Chonnam medical journal最新文献

P2Y12 Inhibitor Selection and Ischemic Outcomes in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: A Real-World Registry Analysis. 经皮冠状动脉介入治疗急性冠脉综合征患者的P2Y12抑制剂选择和缺血结局：一项真实世界注册分析

Chonnam medical journal Pub Date : 2026-09-01 Epub Date: 2026-09-21 DOI: 10.4068/cmj.2026.62.3.112

Donghyeon Joo, Jeong Tae Byoun, Sungho Jo, Jae Young Cho, Kyeong Ho Yun

{"title":"P2Y12 Inhibitor Selection and Ischemic Outcomes in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: A Real-World Registry Analysis.","authors":"Donghyeon Joo, Jeong Tae Byoun, Sungho Jo, Jae Young Cho, Kyeong Ho Yun","doi":"10.4068/cmj.2026.62.3.112","DOIUrl":"10.4068/cmj.2026.62.3.112","url":null,"abstract":"This study evaluated whether ticagrelor use is associated with improved ischemic outcomes compared with clopidogrel in Korean patients with acute coronary syndrome undergoing percutaneous coronary intervention. We analyzed patient-level data from 1,199 patients (614 clopidogrel, 585 ticagrelor) enrolled in two prospective registries. Stabilized inverse probability of treatment weighting (IPTW) was applied to balance baseline characteristics between the two groups. The primary endpoint was major adverse cardiovascular events (MACE), defined as a composite of all-cause death, myocardial infarction, stroke, or any revascularization. After IPTW adjustment, the weighted incidence of MACE was 8.1% in the clopidogrel group and 5.0% in the ticagrelor group, but this difference did not reach statistical significance (hazard ratio [HR], 0.61; 95% confidence interval [CI], 0.33-1.14; p=0.120). Target vessel failure also showed no significant differences between the groups (HR, 0.54; p=0.177). All-cause death was nominally lower in the ticagrelor group (3.4% vs. 1.1%; HR, 0.33; p=0.025); however, this was not accompanied by a reduction in other ischemic endpoints. Subgroup analyses revealed no significant treatment-by-subgroup interactions across various ischemic- or bleeding-risk features. In conclusion, ticagrelor did not demonstrate a statistically significant reduction in ischemic events compared with clopidogrel in this real-world Korean registry. These findings support the importance of individualized P2Y12 inhibitor selection based on patient-specific risk profiles.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"62 3","pages":"112-121"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149140217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age-Dependent Benefit of ECPR in OHCA: An Interaction Analysis. OHCA中ECPR的年龄依赖性获益：相互作用分析。

Chonnam medical journal Pub Date : 2026-09-01 Epub Date: 2026-09-21 DOI: 10.4068/cmj.2026.62.3.122

Mao-Hsien Chang, Yi-En Lin, Mao-Chang Chang, Wei-Hsi Chang

引用次数: 0

Screening Bacteriuria Using the Sysmex UF-5000 during Intravesical Bacillus Calmette-Guérin Therapy for Bladder Cancer. 用Sysmex UF-5000筛选膀胱内卡介苗-谷氨酰胺治疗膀胱癌期间的细菌尿。

Chonnam medical journal Pub Date : 2026-09-01 Epub Date: 2026-09-21 DOI: 10.4068/cmj.2026.62.3.99

