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Burger's Medicinal Chemistry and Drug Discovery最新文献

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Advances in NMR ‐based Characterization of Drug Substances, Impurities, Degradants, and Drug Metabolites 基于NMR表征原料药、杂质、降解物和药物代谢物的研究进展
Burger's Medicinal Chemistry and Drug Discovery Pub Date : 2021-04-27 DOI: 10.1002/0471266949.BMC302
J. Saurí, M. Reibarkh, R. Williamson, G. Martin
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引用次数: 0
Allosterism and Drug Discovery 变构和药物发现
Burger's Medicinal Chemistry and Drug Discovery Pub Date : 2021-04-27 DOI: 10.1002/0471266949.BMC299
J. Bell, J. Bell
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引用次数: 0
Docking, Scoring, and Virtual Screening in Drug Discovery 药物发现中的对接、评分和虚拟筛选
Burger's Medicinal Chemistry and Drug Discovery Pub Date : 2021-04-27 DOI: 10.1002/0471266949.BMC301
F. Spyrakis, Aurijit Sarkar, G. Kellogg
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引用次数: 0
2010 to 2020: Ten Years of Malaria Drug Discovery 2010年至2020年:疟疾药物发现的十年
Burger's Medicinal Chemistry and Drug Discovery Pub Date : 2021-04-26 DOI: 10.1002/0471266949.BMC234.PUB2
B. Yeung, Félix Calderón
{"title":"2010 to 2020: Ten Years of Malaria Drug Discovery","authors":"B. Yeung, Félix Calderón","doi":"10.1002/0471266949.BMC234.PUB2","DOIUrl":"https://doi.org/10.1002/0471266949.BMC234.PUB2","url":null,"abstract":"","PeriodicalId":9514,"journal":{"name":"Burger's Medicinal Chemistry and Drug Discovery","volume":"42 1","pages":"1-38"},"PeriodicalIF":0.0,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79327438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medicinal Chemistry of β‐Lactam Antibiotics β -内酰胺类抗生素的药物化学
Burger's Medicinal Chemistry and Drug Discovery Pub Date : 2021-04-26 DOI: 10.1002/0471266949.BMC226.PUB2
S. Testero, Leticia I. Llarrull, J. Fisher, S. Mobashery
{"title":"Medicinal Chemistry of β‐Lactam Antibiotics","authors":"S. Testero, Leticia I. Llarrull, J. Fisher, S. Mobashery","doi":"10.1002/0471266949.BMC226.PUB2","DOIUrl":"https://doi.org/10.1002/0471266949.BMC226.PUB2","url":null,"abstract":"","PeriodicalId":9514,"journal":{"name":"Burger's Medicinal Chemistry and Drug Discovery","volume":"1 1","pages":"1-188"},"PeriodicalIF":0.0,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82954948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Physicochemical Characterization and Oral Dosage Form Design and Selection 理化性质及口服剂型设计与选择
Burger's Medicinal Chemistry and Drug Discovery Pub Date : 2021-04-26 DOI: 10.1002/0471266949.BMC038.PUB3
Tahnee J Dening, G. Amidon, Xiaorong He, M. Hageman
{"title":"Physicochemical Characterization and Oral Dosage Form Design and Selection","authors":"Tahnee J Dening, G. Amidon, Xiaorong He, M. Hageman","doi":"10.1002/0471266949.BMC038.PUB3","DOIUrl":"https://doi.org/10.1002/0471266949.BMC038.PUB3","url":null,"abstract":"","PeriodicalId":9514,"journal":{"name":"Burger's Medicinal Chemistry and Drug Discovery","volume":"18 1","pages":"1-49"},"PeriodicalIF":0.0,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81762324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Osteoporosis Therapy: Mechanistic Antiresorptives 骨质疏松症治疗:机械性抗吸收剂
Burger's Medicinal Chemistry and Drug Discovery Pub Date : 2021-04-26 DOI: 10.1002/0471266949.BMC197
J. Dodge, H. Bryant
{"title":"Osteoporosis Therapy: Mechanistic Antiresorptives","authors":"J. Dodge, H. Bryant","doi":"10.1002/0471266949.BMC197","DOIUrl":"https://doi.org/10.1002/0471266949.BMC197","url":null,"abstract":"Osteoporosis is defined as the thinning of bone resulting from the imbalance between bone resorption and bone formation, the two cellular mechanisms that regulate the remodeling of skeletal tissue. This loss of bone ultimately results in an increased risk of fracture. One therapeutic approach to treating patients with osteoporosis is to inhibit the process of bone resorption. This has been clinically manifested by the development of a number of large and small molecules that include calcitonin, integrin inhibitors, cathepsin K inhibitors, OPG/RANKL inhibitors, bisphosponates, and SERMS. This chapter describes recent advances in the anti-resorptive field with a focus on clinically validated targets and the molecules that have been developed to regulate these pathways. \u0000 \u0000 \u0000Keywords: \u0000 \u0000Osteoporosis; \u0000Osteoclast; \u0000Osteoblast; \u0000Calcitonin; \u0000Cathepsin K Inhibitors; \u0000Osteoprotegerin; \u0000RANKL; \u0000Bisphosponates; \u0000Selective Estrogen Receptor Modulators; \u0000SERMs","PeriodicalId":9514,"journal":{"name":"Burger's Medicinal Chemistry and Drug Discovery","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81673932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
US FDA‐Approved Small‐Molecule Kinase Inhibitors for Cancer Therapy 美国FDA批准用于癌症治疗的小分子激酶抑制剂
Burger's Medicinal Chemistry and Drug Discovery Pub Date : 2021-04-26 DOI: 10.1002/0471266949.BMC214.PUB2
Mingfeng Yu, S. Tadesse, Shudong Wang
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引用次数: 1
Large‐Scale Synthesis 大尺度应承担的合成
Burger's Medicinal Chemistry and Drug Discovery Pub Date : 2021-04-26 DOI: 10.1002/0471266949.bmc032.pub3
K. P. Cole
{"title":"Large‐Scale Synthesis","authors":"K. P. Cole","doi":"10.1002/0471266949.bmc032.pub3","DOIUrl":"https://doi.org/10.1002/0471266949.bmc032.pub3","url":null,"abstract":"","PeriodicalId":9514,"journal":{"name":"Burger's Medicinal Chemistry and Drug Discovery","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72920456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assay Development and High‐Throughput Screening 试验开发和高通量筛选
Burger's Medicinal Chemistry and Drug Discovery Pub Date : 2021-04-26 DOI: 10.1002/0471266949.BMC165.PUB2
D. Carettoni, B. Bader
{"title":"Assay Development and High‐Throughput Screening","authors":"D. Carettoni, B. Bader","doi":"10.1002/0471266949.BMC165.PUB2","DOIUrl":"https://doi.org/10.1002/0471266949.BMC165.PUB2","url":null,"abstract":"","PeriodicalId":9514,"journal":{"name":"Burger's Medicinal Chemistry and Drug Discovery","volume":"1 1","pages":"1-42"},"PeriodicalIF":0.0,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76143242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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