Canadian journal of physiology and pharmacology最新文献_第5页

The acute effects of dietary nitrate supplementation on postmenopausal endothelial resistance to ischemia reperfusion injury: a randomized, placebo-controlled, double blind, crossover clinical trial. 膳食硝酸盐补充剂对绝经后血管内皮抵抗缺血再灌注损伤的急性影响：一项随机、安慰剂对照、双盲、交叉临床试验。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-11-01 Epub Date: 2024-06-20 DOI: 10.1139/cjpp-2024-0061

Jocelyn M Delgado Spicuzza, Jigar Gosalia, Matthew Studinski, Chenée Armando, Elmira Alipour, Daniel B Kim-Shapiro, Michael Flanagan, Yasina B Somani, David N Proctor

{"title":"The acute effects of dietary nitrate supplementation on postmenopausal endothelial resistance to ischemia reperfusion injury: a randomized, placebo-controlled, double blind, crossover clinical trial.","authors":"Jocelyn M Delgado Spicuzza, Jigar Gosalia, Matthew Studinski, Chenée Armando, Elmira Alipour, Daniel B Kim-Shapiro, Michael Flanagan, Yasina B Somani, David N Proctor","doi":"10.1139/cjpp-2024-0061","DOIUrl":"10.1139/cjpp-2024-0061","url":null,"abstract":"Postmenopausal cardiovascular health is a critical determinant of longevity. Consumption of beetroot juice (BR) and other nitrate-rich foods is a safe, effective non-pharmaceutical intervention to increase systemic bioavailability of the vasoprotective molecule, nitric oxide, through the exogenous nitrate (NO3 -)-nitrite (NO2 -)-nitric oxide (NO) pathway. We hypothesized that a single dose of nitrate-rich beetroot juice (BRnitrate 600 mg NO3 -/140 mL, BRplacebo ∼ 0 mg/140 mL) would improve resting endothelial function and resistance to ischemia-reperfusion (IR) injury to a greater extent in early-postmenopausal (1-6 years following their final menstrual period (FMP), n = 12) compared to late-postmenopausal (6+ years after FMP, n = 12) women. Analyses with general linear models revealed a significant (p < 0.05) time*treatment interaction effect for brachial artery adjusted flow-mediated dilation (FMD). Pairwise comparisons revealed that adjusted FMD was significantly lower following IR-injury in comparison to all other time points with BRplacebo (early FMD 2.51 ± 1.18%, late FMD 1.30 ± 1.10, p < 0.001) and was lower than post-IR with BRnitrate (early FMD 3.84 ± 1.21%, late FMD 3.21 ± 1.13%, p = 0.014). A single dose of BRnitrate significantly increased resting macrovascular function in the late postmenopausal group only (p = 0.005). Considering the postmenopausal stage-dependent variations in endothelial responsiveness to dietary nitrate, we predict differing mechanisms underpin macrovascular protection against IR injury.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"634-647"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of concern: Acrolein induces apoptosis through the death receptor pathway in A549 lung cells: role of p53. 表达关切：丙烯醛通过死亡受体途径诱导 A549 肺细胞凋亡：p53 的作用。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-11-01 Epub Date: 2024-07-19 DOI: 10.1139/cjpp-2024-0220

引用次数: 0

Echocardiographic assessment of epicardial adipose tissue thickness as independent predictor in coronary artery disease. 超声心动图评估心外膜脂肪组织厚度作为冠状动脉疾病的独立预测指标

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-11-01 Epub Date: 2024-09-03 DOI: 10.1139/cjpp-2024-0188

Laurentiu Braescu, Adrian Sturza, Raluca Sosdean, Oana Maria Aburel, Mihai Andrei Lazar, Danina Muntean, Constantin Tudor Luca, Daniel Miron Brie, Horea Feier, Simina Crisan, Cristian Mornos

