Chonnam medical journal最新文献_第7页

Systemic Inflammatory Response Following Preoperative Chemoradiotherapy Can Affect Oncologic Outcomes in MSI-H/dMMR Rectal Cancer. 术前化放疗后的全身炎症反应会影响MSI-H/dMMR直肠癌的肿瘤预后

Chonnam medical journal Pub Date : 2024-05-01 Epub Date: 2024-05-24 DOI: 10.4068/cmj.2024.60.2.105

Hyukjin Choi, Jin Ho Baek, An Na Seo, Su Yeon Park, Hye Jin Kim, Jun Seok Park, Gyu Seog Choi, Jong Gwang Kim, Byung Woog Kang

{"title":"Systemic Inflammatory Response Following Preoperative Chemoradiotherapy Can Affect Oncologic Outcomes in MSI-H/dMMR Rectal Cancer.","authors":"Hyukjin Choi, Jin Ho Baek, An Na Seo, Su Yeon Park, Hye Jin Kim, Jun Seok Park, Gyu Seog Choi, Jong Gwang Kim, Byung Woog Kang","doi":"10.4068/cmj.2024.60.2.105","DOIUrl":"10.4068/cmj.2024.60.2.105","url":null,"abstract":"Systemic inflammatory response (SIR) is a crucial determinant of disease progression and survival in patients with colorectal cancer. This study investigated the prognostic relevance of changes in the platelet count on survival and the predictive value of changes in the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) on the pathological tumor response to preoperative chemoradiotherapy (CRT) in patients with microsatellite instability-high (MSI-H) rectal cancer. From 2011 to 2022, data of 46 consecutive patients with MSI-H rectal cancer who were treated with preoperative CRT followed by curative surgery at Kyungpook National University Chilgok Hospital (Daegu, South Korea) were retrospectively analyzed. A 235 cut-off value was used to define whether PLR was high or low. Any change in the PLR or NLR was calculated on the basis of subtracting the pre-CRT PLR or NLR from the post-CRT values. Both pre-CRT and post-CRT values of the NLR and PLR were not significantly associated with clinical outcomes. Simple logistic regression analysis showed that a change in the PLR following CRT was not significantly associated with survival outcomes; however, patients who maintained a high change in the PLR following CRT showed significantly better pathologic T-stage. No statistically significant association was noted between changes in the platelet count and clinical outcomes of patients. The results suggested that changes in the PLR following CRT are associated with pathologic T-stage of the group. However, the SIR markers showed no prognostic values on the survival outcomes of the patients with MSI-H/mismatch repair-deficient (dMMR) locally advanced rectal cancer (LARC).","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"60 2","pages":"105-112"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Unusual Cause of Severe Splenomegaly. 严重脾肿大的不寻常原因

Chonnam medical journal Pub Date : 2024-05-01 Epub Date: 2024-05-24 DOI: 10.4068/cmj.2024.60.2.136

Yusaku Kajihara

引用次数: 0

Ayurvedic Medicine: A Traditional Medical System and Its Heavy Metal Poisoning. 阿育吠陀医学：传统医学体系及其重金属中毒。

Chonnam medical journal Pub Date : 2024-05-01 Epub Date: 2024-05-24 DOI: 10.4068/cmj.2024.60.2.97

Mohammad Mamun Sikder

引用次数: 0

The Effects of Coenzyme Q10 on Contrast-Induced Acute Kidney Injury in Type 2 Diabetes: A Randomized Clinical Trial. 辅酶Q10对2型糖尿病造影剂诱发的急性肾损伤的影响：随机临床试验

Chonnam medical journal Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.4068/cmj.2024.60.1.59

Ashkan Karbasi, Ali Abbasi, Abbas Mohagheghi, Jalal Poorolajal, Farzad Emami, Shirin Moradkhani, Iraj Khodadadi, Mahmoud Gholyaf, Heidar Tavilani

