C. Caffrey, D. Steverding, R. S. Ferreira, R. B. Oliveira, A. O’Donoghue, Ludovica Monti, C. Ballatore, K. Bachovchin, Lori Ferrins, M. Pollastri, Kimberley M. Zorn, Daniel H. Foil, A. Clark, M. Mottin, C. Andrade, J. Siqueira-Neto, S. Ekins
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引用次数: 5
摘要
我们对着丝质体的疾病、生物学和生物化学以及近十年来进入临床的新药和候选药物进行了综述。我们还描述了针对各种蛋白质靶点的小分子临床前探索的例子，(例如，半胱氨酸蛋白酶，蛋白酶体和微管蛋白)，以及尖端的分子和计算策略，以及用于发现和开发新的抗锥虫药物的技术。对于2011年之前的疾病、生物学和药物治疗的全面描述，鼓励读者阅读pm这篇文章于2010年发表在第七版的《Burger’s Medicinal Chemistry, Drug Discovery, and Development》杂志上，题目是Antiprotozoal/ antiparasite Agents。
Drug Discovery and Development for Kinetoplastid Diseases
We review the disease, biology and biochemistry of kinetoplastids, as well as the new drugs and drug candidates that have entered the clinic in the last decade. We also describe examples of the pre-clinical exploration of small molecules against various protein targets, (e.g., cysteine proteases, the proteasome and tubulin), as well as cutting-edge molecular and computational strategies, and technologies being brought to bear to discover and develop new anti-trypanosomal drugs. For comprehensive descriptions of the disease, biology and drug therapies prior to 2011, the reader is encouraged to review the chapter by P.M. Woster that appeared in 2010 in the seventh edition of Burger’s Medicinal Chemistry, Drug Discovery, and Development, with the title Antiprotozoal/Antiparasitic Agents.
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