Chonnam medical journal最新文献_第4页

Gestational Transient Thyrotoxicosis Can Lead to Hypokalemic Periodic Paralysis. 妊娠期一过性甲亢可导致低钾血症性周期性麻痹

Chonnam medical journal Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.4068/cmj.2024.60.1.95

Jin Woo Jeong, Tae Yang Yu

引用次数: 0

Comparative Study on the Immunogenicity of COVID-19 mRNA Vaccines in Patients Receiving Adjuvant and Palliative Chemotherapy. COVID-19 mRNA 疫苗在接受辅助化疗和姑息化疗患者中的免疫原性比较研究

Chonnam medical journal Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.4068/cmj.2024.60.1.69

Hyun-Woo Choi, Younggon Jung, Uh Jin Kim, Sang-Cheol Lee, Jung Hye Kwon, Hyeonjong Kim, Sarah Kim, Yoonjung Lee, Hyun-Jung Shim, Sang-Hee Cho, Ik-Joo Chung, Eu Chang Hwang, Seung Ji Kang, Woo Kyun Bae, Seung-Jung Kee

{"title":"Comparative Study on the Immunogenicity of COVID-19 mRNA Vaccines in Patients Receiving Adjuvant and Palliative Chemotherapy.","authors":"Hyun-Woo Choi, Younggon Jung, Uh Jin Kim, Sang-Cheol Lee, Jung Hye Kwon, Hyeonjong Kim, Sarah Kim, Yoonjung Lee, Hyun-Jung Shim, Sang-Hee Cho, Ik-Joo Chung, Eu Chang Hwang, Seung Ji Kang, Woo Kyun Bae, Seung-Jung Kee","doi":"10.4068/cmj.2024.60.1.69","DOIUrl":"10.4068/cmj.2024.60.1.69","url":null,"abstract":"This study was conducted to investigate potential differences in vaccine efficacy between patients undergoing palliative chemotherapy and receiving adjuvant chemotherapy. Additionally, the study proved the influence of vaccination timing on vaccine efficacy during active chemotherapy. Anti-receptor-binding domain (RBD) IgG binding antibody assays and surrogate neutralizing antibody assays were performed after BNT162b2 or mRNA-1273 vaccination in 45 solid cancer patients (23 adjuvant and 22 palliative chemotherapy) and in 24 healthy controls before vaccination (baseline), at every two to four weeks after the first (post-dose 1) and the second vaccination (post-dose 2). The levels of anti-RBD IgG and neutralizing antibodies increased significantly from baseline through post-dose 1 to post-dose 2 in all three groups. At the post-dose 1, the anti-RBD IgG and neutralizing antibody levels were significantly lower in cancer patients than in healthy controls. However, by post-dose 2, the seropositivity of anti-RBD IgG and neutralizing antibodies uniformly reached 100% across all groups, with no significant disparity in antibody levels among the three groups. Moreover, the antibody titers were not significantly different between patients with a vaccine and chemotherapy interval of more than 14 days or those with less than 14 days. This study demonstrated that after second doses of mRNA COVID-19 vaccines, humoral immune responses in patients receiving chemotherapy were comparable to those of healthy controls, regardless of whether the purpose of the anti-cancer treatment was palliative or adjuvant. Furthermore, the timing of vaccination did not affect the level of humoral immunity after the second vaccination.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"60 1","pages":"69-77"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139674021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MiR-4492, a New Potential MicroRNA for Cancer Diagnosis and Treatment: A Mini Review. MiR-4492，一种用于癌症诊断和治疗的新型潜在 MicroRNA：微型综述。

Chonnam medical journal Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.4068/cmj.2024.60.1.21

Aida Alizamir, Mohammad Amin Amini, Ashkan Karbasi, Mehdi Beyrami

{"title":"MiR-4492, a New Potential MicroRNA for Cancer Diagnosis and Treatment: A Mini Review.","authors":"Aida Alizamir, Mohammad Amin Amini, Ashkan Karbasi, Mehdi Beyrami","doi":"10.4068/cmj.2024.60.1.21","DOIUrl":"10.4068/cmj.2024.60.1.21","url":null,"abstract":"There is no doubt that the incidence of cancer sufferers is rising in the world, and it is estimated that in the next several decades, the number of people suffering from malignancies or the cancer rate will double. Diagnostic and therapeutic targeting of noncoding RNAs (ncRNAs), especially microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), represent an excellent approach for cancer diagnosis and treatment, as well as many other diseases. One of the latest miRNAs is miR-4492, upregulating some genes in tumor tissues including ROMO1, HLA-G, NKIRAS2, FOXK1, and UBE2C. It represents an attractant example of a miRNA acting at multiple levels to affect the same malignancy hallmark. Based on the studies, miR-4492 plays a key role in several cancers such as, breast cancer, bladder cancer, osteosarcoma, glioblastoma multiforme, hepatocellular carcinoma, colorectal cancer, and ovarian cancer. Putting it all together, identifying the precise mechanisms of miR-4492 in the pathogenesis of cancer, could pave the way to find better diagnostic and therapeutic strategies for cancer sufferers. For this reason, it might be a novel potential diagnostic biomarker and therapeutic target for neoplasms.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"60 1","pages":"21-26"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139673979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Gastric Cancer Concurrent with Gastritis Cystica Profunda Resembling Advanced Cancer. 早期胃癌并发类似晚期癌症的深部糜烂性胃炎

