Cardiovascular Intervention and Therapeutics最新文献

{"title":"Complex PCI and 1-year outcomes in the OPTIVUS-complex PCI study multivessel cohort.","authors":"Masaomi Gohbara, Kiyoshi Hibi, Takeshi Morimoto, Hidekuni Kirigaya, Ko Yamamoto, Koh Ono, Hiroki Shiomi, Masanobu Ohya, Kyohei Yamaji, Hiroki Watanabe, Tetsuya Amano, Yoshihiro Morino, Kensuke Takagi, Junko Honye, Hitoshi Matsuo, Mitsuru Abe, Kazushige Kadota, Kenji Ando, Koichi Nakao, Shinjo Sonoda, Satoru Suwa, Kazuya Kawai, Ken Kozuma, Yoshihisa Nakagawa, Yuji Ikari, Mamoru Nanasato, Keiichi Hanaoka, Kengo Tanabe, Yoshiki Hata, Takashi Akasaka, Takeshi Kimura","doi":"10.1007/s12928-025-01110-z","DOIUrl":"10.1007/s12928-025-01110-z","url":null,"abstract":"<p><p>It remains unknown whether intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) can improve the clinical outcomes of complex PCI to a level equivalent to that of non-complex PCI. In the OPTIVUS-Complex PCI (Optimal Intravascular Ultrasound-Guided Complex PCI) Study multivessel cohort, a total of 1011 patients who underwent multivessel PCI involving a target lesion in the left anterior descending coronary artery (LAD) were divided into 2 groups: complex PCI (N = 760) and non-complex PCI groups (N = 251). Complex PCI was defined as a procedure with the following characteristics: 3 vessels treated, 3 stents implanted, 3 lesions treated, bifurcation with 2 stents implanted, total stent length > 60 mm, or target of chronic total occlusion. The primary endpoint was major adverse cardiac and cerebrovascular event (MACCE) defined by a composite of death, myocardial infarction, stroke, or any coronary revascularization. The cumulative 1-year incidences of the primary endpoint and any coronary revascularization were not significantly different between the complex and non-complex PCI groups (10.9% vs. 8.3%, P = 0.24, and 7.7% vs. 4.8%, P = 0.12, respectively). In the multivariable Cox proportional hazards models, there was no significant excess risk of the complex PCI group relative to the non-complex PCI group for the primary endpoint (HR, 1.35; 95%CI, 0.83-2.18; P = 0.22), or for any coronary revascularization (HR, 1.64; 95%CI, 0.87-3.06; P = 0.11). After optimal IVUS-guided multivessel PCI with a target lesion in the LAD, 1-year risk of MACCE or coronary revascularization in patients with complex PCI was numerically higher than that in patients with non-complex PCI.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"516-526"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter edge-to-edge repair for a small mitral valve following surgical annuloplasty.","authors":"Ryo Shigeno, Takao Morikawa, Arudo Hiraoka, Misako Toki, Atsushi Hirohata","doi":"10.1007/s12928-025-01103-y","DOIUrl":"10.1007/s12928-025-01103-y","url":null,"abstract":"","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"721-722"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simple bailout method for burr entrapment in rotational atherectomy.","authors":"Yusuke Watanabe, Kenichi Sakakura, Hideo Fujita","doi":"10.1007/s12928-025-01107-8","DOIUrl":"10.1007/s12928-025-01107-8","url":null,"abstract":"","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"705-706"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pericoronary adipose tissue: potential for pathological diagnosis and therapeutic applications.","authors":"Tomoya Hara, Masataka Sata","doi":"10.1007/s12928-025-01126-5","DOIUrl":"10.1007/s12928-025-01126-5","url":null,"abstract":"<p><p>Excessive accumulation of epicardial adipose tissue (EAT) is known to be a risk factor for coronary artery disease and heart failure. In particular, it is thought that inflammation of pericoronary adipose tissue (PCAT) affects the pathology of various coronary artery diseases (CAD). EAT and PCAT are thought to be new therapeutic targets for preventing cardiovascular disease. Although there are no established drugs that specifically reduce inflammation of EAT or PCAT, the basic approach is to improve lifestyle-related diseases through exercise and diet, and to use metabolic improvement drugs and anti-inflammatory drugs as soft support. Potential candidates include statins, SGLT2 inhibitors, and GLP- 1 receptor agonists. In addition to conventional treatments that target substances within blood vessels, treatments that target EAT and PCAT by directly enveloping the coronary arteries and myocardium from outside the body are expected to further suppress cardiovascular events.