Chonnam medical journal最新文献_第2页

Overexpression of Long Non-Coding RNA, LINC01748, Predicts Extracellular Matrix Remodeling in Colorectal Cancer Through Let-7b-5p/CTHRC1 Axis. 长链非编码RNA LINC01748的过表达通过Let-7b-5p/CTHRC1轴预测结直肠癌细胞外基质重塑

Chonnam medical journal Pub Date : 2026-05-01 Epub Date: 2026-05-22 DOI: 10.4068/cmj.2026.62.2.64

Erfan Golestannejad, Heidar Tayebinia, Jamshid Karimi, Amirnader Emami Razavi, Iraj Khodadadi

{"title":"Overexpression of Long Non-Coding RNA, LINC01748, Predicts Extracellular Matrix Remodeling in Colorectal Cancer Through Let-7b-5p/CTHRC1 Axis.","authors":"Erfan Golestannejad, Heidar Tayebinia, Jamshid Karimi, Amirnader Emami Razavi, Iraj Khodadadi","doi":"10.4068/cmj.2026.62.2.64","DOIUrl":"10.4068/cmj.2026.62.2.64","url":null,"abstract":"Colorectal cancer (CRC) is a leading cause of cancer-related deaths. Long non-coding RNAs are emerging as key regulators in cancer by modulating functions of microRNAs thereby affecting expression of genes involved in the pathogenesis of cancers. Since the CTHRC1 gene (Collagen Triple-Helix-Repeat Containing-1) encodes an extracellular matrix protein involved in collagen regulation and cell migration, this study investigated the role of LINC01748 in CRC and its interaction with the Let-7b-5p/CTHRC1 axis. RNA sequencing data from The Cancer Genome Atlas database was analyzed to identify differentially expressed lncRNAs, miRNAs, and mRNAs in CRC. Interactions between LINC01748, miRNAs, and mRNAs were predicted, a protein-protein interaction network was constructed, and functional enrichment analysis was performed to reveal the biological activity of target genes. Additionally, the expression of LINC01748, Let-7b-5p, and CTHRC1 in CRC tissues and adjacent non-cancerous tissues were determined using RT-qPCR and western blotting. Collagen density was also evaluated by histopathological examination. 107 differentially expressed lncRNAs, 313 miRNAs, and 1,479 mRNAs were identified in CRC samples. Bioinformatics analysis indicated that LINC01748 may function as a competing endogenous-RNA for Let-7b-5p, regulating CTHRC1 expression. RT-qPCR confirmed upregulation of LINC01748 and CTHRC1 and downregulation of Let-7b-5p in CRC. Significant positive correlation of LINC01748 with CTHRC1, and a negative correlation with Let-7b-5p were detected. Gene Ontology and KEGG pathway analysis suggested the involvement of LINC01748/Let-7b-5p/CTHRC1 axis in ECM organization and collagen content. This study revealed the role of LINC01748 in the Let-7b-5p/CTHRC1 axis, highlighting its clinical significance in CRC.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"62 2","pages":"64-78"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13225935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Outcomes and Use of Implantable Cardioverter-Defibrillator in Ischemic Heart Failure Patients with Reduced Ejection Fraction: A Retrospective Observational Study. 缺血性心力衰竭患者射血分数降低的临床结果和使用植入式心律转复除颤器：一项回顾性观察研究。

Chonnam medical journal Pub Date : 2026-05-01 Epub Date: 2026-05-22 DOI: 10.4068/cmj.2026.62.2.55

Kyung Hoon Cho, Ki Hong Lee, Yong-Kyu Lee, Seok Oh, Yongwhan Lim, Joon Ho Ahn, Seung Hun Lee, Dae Young Hyun, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn, Jang Hoon Lee, Joo-Yong Hahn, Yu-Ri Kim, Nam Sik Yoon, Hyung Wook Park, Weon Kim, Myung Ho Jeong

