system (FAERS). 与治疗偏头痛的三苯氧胺相关的心血管不良事件：美国食品药物管理局不良事件报告系统 (FAERS) 药物警戒研究。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-12-01 Epub Date: 2024-10-22 DOI: 10.1139/cjpp-2024-0117

Priyanka Sharma, Sheeba Varghese Gupta, Priyanka Bhatt, Abhishek Kandukuru, Feng Cheng, Gunjan Upadhyay, Vijaykumar Sutariya

{"title":"Cardiovascular adverse events associated with triptans for treatment of migraine: a pharmacovigilance study of the FDA adverse event reporting system (FAERS).","authors":"Priyanka Sharma, Sheeba Varghese Gupta, Priyanka Bhatt, Abhishek Kandukuru, Feng Cheng, Gunjan Upadhyay, Vijaykumar Sutariya","doi":"10.1139/cjpp-2024-0117","DOIUrl":"10.1139/cjpp-2024-0117","url":null,"abstract":"The purpose of this study was to determine the relationship between triptans (sumatriptan, rizatriptan, and zolmitriptan) and cardiovascular (CV) adverse events with data from the FDA Adverse Event Reporting System (FAERS). FAERS database was used to collect data on triptans from 1997 to 2023. Disproportionality methods were utilized to quantify triptan-associated CV events and to identify the potential risk. The reporting odds ratio was used to identify the risk signals. CV outcomes related to age, sex, clinical results, and other factors were also examined for triptans; 820 reports involving the triptans were recognized as CV adverse events out of total of 12 699 reports that were gathered from on FAERS database. Women reported more CV adverse events with rizatriptan and zolmitriptan as compared to men. The CV adverse event risk was highest among individuals aged 18-64. Clinical outcome analysis showed that sumatriptan carries a higher CV risk than rizatriptan and zolmitriptan, and most deaths and serious cases have been documented for sumatriptan. The patients prescribed sumatriptan or zolmitriptan were at a higher risk of reporting CV events for chest pain and chest discomfort, compared to rizatriptan. This finding may provide support for the clinical observation and risk evaluation of triptan treatment.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"720-728"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Cardiac physiology and pathophysiology in pregnancy. 更正：妊娠期心脏生理学和病理生理学。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-11-01 Epub Date: 2024-10-16 DOI: 10.1139/cjpp-2024-0319

Shekoofeh Saboktakin Rizi, Evan Wiens, Jennifer Hunt, Robin Ducas

引用次数: 0

Chloramphenicol alleviates 5-fluorouracil-induced cellular senescence through activation of autophagy. 氯霉素通过激活自噬缓解5-氟尿嘧啶诱导的细胞衰老

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-11-01 Epub Date: 2024-05-22 DOI: 10.1139/cjpp-2023-0432

Shi-Rui Bai, Qi Zhao, Hui-Jie Jia, Fei He, Xiao-Bo Wang

{"title":"Chloramphenicol alleviates 5-fluorouracil-induced cellular senescence through activation of autophagy.","authors":"Shi-Rui Bai, Qi Zhao, Hui-Jie Jia, Fei He, Xiao-Bo Wang","doi":"10.1139/cjpp-2023-0432","DOIUrl":"10.1139/cjpp-2023-0432","url":null,"abstract":"5-Fluorouracil (5-FU) is a first-line treatment for colorectal cancer, but side effects such as severe diarrhea are common in clinical use and have been linked to its induction of normal cell senescence. Chloramphenicol (CAP) is an antibiotic commonly used to treat typhoid or anaerobic infections, but its senescence-related aspects have not been thoroughly investigated. Here, we used 5-FU to induce senescence in human umbilical vein endothelial cells (HUVECs) and investigated the relationship between CAP and cellular senescence at the cellular level. In a model of cellular senescence induced by 5-FU treatment, we discovered that CAP treatment reversed the rise in the percentage of senescence-associated galactosidase (SA-β-gal)-positive cells and decreased the expression of senescence-associated proteins (p16), senescence-associated genes (p21), and senescence-associated secretory phenotypes (SASPs: IL-6, TNF-α). In addition, CAP subsequently restored the autophagic process inhibited by 5-FU and upregulated the levels of autophagy-related proteins. Mechanistically, we found that CAP restored autophagic flux by inhibiting the mTOR pathway, which in turn alleviated FU-induced cellular senescence. Our findings suggest that CAP may help prevent cellular senescence and restore autophagy, opening up new possibilities and approaches for the clinical management of colorectal cancer.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"661-671"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction: Endothelin axis induces metalloproteinase activation and invasiveness in human lymphatic endothelial cells. 撤回：内皮素轴诱导金属蛋白酶活化和人淋巴内皮细胞的侵袭性