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"465-473"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of pullback speed on evaluation of lipid core plaque using near-infrared spectroscopy-intravascular ultrasound.","authors":"Tetsuharu Kasahara, Hideki Kitahara, Kenta Takou, Kazuya Tateishi, Yuichi Saito, Ken Kato, Takashi Iimori, Yoshio Kobayashi","doi":"10.1007/s12928-025-01124-7","DOIUrl":"10.1007/s12928-025-01124-7","url":null,"abstract":"<p><p>Near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) can assess the amount of lipid core plaque, and the latest generation catheter allows for imaging at several different pullback speeds. The purpose of this study was to investigate the impact of pullback speed on evaluation of lipid core plaque using the latest generation NIRS-IVUS catheter. Patients with coronary artery disease who underwent coronary angiography or percutaneous coronary intervention with NIRS-IVUS examination at 2 different pullback speeds (0.5 and 2.0 mm/sec) for the same vessel were enrolled. The values of lipid core burden index (LCBI) and maxLCBI4mm were compared between the images recorded with pullback speeds of 0.5 and 2.0 mm/sec, and match or mismatch of the location where maxLCBI4mm was detected was investigated. In a total of 286 NIRS-IVUS image sets, the location of maxLCBI4mm measured at 0.5 and 2.0 mm/sec was mismatched in 81 (28.3%) image sets. In comparison by vessel type, 20.8% were mismatched in LAD, 31.1% in LCx, and 37.8% in RCA (p = 0.023). In 205 image sets with matched maxLCBI4mm location, the maxLCBI4mm value at 2.0 mm/sec was significantly greater compared with that at 0.5 mm/sec (348.0 vs. 302.0 in median, p < 0.001). In a substantial proportion of patients, the location of maxLCBI4mm values measured at 0.5 and 2.0 mm/sec was mismatched. In the image sets with matched maxLCBI4mm location, the maxLCBI4mm value at 2.0 mm/sec was significantly greater compared with that at 0.5 mm/sec. These results should be noted when applying the cut-off values of maxLCBI4mm recorded at 2.0 mm/sec.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"536-543"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incremental value of physiological indices to predict high-risk plaques detected by NIRS-IVUS.","authors":"Kazuyoshi Kakehi, Masafumi Ueno, Nobuhiro Yamada, Kyohei Onishi, Keishiro Sugimoto, Yohei Funauchi, Takayuki Kawamura, Kosuke Fujita, Hiroki Matsuzoe, Koichiro Matsumura, Gaku Nakazawa","doi":"10.1007/s12928-025-01116-7","DOIUrl":"10.1007/s12928-025-01116-7","url":null,"abstract":"<p><p>Identification of vulnerable plaques is important for reducing future cardiovascular events. This study aimed to investigate optimal modalities other than intravascular imaging in evaluating vulnerable plaques. We prospectively evaluated 105 non-culprit coronary lesions by CCTA imaging and near-infrared spectroscopy-intravascular ultrasound in 32 patients with acute coronary syndrome. Angiographically-derived ΔQFR and ΔFFR_CT were measured as the difference in QFR and FFR_CT across the stenosis. A receiver operating characteristic curve analysis was performed to determine the optimal cutoff values of angiographically- and CCTA-derived plaque features for a maxLCBI_4mm ≥ 400. The best cutoff values for ΔQFR and ΔFFR_CT to predict a maxLCBI_4mm ≥ 400 were 0.05 and 0.06, respectively. ΔQFR and ΔFFR_CT values and percent diameter stenosis on QCA or CCTA were associated with a maxLCBI_4mm ≥ 400 (both P < 0.05). The combination of ΔFFR_CT ≥ 0.06 and plaque density predicted a maxLCBI_4mm ≥ 400 with 89.4% sensitivity and 84.5% specificity (area under the curve, 0.90; P < 0.0001). There was no significant difference in area under the curve values between ΔQFR and plaque density + ΔFFR_CT ≥ 0.06 (0.92 vs. 0.90, P = 0.50). In the diagnosis of vulnerable plaques in acute coronary syndrome, the combination of ΔFFR_CT and plaque density shows a diagnostic capability similar to that of ΔQFR in non-culprit lesions.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"588-598"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balloon blocking technique for antegrade wiring in a chronic total occlusion of the left anterior descending artery ostium.","authors":"Yoshinobu Murasato, Jinya Takahashi, Kyohei Meno, Takahiro Mori","doi":"10.1007/s12928-025-01108-7","DOIUrl":"10.1007/s12928-025-01108-7","url":null,"abstract":"","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"707-709"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between myocardial bridge and upstream plaque morphology in patients with acute coronary syndrome.","authors":"Eisuke Usui, Tatsuhiro Nagamine, Yoshihisa Kanaji, Masahiro Hada, Kai Nogami, Hiroki Ueno, Mirei Setoguchi, Kodai Sayama, Takahiro Watanabe, Hikaru Shimosato, Takashi Mineo, Tomoyo Sugiyama, Taishi Yonetsu, Tetsuo Sasano, Tsunekazu Kakuta","doi":"10.1007/s12928-025-01134-5","DOIUrl":"10.1007/s12928-025-01134-5","url":null,"abstract":"<p><p>Myocardial bridging (MB), characterized by systolic coronary artery compression, alters coronary flow and may influence upstream atherosclerotic plaque morphology. We aimed to investigate the relationship between MB and morphological features of upstream culprit plaques in patients with acute coronary syndrome (ACS). We retrospectively analyzed 370 ACS patients who underwent optical coherence tomography (OCT)-guided PCI for a de novo culprit lesion in the proximal left anterior descending artery (LAD). OCT images identified plaque rupture (PR), classifying lesions into PR and intact fibrous cap (IFC) groups. The IFC group was further divided based on the presence of lipid-rich plaque (LRP), defined as a plaque with a maximum lipid angle > 90°. This study included 370 ACS patients (mean age 65.2 ± 12.3 years, 82.4% male). Angiographic evidence of MB was present in 8.6% (32/370) of patients prior to PCI and increased to 17.0% (63/370) post-PCI; all MBs identified pre-PCI were also observed post-PCI. OCT identified 213 lesions with plaque rupture and 157 lesions with IFC (of which 83 exhibited underlying LRP and 74 did not). The prevalence of post-PCI angiographically detected MB differed significantly among the OCT-defined morphological groups: 11.3% (24/213) in the PR group, 18.1% (15/83) in the IFC-LRP group, and 32.4% (24/74) in the IFC-non-LRP group (P < 0.01). No periprocedural myocardial injury occurred in the IFC-non-LRP group. In patients with ACS, the presence of MB was significantly associated with a lower likelihood of plaque rupture and LRP in the upstream culprit lesion as assessed by OCT.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"565-575"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proximal SFA CTO puncture for femoropopliteal occlusive disease.","authors":"Yusuke Sato, Yutaro Nakano, Hiroyuki Ikeda, Kentaro Ishida, Hiroyasu Uzui, Hiroshi Tada","doi":"10.1007/s12928-025-01119-4","DOIUrl":"10.1007/s12928-025-01119-4","url":null,"abstract":"","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"715-716"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-Prep registry: atherectomy devices and intravascUlAr lithotripsy for the PREParation of heavily calcified coronary lesions registry.","authors":"Masato Nakamura, Nehiro Kuriyama, Yutaka Tanaka, Seiji Yamazaki, Tomohiro Kawasaki, Takashi Muramatsu, Kazushige Kadota, Takashi Ashikaga, Akihiko Takahashi, Satoru Otsuji, Kenji Ando, Masaru Ishida, Shigeru Nakamura, Yoshiaki Ito, Raisuke Iijima, Gaku Nakazawa, Junya Shite, Junko Honye, Junya Ako, Hiroyoshi Yokoi, Ken Kozuma, Hiromasa Otake, Kazuho Masumura, Tomomi Yamada, Yohei Sotomi","doi":"10.1007/s12928-025-01130-9","DOIUrl":"10.1007/s12928-025-01130-9","url":null,"abstract":"<p><p>Evaluation of calcified lesions by intravascular imaging has revealed that atherectomy devices have only limited impact. However, subsequent use of coronary intravascular lithotripsy (IVL) may increase treatment effectiveness without increasing risk of complications. This study was designed to evaluate the safety and effectiveness of IVL use after atherectomy in severely calcified coronary lesions as pre-treatment for drug-eluting stents (DES). The Dual-Prep registry is a multicenter, prospective registry of consecutive image-guided percutaneous coronary interventions (PCI). The primary effectiveness and safety endpoints were procedural success (residual stenosis < 50% by quantitative coronary angiography) without an in-hospital major adverse cardiac event (MACE) and 30-day freedom from MACE, respectively. Baseline vessel calcification score and final DES expansion were evaluated by optical coherence tomography (OCT). A total of 118 patients with 120 lesions were enrolled at 20 sites. The calcification score of lesions after atherectomy by core-lab assessment was 4.0 in all cases. Rotational atherectomy was applied prior to IVL in 83.9% cases with mean burr size of 1.57 ± 0.20 mm; IVL was subsequently successfully delivered in all cases (mean balloon diameter 3.02 ± 0.45 mm), followed by DES deployment (mean diameter 3.19 ± 0.51 mm, length of 36.3 ± 16.0 mm). The primary efficacy and safety endpoints were met in 98.3% and 98.3% of cases, respectively. A DES expansion index < 0.8 was seen in 42.2%, and an eccentricity index < 0.7 was not observed in any patient. In severely calcified lesions, image-guided atherectomy followed by IVL lesion preparation demonstrated high procedural success rates and satisfactory non-eccentric stent expansion. This approach may be considered for lesions where an 'IVL-first' strategy may not be feasible. jRCT1032230384 (Oct 7, 2023).</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"553-564"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}