Canadian journal of physiology and pharmacology最新文献_第7页

Epigenetic regulation of sex dimorphism in cardiovascular health. 心血管健康中性别二形性的表观遗传调控。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-09-01 Epub Date: 2024-03-01 DOI: 10.1139/cjpp-2023-0406

Charan Thej, Raj Kishore

{"title":"Epigenetic regulation of sex dimorphism in cardiovascular health.","authors":"Charan Thej, Raj Kishore","doi":"10.1139/cjpp-2023-0406","DOIUrl":"10.1139/cjpp-2023-0406","url":null,"abstract":"Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality, affecting people of all races, ages, and sexes. Substantial sex dimorphism exists in the prevalence, manifestation, and outcomes of CVDs. Understanding the role of sex hormones as well as sex-hormone-independent epigenetic mechanisms could play a crucial role in developing effective and sex-specific cardiovascular therapeutics. Existing research highlights significant disparities in sex hormones, epigenetic regulators, and gene expression related to cardiac health, emphasizing the need for a nuanced understanding of these variations between men and women. Despite these differences, current treatment approaches for CVDs often lack sex-specific considerations. A pivotal shift toward personalized medicine, informed by comprehensive insights into sex-specific DNA methylation, histone modifications, and non-coding RNA dynamics, holds the potential to revolutionize CVD management. By understanding sex-specific epigenetic complexities, independent of sex hormone influence, future cardiovascular research can be tailored to achieve effective diagnostic and therapeutic interventions for both men and women. This review summarizes the current knowledge and gaps in epigenetic mechanisms and sex dimorphism implicated in CVDs.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"498-510"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140012213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing feasibility and sex-related inequity in the cardiac rehabilitation quality indicators in Manitoba. 评估马尼托巴省心脏康复质量指标的可行性和与性别相关的不平等。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-09-01 Epub Date: 2024-06-25 DOI: 10.1139/cjpp-2024-0076

Jacqueline L Hay, Gerren K D McDonald, Robert Pryce, Gordon G Giesbrecht, Sue Boreskie, Todd A Duhamel

{"title":"Assessing feasibility and sex-related inequity in the cardiac rehabilitation quality indicators in Manitoba.","authors":"Jacqueline L Hay, Gerren K D McDonald, Robert Pryce, Gordon G Giesbrecht, Sue Boreskie, Todd A Duhamel","doi":"10.1139/cjpp-2024-0076","DOIUrl":"10.1139/cjpp-2024-0076","url":null,"abstract":"The cardiac rehabilitation quality indicators (CRQIs) developed by the Canadian Cardiovascular Society provide a means to standardize program assessment and identify sex-related inequities. No formal evaluation of the CRQIs has been conducted in Manitoba. An environmental scan for the CRQIs was performed using data in the electronic medical record at two cardiac rehabilitation (CR) sites in Winnipeg for 2016-2019 referrals. Of the 8116 referrals, 7758 (5491 males and 2267 females) had geographical access and were eligible for CR. The Manitoba Centre for Health Policy Data Quality Framework informed the data quality assessment. Thirteen CRQIs were available; four were considered high quality; nine demonstrated moderate to significant missing data. In addition to missing values, potential misclassification of risk (CR-4) and physiologically implausible and invalid dates were assessed and identified (CR-13 and CR-17). Each site had a physician medical director (CR-31) and a documented emergency response strategy (CR-32). Only high-quality data were evaluated for sex-related differences using chi-square and median tests. Women had lower enrollment (CR-3), and more women enrolled after the median of 41 days (CR-2b). Engagement with CR partners, including frontline staff, and utilizing strategies to assess and limit physiologically implausible values and dates will enhance data capture and quality.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"538-551"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of estrogen on myocardial post-translational modifications and cardiac function in women. 雌激素对女性心肌翻译后修饰和心功能的影响

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-08-01 Epub Date: 2024-01-24 DOI: 10.1139/cjpp-2023-0412

Samantha K Shorthill, Timothy L M Jones, Kathleen C Woulfe, Brian D Cherrington, Danielle R Bruns

