Nigerian medical journal : journal of the Nigeria Medical Association最新文献

{"title":"Fallopian Tube Papilloma: A Systematic Review of Case Reports.","authors":"Asmita Kaundal, Gurwinder Kaur, Prachi Renjhen, Sonal Parsad, Shikha Sharma","doi":"10.60787/nmj.v65i6.521","DOIUrl":"10.60787/nmj.v65i6.521","url":null,"abstract":"<p><p>Fallopian tube papilloma (FTP) is one of the benign lesions of the oviduct and is a rare proliferative epithelial lesion. Low incidence and underreporting of the disease limit our knowledge of these lesions. These lesions cause a diagnostic dilemma and need to be differentiated from several other conditions of the fallopian tubes both benign and malignant. Fallopian tube papilloma may lead to tubal obstruction and can be a cause of subfertility, ectopic gestation, or mass lesions in the fallopian tubes and hence should be considered as an important differential while managing these women. A high index of suspicion is required, and the final diagnosis can only be made after histopathological results. The reporting of such lesions is important to know the true prevalence of these tumors and to increase our knowledge about these benign neoplasms. This systematic review of case reports was done to enhance knowledge regarding the etiology, natural course, complication, and recurrence of FTP. An electronic search of Scopus, Pubmed, Embase, Web of Science, Google Scholar, and other databases was conducted for case reports and case series published in English from inception till January 2024.</p>","PeriodicalId":94346,"journal":{"name":"Nigerian medical journal : journal of the Nigeria Medical Association","volume":"65 6","pages":"811-823"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perception of Learning Environment Among Undergraduate Medical Students at University of Jos Using Johns Hopkins Learning Environment Scale.","authors":"Moses Ahangba Adamgbe, Joshua Adejo Okpanachi, Adole John Inalegwu, Emmanuel Firima, Nenkimun Dirting Bakwa, Sophia Atoshi Gani, Davou Samuel Dung, Emmanuel Yohanna Bature, Victor Ibukun Imade, Gideon Ikemdinachukwu Anuligo, Glory Enoche Alapa, Atarang Aposat Dafong, Iorwuese Joshua Agbatse, James Ichukwu Ojile, Chukwuma Ikem Okoye","doi":"10.60787/nmj.v65i6.570","DOIUrl":"10.60787/nmj.v65i6.570","url":null,"abstract":"<p><strong>Background: </strong>The learning environment (LE) plays a crucial role in the performance and training of medical students. Different tools have been used to assess the LE with various conclusions. However, the John Hopkins Learning Environment Scale (JHLES) which is a relatively newer scale is more specific, less cumbersome to administer, and has a wider scope. The study aims to assess the perception of the LE of undergraduate medical students in a Nigerian institution using the JHLES.</p><p><strong>Methodology: </strong>This was a cross-sectional study carried out on clinical medical students of the College of Health Sciences, University of Jos. A self-administered questionnaire containing socio-demographic data and the 28 JHLES questions was used. Data was analysed using SPSS version 25.0. The Overall mean JHLES Score was obtained by calculating the average of the JHLES scores attained by all participants.</p><p><strong>Results: </strong>A total of 400 clinical medical students were enrolled and a mean JHLES Score of 77.90 (±14.03) was obtained. The males were found to have statistically significantly higher mean JHLES scores than the females, particularly in the domain of Faculty relationships, Academic climate, and Mentoring. The domain of \"community of peers\" had the highest ratings while \"mentoring\" and \"meaningful engagement\" recorded the least scores.</p><p><strong>Conclusion: </strong>The clinical medical students had a fair perception of their LE. The areas of strength should be encouraged while faculty may enact programs that will improve the domains with low scores to ultimately make better the learning environment and training of these future doctors.