Cancer and Metastasis Reviews最新文献_第2页

The biological function of extracellular vesicles in prostate cancer and their clinical application as diagnostic and prognostic biomarkers. 前列腺癌细胞外囊泡的生物功能及其作为诊断和预后生物标志物的临床应用。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-12-01 Epub Date: 2024-09-24 DOI: 10.1007/s10555-024-10210-w

Patrizia Limonta, Sara Marchesi, Gaia Giannitti, Lavinia Casati, Fabrizio Fontana

{"title":"The biological function of extracellular vesicles in prostate cancer and their clinical application as diagnostic and prognostic biomarkers.","authors":"Patrizia Limonta, Sara Marchesi, Gaia Giannitti, Lavinia Casati, Fabrizio Fontana","doi":"10.1007/s10555-024-10210-w","DOIUrl":"10.1007/s10555-024-10210-w","url":null,"abstract":"Prostate cancer (PCa) is one of the most commonly diagnosed malignancies and main causes of cancer-related deaths worldwide. It is characterized by high heterogeneity, ranging from slow-growing tumor to metastatic disease. Since both therapy selection and outcome strongly rely on appropriate patient stratification, it is crucial to differentiate benign from more aggressive conditions using new and improved diagnostic and prognostic biomarkers. Extracellular vesicles (EVs) are membrane-coated particles carrying a specific biological cargo composed of nucleic acids, proteins, and metabolites. Here, we provide an overview of the role of EVs in PCa, focusing on both their biological function and clinical value. Specifically, we summarize the oncogenic role of EVs in mediating the interactions with PCa microenvironment as well as the horizontal transfer of metastatic traits and drug resistance between PCa cells. Furthermore, we discuss the potential usage of EVs as innovative tools for PCa diagnosis and prognosis.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional links between the microbiome and the molecular pathways of colorectal carcinogenesis. 微生物组与结直肠癌发生的分子途径之间的功能联系。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-12-01 Epub Date: 2024-09-28 DOI: 10.1007/s10555-024-10215-5

Jessica Permain, Barry Hock, Timothy Eglinton, Rachel Purcell

引用次数: 0

The role of mitochondria in tumor metastasis and advances in mitochondria-targeted cancer therapy. 线粒体在肿瘤转移中的作用以及线粒体靶向癌症疗法的进展。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-12-01 Epub Date: 2024-09-23 DOI: 10.1007/s10555-024-10211-9

Fanglu Chen, Yucheng Xue, Wenkan Zhang, Hao Zhou, Zhiyi Zhou, Tao Chen, Eloy YinWang, Hengyuan Li, Zhaoming Ye, Junjie Gao, Shengdong Wang

引用次数: 0

The effect of GLP-1R agonists on the medical triad of obesity, diabetes, and cancer. GLP-1R 激动剂对肥胖、糖尿病和癌症三联症的影响。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-12-01 Epub Date: 2024-05-27 DOI: 10.1007/s10555-024-10192-9

Shahad Sabaawi Ibrahim, Raghad Sabaawi Ibrahim, Batoul Arabi, Aranka Brockmueller, Mehdi Shakibaei, Dietrich Büsselberg

{"title":"The effect of GLP-1R agonists on the medical triad of obesity, diabetes, and cancer.","authors":"Shahad Sabaawi Ibrahim, Raghad Sabaawi Ibrahim, Batoul Arabi, Aranka Brockmueller, Mehdi Shakibaei, Dietrich Büsselberg","doi":"10.1007/s10555-024-10192-9","DOIUrl":"10.1007/s10555-024-10192-9","url":null,"abstract":"Glucagon-like peptide-1 receptor (GLP-1R) agonists have garnered significant attention for their therapeutic potential in addressing the interconnected health challenges of diabetes, obesity, and cancer. The role of GLP-1R in type 2 diabetes mellitus (T2DM) is highlighted, emphasizing its pivotal contribution to glucose homeostasis, promoting β-cell proliferation, and facilitating insulin release. GLP-1R agonists have effectively managed obesity by reducing hunger, moderating food intake, and regulating body weight. Beyond diabetes and obesity, GLP-1R agonists exhibit a multifaceted impact on cancer progression across various malignancies. The mechanisms underlying these effects involve the modulation of signaling pathways associated with cell growth, survival, and metabolism. However, the current literature reveals a lack of in vivo studies on specific GLP-1R agonists such as semaglutide, necessitating further research to elucidate its precise mechanisms and effects, particularly in cancer. While other GLP-1R agonists have shown promising outcomes in mitigating cancer progression, the association between some GLP-1R agonists and an increased risk of cancer remains a topic requiring more profound investigation. This calls for more extensive research to unravel the intricate relationships between the GLP-1R agonist and different cancers, providing valuable insights for clinicians and researchers alike.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lost at SCLC: a review of potential platinum sensitizers. 迷失在 SCLC：潜在铂敏化剂综述。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-12-01 Epub Date: 2024-08-23 DOI: 10.1007/s10555-024-10207-5

