Chonnam medical journal最新文献_第5页

Transcranial Direct Current Stimulation for Global Cognition in Mild Cognitive Impairment. 经颅直流电刺激对轻度认知障碍患者整体认知的影响。

Chonnam medical journal Pub Date : 2025-01-01 Epub Date: 2025-01-24 DOI: 10.4068/cmj.2025.61.1.1

Jenny Jeaeun Chan, Yeryeong Cho, Jae-Hon Lee

{"title":"Transcranial Direct Current Stimulation for Global Cognition in Mild Cognitive Impairment.","authors":"Jenny Jeaeun Chan, Yeryeong Cho, Jae-Hon Lee","doi":"10.4068/cmj.2025.61.1.1","DOIUrl":"10.4068/cmj.2025.61.1.1","url":null,"abstract":"Mild cognitive impairment (MCI) is a condition characterized by noticeable deficits in memory retrieval or other cognitive domains than the individuals with the same age but do not significantly interfere with daily functioning. It represents an intermediate stage between normal aging and dementia, and a crucial opportunity for intervention prior to extensive cognitive decline. Transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique, has shown promise in enhancing global cognition in MCI. Current evidence suggests that tDCS provides short-term cognitive benefits, particularly in memory and attention, with moderate effects observed in processing speed. However, its impact on executive function and language remains inconsistent, highlighting variability in individual responses and study methodologies. While long-term efficacy remains uncertain due to limited longitudinal research and short follow-up periods, safety concerns, especially with self-administered tDCS such as in home-based tDCS, underscore the need for proper training and device innovation. Despite this, tDCS is a promising, portable tool for cognitive enhancement in MCI, with potential to delay progression to dementia. Addressing challenges such as optimizing stimulation protocols, accounting for individual neuroanatomical variability, and establishing long-term effectiveness will be essential for its broader clinical adoption. Future research should focus on standardizing methodologies, incorporating biomarkers to predict treatment response, and conducting large-scale, longitudinal studies to refine its therapeutic application.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reactive Oxygen Species: Role in Pathophysiology, and Mechanism of Endogenous and Dietary Antioxidants during Oxidative Stress. 活性氧：内源性和膳食抗氧化剂在氧化应激中的病理生理作用和机制。

Chonnam medical journal Pub Date : 2025-01-01 Epub Date: 2025-01-24 DOI: 10.4068/cmj.2025.61.1.32

Mohammad Mamun Sikder, Xiaodong Li, Steeve Akumwami, Sanzida Akter Labony

{"title":"Reactive Oxygen Species: Role in Pathophysiology, and Mechanism of Endogenous and Dietary Antioxidants during Oxidative Stress.","authors":"Mohammad Mamun Sikder, Xiaodong Li, Steeve Akumwami, Sanzida Akter Labony","doi":"10.4068/cmj.2025.61.1.32","DOIUrl":"10.4068/cmj.2025.61.1.32","url":null,"abstract":"Redox imbalances, which result from excessive production of reactive oxygen species (ROS) or malfunctioning of the antioxidant system, are the source of oxidative stress. ROS affects all structural and functional components of cells, either directly or indirectly. In addition to causing genetic abnormalities, excessive ROS also oxidatively modifies proteins by protein oxidation and peroxidation and alters lipid structure via advanced lipoxidation, decreasing function and promoting damage or cell death. On the other hand, low levels of ROS constitute important redox-signaling molecules in various pathways that maintain cellular homeostasis and regulate key transcription factors. As a result, ROS can affect various cellular processes, such as apoptosis, migration, differentiation, and proliferation. ROS can act as signaling molecules, controlling various normal physiological activities at the cellular level. Furthermore, there is an increasing body of evidence indicating the role of ROS in various clinical conditions. In this review, we will summarize the role of ROS in physiological and pathological processes and antioxidant action during oxidative stress.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 1","pages":"32-45"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biopharmaceutical Analysis by HPLC: Practices and Challenges. 生物制药分析：实践与挑战。

Chonnam medical journal Pub Date : 2025-01-01 Epub Date: 2025-01-24 DOI: 10.4068/cmj.2025.61.1.19