</p>","PeriodicalId":94346,"journal":{"name":"Nigerian medical journal : journal of the Nigeria Medical Association","volume":"65 6","pages":"934-945"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and perception of disrespect and abuse during childbirth in public healthcare facilities in Lagos, Nigeria.","authors":"Olufunso Joseph Naiyeju, Tersur Terry Saalu, Lucky Enajite Tietie, Okechukwu Uche Ofoegbu, Charity Opeoluwapo Maduagu, Oluwaseun Emmanuel Familusi, Adaiah Soibi-Harry, Ochuwa Adiketu Babah","doi":"10.60787/nmj.v65i6.568","DOIUrl":"10.60787/nmj.v65i6.568","url":null,"abstract":"<p><strong>Background: </strong>There is increasing awareness of disrespect and abuse (DAA) during childbirth. Globally, DAA during delivery is a common cause of suffering and violation of the human rights of birthing mothers. Respectful maternal care is necessary to improve the quality of care and uptake of institutional delivery services to reduce maternal and perinatal morbidity and mortality. The study aims to determine the prevalence, common forms, and perception of maternal DAA among mothers who just gave birth and are still in the hospital.</p><p><strong>Methodology: </strong>A cross-sectional study on 261 consenting postnatal women at four public healthcare facilities in Lagos, Nigeria. An interviewer-administered pretested questionnaire was used to obtain data on sociodemographic characteristics and experiences of DAA. We analysed the data using Statistical Package for Social Sciences (SPSS) version 25. Logistic regression analysis was used to assess significant risk factors for DAA during delivery and early puerperium.</p><p><strong>Results: </strong>The prevalence of DAA during childbirth was 82%. Perceptions of non-consented care and abandonment/neglect were the most reported forms of DAA reported by 86.8% and 45.6% of respondents, respectively. The odds for DAA were four times greater in women who had pregnancy complications compared to those who did not (aOR: 4.50, 95%CI: 1.5013.46) and doubled in women who had vaginal delivery compared to Caesarean section (aOR: 2.10, 95%CI: 1.07-4.12).</p><p><strong>Conclusion: </strong>DAA is prevalent during childbirth in our public healthcare facilities. This goes against the proposed standard of care where respectful maternal care is every womans right, posing a risk for reduced use of institutional delivery services.</p>","PeriodicalId":94346,"journal":{"name":"Nigerian medical journal : journal of the Nigeria Medical Association","volume":"65 6","pages":"1016-1025"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probable Case of Cutaneous Anthrax with Toxic Manifestations and Fatality seen in an adolescent in Sokoto, Nigeria: A postmortem review.","authors":"Khadijat Omeneke Isezuo, Usman Muhammad Sani, Usman Muhammad Waziri, Sa'ima Abdullahi Zaiyanu, Abdulrasheed Folorunsho, Sirajo Shehu, Hechime Enyida Akpelu, Maryam Amodu-Sanni, Nuhu Dogondaji Aliyu, Yahaya Mohammed","doi":"10.60787/nmj.v65i6.597","DOIUrl":"10.60787/nmj.v65i6.597","url":null,"abstract":"<p><strong>Background: </strong>Anthrax is a life-threatening zoonotic disease caused by Gram-positive, spore-forming bacterium <i>Bacillus anthracis</i>. It manifests as a cutaneous, gastrointestinal, and respiratory disease. The cutaneous form ranges from a self-limiting lesion to severe edematous lesions with toxemic shock. Of recent, increasing cases of anthrax have been reported in Nigeria warranting heightened surveillance. A patient with skin lesions suggestive of cutaneous anthrax and toxic manifestations is reviewed to emphasize the need for a high index of suspicion.</p><p><strong>Case report: </strong>A 14-year-old boy presented with skin lesions of one month involving the hands, face, and legs, left lower limb swelling of two weeks, fever of 10 days, and fast breathing of five days duration. There was a positive history of contact with cattle carcasses at the abattoir. He was febrile (38.1^oc), mildly pale, and mildly dehydrated, oxygen saturation was 95%. He was tachypnoeic and tachycardic with a low-volume pulse. There was extensive left lower limb swelling, a raised necrotic ulcer with a black surface on the calf, measuring 9cmx5cm with serosanguinous discharge, and another confluent vesicular lesion on the anterolateral aspect of the left leg measuring 8cmx6cm. Differential diagnoses considered were cellulitis, osteomyelitis, leishmaniasis, and malignancy.