Myung Soo Kim, Do Gyeong Lim, Seung Il Jung, Eu Chang Hwang, Dong Deuk Kwon

{"title":"Screening Bacteriuria Using the Sysmex UF-5000 during Intravesical Bacillus Calmette-Guérin Therapy for Bladder Cancer.","authors":"Myung Soo Kim, Do Gyeong Lim, Seung Il Jung, Eu Chang Hwang, Dong Deuk Kwon","doi":"10.4068/cmj.2026.62.3.99","DOIUrl":"10.4068/cmj.2026.62.3.99","url":null,"abstract":"Intravesical Bacillus Calmette-Guérin (BCG) therapy for bladder cancer requires screening for urinary tract infection during treatment, but conventional urinalysis cannot reliably distinguish bacteriuria from BCG-induced inflammatory cystitis. This study evaluated the ability of the Sysmex UF-5000 urine flow cytometer to detect significant bacteriuria and predict Gram stainability during intravesical BCG. This retrospective study included 145 patients who underwent intravesical BCG therapy after transurethral resection of bladder tumors (TURBT). Urine flow cytometry and cultures were performed at baseline, after TURBT, and weekly during BCG instillation. Diagnostic performance was assessed at the patient level over the BCG induction course, using urine cultures (≥105 CFU/mL) as the reference standard. Among 145 patients (median age 71 years; 88.3% male), 37 (25.5%) developed significant bacteriuria. A UF-5000 cutoff of >100 bacteria/µL identified bacteriuria with a sensitivity of 94.6% (95% CI, 82.3-98.5) and specificity of 68.5% (95% CI, 59.3-76.5), and a binary-classifier AUC of 0.816 (95% CI, 0.727-0.905); >1,000 bacteria/µL yielded 62.2% sensitivity, 96.3% specificity, and AUC 0.792. For Gram-stain prediction, sensitivity/specificity reached 83.3%/92.2% (Gram-negative) and 81.0%/84.2% (Gram-positive). The Sysmex UF-5000 shows promise as a rapid screening tool for bacteriuria and Gram-stain prediction during intravesical BCG therapy. Larger prospective studies are needed to validate optimal cutoff values for routine clinical application.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"62 3","pages":"99-106"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149140213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic Management of Recurrent Biliary Sepsis Associated with Prolonged Biliary Stent Exposure into the Duodenal Bulb and Concurrent Duodenal Obstruction in Advanced Pancreatic Cancer. 内镜下治疗晚期胰腺癌伴胆道支架长期暴露于十二指肠球部及并发十二指肠梗阻的复发性胆道脓毒症。

Chonnam medical journal Pub Date : 2026-09-01 Epub Date: 2026-09-21 DOI: 10.4068/cmj.2026.62.3.136

Wonjai Hur, Gyuyeong Kim, Bohyun Jang, Haegwang Shin, Kyoohyun Park, Yoosuk Suh, Donghui Kim, Hongsik Lee, Jaeil Chung

引用次数: 0

The Relationship between Cardiovascular Function and Decreased Intra-Abdominal Pressure Following Stool Evacuation. 排便后心血管功能与腹内压降低的关系。

Chonnam medical journal Pub Date : 2026-09-01 Epub Date: 2026-09-21 DOI: 10.4068/cmj.2026.62.3.107

Jun Seong Chung, Jae Kyun Ju

{"title":"The Relationship between Cardiovascular Function and Decreased Intra-Abdominal Pressure Following Stool Evacuation.","authors":"Jun Seong Chung, Jae Kyun Ju","doi":"10.4068/cmj.2026.62.3.107","DOIUrl":"10.4068/cmj.2026.62.3.107","url":null,"abstract":"Abdominal organs, though less than one-tenth of body mass, receive about 30% of cardiac output, with two-thirds passing through the descending aorta. The abdominal cavity contents-including organs, adipose tissue, and stool-affect peripheral vascular resistance. This study evaluated the impact of stool evacuation exceeding routine daily volume on intra-abdominal vascular resistance and systemic blood pressure. We retrospectively reviewed records of 56 patients who underwent tap water enemas for bloating and constipation. Episodes with >400 g body weight reduction after evacuation were analyzed. Blood pressure, body weight, BMI, mean arterial pressure (MAP), and pulse pressure (PP) were measured before and after evacuation. In hypertensive patients (systolic BP ≥140 mmHg), MAP decreased significantly, with notable PP differences between groups (p<.05). Comparisons among normotensive (≤119 mmHg), prehypertensive (120-139 mmHg), and hypertensive (≥140 mmHg) groups revealed significant MAP changes (p<.001). These findings suggest that stool evacuation beyond routine volume is associated with changes in intra-abdominal vascular resistance and correlates with systemic circulation, particularly showing a reduction in blood pressure among hypertensive individuals.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"62 3","pages":"107-111"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Value of Serum Neutrophil Gelatinase-Associated Lipocalin for Adrenal Insufficiency. 血清中性粒细胞明胶酶相关脂钙素对肾上腺功能不全的诊断价值。

Chonnam medical journal Pub Date : 2026-09-01 Epub Date: 2026-09-21 DOI: 10.4068/cmj.2026.62.3.129