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-11-01 Epub Date: 2024-08-23 DOI: 10.1139/cjpp-2024-0264

引用次数: 0

Behavioral dynamics of medicinal signaling cells from porcine bone marrow in long-term culture. 长期培养猪骨髓药用信号细胞的行为动力学。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-11-01 Epub Date: 2024-08-27 DOI: 10.1139/cjpp-2023-0458

Wanderson Gabriel Gomes de Melo, Dayseanny de Oliveira Bezerra, Elis Rosélia Dutra de Freitas Siqueira Silva, Camile Benício Campêlo, Maria Acelina Martins de Carvalho, Napoleão Martins Argôlo Neto

{"title":"Behavioral dynamics of medicinal signaling cells from porcine bone marrow in long-term culture.","authors":"Wanderson Gabriel Gomes de Melo, Dayseanny de Oliveira Bezerra, Elis Rosélia Dutra de Freitas Siqueira Silva, Camile Benício Campêlo, Maria Acelina Martins de Carvalho, Napoleão Martins Argôlo Neto","doi":"10.1139/cjpp-2023-0458","DOIUrl":"10.1139/cjpp-2023-0458","url":null,"abstract":"Medicinal signaling cells (MSC) hold promise for regenerative medicine due to their ability to repair damaged tissues. However, their effectiveness can be affected by how long they are cultured in the lab. This study investigated how passage number influences key properties for regenerative medicine of pig bone marrow MSC. The medicinal signiling cells derived from pig bone marrow (BM-MSC) were cultured in D-MEM High Glucose supplemented with 15% foetal bovine serum until the 25th passage and assessed their growth, viability, ability to differentiate into different cell types (plasticity), and cell cycle activity. Our findings showed that while the cells remained viable until the 25th passage, their ability to grow and differentiate declined after the 5th passage. Additionally, cells in later passages spent more time in a resting phase, suggesting reduced activity. In conclusion, the number of passages is a critical factor for maintaining ideal MSC characteristics. From the 9th passage BM-MSC exhibit decline in proliferation, differentiation potential, and cell cycle activity. Given this, it is possible to suggest that the use of 5th passage cells is the most suitable for therapeutic applications.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"672-679"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The acute effects of dietary nitrate supplementation on postmenopausal endothelial resistance to ischemia reperfusion injury: a randomized, placebo-controlled, double blind, crossover clinical trial. 膳食硝酸盐补充剂对绝经后血管内皮抵抗缺血再灌注损伤的急性影响：一项随机、安慰剂对照、双盲、交叉临床试验。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-11-01 Epub Date: 2024-06-20 DOI: 10.1139/cjpp-2024-0061

Jocelyn M Delgado Spicuzza, Jigar Gosalia, Matthew Studinski, Chenée Armando, Elmira Alipour, Daniel B Kim-Shapiro, Michael Flanagan, Yasina B Somani, David N Proctor