</p><p><strong>Result treatment & outcome: </strong>His packed cell volume was 33%, retroviral screening, and hepatitis screening were nonreactive, and erythrocyte sedimentation rate was 3mm/hr. Leg X-ray was normal. Other investigations could not be done due to financial constraints and the patient's demise. He received intravenous (IV) fluid, IV ceftriaxone, IV metronidazole, tetanus toxoid, and antiseptic wound dressing. He succumbed to the illness 72 hours later. Anthrax was considered after the patient's demise due to the type of skin lesion and progression of the illness in line with the standard case definition.</p><p><strong>Conclusion: </strong>Cutaneous anthrax with systemic manifestations should be considered as a probable diagnosis in patients with typical skin lesions and toxic features.</p>","PeriodicalId":94346,"journal":{"name":"Nigerian medical journal : journal of the Nigeria Medical Association","volume":"65 6","pages":"1176-1184"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circumventing the Challenges of Inappropriately Filled Radiological Requests in Sub-Saharan Africa: Experiences from an Infectious Disease Hospital.","authors":"Stephen Ohikhuemei Izevbekhai, Pamela Faith Isioma Irabor, Bosede Belinda Oriaifo, Sylvester Uche Eluehike, Anthony Owolabi","doi":"10.60787/nmj.v65i6.602","DOIUrl":"10.60787/nmj.v65i6.602","url":null,"abstract":"<p><p>Radiological requests are vital communicative tools by Physicians to Radiologists. Improperly filled radiological requests are frequently encountered in our practices as radiologists; a trend which can negatively impact patient care. A properly filled request will prevent unwarranted radiation exposures and improve service delivery by Radiology departments. This article amply expresses our practice experiences (not unique to our centre alone) as they relate to poorly filled radiological investigation requests and the practical approach we have developed and adopted over time which has been quite helpful in addressing this age-long problem.</p>","PeriodicalId":94346,"journal":{"name":"Nigerian medical journal : journal of the Nigeria Medical Association","volume":"65 6","pages":"1190-1193"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of Siriraj Stroke Scoring System in the Clinical Differentiation of Stroke Sub-types in a resource-limited Setting.","authors":"Halimat Hassan Amin, Farouk Kabir Umar","doi":"10.60787/nmj.v65i6.595","DOIUrl":"10.60787/nmj.v65i6.595","url":null,"abstract":"<p><strong>Background: </strong>Stroke remains one of the major non-communicable public health disease conditions with resultant high morbidity and mortality. Neuroimaging in the form of Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) is adjudged to be the most reliable and efficient method of accurately diagnosing stroke and ruling out differentials. However, in view of cost implication and non-availability, a clinical scoring system known as the Siriraj Stroke Score (SSS) was developed to clinically differentiate stroke types, especially in resource-limited settings. This study sought to validate and determine the role of Siriraj stroke score in the clinical evaluation of patients presenting with acute stroke.</p><p><strong>Methodology: </strong>This is a descriptive prospective study that was conducted over a one-year period. The study populations were adult patients presenting with acute stroke in a tertiary health facility in North-Western Nigeria. Clinical details with neuroimaging in the form of a CT scan were obtained. Data obtained was analyzed using Stata 15.</p><p><strong>Results: </strong>Fifty-four percent (54%) of patients enrolled were males and ischaemic stroke is the commonest stroke subtype present in 69% of patients studied. Altered levels of consciousness, headache and vomiting are important discriminatory variables of the scoring system. The sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) and accuracy of Siriraj Stroke Score for haemorrhagic stroke is 92%, 72%, 62%, 95% and 62% respectively.</p><p><strong>Conclusion: </strong>Siriraj Stroke Score with sensitivity greater than 90% is reliable in differentiating the stroke sub-types; the patients in the 'grey zone' will however require neuroimaging.