Chonnam medical journal最新文献_第5页

Diffusion Weighted Imaging in a Patient with Transient Global Amnesia. 一例短暂性整体失忆患者的扩散加权成像。

Chonnam medical journal Pub Date : 2023-09-01 Epub Date: 2023-09-25 DOI: 10.4068/cmj.2023.59.3.205

Keizo Tanitame, Hayato Araki

引用次数: 0

Complement Regulatory Protein CD46 Manifests a Unique Role in Promoting the Migration of Bladder Cancer Cells. 补体调节蛋白CD46在促进膀胱癌症细胞迁移中发挥独特作用。

Chonnam medical journal Pub Date : 2023-09-01 Epub Date: 2023-09-25 DOI: 10.4068/cmj.2023.59.3.160

Thuy Thi Nguyen, Hien Duong Thanh, Manh-Hung Do, Chaeyong Jung

{"title":"Complement Regulatory Protein CD46 Manifests a Unique Role in Promoting the Migration of Bladder Cancer Cells.","authors":"Thuy Thi Nguyen, Hien Duong Thanh, Manh-Hung Do, Chaeyong Jung","doi":"10.4068/cmj.2023.59.3.160","DOIUrl":"10.4068/cmj.2023.59.3.160","url":null,"abstract":"CD46 is a membrane-bound complement regulatory protein (mCRP) possessing a regulatory role with the complement system. CD46 protects the host cells from damage by complement. Expression of CD46 is also highly maintained in many cancers, including bladder cancers, and thus functions as a receptor for many cancer therapeutic viruses. In this study we report a unique role of CD46 as a progression factor of cancer cells in bladder cancers. Resulting data from a DNA microarray using CD46-altered HT1376 bladder cancers demonstrated a pool of target genes, including complement C3 α chain (C3α), matrix Gla protein (MGP), AFAP-AS1, follicular dendritic cell secreted protein (FDCSP), MAM domain containing 2 (MAMDC2), gamma-aminobutyric acid A receptor pi (GABRP), transforming growth factor, beta-induced (TGFBI), a family of cytochrome P450 (CYP24A1), sialic acid binding Ig-like lectin 6 (SIGLEC6), metallothionein 1E (MT1E), and several members of cytokeratins. Subsequent studies using quantitative RT-PCR and Western blot analyses confirmed CD46-mediated regulation of C3α, MGP, and keratin 13 (KRT13). MGP and KRT13 are known to be involved in cell migration and cancer cell metastasis. A cell migration assay demonstrated that CD46 enhanced migratory potential of bladder cancer cells. Taken all together, this report demonstrated that CD46 is generally overexpressed in bladder cancers and plays a unique role in the promotion of cancer cell migration. Further detailed studies are needed to be performed to clarify the action mechanism of CD46 and its application to cancer therapeutics.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"59 3","pages":"160-166"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cc/7e/cmj-59-160.PMC10570858.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41242928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ileal Perforation Caused by Metastasis of Breast Carcinoma. 乳腺癌转移引起的回肠穿孔。

Chonnam medical journal Pub Date : 2023-09-01 Epub Date: 2023-09-25 DOI: 10.4068/cmj.2023.59.3.198

Daijiro Kagawa, Mikako Kotani, Takao Miyaguni, Tomofumi Chibana, Ippei Uezu, Yoshiki Chinen, Kanetaka Maeshiro, Ryoko Ono, Masayoshi Nagahama, Izumi Kinjo, Hirofumi Tomori, Hiroshi Miyazato, Kyoko Arakaki, Akira Hokama

引用次数: 0

The Boosting Effects of Melatonin on the In Vitro Fertilization (IVF) of Women with Polycystic Ovary Syndrome. 褪黑素对多囊卵巢综合征妇女体外受精（IVF）的促进作用。

Chonnam medical journal Pub Date : 2023-09-01 Epub Date: 2023-09-25 DOI: 10.4068/cmj.2023.59.3.188

Shamim Pilehvari, Mahnaz Yavangui, Elham Paknahad, Zahra Cheraghi, Marzieh Ghorbani