{"title":"Clinical Outcomes and Use of Implantable Cardioverter-Defibrillator in Ischemic Heart Failure Patients with Reduced Ejection Fraction: A Retrospective Observational Study.","authors":"Kyung Hoon Cho, Ki Hong Lee, Yong-Kyu Lee, Seok Oh, Yongwhan Lim, Joon Ho Ahn, Seung Hun Lee, Dae Young Hyun, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn, Jang Hoon Lee, Joo-Yong Hahn, Yu-Ri Kim, Nam Sik Yoon, Hyung Wook Park, Weon Kim, Myung Ho Jeong","doi":"10.4068/cmj.2026.62.2.55","DOIUrl":"10.4068/cmj.2026.62.2.55","url":null,"abstract":"Limited data exist regarding the real-world practices and clinical outcomes in patients with ischemic heart failure with reduced left ventricular ejection fractions (LVEFs). Using nationwide registry data from South Korea, we aimed to investigate long-term outcomes and clinical practices, especially implantable cardioverter defibrillators (ICDs) implantation, in patients with reduced LVEFs at least 40 days after acute myocardial infarction (AMI). Of 13,056 patients with AMI between 2011 and 2015, we analyzed 350 (median age, 66 years [interquartile range, 56-75]) who had LVEFs <40% on follow-up transthoracic echocardiogram 40 days after the index event. The primary outcome was cardiac-cause mortality at 3 years. Secondary outcomes comprised major cardiovascular events as well as outcomes defined by the use of ICDs, cardiac resynchronization therapy defibrillators (CRT-Ds), and electrophysiology studies. Among 350 patients, 39 (11.1%) died from cardiac causes during 3 years of follow-up. Eleven (3.1%) were hospitalized for ventricular tachycardia. The rate of ICD or CRT-D implantation up to 3 years was 5.7% (20/350). Cox time-to-event analysis revealed older age, LVEF <30%, diabetes mellitus, and previous MI or revascularization as positively associated with cardiac death, whereas the use of statins and body weight <67 kg were negatively associated. This nationwide Korean registry demonstrated that only 5.7% of patients who had reduced LVEFs after 40 days of AMI underwent ICD implantations over 3 years. Considering the high mortality, concerted efforts are needed to improve clinical outcomes for patients who may have been candidates for ICD implantation.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"62 2","pages":"55-63"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13225942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Unusual Cause of Abdominal Pain. 一种不寻常的腹痛原因。

Chonnam medical journal Pub Date : 2026-05-01 Epub Date: 2026-05-22 DOI: 10.4068/cmj.2026.62.2.97

Yusaku Kajihara, Mamoru Munakata

引用次数: 0

Structural Comparison of the Optic Nerve Head Based on Visual Prognosis after Acute Primary Angle Closure. 基于急性初级角闭合后视觉预后的视神经头结构比较。

Chonnam medical journal Pub Date : 2026-01-01 Epub Date: 2026-01-23 DOI: 10.4068/cmj.2026.62.1.15

Mi Sun Sung, Jong Hoon Lee, Sang Woo Park

{"title":"Structural Comparison of the Optic Nerve Head Based on Visual Prognosis after Acute Primary Angle Closure.","authors":"Mi Sun Sung, Jong Hoon Lee, Sang Woo Park","doi":"10.4068/cmj.2026.62.1.15","DOIUrl":"10.4068/cmj.2026.62.1.15","url":null,"abstract":"To compare optic nerve head (ONH) and peripapillary structural OCT parameters between eyes with and without visual field (VF) defects one year after an episode of acute primary angle closure (APAC) in a cohort treated uniformly treated with early clear-lens extraction. Forty-seven eyes of 47 patients with a history of APAC episode who underwent early clear-lens extraction at Chonnam National University Hospital were retrospectively reviewed. Spectral-domain optical coherence tomography (SD-OCT) performed one year after the episode was used to assess Bruch's membrane opening-minimum rim width (BMO-MRW), retinal nerve fiber layer (RNFL) thickness, lamina cribrosa (LC) thickness and depth, and parapapillary atrophy (PPA) subdivided into PPA+BM and PPA-BM. Patients were classified according to the presence or absence of VF defects. At one year, 23 eyes (48.9%) had variable degrees of visual field (VF) defects. Compared with eyes with normal VF, the VF-defect group showed significantly thinner global BMO-MRW (p<0.001) and peripapillary RNFL (p<0.001), reduced LC thickness (p<0.001), shallower LC depth (p=0.028), and a wider PPA+BM (p<0.001). APAC patients who underwent early lens extraction may develop residual VF defect despite normalization of IOP. These defects were associated with structural damage in the rim, RNFL, LC, and PPA+BM as detected by SD-OCT. Comprehensive OCT analysis may help identify patients at risk of long-term functional sequelae after APAC.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"62 1","pages":"15-20"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12884697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrence Rate of Pelvic Organ Prolapse after Total Vaginal Hysterectomy with Anteroposterior Colporrhaphy. 阴道全子宫切除术合并阴道前后切开术后盆腔器官脱垂的复发率。