{"title":"Echocardiographic assessment of epicardial adipose tissue thickness as independent predictor in coronary artery disease.","authors":"Laurentiu Braescu, Adrian Sturza, Raluca Sosdean, Oana Maria Aburel, Mihai Andrei Lazar, Danina Muntean, Constantin Tudor Luca, Daniel Miron Brie, Horea Feier, Simina Crisan, Cristian Mornos","doi":"10.1139/cjpp-2024-0188","DOIUrl":"10.1139/cjpp-2024-0188","url":null,"abstract":"This study aimed to assess the utility of echocardiography-measured epicardial adipose tissue (EAT) thickness (EATT) as an independent predictor for coronary artery disease (CAD), examining its correlation with oxidative stress levels in epicardial tissue and the complexity of the disease in patients undergoing open-heart surgery. This study included a total of 25 patients referred for cardiac surgery with 14 in the CAD group and 11 in the non-CAD group. Epicardial fat was sampled from patients subjected to open-heart surgery. EATT was higher in the CAD group compared to the non-CAD group (8.15 ± 2.09 mm vs. 5.12 ± 1.8 mm, p = 0.001). The epicardial reactive oxygen species level was higher in the CAD group compared to the non-CAD group (21.4 ± 2.47 nmol H2O2/g tisssue/h vs. 15.7 ± 1.55 nmol H2O2/g tisssue/h, p < 0.001). EATT greater than 6.05 mm was associated with CAD, with a sensitivity of 86% and specificity of 73%. Echocardiographically measured EATT is a significant, independent predictor of CAD. Its relationship with increased EAT oxidative stress levels suggests a potential mechanistic link between EATT and CAD pathogenesis. These findings highlight the importance of EATT as a diagnostic tool in assessing the complexity of CAD in patients undergoing cardiac surgery.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"648-660"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142124913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction: β-arrestin-1 mediates the endothelin-1-induced activation of Akt and integrin-linked kinase. 撤稿：β-arrestin-1 介导内皮素-1 诱导的 Akt 和整合素连接激酶活化。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-11-01 Epub Date: 2024-08-23 DOI: 10.1139/cjpp-2024-0265

引用次数: 0

Agonists, inverse agonists, and antagonists as therapeutic approaches to manipulate retinoic acid-related orphan receptors. 将激动剂、反向激动剂和拮抗剂作为操控维甲酸相关孤儿受体 (ROR) 的治疗方法。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-11-01 Epub Date: 2024-05-10 DOI: 10.1139/cjpp-2024-0099

Darya Nematisouldaragh, Huong Nguyen, Inna Rabinovich-Nikitin

{"title":"Agonists, inverse agonists, and antagonists as therapeutic approaches to manipulate retinoic acid-related orphan receptors.","authors":"Darya Nematisouldaragh, Huong Nguyen, Inna Rabinovich-Nikitin","doi":"10.1139/cjpp-2024-0099","DOIUrl":"10.1139/cjpp-2024-0099","url":null,"abstract":"Retinoic acid-related orphan receptors (RORs) serve as transcription factors that play a pivotal role in a myriad of physiological processes within the body. Their involvement extends to critical biological processes that confer protective effects in the heart, immune system, and nervous system, as well as contributing to the mitigation of several aggressive cancer types. These protective functions are attributed to ROR's regulation of key proteins and the management of various cellular processes, including autophagy, mitophagy, inflammation, oxidative stress, and glucose metabolism, highlighting the emerging need for pharmacological approaches to modulate ROR expression. Thus, the modulation of RORs is a rapidly growing area of research aimed not only at comprehending these receptors, but also at manipulating them to attain the desired physiological response. Despite the presence of natural ROR ligands, the development of synthetic agonists with high selectivity for these receptors holds substantial therapeutic potential. The exploration and advancement of such compounds can effectively target diseases associated with ROR dysregulation, thereby providing avenues for therapeutic interventions. Herein, we provide a comprehensive examination of the multifaceted role of ROR in diverse physiological and pathophysiological conditions, accompanied by an in-depth exploration of a spectrum of ROR agonists, inverse agonists, and antagonists.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"620-633"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140903907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Canadian Society of Pharmacology and Therapeutics. 加拿大药理学和治疗学学会。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-10-01 DOI: 10.1139/cjpp-2024-0260

引用次数: 0

Oral hormonal contraceptives and cardiovascular risks in females. 口服荷尔蒙避孕药与女性心血管风险。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-10-01 Epub Date: 2024-05-23 DOI: 10.1139/cjpp-2024-0041

