Chonnam medical journal最新文献

{"title":"Helix Retraction of Stylet-Driven Pacing Leads with Extendable Helix Used for Left Bundle Branch Area Pacing.","authors":"Young Jae Ki, Sung Soo Kim","doi":"10.4068/cmj.2025.61.2.104","DOIUrl":"10.4068/cmj.2025.61.2.104","url":null,"abstract":"","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 2","pages":"104-105"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Obstructive General Angioscopy-Derived Aortic Atherosclerotic Ulceration Leading to a Fatal Type 1a Endoleak.","authors":"Keisuke Kojima, Takahiro Tamaki, Yasuo Okumura","doi":"10.4068/cmj.2025.61.2.102","DOIUrl":"10.4068/cmj.2025.61.2.102","url":null,"abstract":"","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 2","pages":"102-103"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alleviating Effects of Vitamins E and D on Tamoxifen-Induced Hepatotoxicity in Female Wistar Rats.","authors":"Sabah Karim D Salih, Nasrin Ziamajidi, Alireza Nourian, Roghayeh Abbasalipourkabir, Mahdi Bahmani","doi":"10.4068/cmj.2025.61.2.75","DOIUrl":"10.4068/cmj.2025.61.2.75","url":null,"abstract":"<p><p>The protective effects of vitamins E and D, stemming from their antioxidant and anti-inflammatory capabilities were investigated in the context of tamoxifen-induced liver toxicity. The study involved twenty-five female rats divided into five experimental groups: group C (olive oil: 500 µL), group T (tamoxifen: 40 mg/kg), groups TE (tamoxifen: 40 mg/kg and vitamin E: 100 IU/kg), group TD (tamoxifen: 40 mg/kg and vitamin D: 500 IU/kg) and group TED (tamoxifen: 40 mg/kg, vitamin E: 100 IU/kg and vitamin D: 500 IU/kg). Calorimetric methods were used to measure biochemical variables, hepatic level of Total antioxidant capacity (TAC), Total oxidant status (TOS), Malondialdehyde (MDA), Superoxide dismutase (SOD), Catalase (CAT), and Glutathione peroxidase (GPx). Hepatic level of tumor necrosis factor-α (TNF-α) was assayed by ELISA. Hematoxylin-eosin staining method was also employed to assess Tamoxifen-induced liver lesions. Tamoxifen treatment resulted in a significant increase in ALP (p-value<0.01), TOS, and OSI (p-value<0.01), a marked decrease in TAC level (p-value<0.01), and an increase in TNF-α level. Simultaneous treatment with combined supplementation of vitamins E and D effectively stopped the decrease of TAC and the increase of TOS, OSI, and MDA. Although treatment with tamoxifen led to a decrease SOD, CAT, and GPX compared with group C, the difference wasn't significant. Treatment with vitamins considerably caused to increase SOD and CAT activity in comparison with groups C and T. The current study's findings demonstrated that the combined supplementation of vitamins E, and D effectively alleviated Tamoxifen-associated liver damage and oxidative stress.</p>","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 2","pages":"75-83"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrence of Five Synchronous Gastric Tumors Including Early Gastric Cancer after Endoscopic Submucosal Dissection of a Gastric Adenoma.","authors":"Bohyun Jang, Sangmin Lee, Gyuhyun Park, You Suk Suh, Jae Il Chung, Donghui Kim","doi":"10.4068/cmj.2025.61.2.100","DOIUrl":"10.4068/cmj.2025.61.2.100","url":null,"abstract":"","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 2","pages":"100-101"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aortic Ring Sign: A Radiological Indicator of Anemia.","authors":"Yusaku Kajihara","doi":"10.4068/cmj.2025.61.2.94","DOIUrl":"10.4068/cmj.2025.61.2.94","url":null,"abstract":"","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 2","pages":"94"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin and Breast Cancer: A Review Article.","authors":"Alireza Nemati Motehaver, Fateme Sheida, Seyed Alireza Javadinia, Behnaz Behzadi, Saeid Afshar, Ali Khezrian, Mostafa Ganjuri, Shadi Eslah, Parisa Mokhles, Zahra Keshtpour Amlashi, Mohammad Esmaeil Akbari","doi":"10.4068/cmj.2025.61.2.63","DOIUrl":"10.4068/cmj.2025.61.2.63","url":null,"abstract":"<p><p>Breast cancer is one of the most common causes of death all over the world. Therapeutic options applied to the patients include surgery, chemotherapy, and radiotherapy. However, far advanced disease often leads to chemoresistance and toxicity. Innovative therapies are needed to address these challenges. Melatonin has the potential to prevent and treat cancer, as it has been revealed in numerous clinical studies. Melatonin is a nontoxic agent that is mostly produced in the pineal gland, inducing various mechanisms of action such as the induction of apoptosis, antiangiogenic, antiproliferative, and metastasis-inhibitory effects. Therefore, melatonin increases therapeutic sensitivity when combined with conventional medication in breast