Chonnam medical journal Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.4068/cmj.2024.60.1.87

Yasuka Eriksson, Manabu Nakamoto, Hitoshi Orita, Takumi Miyahira, Hajime Aoyama, Akira Hokama

引用次数: 0

Spinal Cord Infarction due to Aortic Atherosclerosis. 主动脉粥样硬化导致脊髓梗死

Chonnam medical journal Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.4068/cmj.2024.60.1.91

Mi-Yeon Eun, Hung Youl Seok

引用次数: 0

Bile Leak from the Cystic Duct during Endoscopic Retrograde Cholangiopancreatography. 内镜逆行胰胆管造影术中胆汁从胆囊管漏出。

Chonnam medical journal Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.4068/cmj.2024.60.1.93

Yusaku Kajihara

引用次数: 0

Clinical Outcome after Everolimus-Eluting Stent Implantation for Small Vessel Coronary Artery Disease: XIENCE Asia Small Vessel Study. 小血管冠状动脉疾病植入依维莫司洗脱支架后的临床效果：XIENCE 亚洲小血管研究》。

Chonnam medical journal Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.4068/cmj.2024.60.1.78

Doo Sun Sim, Dae Young Hyun, Young Joon Hong, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong, Sang Rok Lee, Jei Keon Chae, Keun Ho Park, Young Youp Koh, Kyeong Ho Yun, Seok Kyu Oh, Seung Jae Joo, Sun Ho Hwang, Jong Pil Park, Jay Young Rhew, Su Hyun Kim, Jang Hyun Cho, Seung Uk Lee, Dong Goo Kang

{"title":"Clinical Outcome after Everolimus-Eluting Stent Implantation for Small Vessel Coronary Artery Disease: XIENCE Asia Small Vessel Study.","authors":"Doo Sun Sim, Dae Young Hyun, Young Joon Hong, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong, Sang Rok Lee, Jei Keon Chae, Keun Ho Park, Young Youp Koh, Kyeong Ho Yun, Seok Kyu Oh, Seung Jae Joo, Sun Ho Hwang, Jong Pil Park, Jay Young Rhew, Su Hyun Kim, Jang Hyun Cho, Seung Uk Lee, Dong Goo Kang","doi":"10.4068/cmj.2024.60.1.78","DOIUrl":"10.4068/cmj.2024.60.1.78","url":null,"abstract":"There are limited data on outcomes after implantation of everolimus-eluting stents (EES) in East Asian patients with small vessel coronary lesions. A total of 1,600 patients treated with XIENCE EES (Abbott Vascular, CA, USA) were divided into the small vessel group treated with one ≤2.5 mm stent (n=119) and the non-small vessel group treated with one ≥2.75 mm stent (n=933). The primary end point was a patient-oriented composite outcome (POCO), a composite of all-cause death, myocardial infarction (MI), and any repeat revascularization at 12 months. The key secondary end point was a device-oriented composite outcome (DOCO), a composite of cardiovascular death, target-vessel MI, and target lesion revascularization at 12 months. The small vessel group was more often female, hypertensive, less likely to present with ST-elevation MI, and more often treated for the left circumflex artery, whereas the non-small vessel group more often had type B2/C lesions, underwent intravascular ultrasound, and received unfractionated heparin. In the propensity matched cohort, the mean stent diameter was 2.5±0.0 mm and 3.1±0.4 mm in the small and non-small vessel groups, respectively. Propensity-adjusted POCO at 12 months was 6.0% in the small vessel group and 4.3% in the non-small vessel group (p=0.558). There was no significant difference in DOCO at 12 months (small vessel group: 4.3% and non-small vessel group: 1.7%, p=0.270). Outcomes of XIENCE EES for small vessel disease were comparable to those for non-small vessel disease at 12-month clinical follow-up in real-world Korean patients.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"60 1","pages":"78-86"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139674020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Oligomeric Form of Amyloid Beta Triggers Astrocyte Activation, Independent of Neurons. 独立于神经元的淀粉样蛋白β低聚物形式可触发星形胶质细胞活化

Chonnam medical journal Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.4068/cmj.2024.60.1.27