Jee Hee Yoon, Ji Yong Park, A Ram Hong, Hee Kyung Kim, Ho-Cheol Kang

{"title":"Diagnostic Value of Serum Neutrophil Gelatinase-Associated Lipocalin for Adrenal Insufficiency.","authors":"Jee Hee Yoon, Ji Yong Park, A Ram Hong, Hee Kyung Kim, Ho-Cheol Kang","doi":"10.4068/cmj.2026.62.3.129","DOIUrl":"10.4068/cmj.2026.62.3.129","url":null,"abstract":"The adrenocorticotropic hormone (ACTH) stimulation test is the gold standard for confirming adrenal insufficiency (AI); however, its requirement for frequent blood draws and pharmacologic stimulation can be a barrier to early diagnosis. This study aims to evaluate the diagnostic value of serum neutrophil gelatinase-associated lipocalin (NGAL) as a novel biomarker for diagnosing AI. This prospective study was conducted at Chonnam National University Hwasun Hospital between June 2020 and November 2021. Patients with either pituitary tumors or a history of exogenous steroid use who underwent the rapid ACTH stimulation test were included in the analysis. A total of 75 patients suspected of having AI were analyzed, with 31 patients (41.3%) being diagnosed with AI. Serum NGAL levels were significantly higher in the secondary AI group with pituitary tumors compared to the non-AI group (92.2±33.6 ng/mL vs. 74.7±24.1 ng/mL, p=0.037). There was a negative correlation between serum NGAL levels and cortisol levels 60 minutes after ACTH administration in patients with pituitary tumors (r=-0.246, p=0.043). A positive correlation was found between serum NGAL and baseline serum creatinine levels in the secondary AI group with pituitary tumors (r=0.400, p=0.002). The Receiver operating characteristic curve analysis revealed that the area under the curve for secondary AI was 0.673, with an optimal cut-off value of 78.4 ng/mL, yielding a sensitivity of 60.0% and specificity of 59.4% (p=0.038). Serum NGAL may serve as a supportive diagnostic tool for secondary AI when confirmatory tests are not feasible.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"62 3","pages":"129-135"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149140171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Cross-Sectional Study on Oral Anticoagulant Utilization and Adverse Drug Reactions at Teaching Hospital, Iran. 伊朗教学医院口服抗凝血药物使用及不良反应的横断面研究

Chonnam medical journal Pub Date : 2026-05-01 Epub Date: 2026-05-22 DOI: 10.4068/cmj.2026.62.2.47

Shima Jafari, Sara Farooghi, Mandana Moradi

{"title":"A Cross-Sectional Study on Oral Anticoagulant Utilization and Adverse Drug Reactions at Teaching Hospital, Iran.","authors":"Shima Jafari, Sara Farooghi, Mandana Moradi","doi":"10.4068/cmj.2026.62.2.47","DOIUrl":"10.4068/cmj.2026.62.2.47","url":null,"abstract":"Oral anticoagulants are widely used to prevent and treat thromboembolic disorders, but inappropriate use can increase adverse effects and reduce therapeutic efficacy. This study evaluated the utilization patterns, dosing appropriateness, and adverse effects of oral anticoagulants in a tertiary hospital in Iran. A retrospective cross-sectional study was conducted at Razi Educational Hospital, Birjand University of Medical Sciences, from April 2020 to September 2022. Data were collected from medical records and pharmacy databases for patients aged ≥18 years who received warfarin, rivaroxaban, or apixaban. Dosing appropriateness was assessed using 2021 European Heart Rhythm Association (EHRA) and UpToDate guidelines, while adverse effects were classified according to 2020 American College of Cardiology (ACC) criteria. Among 1,027 patients (mean age 64±16.4 years; 52.3% male), rivaroxaban was the most prescribed anticoagulant (43.5%), followed by warfarin (33.2%) and apixaban (23.3%). Warfarin was primarily used for valvular heart disease, whereas DOACs were mainly prescribed for non-valvular atrial fibrillation and venous thromboembolism. Adverse effects occurred in 12.1% of patients, mostly minor bleeding, with warfarin accounting for the majority. Guideline-based dosing was achieved in 61.9% of apixaban and 58.6% of rivaroxaban users; 46.9% of warfarin patients reached therapeutic INR (2-3). Correct renal dose adjustments were applied in 40.5% of apixaban and 33% of rivaroxaban users. Guideline adherence for oral anticoagulant dosing was suboptimal. Improved prescriber education, enhanced drug utilization evaluation, and routine renal monitoring may enhance patient safety and optimize anticoagulation outcomes.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"62 2","pages":"47-54"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13225941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Black Pleural Effusion Related to Lung Adenocarcinoma. 黑色胸腔积液与肺腺癌有关。

Chonnam medical journal Pub Date : 2026-05-01 Epub Date: 2026-05-22 DOI: 10.4068/cmj.2026.62.2.95

Koichi Yano, Kyoko Yokosuka, Takuto Ishida

引用次数: 0

The Functional Study of Prostaglandin E₂ via EP Receptor on Pacemaker Activity in Interstitial Cells of Cajal from Murine Colon. 前列腺素E2通过EP受体对小鼠结肠Cajal间质细胞起搏器活性的影响。

Chonnam medical journal Pub Date : 2026-05-01 Epub Date: 2026-05-22 DOI: 10.4068/cmj.2026.62.2.79