cancer. Melatonin (3-20 mg/day) may reduce breast cancer cell growth in preclinical studies and enhance chemotherapy efficacy. Small human trials suggest potential benefits, but larger studies are needed. Higher doses (≥20 mg/day) are sometimes used alongside chemotherapy. This manuscript reviews research that has demonstrated the antitumor properties of melatonin, thereby focusing on its actions on angiogenesis, apoptosis, metastasis, and antiproliferative properties. We also discuss recent advances in the understanding of the actions of melatonin on epigenetic mechanisms (especially DNA methylation) and telomere length. The data in this review were obtained from journal articles up to May 2024. Regarding the study, Google Scholar and ScienceDirect were used as engines to search for open access. We searched the ISI, Pubmed and Scopus as valid external databases, and as internal databases, ISC and Iran medex. By finding mean keywords such as 'breast cancer', 'estrogen', 'melatonin', 'cell death', 'cell proliferation', 'telomerase' and 'DNA methylation', we reached to the formula with maximum collectivity in searching, then equivalent terms were found by Mesh database. The review also covers recent clinical investigations of melatonin in breast cancer.</p>","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 2","pages":"63-74"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric Mixed Adenoma-Well Differentiated Neuroendocrine Tumor: A Case Report.","authors":"Nah Ihm Kim, Ji Shin Lee","doi":"10.4068/cmj.2025.61.2.95","DOIUrl":"10.4068/cmj.2025.61.2.95","url":null,"abstract":"","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 2","pages":"95-96"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming the Barrier: Intracardiac Echocardiography-Guided Transseptal Puncture in an Atrial Septal Defect Device Closure Patient.","authors":"Donghyeon Joo, Sung Soo Kim, Hyung Ki Jeong","doi":"10.4068/cmj.2025.61.2.106","DOIUrl":"10.4068/cmj.2025.61.2.106","url":null,"abstract":"","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 2","pages":"106-107"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Candidemia during the COVID-19 Pandemic: Species Distribution, Antifungal Susceptibility, Initial Antifungal Usage, and Mortality Trends in Two Korean Tertiary Care Hospitals.","authors":"Ahrang Lee, Minji Kim, Sarah Kim, Hae Seong Jeong, Sung Un Shin, David Cho, Doyoung Han, Uh Jin Kim, Jung Ho Yang, Seong Eun Kim, Kyung-Hwa Park, Sook-In Jung, Seung Ji Kang","doi":"10.4068/cmj.2025.61.1.52","DOIUrl":"10.4068/cmj.2025.61.1.52","url":null,"abstract":"<p><p>This study aimed to investigate changes in candidemia incidence, species distribution, antifungal susceptibility, initial antifungal use, and mortality trends in Korea before and during the COVID-19 pandemic. A retrospective analysis was conducted on candidemia cases from two tertiary care hospitals in Korea between 2017 and 2022. Data were compared between the pre-pandemic (2017-2019) and pandemic (2020-2022) periods. Statistical methods included incidence rate ratios (IRRs) and multivariate Cox regression to assess 30-day mortality risk factors. A total of 470 candidemia cases were identified, with 48.7% occurring pre-pandemic and 51.3% during the pandemic. While the overall incidence of candidemia remained similar across the two periods (IRR 1.15; p=0.13), the incidence in intensive care units (ICUs) significantly increased during the pandemic (IRR 1.50; p<0.01). The distribution of <i>Candida</i> species did not differ significantly between the two periods. Fluconazole non-susceptibility in <i>C. albicans</i> markedly decreased (10.0% vs. 0.9%, p<0.01), whereas <i>C. glabrata</i> exhibited a significant rise in caspofungin non-susceptibility during the pandemic (0% vs. 22.4%, p<0.01). Echinocandin use increased (21.8% vs. 34.4%; p<0.01), while fluconazole use declined (48.0% vs. 32.8%; p<0.01). Although the 30-day mortality rate was higher during the pandemic (60.2% vs. 57.2%), the difference was not statistically significant (p=0.57). The findings highlight the need for region-specific surveillance and tailored management strategies to improve candidemia outcomes, especially during healthcare disruptions like the COVID-19 pandemic.</p>","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 1","pages":"52-58"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly Mobile and Pedunculated Left Ventricular Myxoma in a 5-Year-Old Child.","authors":"Ah Rom Hwang, Gi Beom Kim, Sang Yun Lee, Mi Kyoung Song, Eun Jung Bae, Jae Gun Kwak","doi":"10.4068/cmj.2025.61.1.59","DOIUrl":"10.4068/cmj.2025.61.1.59","url":null,"abstract":"","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 1","pages":"59-60"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}