Bryan Oronsky, Nacer Abrouk, Li Mao, Yunle Shen, Xiaohui Wang, Luyang Zhao, Scott Caroen, Tony Reid

引用次数: 0

Mitochondrial ribosomal proteins in metastasis and their potential use as prognostic and therapeutic targets. 转移中的线粒体核糖体蛋白及其作为预后和治疗靶点的潜力。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-12-01 Epub Date: 2024-10-01 DOI: 10.1007/s10555-024-10216-4

Jasmine M Bacon, Johanna L Jones, Guei-Sheung Liu, Joanne L Dickinson, Kelsie Raspin

{"title":"Mitochondrial ribosomal proteins in metastasis and their potential use as prognostic and therapeutic targets.","authors":"Jasmine M Bacon, Johanna L Jones, Guei-Sheung Liu, Joanne L Dickinson, Kelsie Raspin","doi":"10.1007/s10555-024-10216-4","DOIUrl":"10.1007/s10555-024-10216-4","url":null,"abstract":"The mitochondrion is an essential cell organelle known as the powerhouse of the cell. Mitochondrial ribosomal proteins (MRPs) are nuclear encoded, synthesised in the cytoplasm but perform their main functions in the mitochondria, which includes translation, transcription, cell death and maintenance. However, MRPs have also been implicated in cancer, particularly advanced disease and metastasis across a broad range of cancer types, where they play a central role in cell survival and progression. For some, their altered expression has been investigated as potential prognostic markers, and/or therapeutic targets, which is the focus of this review. Several therapies targeting MRPs are currently approved by the Food and Drug Administration and the European Medicines Agency for use in other diseases, revealing the opportunity for repurposing their use in advanced and metastatic cancer. Herein, we review the evidence supporting key MRPs as molecular drivers of advanced disease in multiple cancer types. We also highlight promising avenues for future use of MRPs as precision targets in the treatment of late-stage cancers for which there are currently very limited effective treatment options.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of MARCH E3 ubiquitin ligases in cancer development. MARCH E3 泛素连接酶在癌症发展中的作用。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-12-01 Epub Date: 2024-07-22 DOI: 10.1007/s10555-024-10201-x

Abhayananda Behera, Deepanshi Sachan, Ganesh Kumar Barik, Aramati Bindu Madhava Reddy

{"title":"Role of MARCH E3 ubiquitin ligases in cancer development.","authors":"Abhayananda Behera, Deepanshi Sachan, Ganesh Kumar Barik, Aramati Bindu Madhava Reddy","doi":"10.1007/s10555-024-10201-x","DOIUrl":"10.1007/s10555-024-10201-x","url":null,"abstract":"Membrane-associated RING-CH (MARCH) E3 ubiquitin ligases, a family of RING-type E3 ubiquitin ligases, have garnered increased attention for their indispensable roles in immune regulation, inflammation, mitochondrial dynamics, and lipid metabolism. The MARCH E3 ligase family consists of eleven distinct members, and the dysregulation of many of these members has been documented in several human malignancies. Over the past two decades, extensive research has revealed that MARCH E3 ligases play pivotal roles in cancer progression by ubiquitinating key oncogenes and tumor suppressors and orchestrating various signaling pathways. Some MARCH E3s act as oncogenes, while others act as tumor suppressors, and the majority of MARCH E3s play both oncogenic and tumor suppressive roles in a context-dependent manner. Notably, there is special emphasis on the sole mitochondrial MARCH E3 ligase MARCH5, which regulates mitochondrial homeostasis within cancer cells. In this review, we delve into the diverse functions of MARCH E3 ligases across different cancer types, shedding light on the underlying molecular mechanisms mediating their effects, their regulatory effects on cancer and their potential as therapeutic targets.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular and cellular mechanisms of chemoresistance in paediatric pre-B cell acute lymphoblastic leukaemia. 小儿前 B 细胞急性淋巴细胞白血病化疗抗药性的分子和细胞机制。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-12-01 Epub Date: 2024-08-05 DOI: 10.1007/s10555-024-10203-9

Caleb B Lill, Stephen Fitter, Andrew C W Zannettino, Kate Vandyke, Jacqueline E Noll