Golshan Mahdi, Ashkan Alamdary, Hooman Kaghazian, Nayebali Ahmadi, Rajab Mardani, Alireza Gholami

{"title":"Biopharmaceutical Analysis by HPLC: Practices and Challenges.","authors":"Golshan Mahdi, Ashkan Alamdary, Hooman Kaghazian, Nayebali Ahmadi, Rajab Mardani, Alireza Gholami","doi":"10.4068/cmj.2025.61.1.19","DOIUrl":"10.4068/cmj.2025.61.1.19","url":null,"abstract":"High-Performance Liquid Chromatography (HPLC) is an essential analytical technique in the biopharmaceutical industry, crucial for the separation, identification, and quantification of complex biological molecules such as monoclonal antibodies and recombinant proteins. It plays a vital role in assessing the purity, potency, and stability of biopharmaceutical products, which are critical for regulatory approval. HPLC offers high resolution and sensitivity, allowing for the detection of small quantities of compounds in complex samples. Its versatility is evident in various modes, including reversed-phase, ion-exchange, size-exclusion, and affinity chromatography. However, challenges remain, such as selecting the appropriate stationary phase, addressing peak overlapping and matrix interference, and optimizing operational parameters like flow rate and mobile phase composition. Standardization and method validation are essential for ensuring reproducibility, accuracy, and regulatory compliance in HPLC analyses. The need for reliable reference materials and calibration methods is also a significant challenge. Recent advancements in HPLC technology, including ultra-high-performance liquid chromatography (UHPLC) and hybrid systems that integrate HPLC with mass spectrometry, are helping to overcome these challenges by enhancing sensitivity, resolution, and analysis speed. In summary, as biopharmaceutical products grow more complex, HPLC's role will continue to evolve, highlighting the need for ongoing research and development to refine this critical analytical tool.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 1","pages":"19-31"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Retrospective Cohort Study Investigating the Effect of Intraovarian Platelet-Rich Plasma Therapy on the Oxidative State of Follicular Fluid in Women with Diminished Ovarian Reserve. 一项回顾性队列研究，探讨卵巢储备功能减退妇女卵巢内富血小板血浆治疗对卵泡液氧化状态的影响。

Chonnam medical journal Pub Date : 2025-01-01 Epub Date: 2025-01-24 DOI: 10.4068/cmj.2025.61.1.46

Sahar Mazloomi, Heidar Tayebinia, Marzieh Sanoee Farimani, Marzieh Ghorbani

{"title":"A Retrospective Cohort Study Investigating the Effect of Intraovarian Platelet-Rich Plasma Therapy on the Oxidative State of Follicular Fluid in Women with Diminished Ovarian Reserve.","authors":"Sahar Mazloomi, Heidar Tayebinia, Marzieh Sanoee Farimani, Marzieh Ghorbani","doi":"10.4068/cmj.2025.61.1.46","DOIUrl":"10.4068/cmj.2025.61.1.46","url":null,"abstract":"This study hypothesized that oxidative stress in women with diminished ovarian reserve (DOR) can influence in vitro fertilization (IVF) outcomes. Therefore, we investigated the effect of intraovarian platelet-rich plasma (PRP) administration on the oxidative stress state in follicular fluid in DOR patients. Following the follow-up of a retrospective cohort study, follicular fluid was isolated from twenty-five DOR patients. The total antioxidant capacity (TAC), catalase (CAT), and superoxide dismutase (SOD) activities, total oxidant status (TOS), and malondialdehyde (MDA) levels were measured before and after intraovarian PRP administration using colorimetric methods. The levels of estradiol (E2), anti-mullerian hormone (AMH), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were measured at baseline and after two menstrual cycles. The quantity and quality of oocytes and embryos were assessed at both stages. Following intraovarian PRP injection, an increase in TAC levels, elevated CAT and SOD activities, and a decline in TOS and MDA content in the follicular fluid of DOR women were observed. AMH and E2 hormone levels also increased post-treatment. Additionally, a relative increase in the number and quality of oocytes and embryos was observed after a single PRP injection. Intraovarian PRP injection improves the oxidative state of follicular fluid and potentially enhances IVF outcomes in DOR women.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 1","pages":"46-51"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aerobic Exercise and Metformin: A Dual Approach to Enhancing Glycemic Maintenance in Type 2 Diabetes Mellitus. 有氧运动和二甲双胍：促进2型糖尿病患者血糖维持的双重途径。