{"title":"The Boosting Effects of Melatonin on the In Vitro Fertilization (IVF) of Women with Polycystic Ovary Syndrome.","authors":"Shamim Pilehvari, Mahnaz Yavangui, Elham Paknahad, Zahra Cheraghi, Marzieh Ghorbani","doi":"10.4068/cmj.2023.59.3.188","DOIUrl":"10.4068/cmj.2023.59.3.188","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is one of the most critical disorders, which affects approximately 20% of women of childbearing age and melatonin supplementation in these women can be effective. However, human studies in this area are particularly limited to IVF candidates. The aim of this clinical trial study was to evaluate the effect of melatonin on the in vitro fertilization (IVF) in PCOS involved women. In this clinical trial study, a total of 320 women with PCOS were randomly assigned to the intervention and control groups. Patients in the intervention group (n=160) received a combination of melatonin and metformin (3 mg and 500 mg, respectively) three times a day. The control group (n=160) received metformin 500 mg from the luteal phase of the cycle before the start of gonadotropin. Oocyte and embryo quality, number of oocytes, and pregnancy outcomes were compared in both groups. Our study revealed that the frequency of Metaphase II oocytes (69.9% vs. 57.9%, p<0.001) and the number of embryos of the top-quality (grade A) were higher in the group treated with melatonin (40.3% vs. 29.9%, p=0.001). The rate of clinical pregnancy and implantation were also higher in the intervention group. The odds of clinical pregnancy in the intervention group was 1.8 times (p=0.039). Moreover, oral melatonin supplementation was effective in patients with PCOS, who were candidates for IVF because of the increased quality of mature oocytes, top-quality embryos, and increased odds of clinical pregnancy.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"59 3","pages":"188-193"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/50/d0/cmj-59-188.PMC10570865.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41242960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When is LABA/LAMA Better than LAMA in GOLD Group B or D Patients for Reducing Acute Exacerbations of COPD? 在GOLD组B或D患者中，LABA/LAMA何时比LAMA更好地减少COPD的急性加重？

Chonnam medical journal Pub Date : 2023-09-01 Epub Date: 2023-09-25 DOI: 10.4068/cmj.2023.59.3.180

Hong-Joon Shin, Yu-Il Kim, Youlim Kim, Chang Youl Lee, Seung Won Ra, Ji-Yong Moon, Ki-Suck Jung, Kwang Ha Yoo, Kyeong-Cheol Shin, Sung-Chul Lim

{"title":"When is LABA/LAMA Better than LAMA in GOLD Group B or D Patients for Reducing Acute Exacerbations of COPD?","authors":"Hong-Joon Shin, Yu-Il Kim, Youlim Kim, Chang Youl Lee, Seung Won Ra, Ji-Yong Moon, Ki-Suck Jung, Kwang Ha Yoo, Kyeong-Cheol Shin, Sung-Chul Lim","doi":"10.4068/cmj.2023.59.3.180","DOIUrl":"10.4068/cmj.2023.59.3.180","url":null,"abstract":"Long-acting β2-agonist (LABA)/long-acting muscarinic-antagonist (LAMA) dual therapy has been found to be more effective than LAMA monotherapy in the treatment of chronic obstructive pulmonary disease (COPD). However, among patients with group B or D COPD, the characteristics of patients for whom LABA/LAMA dual therapy is superior to LAMA monotherapy in minimizing acute exacerbations remain unknown. With data from a prospective COPD cohort, subgroup analyses were conducted to determine whether LABA/LAMA dual therapy was superior to LAMA monotherapy in reducing the rate of acute exacerbations in group B and D COPD patients. Group B and D COPD patients taking LAMA or LABA/LAMA were enrolled according to the 2022 Global initiative for Chronic Obstructive Pulmonary Disease guidelines. A total of 737 patients were included in this study: 600 with group B COPD and 137 with group D COPD. Compared with patients taking LAMA monotherapy, those taking LABA/LAMA had a significantly lower incidence of acute exacerbations over 1 year. In the subgroup of patients ≥70 years old, there was a significantly lower risk of severe COPD exacerbations among group B patients taking LABA/LAMA than among those taking LAMA monotherapy (odds ratio [OR], 0.258; 95% confidence interval [CI], 0.095-0.703). In contrast, in the subgroup of group D patients with COPD Assessment Test scores ≥25, compared with LAMA monotherapy, LABA/LAMA treatment was associated with lower risk of severe COPD exacerbations (OR, 0.115; 95% CI, 0.018-0.749). The combination of LABA and LAMA was found to be superior to LAMA monotherapy, especially for treating older adults with group B COPD, as well as for group D patients with severe symptoms.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"59 3","pages":"180-187"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ef/24/cmj-59-180.PMC10570857.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41242961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fungating Breast Cancer with Metastasis in a Developed Country: A Caveat to Our Strategy. 发达国家真菌性癌症转移：我们战略的一个启示。

