Chonnam medical journal最新文献_第2页

Curcuminoid-Piperine Combination Improves Radical Scavenging Activity in Women with Premenstrual Syndrome and Dysmenorrhea: A Post-hoc Analysis of a Randomized Clinical Study. 姜黄素-哌啶复方制剂可提高经前综合征和痛经妇女的自由基清除活性：一项随机临床研究的事后分析。

Chonnam medical journal Pub Date : 2024-05-01 Epub Date: 2024-05-24 DOI: 10.4068/cmj.2024.60.2.113

Samira Karbasi, Saman Seyedabadi, Samira Mozaffari, Zahra Foroutan, Gordon A Ferns, Asghar Zarban, Afsane Bahrami

{"title":"Curcuminoid-Piperine Combination Improves Radical Scavenging Activity in Women with Premenstrual Syndrome and Dysmenorrhea: A Post-hoc Analysis of a Randomized Clinical Study.","authors":"Samira Karbasi, Saman Seyedabadi, Samira Mozaffari, Zahra Foroutan, Gordon A Ferns, Asghar Zarban, Afsane Bahrami","doi":"10.4068/cmj.2024.60.2.113","DOIUrl":"10.4068/cmj.2024.60.2.113","url":null,"abstract":"Oxidative stress maybe involved in the patho-etiology of menstrual-associated complications. Curcuminoids, are polyphenolic natural compounds that have potentially important functional activities. This triple-blind, randomized, placebo-controlled trial was performed to investigate the effects of a curcuminoids on oxidative stress and antioxidant capacity in girls with premenstrual syndrome (PMS) and dysmenorrhea. Eighty young girls with both PMS and dysmenorrhea were randomly given either curcuminoids (500 mg+5 mg piperine) or a placebo daily, for a period from 7 days pre- until 3 days post- initiation of menstrual bleeding for 3 successive menstrual cycles. The total antioxidant capacity and free radical scavenging activity of serum and urine were quantified via ferric reducing/antioxidant power (FRAP) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) methods, respectively. There were no significant differences between the placebo and curcumin groups, with respect to the age, dietary intake and biochemical/anthropometric indices (p>0.05). The curcumin treatment significantly increased the free-radical scavenging activity of serum compared to the treatment with placebo (p=0.031). Although, no significant changes were found in serum and urinary levels of FRAP, DPPH and MDA between the groups (p>0.05). Curcumin treatment did increase free-radical scavenging activity and antioxidant potential in girls with PMS and dysmenorrhea. Investigations with higher doses and duration of curcumin are required to verify our findings.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"60 2","pages":"113-119"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic Clipping for a Hemorrhagic Ileal Ulcer Caused by Campylobacter Enterocolitis. 内镜下剪除弯曲杆菌肠炎引起的出血性回肠溃疡

Chonnam medical journal Pub Date : 2024-05-01 Epub Date: 2024-05-24 DOI: 10.4068/cmj.2024.60.2.129

Mayumi Shiroma, Mami Tomiyama, Yuko Tasato, Maki Setake, Hitoshi Mabuchi, Yuzuru Kinjo, Masaru Miyazato, Noriya Nakachi, Hiroto Shimajiri, Ryosaku Tomiyama, Akira Hokama

引用次数: 0

Huge Left Atrial Myxoma Obstructs the Mitral Valve and Causes Massive Pleural Effusion. 巨大左心房肌瘤阻塞二尖瓣并导致大量胸腔积液

Chonnam medical journal Pub Date : 2024-05-01 Epub Date: 2024-05-24 DOI: 10.4068/cmj.2024.60.2.138

Wei-Chieh Lee, Jhih-Yuan Shih, Nan-Chun Wu

引用次数: 0

Ischemic Gastropathy and Septic Pulmonary Embolism in a Patient with End-Stage Renal Disease. 一名终末期肾病患者的缺血性胃病和化脓性肺栓塞。

Chonnam medical journal Pub Date : 2024-05-01 Epub Date: 2024-05-24 DOI: 10.4068/cmj.2024.60.2.134

Masayoshi Nagahama, Ryo Shimoji, Noriya Nakachi, Daijiro Kagawa, Hiroshi Miyazato, Akira Hokama, Hirofumi Tomori

引用次数: 0

Long-Term Prognostic Value of Infarct Transmurality Determined by Contrast-Enhanced Cardiac Magnetic Resonance after ST-Segment Elevation Myocardial Infarction. ST段抬高型心肌梗死后通过对比增强心脏磁共振检查确定梗死透射性的长期预后价值