Chonnam medical journal Pub Date : 2025-01-01 Epub Date: 2025-01-24 DOI: 10.4068/cmj.2025.61.1.9

Zahra Eslami, Gholamreza Roshandel, Seyed Javad Mirghani

{"title":"Aerobic Exercise and Metformin: A Dual Approach to Enhancing Glycemic Maintenance in Type 2 Diabetes Mellitus.","authors":"Zahra Eslami, Gholamreza Roshandel, Seyed Javad Mirghani","doi":"10.4068/cmj.2025.61.1.9","DOIUrl":"10.4068/cmj.2025.61.1.9","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) is a widespread metabolic condition characterized by elevated glucose levels followed by deficiency in insulin secretion. Metformin notably decreased the incidence of T2DM by 31% and it exerts its effects through various signaling pathways. Databases searched included PubMed, Google Scholar, and Scopus from 2000 to 2024. One of the primary mechanisms involves AMPK activation which causes reduced lipogenesis and improved fatty acid oxidation in the liver and muscles. Key molecules affected by metformin include acetyl-CoA carboxylase (ACC) and sterol regulatory element-binding protein 1c (SREBP-1c), both involved in lipid synthesis regulation. Aerobic exercise has also emerged as a crucial component in managing T2DM due to its improved effects on hyperglycemia and insulin sensitivity. Key signaling pathways affected in T2DM include the PI3K/Akt, AMP-activated protein kinase (AMPK), and MAPK/ERK pathways which play essential roles in regulating glucose homeostasis, glycogenesis, and insulin secretion. When comparing the mechanisms and efficacy of aerobic exercise and metformin, it becomes evident that aerobic exercise primarily enhances physical fitness and metabolic function, while metformin exerts its effects through biochemical pathways involving AMPK activation. Aerobic exercise and metformin are effective for managing T2DM, though they operate through different mechanisms. Regular aerobic exercise improves insulin sensitivity, enhances cardiovascular health, and promotes weight loss, while metformin primarily decreases hepatic gluconeogenesis and enhances insulin secretion. Understanding the intricate signaling pathways affected by metformin and aerobic exercise provides valuable insights into its mechanisms of action and clinical implications for treating diabetic patients effectively.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"61 1","pages":"9-18"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Synergistic Sedation with Midazolam and Propofol Versus Midazolam and Pethidine in Colonoscopies: A Prospective, Randomized Controlled Study. 比较咪达唑仑和丙泊酚与咪达唑仑和哌替啶在结肠镜检查中的协同镇静作用：一项前瞻性随机对照研究。

Chonnam medical journal Pub Date : 2024-09-01 Epub Date: 2024-09-25 DOI: 10.4068/cmj.2024.60.3.192

Jae Woong Lim, Min Jae Kim, Gang Han Lee, Dae Sol Kim, Sang Hyuk Jung, Yu Yeon Kim, Jin Won Kim, Yohan Lee, Hyun Soo Kim, Seon Young Park, Dong Hyun Kim