Chonnam medical journal Pub Date : 2023-09-01 Epub Date: 2023-09-25 DOI: 10.4068/cmj.2023.59.3.194

Justine Chinnappan, Huda Marcus, Thair Dawood, Ghassan Bachuwa

引用次数: 0

Overexpression of miR-146a and miR-155 are Potentially Biomarkers and Predict Unfavorable Relationship between Gastric Cancer and Helicobacter pylori Infection. miR-146a和miR-155的过度表达是潜在的生物标志物，可预测癌症与幽门螺杆菌感染之间的不利关系。

Chonnam medical journal Pub Date : 2023-09-01 Epub Date: 2023-09-25 DOI: 10.4068/cmj.2023.59.3.167

Masoud Karimi, Abdolreza Mohammadnia, Mohammad Amin Amini, Azar Ghavimi Shamekh, Elahe Derakhshanfar, Farzaneh Hosseini

{"title":"Overexpression of miR-146a and miR-155 are Potentially Biomarkers and Predict Unfavorable Relationship between Gastric Cancer and Helicobacter pylori Infection.","authors":"Masoud Karimi, Abdolreza Mohammadnia, Mohammad Amin Amini, Azar Ghavimi Shamekh, Elahe Derakhshanfar, Farzaneh Hosseini","doi":"10.4068/cmj.2023.59.3.167","DOIUrl":"10.4068/cmj.2023.59.3.167","url":null,"abstract":"Gastric Cancer (GC) is one of the most dangerous malignancies in the world. This study aims to evaluate the relationship between miR-146a and miR-155 in patients with H. pylori infections with GC compared to H. pylori-infected patients and healthy subjects. Forty patients with H. pylori and GC positive diagnoses and 40 patients with H. pylori positive and GC negative diagnoses, and 40 healthy persons were selected. The expression of miR-146a and miR-155 genes in the whole blood was examined using qRT-PCR. Moreover, ROC curves were drawn to represent the sensitivity and specificity of miR-146a and miR-155 expression as biomarkers. The results showed the expression of miR-146a and miR-155 in the whole blood of patients with H. pylori and GC positive diagnoses are significantly higher than in healthy individuals and are non-significantly enhanced compared to H. pylori positive and GC negative. Also, the results stated miR-146a and miR-155 expression in the whole blood of patients who are H. pylori positive and GC negative are significantly increased compared to healthy individuals. Furthermore, the ROC curve analysis of miR-146a and miR-155 RNA level demonstrated the two miRNAs have an appropriate sensitivity and specificity for diagnostic goals. In conclusion, H. pylori infection may increase the expression of miR-146a and miR-155 in patients with H. pylori and GC positive diagnoses, which can be effective in the curbing the progression of GC. For this reason, up-regulation of miR-146a and miR-155 along with H. pylori infection might contribute to the pathogenesis of GC, and also can be suggested as biomarkers for GC diagnosis and treatment.","PeriodicalId":94372,"journal":{"name":"Chonnam medical journal","volume":"59 3","pages":"167-173"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/87/97/cmj-59-167.PMC10570867.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41242956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coarctation of the Aorta. 主动脉缩窄。

Chonnam medical journal Pub Date : 2023-09-01 Epub Date: 2023-09-25 DOI: 10.4068/cmj.2023.59.3.202

Masatsugu Miyagawa, Daisuke Kitano, Yasuo Okumura

引用次数: 0

Primary Cardiac Angiosarcoma in a Patient with Syncope: A Case Report. 晕厥患者原发性心脏血管肉瘤1例报告。

Chonnam medical journal Pub Date : 2023-09-01 Epub Date: 2023-09-25 DOI: 10.4068/cmj.2023.59.3.211

Bo Eun Park, Dong Heon Yang, Se Yong Jang

引用次数: 0