{"title":"The Effects of Coenzyme Q10 on Contrast-Induced Acute Kidney Injury in Type 2 Diabetes: A Randomized Clinical Trial.","authors":"Ashkan Karbasi, Ali Abbasi, Abbas Mohagheghi, Jalal Poorolajal, Farzad Emami, Shirin Moradkhani, Iraj Khodadadi, Mahmoud Gholyaf, Heidar Tavilani","doi":"10.4068/cmj.2024.60.1.59","DOIUrl":"10.4068/cmj.2024.60.1.59","url":null,"abstract":"Contrast-induced acute kidney injury (CI-AKI) is a frequent challenge following the injection of contrast media and its subsequent oxidative stress. The aim of the present study was to evaluate the preventive effects of coenzyme Q10 (Q10), as a mitochondrial-targeted antioxidant in CI-AKI in diabetic patients, who account for a large proportion of angiographic cases. A total of 118 diabetic patients were randomly assigned to receive 120 mg of oral coenzyme Q10 (Q10 group) or placebo (Placebo group) for four days, starting 24 hours before contrast media injection. Blood urea nitrogen (BUN), serum and urinary creatinine, estimated glomerular filtration rate (eGFR), urinary malondialdehyde (UMDA), urinary total antioxidant capacity (UTAC), and urinary mitochondrial to nuclearDNA ratios (mtDNA/nDNA ratio) were evaluated before and after the treatment period. Urine sediments were also evaluated to report the urine microscopy score (UMS).The levels of BUN, serum and urine creatinine, and UMS were similar in the Q10 and placebo groups. EGFR was lower in the Q10 group before the treatment (p=0.013) but not after. The urinary mtDNA/nDNA ratio was 3.05±1.68 and 3.69±2.58 in placebo and Q10 groups, but UTAC was found to be lower in Q10 both before (p=0.006) and after the treatment (p<0.001). The incidence of CI-AKI was 14.40% and the mtDNA/nNDA ratio was similar between CI-AKI and non-CI-AKI patients. In conclusion, Q10 treatment shows no favorable effect on prevention of CI-AKI or a urinary mtDNA/nDNA ratio among diabetic patients.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"60 1","pages":"59-68"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139673981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Gastric Lipoma That Grew in Size in Seven Years Presenting Bleeding. 胃脂肪瘤在七年内不断增大，并伴有出血。

Chonnam medical journal Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.4068/cmj.2024.60.1.89

Maki Setake, Mayumi Shiroma, Mami Tomiyama, Yuko Tasato, Hitoshi Mabuchi, Yuzuru Kinjo, Masaru Miyazato, Noriya Nakachi, Hiroto Shimajiri, Ryosaku Tomiyama, Yoshiki Chinen, Akira Hokama

引用次数: 0

Blood Lymphocytes as a Prognostic Factor for Stage III Non-Small Cell Lung Cancer with Concurrent Chemoradiation. 血淋巴细胞作为同期化疗的 III 期非小细胞肺癌的预后因素

Chonnam medical journal Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.4068/cmj.2024.60.1.40

Yong-Hyub Kim, Yoo-Duk Choi, Sung-Ja Ahn, Young-Chul Kim, In-Jae Oh, Taek-Keun Nam, Jae-Uk Jeong, Ju-Young Song