Chonnam medical journal Pub Date : 2026-01-01 Epub Date: 2026-01-23 DOI: 10.4068/cmj.2026.62.1.37

Moon Kyoung Cho

{"title":"Recurrence Rate of Pelvic Organ Prolapse after Total Vaginal Hysterectomy with Anteroposterior Colporrhaphy.","authors":"Moon Kyoung Cho","doi":"10.4068/cmj.2026.62.1.37","DOIUrl":"10.4068/cmj.2026.62.1.37","url":null,"abstract":"This study aimed to estimate the recurrence rate of pelvic organ prolapse (POP) following traditional total vaginal hysterectomy (TVH) with anteroposterior (AP) colporrhaphy using the Pelvic Organ Prolapse-Quantification (POP-Q) system, to evaluate the utility of these classical surgical approaches, and to identify risk factors associated with recurrence after pelvic organ prolapse surgery. In this retrospective cohort study, data were collected from 158 patients who underwent TVH with AP colporrhaphy for POP at Chonnam National University Hospital between January 2015 and April 2020 and had follow-up data exceeding 6 months. Data regarding age, body mass index, menopausal status, prolapse severity, surgical method, and POP-Q stage during outpatient post-operative tracking were collected. All 158 patients underwent TVH. Of these, 147 (93.0%) underwent TVH with AP colporrhaphy; two (1.3%) underwent hysterectomy with anterior colporrhaphy, and nine (5.7%) underwent hysterectomy with posterior colporrhaphy. Before the initial surgery, 16 (10.1%), 113 (71.5%), and 29 (18.3%) patients had stages II, III, and IV disease, respectively. The anterior compartment was the most commonly affected (74.1%), followed by the apical (19.6%) and the posterior (6.3%) compartments. Recurrence was observed in 13 patients (8.2%). Parity, menopausal status, and stage of POP did not significantly influence disease recurrence. Traditional TVH with AP colporrhaphy is associated with a relatively low recurrence rate and, thus, remains a valuable surgical treatment option for POP.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"62 1","pages":"37-40"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12884695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Associated with Acute and Persistence of Depressive Symptoms among the General Population during the COVID-19 Pandemic in South Korea: An Online Longitudinal Survey Study. 韩国COVID-19大流行期间普通人群中与急性和持续抑郁症状相关的因素：一项在线纵向调查研究

Chonnam medical journal Pub Date : 2026-01-01 Epub Date: 2026-01-23 DOI: 10.4068/cmj.2026.62.1.21

Ju-Yeon Lee, Honey Kim, Ju-Wan Kim, Hee-Ju Kang, Seunghyong Ryu, Jae-Min Kim, Il-Seon Shin, Sung-Wan Kim