{"title":"The influence of estrogen on myocardial post-translational modifications and cardiac function in women.","authors":"Samantha K Shorthill, Timothy L M Jones, Kathleen C Woulfe, Brian D Cherrington, Danielle R Bruns","doi":"10.1139/cjpp-2023-0412","DOIUrl":"10.1139/cjpp-2023-0412","url":null,"abstract":"The lifetime risk of heart failure (HF) is comparable in men and women; nevertheless, disparities exist in our understanding of how HF differs between sexes. Several differences in cardiac physiology exist between men and women including the propensity to develop specific HF phenotypes. Men are more likely to be diagnosed with HF failure with reduced ejection fraction, while women have a greater propensity to develop HF with preserved ejection fraction. The mechanisms responsible for these differences remain unclear. Post-translational modifications (PTMs) of myofilament proteins likely contribute to these sex-specific propensities. The role of PTMs in heart disease is an expanding field with immense potential therapeutic targets. However, numerous PTMs remain underexplored, particularly in the context of the female heart. Estrogen, a key gonadal hormone, cardioprotective in pre-menopausal women and its loss with menopause likely contributes to disease in aging women. However, how estrogen regulates PTMs to contribute to HF development is not fully clear. This review outlines key sex differences in HF along with characterizing the contributions of novel myocardial PTMs in cardiac physiology and their regulation by estrogen. Collectively, we highlight the necessity for further investigation into women's heart health and the distinctive mechanisms distinguishing women from men.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"452-464"},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139545818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HFpEF and sex: understanding the role of sex differences. "高频低氧血症与性别：了解性别差异的作用"。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-08-01 Epub Date: 2024-03-06 DOI: 10.1139/cjpp-2023-0403

Yuliia Smereka, Justin A Ezekowitz

{"title":"HFpEF and sex: understanding the role of sex differences.","authors":"Yuliia Smereka, Justin A Ezekowitz","doi":"10.1139/cjpp-2023-0403","DOIUrl":"10.1139/cjpp-2023-0403","url":null,"abstract":"Heart failure is a complex clinical syndrome with many etiological factors and complex pathophysiology affecting millions worldwide. Males and females can have distinct clinical presentation and prognosis, and there is an emerging understanding of the factors that highlight the similarities and differences to synthesize and present available data for sex-specific differences in heart failure with preserved ejection fraction (HFpEF). While the majority of data demonstrate more similarities than differences between females and males in terms of heart failure, there are key differences. Data showed that females have a higher risk of developing HFpEF, but a lower risk of mortality and hospitalization. This can be conditioned by different profiles of comorbidities, postmenopausal changes in sex hormone levels, higher levels of inflammation and chronic microvascular dysfunction in females. These factors, combined with different left ventricular dimensions and function, which are more pronounced with age, lead to a higher prevalence of LV diastolic dysfunction at rest and exercise. As a result, females have lower exercise capacity and quality of life when compared to males. Females also have different activities of systems responsible for drug transformation, leading to different efficacy of drugs as well as higher risk of adverse drug reactions. These data prove the necessity for creating sex-specific risk stratification scales and treatment plans.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"465-475"},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140048854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engaging women in decision-making about their heart health: a literature review with patients' perspective. 让女性参与有关心脏健康的决策：从患者角度进行文献综述。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-08-01 Epub Date: 2024-05-30 DOI: 10.1139/cjpp-2023-0471

Alexandra Bastiany, Cindy Towns, Donna May Kimmaliardjuk, Cindy Z Kalenga, Sonya N Burgess

{"title":"Engaging women in decision-making about their heart health: a literature review with patients' perspective.","authors":"Alexandra Bastiany, Cindy Towns, Donna May Kimmaliardjuk, Cindy Z Kalenga, Sonya N Burgess","doi":"10.1139/cjpp-2023-0471","DOIUrl":"10.1139/cjpp-2023-0471","url":null,"abstract":"Cardiovascular disease (CVD) remains the leading cause of death globally. Although the burden of CVD risk factors tends to be lower in women, they remain at higher risk of developing complications when affected by these risk factors. There is still a lack of awareness surrounding CVD in women, both from a patient's and a clinician's perspective, especially among visible minorities. However, women who are informed about their heart health and who engage in decision-making with their healthcare providers are more likely to modify their lifestyle, and improve their CVD risk. A patient-centered care approach benefits patients' physical and mental health, and is now considered gold-standard for efficient patient care. Engaging women in their heart health will contribute in closing the gap of healthcare disparities between men and women, arising from sociocultural, socioeconomic, and political factors. This comprehensive review of the literature discusses the importance of engaging women in decision-making surrounding their heart health and offers tools for an effective and culturally sensitive patient-provider relationship.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"431-441"},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141178535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction-Unveiling gender disparity in heart disease. 导言--揭示心脏病的性别差异。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-08-01 DOI: 10.1139/cjpp-2024-0239