{"title":"Comparison of Synergistic Sedation with Midazolam and Propofol Versus Midazolam and Pethidine in Colonoscopies: A Prospective, Randomized Controlled Study.","authors":"Jae Woong Lim, Min Jae Kim, Gang Han Lee, Dae Sol Kim, Sang Hyuk Jung, Yu Yeon Kim, Jin Won Kim, Yohan Lee, Hyun Soo Kim, Seon Young Park, Dong Hyun Kim","doi":"10.4068/cmj.2024.60.3.192","DOIUrl":"https://doi.org/10.4068/cmj.2024.60.3.192","url":null,"abstract":"Colonoscopy is a key procedure for the early detection of colorectal cancer. Despite its importance, the discomfort associated with colonoscopy often requires sedation, and the ideal sedation regimen remains to be determined. In this prospective randomized controlled trial, patients scheduled for colonoscopy were randomly assigned to two different sedation protocols. Group A received a combination of midazolam and propofol, while group B was given midazolam and pethidine. The study analyzed data from 51 patients, with 23 in group A and 28 in group B. The incidence of adverse events was similar across both groups. Additionally, no significant differences were observed in cecal intubation times or total procedure durations. Notably, group A had a lower frequency of required postural changes (1.0±.7 vs. 1.5±0.7, p=0.02) and a reduced rate of manual compression (52.2% vs. 82.1%, p=0.02). There were no significant differences between the groups regarding subjective pain or overall satisfaction. Both sedation regimens were found to be safe and effective. The midazolam and propofol combination was associated with a smoother procedure, evidenced by fewer postural adjustments and less manual compression needed during colonoscopy.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"60 3","pages":"192-197"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11458312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corticosteroid Therapy Duration and Dosage According to the Timing of Treatment Initiation for Post-COVID-19 Organizing Pneumonia. 皮质类固醇治疗的持续时间和剂量与 19COVID 后组织性肺炎开始治疗的时间有关。

Chonnam medical journal Pub Date : 2024-09-01 Epub Date: 2024-09-25 DOI: 10.4068/cmj.2024.60.3.166

Chang-Seok Yoon, Hwa-Kyung Park, Jae-Kyeong Lee, Bo-Gun Kho, Tae-Ok Kim, Hong-Joon Shin, Yong-Soo Kwon, Sung-Chul Lim, Yu-Il Kim

{"title":"Corticosteroid Therapy Duration and Dosage According to the Timing of Treatment Initiation for Post-COVID-19 Organizing Pneumonia.","authors":"Chang-Seok Yoon, Hwa-Kyung Park, Jae-Kyeong Lee, Bo-Gun Kho, Tae-Ok Kim, Hong-Joon Shin, Yong-Soo Kwon, Sung-Chul Lim, Yu-Il Kim","doi":"10.4068/cmj.2024.60.3.166","DOIUrl":"https://doi.org/10.4068/cmj.2024.60.3.166","url":null,"abstract":"COVID-19 can lead to pulmonary complications, including organizing pneumonia. Steroids are essential in treating post-COVID-19 organizing pneumonia. However, research on the clinical benefits of initiating steroid treatment early for this condition is limited. To investigate the steroid initiation time in its association with treatment duration and corticosteroid dose for treating post-COVID-19 organizing pneumonia, we analyzed the data of 91 patients with post-COVID-19 organizing pneumonia at Chonnam National University Hospital between October 2020 and December 2022. Patients were categorized into early and late groups based on time from COVID-19 diagnosis to steroid initiation time for organizing pneumonia. The mean time interval between COVID-19 infection and steroid initiation time for treating organizing pneumonia, was 18.4±8.6 days. Within the early treatment group (treatment initiated <18.4 days after COVID-19), which included 55 patients, the mean duration of steroid treatment was 43.1±18.3days. In contrast, the late treatment group (initiated ≥18.4 days after COVID-19), which consisted of 36 patients, had a longer mean duration of steroid treatment 59.1±22.6 days) (p<0.01). Regarding corticosteroid dosing, the early treatment group had an average dosage of 0.5±0.3 mg/kg/day, in contrast to the late group, which averaged 0.8±0.3 mg/kg/day (p<0.01). Regression analysis showed steroid initiation time significantly influenced treatment duration (β=0.80 , p<0.01) and dosage (β=0.03, p<0.01). The clinical benefits of early steroid treatment for post-COVID-19 organizing pneumonia may lie in its association with reduced steroid treatment duration and dosage.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"60 3","pages":"166-173"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11458313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anomalous Origin of the Right Coronary Artery from the Pulmonary Artery. 肺动脉右冠状动脉起源异常。

Chonnam medical journal Pub Date : 2024-09-01 Epub Date: 2024-09-25 DOI: 10.4068/cmj.2024.60.3.198