{"title":"Factors Associated with Acute and Persistence of Depressive Symptoms among the General Population during the COVID-19 Pandemic in South Korea: An Online Longitudinal Survey Study.","authors":"Ju-Yeon Lee, Honey Kim, Ju-Wan Kim, Hee-Ju Kang, Seunghyong Ryu, Jae-Min Kim, Il-Seon Shin, Sung-Wan Kim","doi":"10.4068/cmj.2026.62.1.21","DOIUrl":"10.4068/cmj.2026.62.1.21","url":null,"abstract":"The COVID-19 pandemic has adversely affected the mental health of the global population. This study aimed to assess the acute and persistent symptoms of depression, as well as factors related to their manifestation, through a longitudinal study design. A total of 1,492 community-dwelling adults from an online public panel across three regions were evaluated at baseline, with 908 adults (60.9%) followed up after six months. Depression symptoms were evaluated using Patient Health Questionnaire-9 (PHQ-9). Participants also completed self-administered questionnaires on sociodemographic information, psychosocial experiences related to COVID-19, the UCLA Loneliness Scale, and the Korean version of the Gratitude Questionnaire (K-GQ-6).The prevalence of acute and persistent depression symptoms was 8.4% and 12.0%, respectively. Multivariate logistic regression analysis identified changes in predictors of depression over time, with younger age and self-isolation experience found to be associated with acute depression. Factors such as underlying mental illness, eating and sleeping disturbances, loneliness, and COVID-19-related stress emerged as significant risk factors for persistent depression. A disposition toward gratitude was identified as a protective factor for persistent depressive symptoms. These findings suggest that during any long-term pandemic crisis such as COVID-19, timely support and attention are essential for vulnerable populations, including young people and individuals with mental health conditions, to prevent depression. Specifically, promoting daily routines such as regular eating and sleeping patterns, and managing COVID-19-related stress may be critical in preventing persistent depression. Additionally, psychological support that reduces loneliness and fosters gratitude may help mitigate depression risk.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"62 1","pages":"21-28"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12884699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unexplained Neurological Deterioration in Traumatic Brain Injury: Possible Cerebrospinal Fluid-Related Mechanisms. 外伤性脑损伤中不明原因的神经退化：可能的脑脊液相关机制

Chonnam medical journal Pub Date : 2026-01-01 Epub Date: 2026-01-23 DOI: 10.4068/cmj.2026.62.1.41

Hanseung Ryu

引用次数: 0

Relationship between Multiple HPV Infections and Cervical Cytology: Single Center Experience. 多重HPV感染与宫颈细胞学的关系：单中心经验。

Chonnam medical journal Pub Date : 2026-01-01 Epub Date: 2026-01-23 DOI: 10.4068/cmj.2026.62.1.11

Kyeongmin Kim, In Ho Choi

{"title":"Relationship between Multiple HPV Infections and Cervical Cytology: Single Center Experience.","authors":"Kyeongmin Kim, In Ho Choi","doi":"10.4068/cmj.2026.62.1.11","DOIUrl":"10.4068/cmj.2026.62.1.11","url":null,"abstract":"Cervical cancer remains a significant public health concern, with persistent high-risk human papillomavirus (HPV) infections being a major contributing factor. This retrospective study investigates the correlation between multiple HPV infections and cervical cytology abnormalities in patients tested at a single hospital in Seoul, South Korea. A total of 6,869 HPV genotyping tests conducted between January 2017 and December 2023 were analyzed, with 1,396 cases testing positive for HPV. High-risk HPV (HRHPV) types were detected in 59.0% of HPV-positive cases, with HPV 53 being the most prevalent genotype. The frequency of squamous intraepithelial abnormalities (SIA) increased with the number of concurrent HPV infections. Among single infections, 24.2% had SIA, compared to 38.4% for two genotypes, 43.9% for three, and 70.0% for four. HRHPV-positive cases had a significantly higher prevalence of high-grade lesions (ASC-H and HSIL) compared to non-HRHPV and HPV-negative cases. However, no significant difference in cytological outcomes was observed among different co-infection groups. These findings suggest that multiple HPV infections may associated with increased cytological abnormalities, particularly in HRHPV-positive cases. Regional variations in HPV genotype prevalence highlight the need for tailored vaccination and screening strategies. While this study provides valuable epidemiological insights, its retrospective nature and lack of long-term follow-up warrant further research.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"62 1","pages":"11-14"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12884696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curcumin Attenuates Lipopolysaccharide-Induced Acute Lung Injury Through Anti-Inflammatory Effects in RAW Cells. 姜黄素通过对RAW细胞的抗炎作用减轻脂多糖诱导的急性肺损伤。

Chonnam medical journal Pub Date : 2026-01-01 Epub Date: 2026-01-23 DOI: 10.4068/cmj.2026.62.1.29