</p>","PeriodicalId":94346,"journal":{"name":"Nigerian medical journal : journal of the Nigeria Medical Association","volume":"65 6","pages":"995-1007"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The variability in pattern, presentation, and outcomes in the management of congenital corrected transposition of the great artery (ccTGA): A Systematic Review and Meta-analysis.","authors":"Josephat M Chinawa, Awoere T Chinawa T, Ndubuisi A Uwaezuoke, Peter D Igoche","doi":"10.60787/nmj.v65i6.655","DOIUrl":"10.60787/nmj.v65i6.655","url":null,"abstract":"<p><strong>Background: </strong>Congenitally corrected transposition of the great arteries (ccTGA) is a rare congenital heart disease with varying regional reports in management approach. The meta-analysis is aimed to document various regional differences in the pattern, presentation, and outcomes in the management of congenitally corrected transposition of the great artery(ccTGA).</p><p><strong>Methodology: </strong>Search engines for published articles on ccTGA were used in the meta-analysis. This includes PubMed, Google Scholar, Web of Science, Medline, and Africa journal online. Articles published between 2001 and 2024 were recruited of which the last search was done in August 2024. Selected articles were highlighted and screened by means of PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). Statistical heterogeneity was assessed with the <i>I²</i> statistics.</p><p><strong>Results: </strong>Fifty-one full articles were screened from the initial four hundred and eighty citations. A total of 37 studies were further excluded from the 51 studies after further screening for incomplete data, case reports, non-English language reportage, and studies from autopsy findings. The resultant 14 studies were presented in PRISMA. The statistical significance was observed as evidenced by the significance heterogeneity identified in the selected studies.</p><p><strong>Conclusion: </strong>The review had shown that children with ccTGA presented with varying features with some chromosomal correlates. Management options are directed towards a high index of suspicion, early intervention, and prompt surgical care to avert the numerous complications that follow the disease.</p>","PeriodicalId":94346,"journal":{"name":"Nigerian medical journal : journal of the Nigeria Medical Association","volume":"65 6","pages":"851-864"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic and Clinical Characteristics of Benign Laryngeal Lesions: Insights from a Decade of Experience in a Tertiary Hospital.","authors":"Nurudeen Adebola Shofoluwe, Jamila Lawal, Oladeji Raheem Quadri, Manir Anka Hamza, Amina Muhammad Abdullahi, Saadat Titlayo Yahaya, Rasheedat Sanni, Saleem Zubair, Mustapha Lawal Jimoh","doi":"10.60787/nmj.v65i6.582","DOIUrl":"10.60787/nmj.v65i6.582","url":null,"abstract":"<p><strong>Background: </strong>Benign laryngeal lesions, characterized by non-cancerous growths in the larynx, significantly impact voice quality and respiratory function. These lesions, which include vocal cord polyps, nodules, papillomas, and cysts, often result from factors such as vocal abuse, viral infections, and chronic inflammation. While studies on benign laryngeal lesions are well-documented globally, data specific to Northern Nigeria remains sparse. This study aims to analyze the demographics, clinical features, treatment modalities, and outcomes of benign laryngeal lesions over a decade in a tertiary otolaryngology center in Northern Nigeria.</p><p><strong>Methodology: </strong>A retrospective review of 176 cases of benign laryngeal lesions was conducted over 10-years (2011-2020). Data were collected on patient demographics, clinical presentation, risk factors, lesion characteristics, and treatment outcomes. All patients underwent flexible laryngoscopy, with a subset receiving CT scans and histopathological examination. The study excluded malignant lesions.</p><p><strong>Results: </strong>The study population comprised 123 males (69.9%) and 53 females (30.1%), with a male-to-female ratio of 2.3:1. The age range of patients was from 1.5 to 69 years, with a mean age of 34.74 years (±16.64). The most common presenting symptom was hoarseness (94.8%), and most lesions were vocal cord polyps (52.3%), followed by vocal cord nodules (34.7%) and juvenile-onset respiratory papilloma (6.8%). The glottic region was the most frequent site of lesion occurrence (94.9%). Treatment primarily involved voice rest (43.2%), direct laryngoscopy with excision (22.2%), and microlaryngeal surgery (8.0%). Treatment outcomes showed a cure rate of 40.9%, with a recurrence rate of 29.0%.