Nobuko Tanitame, Keizo Tanitame

引用次数: 0

Resilience Gap in Gastrointestinal Endoscopy Activity during the COVID-19 Pandemic in South Korea. 韩国 COVID-19 大流行期间消化道内窥镜检查活动的应变能力差距。

Chonnam medical journal Pub Date : 2024-09-01 Epub Date: 2024-09-25 DOI: 10.4068/cmj.2024.60.3.180

Hye-Yeon Kim, Jeong-Ho Yang, Sun-Seog Kweon

{"title":"Resilience Gap in Gastrointestinal Endoscopy Activity during the COVID-19 Pandemic in South Korea.","authors":"Hye-Yeon Kim, Jeong-Ho Yang, Sun-Seog Kweon","doi":"10.4068/cmj.2024.60.3.180","DOIUrl":"https://doi.org/10.4068/cmj.2024.60.3.180","url":null,"abstract":"This study assessed the impact of distancing measures during the COVID-19 pandemic on cancer diagnostic activities, including gastrointestinal endoscopy (GIE). It analyzed GIE volumes from 2020 to 2022 in comparison to 2018-2019, considering variations in resilience linked to socioeconomic status (SES). The analysis utilized data from the Korean Health Insurance Review and Assessment Services database, covering the entire population and medical facilities. Diagnostic GIE rates (2018-2022) in Gwangju Metropolitan City and Jeonnam province were examined, comparing age-standardized rates (ASRs) by area, gender, and SES. The results indicated a decline in ASRs for colonoscopy and endoscopic gastroduodenoscopy (EGD) in 2020 compared to 2018-2019, followed by an increase in 2021-2022, except for EGD in the medical aid population. SES based and rural-urban disparities were evident in the recovery of GIE rates. The findings suggest that equity-focused strategies are needed to ensure equitable healthcare access among different socioeconomic groups after pandemic.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"60 3","pages":"180-186"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11458310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Caregiver Knowledge about Self-Medication of Antibiotics in Children Aged 0-12 Years. 初级护理人员对 0-12 岁儿童自行服用抗生素的了解。

Chonnam medical journal Pub Date : 2024-09-01 Epub Date: 2024-09-25 DOI: 10.4068/cmj.2024.60.3.174

Shishir Kumar, Shivani Agrawal, Setu Sinha, Tajwar Yasmeen

{"title":"Primary Caregiver Knowledge about Self-Medication of Antibiotics in Children Aged 0-12 Years.","authors":"Shishir Kumar, Shivani Agrawal, Setu Sinha, Tajwar Yasmeen","doi":"10.4068/cmj.2024.60.3.174","DOIUrl":"https://doi.org/10.4068/cmj.2024.60.3.174","url":null,"abstract":"Globally, it is estimated that more than 50% of antibiotics are obtained without a prescription. The main purpose of this study is to determine the knowledge and practice of primary caregivers about self-medication in children with antibiotics, as studies on self-medication is lacking in India, also, it will help is assessing parents' knowledge and attitude towards self medication. This cross-sectional study conducted in the urban community of Shastri Nagar, Patna, aimed to evaluated antibiotic use in children aged 0-12. From January 2023 to March 2023, 173 caregivers were randomly selected through house visits. Data collection used a pre-tested questionnaire, ensuring confidentiality. In this study of 173 participants, caregivers in an urban community demonstrated varying knowledge regarding antibiotic use in children. Mothers and post-graduates possessed better awareness of antibiotic consequences. Fathers exhibited better understanding of side effects. Knowledge on antibiotics' action was seen among mothers, those aged 30-39, with family income of Rs. 20,000-40,000 and those with family members in medical field. Fathers had more incorrect beliefs about antibiotics treating viral infections. Common conditions for self-medication included cough/cold, fever and diarrhea, with hospitals being the primary source of antibiotics. Majority obtained information from pharmacies but awareness about antibiotic course completion and versatility was limited. Caregivers' antibiotic knowledge varied; mothers and post-graduates were more aware, while fathers understood side effects better.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"60 3","pages":"174-179"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11458318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0