Chonnam medical journal最新文献

{"title":"Comparison of Cement Penetration and Clinical Outcomes in Total Knee Arthroplasty: High-Viscosity vs Low-Viscosity Cement.","authors":"Hong-Yeol Yang, Jae-Hyeok Cheon, Youzhen Zheng, Jong-Keun Seon","doi":"10.4068/cmj.2025.61.2.90","DOIUrl":"10.4068/cmj.2025.61.2.90","url":null,"abstract":"<p><p>This retrospective study compared cement penetration, the radiolucent line (RLL) incidence, and clinical outcomes in total knee arthroplasty (TKA) using high-viscosity cement (HVC) versus low-viscosity cement (LVC) with a minimum follow-up of two years. We hypothesized that LVC would result in superior cement penetration and a reduced RLL incidence compared with HVC without differences in clinical outcomes. A total of 100 patients (50 HVC, 50 LVC) who underwent TKA with the same implant design were included. Cement penetration was assessed in four tibial and two femoral zones. Clinical outcomes including the VAS, WOMAC, KSS, KOOS and FJS were evaluated preoperatively and at the final follow-up visit. Postoperative complications were recorded. LVC demonstrated significantly greater cement penetration in the posterior tibial zone (3.03 mm vs. vs 2.82 mm; p=0.005) and posterior femoral zone (1.76 mm vs. 1.39 mm; p<0.000) than HVC, and no differences were observed in other zones. The RLL incidence and rates of complications including aseptic loosening and prosthetic joint infection were comparable between groups. Both groups showed significant postoperative improvements in the WOMAC, KSS, and KOOS, with no intergroup differences preoperatively and postoperatively. LVC demonstrated superior cement penetration in select zones, which may enhance implant fixation. However, there were no differences in the RLL incidence or clinical outcomes between the HVC and LVC groups. Both cements provided satisfactory fixation and clinical results, suggesting that either may be appropriate based on surgical preferences and fixation goals.</p>","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 2","pages":"90-93"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Significance of Afterdischarges in Late Response Recording for Cramp-Fasciculation Syndrome.","authors":"Hung Youl Seok","doi":"10.4068/cmj.2025.61.2.97","DOIUrl":"10.4068/cmj.2025.61.2.97","url":null,"abstract":"","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 2","pages":"97-99"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidized Mannan: A Novel Adjuvant Candidate for Enhancing Immune Responses in Veterinary Rabies Vaccine.","authors":"Rajab Mardani, Anahita Bahmanje, Yousef Cheraghi Kazeroni, Fereydoon Khoshroo, Bahram Roshanaie, Tahereh Sadeghche, Kourosh Pajaie, Seyed Nezamedin Hosseini, Delaram Doroud, Maryam Shahali","doi":"10.4068/cmj.2025.61.2.84","DOIUrl":"10.4068/cmj.2025.61.2.84","url":null,"abstract":"<p><p>Rabies continues to pose a serious public health threat worldwide, with vaccination being the most effective means of prevention. However, commercially available inactivated rabies vaccines often require multiple doses and lack potent adjuvants to enhance their efficacy. This study aimed to investigate the coupling of whole inactivated rabies virus to mannan under oxidizing conditions to improve immune responses against a standard rabies vaccine. We explored the conjugation of whole inactivated rabies virus with oxidized mannan (Rab-OxMan) to enhance immune responses. Mice were immunized intraperitoneally with 350 µg of the Rab-OxMan formulation on days 1 and 7. Two weeks after immunization, serum samples were collected to measure levels of IgG, IgM, and TNF-α using ELISA. The vaccine's potency was also evaluated using the National Institutes of Health (NIH) assay. Our findings showed a significant increase in IgG levels and a decrease in IgM levels in the Rab-OxMan group compared to the Alum-adjuvanted vaccine group (p<0.05). Additionally, TNF-α levels were notably higher in the Rab-OxMan group (p<0.05). Statistical analysis revealed that IgG levels had the highest sensitivity and specificity, with a significant correlation between the measured variables. Importantly, the Rab-OxMan formulation provided 1.8 times greater protection in challenge tests compared to the alum-adjuvanted group. This study is the first to demonstrate that oxidized mannan can serve as a novel adjuvant for veterinary rabies vaccines. The results highlight significant improvements in the immunogenicity and efficacy of rabies vaccines, suggesting a promising strategy for enhancing rabies prevention and potentially reducing the incidence of this deadly disease.</p>","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 2","pages":"84-89"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Helix Retraction of Stylet-Driven Pacing Leads with Extendable Helix Used for Left Bundle Branch Area Pacing.","authors":"Young Jae Ki, Sung Soo Kim","doi":"10.4068/cmj.2025.61.2.104","DOIUrl":"10.4068/cmj.2025.61.2.104","url":null,"abstract":"","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 2","pages":"104-105"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Obstructive General Angioscopy-Derived Aortic Atherosclerotic Ulceration Leading to a Fatal Type 1a Endoleak.","authors":"Keisuke Kojima, Takahiro Tamaki, Yasuo Okumura","doi":"10.4068/cmj.2025.61.2.102","DOIUrl":"10.4068/cmj.2025.61.2.102","url":null,"abstract":"","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 2","pages":"102-103"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alleviating Effects of Vitamins E and D on Tamoxifen-Induced Hepatotoxicity in Female Wistar