Bo-Ram Mun, Su-Been Park, Won-Seok Choi

{"title":"The Oligomeric Form of Amyloid Beta Triggers Astrocyte Activation, Independent of Neurons.","authors":"Bo-Ram Mun, Su-Been Park, Won-Seok Choi","doi":"10.4068/cmj.2024.60.1.27","DOIUrl":"10.4068/cmj.2024.60.1.27","url":null,"abstract":"The most common aging-related neurodegenerative disorder is Alzheimer's disease (AD), of which the main symptom is memory disturbance. Though the mechanism of AD pathogenesis is not fully defined, abnormal aggregation of amyloid beta (Aβ) plaques and tau have been considered as key factors and main histological hallmarks of the disease. Astrocyte is responsible for the control of cells and the environment around brain and spinal cord cells. Astrocytes have been implicated with AD. However, the exact function of astrocytes in AD has not been established. In this study, we investigated the regulation of astrocytes in the AD model using primary cultures. We have demonstrated that oligomerized Aβ is toxic to neurons and can induce cell death in primary cultures. In the primary cultures containing neurons and astrocytes, amyloid beta uptake was observed in both neurons and astrocytes. To verify if the uptake of amyloid beta in astrocytes is dependent on neurons, we separated and cultured primary astrocytes with no neurons. Amyloid uptake was still observed in this pure astrocyte culture, suggesting that the uptake of amyloid beta is a neuron-independent function of astrocytes. Astrocyte activation was observed in both pure and mixed cultures. Taken together, our data suggest that astrocyte is activated by oligomerized Aβ and uptakes it, which is independent of neurons.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"60 1","pages":"27-31"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139674052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the Complex World of Extracellular Vesicles: Novel Characterization Techniques and Manufacturing Considerations. 揭开细胞外囊泡复杂世界的面纱：新型表征技术和制造注意事项。

Chonnam medical journal Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.4068/cmj.2024.60.1.1

James J Lai, John J Hill, Casey Y Huang, Gino C Lee, Karol W Mai, Maggie Y Shen, Simon K Wang

{"title":"Unveiling the Complex World of Extracellular Vesicles: Novel Characterization Techniques and Manufacturing Considerations.","authors":"James J Lai, John J Hill, Casey Y Huang, Gino C Lee, Karol W Mai, Maggie Y Shen, Simon K Wang","doi":"10.4068/cmj.2024.60.1.1","DOIUrl":"10.4068/cmj.2024.60.1.1","url":null,"abstract":"Extracellular vesicles (EVs) function as potent mediators of intercellular communication for many in vivo processes, contributing to both health and disease related conditions. Given their biological origins and diverse functionality from correspondingly unique \"cargo\" compositions, both endogenous and modified EVs are garnering attention as promising therapeutic modalities and vehicles for targeted therapeutic delivery applications. Their diversity in composition, however, has revealed a significant need for more comprehensive analytical-based characterization methods, and manufacturing processes that are consistent and scalable. In this review, we explore the dynamic landscape of EV research and development efforts, ranging from novel isolation approaches, to their analytical assessment through novel characterization techniques, and to their production by industrial-scale manufacturing process considerations. Expanding the horizon of these topics to EVs for in-human applications, we underscore the need for stringent development and adherence to Good Manufacturing Practice (GMP) guidelines. Wherein, the intricate interplay of raw materials, production in bioreactors, and isolation practices, along with analytical assessments compliant with the Minimal Information for Studies of Extracellular Vesicles (MISEV) guidelines, in conjunction with reference standard materials, collectively pave the way for standardized and consistent GMP production processes.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"60 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139673982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ATN Classification and Clinical Progression of the Amyloid-Negative Group in Alzheimer's Disease Neuroimaging Initiative Participants. 阿尔茨海默病神经影像学倡议参与者中淀粉样蛋白阴性组的 ATN 分类和临床进展。

Chonnam medical journal Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.4068/cmj.2024.60.1.51

Soo Hyun Cho, Shina Kim, Seong-Min Choi, Byeong Chae Kim

{"title":"ATN Classification and Clinical Progression of the Amyloid-Negative Group in Alzheimer's Disease Neuroimaging Initiative Participants.","authors":"Soo Hyun Cho, Shina Kim, Seong-Min Choi, Byeong Chae Kim","doi":"10.4068/cmj.2024.60.1.51","DOIUrl":"10.4068/cmj.2024.60.1.51","url":null,"abstract":"Alzheimer's disease has recently been classified using three biological markers (amyloid [A], tau [T], and neurodegeneration [N]) to help elucidate its progression. We aimed to investigate whether there were differences between cognitive function and the clinical dementia symptoms over time relative to the ATN classification in the amyloid-negative group. In the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort, 310 participants who underwent all the tests required for ATN classification were enrolled. The cognitive function score differences (Alzheimer's Disease Assessment Scale-Cognitive Subscale 13 [ADAS-Cog 13], Clinical Dementia Rating Sum of Boxes [CDR-SOB], and Mini-Mental State Examination [MMSE]) between the groups were analyzed using the analysis of covariance and score changes over time with a linear mixed-effects model. In the cross-sectional analysis, ADAS-Cog 13 scores were higher for A-T-N+ and A-T+N+ than for A-T-N- (p<0.001) and A-T+N- (p<0.001). In the longitudinal analysis, CDR-SOB scores for A-T+N+ deteriorated faster than A-T-N- (p<0.001), A-T+N- (p<0.001) and A-T-N+ (p<0.001). Hippocampal atrophy progressed faster in A-T-N+ (p<0.001) and A-T+N+ (p=0.02) than in A-T-N-. Through this study, we discovered that even in individuals classified as amyloid negative, neurodegeneration with tau deposition exacerbates cognitive decline and worsens clinical symptoms, underscoring the need for continuous monitoring and observation.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"60 1","pages":"51-58"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139674042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0