Mei Li, Joon-Suk Bom, Jinwoo Heo, Cheon Hee Park, Sang Hyun Kwak

{"title":"Curcumin Attenuates Lipopolysaccharide-Induced Acute Lung Injury Through Anti-Inflammatory Effects in RAW Cells.","authors":"Mei Li, Joon-Suk Bom, Jinwoo Heo, Cheon Hee Park, Sang Hyun Kwak","doi":"10.4068/cmj.2026.62.1.29","DOIUrl":"10.4068/cmj.2026.62.1.29","url":null,"abstract":"The pathogenesis of endotoxin-induced acute lung injury is fundamentally driven by dysregulated innate immune responses, where macrophage-mediated cytokine surges and subsequent signaling cascades trigger neutrophil infiltration and tissue damage. This study investigated whether curcumin modulates inflammatory signaling pathways and attenuates lung injury in experimental endotoxemia. Using endotoxin-stimulated murine macrophages and a mouse model of intratracheal lipopolysaccharide challenge, inflammatory cytokine production, mitogen-activated protein kinase activation, pulmonary edema, neutrophil accumulation, histopathologic injury, and short-term survival were assessed. Curcumin suppressed endotoxin-induced tumor necrosis factor-α production and selectively inhibited ERK1/2 and JNK phosphorylation without affecting p38 signaling in macrophages. In vivo, curcumin reduced pulmonary cytokine levels, neutrophil infiltration, lung edema, and histologic injury, and was associated with improved survival following severe endotoxin exposure. These findings indicate that curcumin attenuates acute lung injury by selectively modulating intracellular inflammatory signaling pathways, supporting the concept that targeted inhibition of specific kinase cascades may mitigate inflammatory lung damage without broad immune suppression.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"62 1","pages":"29-36"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12884700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Coding RNAs in Obesity-Driven Vascular Dysfunction: Mechanisms, EndMT, and Translational Opportunities. 非编码rna在肥胖驱动的血管功能障碍：机制，末端转运和翻译机会。

Chonnam medical journal Pub Date : 2026-01-01 Epub Date: 2026-01-23 DOI: 10.4068/cmj.2026.62.1.1

Juhyun Song

{"title":"Non-Coding RNAs in Obesity-Driven Vascular Dysfunction: Mechanisms, EndMT, and Translational Opportunities.","authors":"Juhyun Song","doi":"10.4068/cmj.2026.62.1.1","DOIUrl":"10.4068/cmj.2026.62.1.1","url":null,"abstract":"Obesity is a systemic vascular disease characterized by the convergence of metabolic excess and adipose dysfunction, leading to endothelial injury and plasticity. Beyond hemodynamic stress, chronic nutritional and inflammatory stimuli trigger oxidative and pro-thromboinflammatory pathways, reduce nitric oxide bioavailability, and promote endothelial-to-mesenchymal transition (EndMT). This process contributes to fibrotic remodeling, plaque vulnerability, arterial stiffening, and microvascular rarefaction. Non-coding RNAs (ncRNAs)-microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs)-play pivotal roles as regulators within the vascular wall and across tissues via extracellular vesicles (EVs) derived from adipose tissue and perivascular fat. We synthesize evidence demonstrating that ncRNAs integrate TGF-β/Smad, NF-κB, HIF-1α, and Wnt/β-catenin signaling pathways with the endothelial metabolic state, including the epigenetic regulation of EndMT linked to fatty acid oxidation. Single-cell and lineage-tracing studies identify nascent EndMT subpopulations in obese tissues, while in vitro models reveal cytokine and lipotoxic triggers that shift ncRNA networks, stabilizing mesenchymal programs. Translationally, circulating and EV-associated ncRNAs mirror adiposity, dyslipidemia, insulin resistance, and endothelial dysfunction, improving with weight loss. This underscores their potential as dynamic biomarkers for patient stratification, particularly when integrated with vascular imaging and functional assays. Furthermore, we discuss therapeutic strategies such as miRNA antagomirs, lncRNA gapmers, and circRNA inhibitors, addressing the critical challenge of endothelium-targeted delivery through approaches like ligand-directed nanoparticles, endothelial-tropic liposomes, and engineered EVs. This review positions obesity-associated vascular disease as an ncRNA-driven network disorder and outlines pathways toward precision diagnostics and RNA-based interventions.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"62 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12884702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0