Chonnam medical journal Pub Date : 2024-05-01 Epub Date: 2024-05-24 DOI: 10.4068/cmj.2024.60.2.120

In Young Choi, Hyun-Wook Kim, Dong Hyun Gim, Young-Jae Ki, Hyun Kuk Kim, Sung Soo Kim, Keun-Ho Park, Heesang Song, Dong-Hyun Choi

{"title":"Long-Term Prognostic Value of Infarct Transmurality Determined by Contrast-Enhanced Cardiac Magnetic Resonance after ST-Segment Elevation Myocardial Infarction.","authors":"In Young Choi, Hyun-Wook Kim, Dong Hyun Gim, Young-Jae Ki, Hyun Kuk Kim, Sung Soo Kim, Keun-Ho Park, Heesang Song, Dong-Hyun Choi","doi":"10.4068/cmj.2024.60.2.120","DOIUrl":"10.4068/cmj.2024.60.2.120","url":null,"abstract":"The long-term prognostic significance of maximal infarct transmurality evaluated by contrast-enhanced cardiac magnetic resonance (CE-CMR) in ST-segment elevation myocardial infarction (STEMI) patients has yet to be determined. This study aimed to see if maximal infarct transmurality has any additional long-term prognostic value over other CE-CMR predictors in STEMI patients, such as microvascular obstruction (MVO) and intramyocardial hemorrhage (IMH). The study included 112 consecutive patients who underwent CE-CMR after STEMI to assess established parameters of myocardial injury as well as the maximal infarct transmurality. The primary clinical endpoint was the occurrence of major adverse cardiac events (MACE), which included all-cause death, non-fatal reinfarction, and new heart failure hospitalization. The MACE occurred in 10 patients over a median follow-up of 7.9 years (IQR, 5.8 to 9.2 years) (2 deaths, 3 nonfatal MI, and 5 heart failure hospitalization). Patients with MACE had significantly higher rates of transmural extent of infarction, infarct size >5.4 percent, MVO, and IMH compared to patients without MACE. In stepwise multivariable Cox regression analysis, the transmural extent of infarction defined as 75 percent or more of infarct transmurality was an independent predictor of the MACE after correction for MVO and IMH (hazard ratio 8.7, 95% confidence intervals [CIs] 1.1-71; p=0.043). In revascularized STEMI patients, post-infarction CE-CMR-based maximal infarct transmurality is an independent long-term prognosticator. Adding maximal infarct transmurality to CE-CMR parameters like MVO and IMH could thus identify patients at high risk of long-term adverse outcomes in STEMI.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"60 2","pages":"120-128"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systemic Inflammatory Response Following Preoperative Chemoradiotherapy Can Affect Oncologic Outcomes in MSI-H/dMMR Rectal Cancer. 术前化放疗后的全身炎症反应会影响MSI-H/dMMR直肠癌的肿瘤预后

Chonnam medical journal Pub Date : 2024-05-01 Epub Date: 2024-05-24 DOI: 10.4068/cmj.2024.60.2.105

Hyukjin Choi, Jin Ho Baek, An Na Seo, Su Yeon Park, Hye Jin Kim, Jun Seok Park, Gyu Seog Choi, Jong Gwang Kim, Byung Woog Kang

{"title":"Systemic Inflammatory Response Following Preoperative Chemoradiotherapy Can Affect Oncologic Outcomes in MSI-H/dMMR Rectal Cancer.","authors":"Hyukjin Choi, Jin Ho Baek, An Na Seo, Su Yeon Park, Hye Jin Kim, Jun Seok Park, Gyu Seog Choi, Jong Gwang Kim, Byung Woog Kang","doi":"10.4068/cmj.2024.60.2.105","DOIUrl":"10.4068/cmj.2024.60.2.105","url":null,"abstract":"Systemic inflammatory response (SIR) is a crucial determinant of disease progression and survival in patients with colorectal cancer. This study investigated the prognostic relevance of changes in the platelet count on survival and the predictive value of changes in the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) on the pathological tumor response to preoperative chemoradiotherapy (CRT) in patients with microsatellite instability-high (MSI-H) rectal cancer. From 2011 to 2022, data of 46 consecutive patients with MSI-H rectal cancer who were treated with preoperative CRT followed by curative surgery at Kyungpook National University Chilgok Hospital (Daegu, South Korea) were retrospectively analyzed. A 235 cut-off value was used to define whether PLR was high or low. Any change in the PLR or NLR was calculated on the basis of subtracting the pre-CRT PLR or NLR from the post-CRT values. Both pre-CRT and post-CRT values of the NLR and PLR were not significantly associated with clinical outcomes. Simple logistic regression analysis showed that a change in the PLR following CRT was not significantly associated with survival outcomes; however, patients who maintained a high change in the PLR following CRT showed significantly better pathologic T-stage. No statistically significant association was noted between changes in the platelet count and clinical outcomes of patients. The results suggested that changes in the PLR following CRT are associated with pathologic T-stage of the group. However, the SIR markers showed no prognostic values on the survival outcomes of the patients with MSI-H/mismatch repair-deficient (dMMR) locally advanced rectal cancer (LARC).","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"60 2","pages":"105-112"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Unusual Cause of Severe Splenomegaly. 严重脾肿大的不寻常原因