Rats.","authors":"Sabah Karim D Salih, Nasrin Ziamajidi, Alireza Nourian, Roghayeh Abbasalipourkabir, Mahdi Bahmani","doi":"10.4068/cmj.2025.61.2.75","DOIUrl":"10.4068/cmj.2025.61.2.75","url":null,"abstract":"<p><p>The protective effects of vitamins E and D, stemming from their antioxidant and anti-inflammatory capabilities were investigated in the context of tamoxifen-induced liver toxicity. The study involved twenty-five female rats divided into five experimental groups: group C (olive oil: 500 µL), group T (tamoxifen: 40 mg/kg), groups TE (tamoxifen: 40 mg/kg and vitamin E: 100 IU/kg), group TD (tamoxifen: 40 mg/kg and vitamin D: 500 IU/kg) and group TED (tamoxifen: 40 mg/kg, vitamin E: 100 IU/kg and vitamin D: 500 IU/kg). Calorimetric methods were used to measure biochemical variables, hepatic level of Total antioxidant capacity (TAC), Total oxidant status (TOS), Malondialdehyde (MDA), Superoxide dismutase (SOD), Catalase (CAT), and Glutathione peroxidase (GPx). Hepatic level of tumor necrosis factor-α (TNF-α) was assayed by ELISA. Hematoxylin-eosin staining method was also employed to assess Tamoxifen-induced liver lesions. Tamoxifen treatment resulted in a significant increase in ALP (p-value<0.01), TOS, and OSI (p-value<0.01), a marked decrease in TAC level (p-value<0.01), and an increase in TNF-α level. Simultaneous treatment with combined supplementation of vitamins E and D effectively stopped the decrease of TAC and the increase of TOS, OSI, and MDA. Although treatment with tamoxifen led to a decrease SOD, CAT, and GPX compared with group C, the difference wasn't significant. Treatment with vitamins considerably caused to increase SOD and CAT activity in comparison with groups C and T. The current study's findings demonstrated that the combined supplementation of vitamins E, and D effectively alleviated Tamoxifen-associated liver damage and oxidative stress.</p>","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 2","pages":"75-83"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrence of Five Synchronous Gastric Tumors Including Early Gastric Cancer after Endoscopic Submucosal Dissection of a Gastric Adenoma.","authors":"Bohyun Jang, Sangmin Lee, Gyuhyun Park, You Suk Suh, Jae Il Chung, Donghui Kim","doi":"10.4068/cmj.2025.61.2.100","DOIUrl":"10.4068/cmj.2025.61.2.100","url":null,"abstract":"","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 2","pages":"100-101"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aortic Ring Sign: A Radiological Indicator of Anemia.","authors":"Yusaku Kajihara","doi":"10.4068/cmj.2025.61.2.94","DOIUrl":"10.4068/cmj.2025.61.2.94","url":null,"abstract":"","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 2","pages":"94"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin and Breast Cancer: A Review Article.","authors":"Alireza Nemati Motehaver, Fateme Sheida, Seyed Alireza Javadinia, Behnaz Behzadi, Saeid Afshar, Ali Khezrian, Mostafa Ganjuri, Shadi Eslah, Parisa Mokhles, Zahra Keshtpour Amlashi, Mohammad Esmaeil Akbari","doi":"10.4068/cmj.2025.61.2.63","DOIUrl":"10.4068/cmj.2025.61.2.63","url":null,"abstract":"<p><p>Breast cancer is one of the most common causes of death all over the world. Therapeutic options applied to the patients include surgery, chemotherapy, and radiotherapy. However, far advanced disease often leads to chemoresistance and toxicity. Innovative therapies are needed to address these challenges. Melatonin has the potential to prevent and treat cancer, as it has been revealed in numerous clinical studies. Melatonin is a nontoxic agent that is mostly produced in the pineal gland, inducing various mechanisms of action such as the induction of apoptosis, antiangiogenic, antiproliferative, and metastasis-inhibitory effects. Therefore, melatonin increases therapeutic sensitivity when combined with conventional medication in breast cancer. Melatonin (3-20 mg/day) may reduce breast cancer cell growth in preclinical studies and enhance chemotherapy efficacy. Small human trials suggest potential benefits, but larger studies are needed. Higher doses (≥20 mg/day) are sometimes used alongside chemotherapy. This manuscript reviews research that has demonstrated the antitumor properties of melatonin, thereby focusing on its actions on angiogenesis, apoptosis, metastasis, and antiproliferative properties. We also discuss recent advances in the understanding of the actions of melatonin on epigenetic mechanisms (especially DNA methylation) and telomere length. The data in this review were obtained from journal articles up to May 2024. Regarding the study, Google Scholar and ScienceDirect were used as engines to search for open access. We searched the ISI, Pubmed and Scopus as valid external databases, and as internal databases, ISC and Iran medex. By finding mean keywords such as 'breast cancer', 'estrogen', 'melatonin', 'cell death', 'cell proliferation', 'telomerase' and 'DNA methylation', we reached to the formula with maximum collectivity in searching, then equivalent terms were found by Mesh database. The review also covers recent clinical investigations of melatonin in breast cancer.</p>","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 2","pages":"63-74"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric Mixed Adenoma-Well Differentiated Neuroendocrine Tumor: A Case Report.","authors":"Nah Ihm Kim, Ji Shin Lee","doi":"10.4068/cmj.2025.61.2.95","DOIUrl":"10.4068/cmj.2025.61.2.95","url":null,"abstract":"","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 2","pages":"95-96"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}