{"title":"Molecular and cellular mechanisms of chemoresistance in paediatric pre-B cell acute lymphoblastic leukaemia.","authors":"Caleb B Lill, Stephen Fitter, Andrew C W Zannettino, Kate Vandyke, Jacqueline E Noll","doi":"10.1007/s10555-024-10203-9","DOIUrl":"10.1007/s10555-024-10203-9","url":null,"abstract":"Paediatric patients with relapsed B cell acute lymphoblastic leukaemia (B-ALL) have poor prognosis, as relapse-causing clones are often refractory to common chemotherapeutics. While the molecular mechanisms leading to chemoresistance are varied, significant evidence suggests interactions between B-ALL blasts and cells within the bone marrow microenvironment modulate chemotherapy sensitivity. Importantly, bone marrow mesenchymal stem cells (BM-MSCs) and BM adipocytes are known to support B-ALL cells through multiple distinct molecular mechanisms. This review discusses the contribution of integrin-mediated B-ALL/BM-MSC signalling and asparagine supplementation in B-ALL chemoresistance. In addition, the role of adipocytes in sequestering anthracyclines and generating a BM niche favourable for B-ALL survival is explored. Furthermore, this review discusses the role of BM-MSCs and adipocytes in promoting a quiescent and chemoresistant B-ALL phenotype. Novel treatments which target these mechanisms are discussed herein, and are needed to improve dismal outcomes in patients with relapsed/refractory disease.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CAR T-cells for pediatric solid tumors: where to go from here? CAR T 细胞治疗小儿实体瘤：何去何从？

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-12-01 Epub Date: 2024-09-24 DOI: 10.1007/s10555-024-10214-6

Tina Trautmann, Natalia Yakobian, Rosa Nguyen

{"title":"CAR T-cells for pediatric solid tumors: where to go from here?","authors":"Tina Trautmann, Natalia Yakobian, Rosa Nguyen","doi":"10.1007/s10555-024-10214-6","DOIUrl":"10.1007/s10555-024-10214-6","url":null,"abstract":"Despite the great success that chimeric antigen receptor (CAR) T-cells have had in patients with B-cell malignancies and multiple myeloma, they continue to have limited efficacy against most solid tumors. Especially in the pediatric population, pre- and post-treatment biopsies are rarely performed due to ethical reasons, and thus, our understanding is still very limited regarding the mechanisms in the tumor microenvironment by which tumor cells exclude effectors and attract immune-suppressive cells. Nevertheless, based on the principles that are known, current T-cell engineering has leveraged some of these processes and created more potent CAR T-cells. The recent discovery of new oncofetal antigens and progress made in CAR design have expanded the potential pool of candidate antigens for therapeutic development. The most promising approaches to enhance CAR T-cells are novel CAR gating strategies, creative ways of cytokine delivery to the TME without enhancing systemic toxicity, and hijacking the chemokine axis of tumors for migratory purposes. With these new modifications, the next step in the era of CAR T-cell development will be the clinical validation of these promising preclinical findings.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tissue factor pathway inhibitor-2 (TFPI-2)-an underappreciated partaker in cancer and metastasis. 组织因子通路抑制因子-2（TFPI-2）--癌症和转移中一个未被充分重视的参与者。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-12-01 Epub Date: 2024-08-17 DOI: 10.1007/s10555-024-10205-7

Marek Z Wojtukiewicz, Marta Mysliwiec, Anna Tokajuk, Joanna Kruszewska, Barbara Politynska, Anmbreen Jamroze, Anna M Wojtukiewicz, Dean G Tang, Kenneth V Honn

{"title":"Tissue factor pathway inhibitor-2 (TFPI-2)-an underappreciated partaker in cancer and metastasis.","authors":"Marek Z Wojtukiewicz, Marta Mysliwiec, Anna Tokajuk, Joanna Kruszewska, Barbara Politynska, Anmbreen Jamroze, Anna M Wojtukiewicz, Dean G Tang, Kenneth V Honn","doi":"10.1007/s10555-024-10205-7","DOIUrl":"10.1007/s10555-024-10205-7","url":null,"abstract":"The coagulation system is known to play an important role in cancer development and metastasis, but the precise mechanisms by which it does so remain incompletely understood. With this in mind, we provide an updated overview of the effects of TFPI-2, a protease inhibitor, on cancer development and metastasis. TFPI-2 interacts with the thrombin cascade and also employs other mechanisms to suppress cancer growth and dissemination, which include extracellular matrix stabilization, promotion of caspase-mediated cell apoptosis, inhibition of angiogenesis and transduction of intracellular signals. Down-regulation of TFPI-2 expression is well documented in numerous types of neoplasms, mainly via promoter methylation. However, the exact role of TFPI-2 in cancer progression and possible approaches to up-regulate TFPI-2 expression warrant further studies. Strategies to reactivate TFPI-2 may represent a promising direction for future anticancer studies and therapy development.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0