Burger's Medicinal Chemistry and Drug Discovery最新文献_第5页

Burger's Medicinal Chemistry and Drug Discovery Pub Date : 2021-04-26 DOI: 10.1002/0471266949.bmc032.pub3

K. P. Cole

引用次数: 0

Drug Discovery and Development for Kinetoplastid Diseases 动着质体疾病的药物发现与开发

Burger's Medicinal Chemistry and Drug Discovery Pub Date : 2021-04-26 DOI: 10.1002/0471266949.BMC235.PUB2

C. Caffrey, D. Steverding, R. S. Ferreira, R. B. Oliveira, A. O’Donoghue, Ludovica Monti, C. Ballatore, K. Bachovchin, Lori Ferrins, M. Pollastri, Kimberley M. Zorn, Daniel H. Foil, A. Clark, M. Mottin, C. Andrade, J. Siqueira-Neto, S. Ekins

引用次数: 5

New and Emerging Antiepileptic Drugs 新出现的抗癫痫药物

Burger's Medicinal Chemistry and Drug Discovery Pub Date : 2021-04-26 DOI: 10.1002/0471266949.bmc099.pub3

J. Witkin, L. Golani, Jodi L. Smith

引用次数: 1

Drug Discovery Beyond the Rule of Five 超越五法则的药物发现

Burger's Medicinal Chemistry and Drug Discovery Pub Date : 2021-04-26 DOI: 10.1002/0471266949.BMC258

D. DeGoey, Philip B Cox

引用次数: 0

Health Outcomes Research 健康结果研究

Burger's Medicinal Chemistry and Drug Discovery Pub Date : 2021-04-26 DOI: 10.1002/0471266949.BMC257

P. McCollam, J. Birt, Theresa Hunter

引用次数: 0

Ion Channels as Therapeutic Drug Targets 离子通道作为治疗药物靶点

Burger's Medicinal Chemistry and Drug Discovery Pub Date : 2021-04-26 DOI: 10.1002/0471266949.BMC255

M. L. García, G. Kaczorowski

引用次数: 1

Medicinal Chemical Biology 药物化学生物学

Burger's Medicinal Chemistry and Drug Discovery Pub Date : 2021-04-22 DOI: 10.1002/0471266949.bmc256

L. Jones

引用次数: 0

The Blood–Brain Barrier and CNS Drug Delivery 血脑屏障与中枢神经系统药物传递

Burger's Medicinal Chemistry and Drug Discovery Pub Date : 2021-04-22 DOI: 10.1002/0471266949.BMC285

W. Banks

{"title":"The Blood–Brain Barrier and CNS Drug Delivery","authors":"W. Banks","doi":"10.1002/0471266949.BMC285","DOIUrl":"https://doi.org/10.1002/0471266949.BMC285","url":null,"abstract":"The blood–brain barriers (BBBs) act as the guardians and as the slaves to the rest of the central nervous system (CNS). By preventing the unrestricted leakage typical of most capillary beds, the vascular BBB then engages in CNS-blood exchanges that are largely regulated in ways not typical in other tissue beds. Thus, the BBBs are not simply barriers, but interfaces that are also endowed with roles that include nutrition, homeostasis, and communication [1]. The barriers adapt to the needs of the CNS, changing with maturation, aging, and in response to environmental challenges. The barriers also adapt or attempt to do so in the face of pathological states and can themselves be the target or the cause of diseases, both peripheral and central. This varied and complex interface provides the basis for a nuanced approach to drug delivery to the CNS. An understanding of the underlying ways in which the BBBs make their livings and serve the CNS provide many different rational approaches to the development of therapeutics that can influence the CNS. As this article will illustrate, these strategies typically involve the delivery of substances from the blood to the brain. But this article will also consider other viable approaches which in some cases do not require the xenobiotic to cross the BBB, such as the blockade of substances that would otherwise cross the BBB (resulting in an antagonist effect), the induction of the release of secondary agents from the abluminal side of barrier tissues, and the modulation of transporter functions. The vascular BBB, in general, and its use in CNS drug delivery in particular is a poorly studied area. Yet, it is much better understood than the other barrier systems, such as the blood-cerebrospinal fluid barrier (BCSFB), the tanycytic barrier, or the blood–retinal barrier. As such, most of this article will emphasize the vascular barrier. However, these other barriers likely follow similar concepts and, with further study, will yield treasure troves of mechanisms and pathways unique to them and useful for the development of therapeutic agents that impact the CNS.","PeriodicalId":9514,"journal":{"name":"Burger's Medicinal Chemistry and Drug Discovery","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80370675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Current Status of Approaches to Eradicate HIV Infection 根除艾滋病毒感染方法的现状

Burger's Medicinal Chemistry and Drug Discovery Pub Date : 2021-01-01 DOI: 10.1002/0471266949.bmc281

S. Wolkenberg, Abdellatif El Marrouni, A. Converso, D. Tellers, Richard J. O. Barnard, Tracy L. Diamond

引用次数: 0

Preparative Chromatography for Production 生产用制备色谱法

Burger's Medicinal Chemistry and Drug Discovery Pub Date : 2021-01-01 DOI: 10.1002/0471266949.bmc275

O. Dapremont

{"title":"Preparative Chromatography for Production","authors":"O. Dapremont","doi":"10.1002/0471266949.bmc275","DOIUrl":"https://doi.org/10.1002/0471266949.bmc275","url":null,"abstract":"From a very simple process like sieving to a more complex one such as petrol fractionation by distillation, separations techniques are an essential tool for chemists and chemical engineers to achieve purity. However, every unit operation must be understood thoroughly so it can be used to its fullest potential. Once the science behind the process is understood, then improvements can be imagined, designed, and implemented. Unfortunately, some techniques are rarely used despite their proven performance due to a fundamental lack of understanding. Preparative chromatography is one of these underappreciated techniques. Despite significant improvements in the technology over several decades, this powerful unit operation is still underutilized especially in the pharmaceutical industry. This article provides an overview of preparative chromatography as a unit operation and show how this process, when optimized, can provide a significant cost improvement to a chemical process. The focus is mostly on the use of preparative chromatography, batch and continuous, for small molecule active pharmaceutical ingredients (APIs), however the technique is successfully used in a vast range of applications from the purification of molasses at very large scale to the petroleum industry. In a first part, a short overview of the history of the technique is presented. Focus is placed on the understanding of the process resulting in very powerful computer modeling tools that can be used to compare the process to other techniques. Finally, the development of the process for an API from the early clinical stage to the commercial manufacturing is discussed and the implantation at industrial scale is featured. It is assumed that the reader is familiar with analytical chromatography and basic chromatographic concepts such as retention time, selectivity, resolution, and column efficiency. If the reader is not familiar with these notions we recommend references [1–3].","PeriodicalId":9514,"journal":{"name":"Burger's Medicinal Chemistry and Drug Discovery","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85021913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0