{"title":"The acute effects of dietary nitrate supplementation on postmenopausal endothelial resistance to ischemia reperfusion injury: a randomized, placebo-controlled, double blind, crossover clinical trial.","authors":"Jocelyn M Delgado Spicuzza, Jigar Gosalia, Matthew Studinski, Chenée Armando, Elmira Alipour, Daniel B Kim-Shapiro, Michael Flanagan, Yasina B Somani, David N Proctor","doi":"10.1139/cjpp-2024-0061","DOIUrl":"10.1139/cjpp-2024-0061","url":null,"abstract":"Postmenopausal cardiovascular health is a critical determinant of longevity. Consumption of beetroot juice (BR) and other nitrate-rich foods is a safe, effective non-pharmaceutical intervention to increase systemic bioavailability of the vasoprotective molecule, nitric oxide, through the exogenous nitrate (NO3 -)-nitrite (NO2 -)-nitric oxide (NO) pathway. We hypothesized that a single dose of nitrate-rich beetroot juice (BRnitrate 600 mg NO3 -/140 mL, BRplacebo ∼ 0 mg/140 mL) would improve resting endothelial function and resistance to ischemia-reperfusion (IR) injury to a greater extent in early-postmenopausal (1-6 years following their final menstrual period (FMP), n = 12) compared to late-postmenopausal (6+ years after FMP, n = 12) women. Analyses with general linear models revealed a significant (p < 0.05) time*treatment interaction effect for brachial artery adjusted flow-mediated dilation (FMD). Pairwise comparisons revealed that adjusted FMD was significantly lower following IR-injury in comparison to all other time points with BRplacebo (early FMD 2.51 ± 1.18%, late FMD 1.30 ± 1.10, p < 0.001) and was lower than post-IR with BRnitrate (early FMD 3.84 ± 1.21%, late FMD 3.21 ± 1.13%, p = 0.014). A single dose of BRnitrate significantly increased resting macrovascular function in the late postmenopausal group only (p = 0.005). Considering the postmenopausal stage-dependent variations in endothelial responsiveness to dietary nitrate, we predict differing mechanisms underpin macrovascular protection against IR injury.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"634-647"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of concern: Acrolein induces apoptosis through the death receptor pathway in A549 lung cells: role of p53. 表达关切：丙烯醛通过死亡受体途径诱导 A549 肺细胞凋亡：p53 的作用。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-11-01 Epub Date: 2024-07-19 DOI: 10.1139/cjpp-2024-0220

引用次数: 0

Echocardiographic assessment of epicardial adipose tissue thickness as independent predictor in coronary artery disease. 超声心动图评估心外膜脂肪组织厚度作为冠状动脉疾病的独立预测指标

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-11-01 Epub Date: 2024-09-03 DOI: 10.1139/cjpp-2024-0188

Laurentiu Braescu, Adrian Sturza, Raluca Sosdean, Oana Maria Aburel, Mihai Andrei Lazar, Danina Muntean, Constantin Tudor Luca, Daniel Miron Brie, Horea Feier, Simina Crisan, Cristian Mornos

{"title":"Echocardiographic assessment of epicardial adipose tissue thickness as independent predictor in coronary artery disease.","authors":"Laurentiu Braescu, Adrian Sturza, Raluca Sosdean, Oana Maria Aburel, Mihai Andrei Lazar, Danina Muntean, Constantin Tudor Luca, Daniel Miron Brie, Horea Feier, Simina Crisan, Cristian Mornos","doi":"10.1139/cjpp-2024-0188","DOIUrl":"10.1139/cjpp-2024-0188","url":null,"abstract":"This study aimed to assess the utility of echocardiography-measured epicardial adipose tissue (EAT) thickness (EATT) as an independent predictor for coronary artery disease (CAD), examining its correlation with oxidative stress levels in epicardial tissue and the complexity of the disease in patients undergoing open-heart surgery. This study included a total of 25 patients referred for cardiac surgery with 14 in the CAD group and 11 in the non-CAD group. Epicardial fat was sampled from patients subjected to open-heart surgery. EATT was higher in the CAD group compared to the non-CAD group (8.15 ± 2.09 mm vs. 5.12 ± 1.8 mm, p = 0.001). The epicardial reactive oxygen species level was higher in the CAD group compared to the non-CAD group (21.4 ± 2.47 nmol H2O2/g tisssue/h vs. 15.7 ± 1.55 nmol H2O2/g tisssue/h, p < 0.001). EATT greater than 6.05 mm was associated with CAD, with a sensitivity of 86% and specificity of 73%. Echocardiographically measured EATT is a significant, independent predictor of CAD. Its relationship with increased EAT oxidative stress levels suggests a potential mechanistic link between EATT and CAD pathogenesis. These findings highlight the importance of EATT as a diagnostic tool in assessing the complexity of CAD in patients undergoing cardiac surgery.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"648-660"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142124913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0