Chonnam medical journal Pub Date : 2024-05-01 Epub Date: 2024-05-24 DOI: 10.4068/cmj.2024.60.2.136

Yusaku Kajihara

引用次数: 0

Ayurvedic Medicine: A Traditional Medical System and Its Heavy Metal Poisoning. 阿育吠陀医学：传统医学体系及其重金属中毒。

Chonnam medical journal Pub Date : 2024-05-01 Epub Date: 2024-05-24 DOI: 10.4068/cmj.2024.60.2.97

Mohammad Mamun Sikder

引用次数: 0

The Effects of Coenzyme Q10 on Contrast-Induced Acute Kidney Injury in Type 2 Diabetes: A Randomized Clinical Trial. 辅酶Q10对2型糖尿病造影剂诱发的急性肾损伤的影响：随机临床试验

Chonnam medical journal Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.4068/cmj.2024.60.1.59

Ashkan Karbasi, Ali Abbasi, Abbas Mohagheghi, Jalal Poorolajal, Farzad Emami, Shirin Moradkhani, Iraj Khodadadi, Mahmoud Gholyaf, Heidar Tavilani

{"title":"The Effects of Coenzyme Q10 on Contrast-Induced Acute Kidney Injury in Type 2 Diabetes: A Randomized Clinical Trial.","authors":"Ashkan Karbasi, Ali Abbasi, Abbas Mohagheghi, Jalal Poorolajal, Farzad Emami, Shirin Moradkhani, Iraj Khodadadi, Mahmoud Gholyaf, Heidar Tavilani","doi":"10.4068/cmj.2024.60.1.59","DOIUrl":"10.4068/cmj.2024.60.1.59","url":null,"abstract":"Contrast-induced acute kidney injury (CI-AKI) is a frequent challenge following the injection of contrast media and its subsequent oxidative stress. The aim of the present study was to evaluate the preventive effects of coenzyme Q10 (Q10), as a mitochondrial-targeted antioxidant in CI-AKI in diabetic patients, who account for a large proportion of angiographic cases. A total of 118 diabetic patients were randomly assigned to receive 120 mg of oral coenzyme Q10 (Q10 group) or placebo (Placebo group) for four days, starting 24 hours before contrast media injection. Blood urea nitrogen (BUN), serum and urinary creatinine, estimated glomerular filtration rate (eGFR), urinary malondialdehyde (UMDA), urinary total antioxidant capacity (UTAC), and urinary mitochondrial to nuclearDNA ratios (mtDNA/nDNA ratio) were evaluated before and after the treatment period. Urine sediments were also evaluated to report the urine microscopy score (UMS).The levels of BUN, serum and urine creatinine, and UMS were similar in the Q10 and placebo groups. EGFR was lower in the Q10 group before the treatment (p=0.013) but not after. The urinary mtDNA/nDNA ratio was 3.05±1.68 and 3.69±2.58 in placebo and Q10 groups, but UTAC was found to be lower in Q10 both before (p=0.006) and after the treatment (p<0.001). The incidence of CI-AKI was 14.40% and the mtDNA/nNDA ratio was similar between CI-AKI and non-CI-AKI patients. In conclusion, Q10 treatment shows no favorable effect on prevention of CI-AKI or a urinary mtDNA/nDNA ratio among diabetic patients.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"60 1","pages":"59-68"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139673981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Gastric Lipoma That Grew in Size in Seven Years Presenting Bleeding. 胃脂肪瘤在七年内不断增大，并伴有出血。

Chonnam medical journal Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.4068/cmj.2024.60.1.89

Maki Setake, Mayumi Shiroma, Mami Tomiyama, Yuko Tasato, Hitoshi Mabuchi, Yuzuru Kinjo, Masaru Miyazato, Noriya Nakachi, Hiroto Shimajiri, Ryosaku Tomiyama, Yoshiki Chinen, Akira Hokama

引用次数: 0