{"title":"Blood Lymphocytes as a Prognostic Factor for Stage III Non-Small Cell Lung Cancer with Concurrent Chemoradiation.","authors":"Yong-Hyub Kim, Yoo-Duk Choi, Sung-Ja Ahn, Young-Chul Kim, In-Jae Oh, Taek-Keun Nam, Jae-Uk Jeong, Ju-Young Song","doi":"10.4068/cmj.2024.60.1.40","DOIUrl":"10.4068/cmj.2024.60.1.40","url":null,"abstract":"We aimed to identify blood lymphocytes as a prognostic factor for survival in patients with locally advanced stage III non-small cell lung cancer (NSCLC) treated with concurrent chemoradiotherapy (CCRT). This is a secondary study of 196 patients enrolled in the Korean Radiation Oncology Group 0903 phase III clinical trial to evaluate the prognostic significance of circulating blood lymphocyte levels. The median total lymphocyte count (TLC) reduction ratio during CCRT was 0.74 (range: 0.29-0.97). In multivariate analysis, patient age (p=0.014) and gross tumor volume (GTV, p=0.031) were significant factors associated with overall survival, while TLC reduction (p=0.018) and pretreatment neutrophil-to-lymphocyte ratio (NLR; p=0.010) were associated with progression-free survival (PFS). In multivariate logistic regression analysis, pretreatment NLR, GTV, and heart V20 were significantly associated with TLC reduction. Immunohistochemical analysis of programmed death ligand 1 and CD8 expression on T cells was performed on 84 patients. CD8 expression was not significantly associated with the pretreatment lymphocyte count (p=0.673), and PDL1 expression was not significantly associated with OS or PFS. Univariate analysis revealed that high CD8 expression in TILs was associated with favorable OS and was significantly associated with favorable PFS (p=0.032). TLC reduction during CCRT is a significant prognostic factor for PFS, and heart V20 is significantly associated with TLC reduction. Thus, in the era of immunotherapy, constraining the volume of the radiation dose to the whole heart must be prioritized for the better survival outcomes.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"60 1","pages":"40-50"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139674019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atorvastatin on Treatment of Nonalcoholic Fatty Liver Disease Patients. 治疗非酒精性脂肪肝患者的阿托伐他汀

Chonnam medical journal Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.4068/cmj.2024.60.1.13

Zahra Eslami, Samaneh Sadat Aghili, Amir Ghaleh Ghafi

引用次数: 0

Gallic Acid Inhibits Proliferation and Migration of Smooth Muscle Cells in a Pig In-Stent Restenosis Model. 没食子酸抑制猪支架内再狭窄模型中平滑肌细胞的增殖和迁移

Chonnam medical journal Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.4068/cmj.2024.60.1.32

Han Byul Kim, Young Joon Hong, Seung Hun Lee, Hae Jin Kee, Munki Kim, Youngkeun Ahn, Myung Ho Jeong

{"title":"Gallic Acid Inhibits Proliferation and Migration of Smooth Muscle Cells in a Pig In-Stent Restenosis Model.","authors":"Han Byul Kim, Young Joon Hong, Seung Hun Lee, Hae Jin Kee, Munki Kim, Youngkeun Ahn, Myung Ho Jeong","doi":"10.4068/cmj.2024.60.1.32","DOIUrl":"10.4068/cmj.2024.60.1.32","url":null,"abstract":"In-stent restenosis (ISR) develops primarily due to neointimal hyperplasia. Gallic acid (GA) has anti-inflammatory, antioxidant, and cardioprotective effects. This study sought to investigate the effects of GA on neointimal hyperplasia and proliferation and migration of vascular smooth muscle cells (VSMCs) in a pig ISR model. In vitro proliferation and migration experiments were confirmed, after VSMCs were treated with platelet-derived growth factor (PDGF-BB) and GA (100 µM) using a 3-(4,5-dimethylthiazol)-2,5-diphenyltetrazolium bromide (MTT) assay and a scratch wound assay for 24 hours and 48 hours. A bare metal stent (BMS) was implanted in the pig coronary artery to induce ISR with overdilation (1.1-1.2:1), and GA (10 mg/kg/day) was administered for 4 weeks. At the 4-week follow-up, optical coherence tomography (OCT) and histopathological analyses were performed. GA decreased the proliferation of VSMCs by PDGF-BB for 24 hours (89.24±24.56% vs. 170.04±19.98%, p<0.001) and 48 hours (124.87±7.35% vs. 187.64±4.83%, p<0.001). GA inhibited the migration of VSMCs induced by PDGF-BB for 24 hours (26.73±2.38% vs. 65.38±9.73%, p<0.001) and 48 hours (32.96±3.04% vs. 77.04±10.07%, p<0.001). Using OCT, % neointimal hyperplasia was shown to have significantly decreased in the GA group compared with control vehicle group (28.25±10.07% vs. 37.60±10.84%, p<0.001). GA effectively reduced neointimal hyperplasia by inhibiting the proliferation and migration of VSMCs in a pig ISR model. GA could be a potential treatment strategy for reducing ISR after stent implantation.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"60 1","pages":"32-39"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139673977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gestational Transient Thyrotoxicosis Can Lead to Hypokalemic Periodic Paralysis. 妊娠期一过性甲亢可导致低钾血症性周期性麻痹