Sukhwinder K Bhullar, Inna Rabinovich-Nikitin, Lorrie A Kirshenbaum

{"title":"Oral hormonal contraceptives and cardiovascular risks in females.","authors":"Sukhwinder K Bhullar, Inna Rabinovich-Nikitin, Lorrie A Kirshenbaum","doi":"10.1139/cjpp-2024-0041","DOIUrl":"10.1139/cjpp-2024-0041","url":null,"abstract":"Oral hormonal contraception (OHC) is a widely employed method in females for the prevention of unintended pregnancies, as well as for the treatment of menstrual disorders, endometriosis, and polycystic ovarian syndrome. However, it is believed that with OHCs use, some females may have higher risk of cardiovascular diseases, such as hypertension, diabetes, myocardial infarction, thrombosis, and heart failure. Although such risks are infrequently detected in healthy young females with the use of oral contraceptives, slightly elevated risks of cardiovascular diseases have been observed among reproductive-aged healthy females. However, prolonged use of OHC has also been claimed to have protective cardiac effects and may contribute to reduced risk of cardiovascular disease. In fact, the debate on whether OHC administration increases the risk of cardiovascular diseases has been ongoing with inconsistent and controversial viewpoints. Nevertheless, a great deal of work has been carried out to understand the relationship between OHC use and the occurrence of cardiovascular risk in females who use OHC for preventing the unwanted pregnancy or treatment of other disorders. Therefore, in this review we summarize the most recent available evidence regarding the association between the use of oral hormonal contraceptives and the risk for cardiovascular disease in females who are using OHC to prevent unintended pregnancy.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"572-584"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141086886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of biological sex on valvular heart disease, interventions, and outcomes. 生理性别对瓣膜性心脏病、干预措施和结果的影响。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-10-01 Epub Date: 2024-03-01 DOI: 10.1139/cjpp-2023-0390

Evan J Wiens, Kristal Kawa, Malek Kass, Ashish H Shah

{"title":"Impact of biological sex on valvular heart disease, interventions, and outcomes.","authors":"Evan J Wiens, Kristal Kawa, Malek Kass, Ashish H Shah","doi":"10.1139/cjpp-2023-0390","DOIUrl":"10.1139/cjpp-2023-0390","url":null,"abstract":"Valvular heart disease (VHD) is common, affecting >14% of individuals aged >75, and is associated with morbidity, including heart failure and arrhythmia, and risk of early mortality. Increasingly, important sex differences are being found between males and females with VHD. These sex differences can involve the epidemiology, pathophysiology, presentation, diagnosis, and outcomes of the disease. Females are often disadvantaged, and female sex has been shown to be associated with delayed diagnosis and inferior outcomes in various forms of VHD. In addition, the unique pathophysiologic state of pregnancy is associated with increased risk for maternal and fetal morbidity and mortality in many forms of VHD. Therefore, understanding and recognizing these sex differences, and familiarity with the attendant risks of pregnancy and management of pregnant females with VHD, is of great importance for any primary care or cardiovascular medicine practitioner caring for the female patient. This review will outline sex differences in aortic, mitral, pulmonic, and tricuspid VHD, with particular focus on differences in pathophysiology, clinical presentation, and outcomes. In addition, the pathophysiology and management implications of pregnancy will be discussed.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"585-593"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140012214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac physiology and pathophysiology in pregnancy. 妊娠期心脏生理学和病理生理学。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-10-01 Epub Date: 2024-05-30 DOI: 10.1139/cjpp-2024-0010

Shekoofeh Saboktakin Rizi, Evan Wiens, Jennifer Hunt, Robin Ducas

引用次数: 0

Coronary microvascular disease in women: epidemiology, mechanisms, evaluation, and treatment. 女性冠状动脉微血管疾病：流行病学、机制、评估和治疗。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-10-01 Epub Date: 2024-05-10 DOI: 10.1139/cjpp-2023-0414

Rebecca S Steinberg, Anamaria Dragan, Puja K Mehta, Olga Toleva

{"title":"Coronary microvascular disease in women: epidemiology, mechanisms, evaluation, and treatment.","authors":"Rebecca S Steinberg, Anamaria Dragan, Puja K Mehta, Olga Toleva","doi":"10.1139/cjpp-2023-0414","DOIUrl":"10.1139/cjpp-2023-0414","url":null,"abstract":"Coronary microvascular dysfunction (CMD) involves functional or structural abnormalities of the coronary microvasculature resulting in dysregulation of coronary blood flow (CBF) in response to myocardial oxygen demand. This perfusion mismatch causes myocardial ischemia, which manifests in patients as microvascular angina (MVA). CMD can be diagnosed non-invasively via multiple imaging techniques or invasively using coronary function testing (CFT), which assists in determining the specific mechanisms involving endothelium-independent and dependent epicardial and microcirculation domains. Unlike traditional coronary artery disease (CAD), CMD can often occur in patients without obstructive atherosclerotic epicardial disease, which can make the diagnosis of CMD difficult. Moreover, MVA due to CMD is more prevalent in women and carries increased risk of future cardiovascular events. Successful treatment of symptomatic CMD is often patient-specific risk factor and endotype targeted. This article aims to review newly identified mechanisms and novel treatment strategies for managing CMD, and outline sex-specific differences in the presentation and pathophysiology of the disease.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"594-606"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140903910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0