Hongyang Gong, Han Yi Jiao, Yuan Chang, Seok Choi, Chan Sik Hong, Jae Yeoul Jun

{"title":"The Functional Study of Prostaglandin E2 via EP Receptor on Pacemaker Activity in Interstitial Cells of Cajal from Murine Colon.","authors":"Hongyang Gong, Han Yi Jiao, Yuan Chang, Seok Choi, Chan Sik Hong, Jae Yeoul Jun","doi":"10.4068/cmj.2026.62.2.79","DOIUrl":"10.4068/cmj.2026.62.2.79","url":null,"abstract":"The interstitial cells of Cajal (ICC) generate spontaneous pacemaker activities responsible for producing slow waves in the gut smooth muscles. Prostaglandin E2 (PGE2) is one of the most important prostanoids in the gut, playing a crucial role in multiple physiological and pathological processes. Because information regarding the effects of PGE2 on colonic ICC is limited, we investigated the effects of PGE2 and its underlying signaling pathways in murine colonic ICC. Whole-cell patch-clamp recordings and reverse transcription polymerase chain reaction (RT-PCR) analyses were performed to evaluate the effects of PGE2 on mouse colonic ICC. PGE2 had a dual effect on pacemaker potential in the current-clamp mode. RT-PCR data suggested the expression of EP3 and EP4 receptors in colonic ICC. Low PGE2 concentrations induced membrane depolarization and generation of pacemaker activities. And this effect is mimicked by sulprostone (an EP3 agonist). The low PGE2 concentration-induced effect was inhibited by anoctamin-1 (ANO1) or a T-type Ca2+ channel blocker. Conversely, high PGE2 concentrations induced membrane hyperpolarization and blocked pacemaker potential generation. However, this inhibitory effect was blocked by an ATP-sensitive potassium (KATP) channel blocker but not by other K+ channel blockers. Low concentrations of PGE2 activated EP3 receptors, leading to excitation of pacemaker activity through regulation of ANO1 and T-type Ca2+ channels in colonic ICC. In contrast, higher concentrations of PGE2 activated EP4 receptors and opened ATP-sensitive K+ channels, resulting in inhibition of pacemaker activity in colonic ICC.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"62 2","pages":"79-87"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13225939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Value of the Eosinophil-to-Neutrophil Ratio for In-Hospital Mortality in Patients Hospitalized with Acute Exacerbation of Chronic Obstructive Pulmonary Disease. 嗜酸性粒细胞与中性粒细胞比值对慢性阻塞性肺疾病急性加重住院患者住院死亡率的预后价值

Chonnam medical journal Pub Date : 2026-05-01 Epub Date: 2026-05-22 DOI: 10.4068/cmj.2026.62.2.88

Hong-Joon Shin, Sung-Chul Lim

{"title":"Prognostic Value of the Eosinophil-to-Neutrophil Ratio for In-Hospital Mortality in Patients Hospitalized with Acute Exacerbation of Chronic Obstructive Pulmonary Disease.","authors":"Hong-Joon Shin, Sung-Chul Lim","doi":"10.4068/cmj.2026.62.2.88","DOIUrl":"10.4068/cmj.2026.62.2.88","url":null,"abstract":"Inflammatory biomarkers reflecting acute immune responses may aid prognostic stratification in patients hospitalized with acute exacerbation of chronic obstructive pulmonary disease (COPD). The eosinophil-neutrophil ratio (ENR) integrates two key inflammatory cell populations; however, its prognostic value in the acute exacerbation of COPD has not been fully established. We conducted a retrospective cohort study of patients hospitalized for acute exacerbation of COPD between 2016 and 2021. ENR was calculated using peripheral blood eosinophil and neutrophil counts obtained at hospital admission. Patients were categorized into quartiles based on ENR, and outcomes were compared between the lowest quartile (Q1) and the upper three quartiles (Q2-Q4). The primary outcome was in-hospital mortality, and secondary outcomes included all-cause mortality within one year. A total of 435 patients were included (Q1, n=109; Q2-Q4, n=326). The cohort was predominantly male, with a mean age of 74 years. Mean ENR values were significantly lower in Q1 than in Q2-Q4 (0.0002 vs. 0.0471, p<0.001). In-hospital mortality was significantly higher in the Q1 group compared with the Q2-Q4 group (5.5% vs. 1.2%, p=0.019). In multivariable logistic regression analyses, low ENR remained independently associated with an increased in-hospital (adjusted odds ratio, 9.05; 95% confidence interval, 2.19-37.39; p=0.002). ENR was not associated with long-term survival. A low ENR at hospital admission is an independent predictor of in-hospital mortality in patients hospitalized with acute exacerbation of COPD, reflecting heightened acute-phase disease severity.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"62 2","pages":"88-94"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13225937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0