Chonnam medical journal Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.4068/cmj.2024.60.1.95

Jin Woo Jeong, Tae Yang Yu

引用次数: 0

Comparative Study on the Immunogenicity of COVID-19 mRNA Vaccines in Patients Receiving Adjuvant and Palliative Chemotherapy. COVID-19 mRNA 疫苗在接受辅助化疗和姑息化疗患者中的免疫原性比较研究

Chonnam medical journal Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.4068/cmj.2024.60.1.69

Hyun-Woo Choi, Younggon Jung, Uh Jin Kim, Sang-Cheol Lee, Jung Hye Kwon, Hyeonjong Kim, Sarah Kim, Yoonjung Lee, Hyun-Jung Shim, Sang-Hee Cho, Ik-Joo Chung, Eu Chang Hwang, Seung Ji Kang, Woo Kyun Bae, Seung-Jung Kee

{"title":"Comparative Study on the Immunogenicity of COVID-19 mRNA Vaccines in Patients Receiving Adjuvant and Palliative Chemotherapy.","authors":"Hyun-Woo Choi, Younggon Jung, Uh Jin Kim, Sang-Cheol Lee, Jung Hye Kwon, Hyeonjong Kim, Sarah Kim, Yoonjung Lee, Hyun-Jung Shim, Sang-Hee Cho, Ik-Joo Chung, Eu Chang Hwang, Seung Ji Kang, Woo Kyun Bae, Seung-Jung Kee","doi":"10.4068/cmj.2024.60.1.69","DOIUrl":"10.4068/cmj.2024.60.1.69","url":null,"abstract":"This study was conducted to investigate potential differences in vaccine efficacy between patients undergoing palliative chemotherapy and receiving adjuvant chemotherapy. Additionally, the study proved the influence of vaccination timing on vaccine efficacy during active chemotherapy. Anti-receptor-binding domain (RBD) IgG binding antibody assays and surrogate neutralizing antibody assays were performed after BNT162b2 or mRNA-1273 vaccination in 45 solid cancer patients (23 adjuvant and 22 palliative chemotherapy) and in 24 healthy controls before vaccination (baseline), at every two to four weeks after the first (post-dose 1) and the second vaccination (post-dose 2). The levels of anti-RBD IgG and neutralizing antibodies increased significantly from baseline through post-dose 1 to post-dose 2 in all three groups. At the post-dose 1, the anti-RBD IgG and neutralizing antibody levels were significantly lower in cancer patients than in healthy controls. However, by post-dose 2, the seropositivity of anti-RBD IgG and neutralizing antibodies uniformly reached 100% across all groups, with no significant disparity in antibody levels among the three groups. Moreover, the antibody titers were not significantly different between patients with a vaccine and chemotherapy interval of more than 14 days or those with less than 14 days. This study demonstrated that after second doses of mRNA COVID-19 vaccines, humoral immune responses in patients receiving chemotherapy were comparable to those of healthy controls, regardless of whether the purpose of the anti-cancer treatment was palliative or adjuvant. Furthermore, the timing of vaccination did not affect the level of humoral immunity after the second vaccination.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"60 1","pages":"69-77"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139674021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0