Inna Rabinovich-Nikitin, Shuangbo Liu, Lorrie A Kirshenbaum

引用次数: 0

Sex-specific effects of frailty on cardiac structure and function: insights from preclinical models. 虚弱对心脏结构和功能的性别特异性影响：临床前模型的启示

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-08-01 Epub Date: 2024-03-15 DOI: 10.1139/cjpp-2024-0009

Elise S Bisset, Susan E Howlett

{"title":"Sex-specific effects of frailty on cardiac structure and function: insights from preclinical models.","authors":"Elise S Bisset, Susan E Howlett","doi":"10.1139/cjpp-2024-0009","DOIUrl":"10.1139/cjpp-2024-0009","url":null,"abstract":"Advanced age is an independent risk factor for cardiovascular diseases in both sexes. This is thought to be due, in part, to age-dependent cellular, structural, and functional changes in the heart, a process known as cardiac aging. An emerging view is that cardiac aging leads to the accumulation of cellular and subcellular deficits that increase susceptibility to cardiovascular diseases. Still, people age at different rates, with those aging rapidly considered frail. Evidence suggests that frailty, rather than simply age, is a major risk factor for cardiovascular disease and predicts adverse outcomes in those affected. Recent studies in mouse models of frailty show that many adverse changes associated with cardiac aging are more prominent in mice with a high degree of frailty. This suggests that frailty sets the stage for late life cardiovascular diseases to flourish and raises the possibility that treating frailty may treat cardiovascular diseases. These studies show that ventricular dysfunction increases with frailty in males only, whereas atrial dysfunction increases with frailty in both sexes. These results may shed light on the reasons that men and women can be susceptible to different cardiovascular diseases as they age, and why frail individuals are especially vulnerable to these disorders.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"476-486"},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140136505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular and physiological risk factors in women at mid-life and beyond. 中年及中年以后妇女的心血管和生理风险因素。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-08-01 Epub Date: 2024-05-13 DOI: 10.1139/cjpp-2023-0468

Yenny A Rodriguez de Morales, Beth L Abramson

{"title":"Cardiovascular and physiological risk factors in women at mid-life and beyond.","authors":"Yenny A Rodriguez de Morales, Beth L Abramson","doi":"10.1139/cjpp-2023-0468","DOIUrl":"10.1139/cjpp-2023-0468","url":null,"abstract":"Cardiovascular disease (CVD) is the leading cause of death in women. After menopause, sex-specific and gender-specific factors may play an important role in increasing CVD risk, with changes in sex hormones, body fat distribution, lipid and metabolic profile, and structural and functional vascular modifications. Premature and early-onset menopause are detrimental to cardiovascular health due to the early cessation of the protective effect of endogenous estrogen. An independent association of menopause with an increased risk of CVD has been documented in early menopause (<45 years). Sex-related differences are relevant in pharmacokinetics and pharmacodynamics; different enzyme formations, drug compatibility, efficacy, and side effects vary for different sexes. Despite some progress in sex and gender research in CVD, disparities remain. Menopausal hormone therapy (MHT) is available at mid-life for symptoms of menopause and may impact cardiovascular risk. Taken early, MHT may reduce CVD morbimortality. However, this is balanced against the risk of increased thrombosis. This paper reviews physiologic changes that contribute to cardiovascular risk in postmenopausal women and discusses clinical implications. Specifically, it explores the atheroprotective effects of estrogen and MHT and the associations between menopause with lipid levels, hypertension, body composition, and diabetes for women at mid-life and beyond.","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":"442-451"},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140915913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the molecular landscape of kAE1: a narrative review. 揭开 kAE1 的分子图谱：叙述性综述。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-07-01 Epub Date: 2024-04-26 DOI: 10.1139/cjpp-2023-0482

Priyanka Mungara, Moubarak Waiss, Sunny Hartwig, Dylan Burger, Emmanuelle Cordat

引用次数: 0

Correction: Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1channels. 更正：甲状腺功能亢进导致的大鼠心肌肥大：ATF-6和TRPC1通道的作用。

IF 1.7 4区医学

Canadian journal of physiology and pharmacology Pub Date : 2024-07-01 Epub Date: 2024-06-06 DOI: 10.1139/cjpp-2024-0182

Nuriye Ezgi Bektur Aykanat, Erhan Şahin, Sedat Kaçar, Rıdvan Bağcı, Şerife Karakaya, Dilek Burukoğlu Dönmez, Varol Şahintürk

引用次数: 0