</p><p><strong>Conclusion: </strong>This study provides valuable insights into the demographic and clinical profiles of patients with benign laryngeal lesions in Northern Nigeria. The findings indicate a predominance of vocal cord polyps, significant gender disparity, and the effectiveness of surgical interventions. These results align with regional and international data but highlight the need for more localized studies to better understand the epidemiology and management of these lesions in Northern Nigeria. Further research should explore specific risk factors and the longterm outcomes of different treatment modalities.</p>","PeriodicalId":94346,"journal":{"name":"Nigerian medical journal : journal of the Nigeria Medical Association","volume":"65 6","pages":"961-972"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geospatial Distribution, Accessibility and Utilization of Basic Emergency Obstetric and New-born Care in Jigawa State, Northwest Nigeria.","authors":"Zaharaddeen Shuaibu Babandi, Suleiman Usman, Bilkisu Gulma Abubakar, Ahmad Ayuba Umar, Auwal Garba Suleiman, Aqqad Tilde Aliyu, Maryam Fadila Isa, Tukur Dahiru","doi":"10.60787/nmj-v65i6.403","DOIUrl":"10.60787/nmj-v65i6.403","url":null,"abstract":"<p><strong>Background: </strong>High maternal mortality has remained a problem, especially in developing countries. Ensuring availability and utilization of Basic Emergency Obstetric and Newborn Care services (BEmONC) reduce maternal morbidity and mortality. The study aimed to determine the geospatial distribution, accessibility and utilization of BEmONC services in Jigawa State.</p><p><strong>Methodology: </strong>A cross-sectional study was conducted using the WHO \"30 by 7\" cluster sampling technique and two-stage sampling to select 630 women and 15 Primary Health Care facilities (PHCFs) respectively. The Geo coordinates of the PHCFs and households of respondents were taken using the global positioning system (GPS) on Android devices. Data were analysed using IBM SPSS version 25 and Arc GIS version 10.6.</p><p><strong>Results: </strong>A dispersed distribution was observed for the BEmONC facilities in two LGAs and majority of the respondents (71.9%) fall within 5 Km radius to a BEmONC facility. Only 27% of the respondents utilized BEmONC services for obstetric complications. Predictors of utilization of BEmONC were living within 5 Km to the nearest BEmONC (aOR=3.3; 95% CI=1.565 - 6.822), use of bicycle (aOR=1.930; 95% CI=1.012 - 3.679), cars (aOR=1.838; 95% CI=1.127 - 2.998), and tricycles (aOR=1.833; 95% CI=1.017 - 3.309) as means of transportation to PHCs.</p><p><strong>Conclusions: </strong>A dispersed distribution and good physical accessibility to BEmONC facilities were found, however, utilization was poor. Distance and mode of transportation were predictors of utilization of BEmONC services. Jigawa State Government should intensify awareness campaigns to improve the utilization of BEmONC services and provide emergency transport schemes for women with obstetric complications.</p>","PeriodicalId":94346,"journal":{"name":"Nigerian medical journal : journal of the Nigeria Medical Association","volume":"65 6","pages":"865"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypophosphatemia in pregnancy: A case report.","authors":"Poojan Marwaha Dogra, Bharti Bhavna, Asmita Kaundal, Nisha Malik, Sushruti Kaushal","doi":"10.60787/nmj.v65i6.603","DOIUrl":"10.60787/nmj.v65i6.603","url":null,"abstract":"<p><p>Autosomal hypophosphatemic rickets though a rare genetic disorder can lead to significant discomfort to the patient resulting in clinical deterioration and a poor quality of life. We describe a case of a 33-year-old woman G2P1001 at 6 weeks of gestation with complaints of myalgia and bony pains. Keeping her history of bony pains and fractures in mind, she was further evaluated. On evaluation, she was found to have low levels of phosphates 0.99 mg/dl (2.40-4.40) and high levels of fibroblast growth factor 23 (FGF 23) 231.70pg/ml (23.20-95.40). These biochemical parameters were suggestive of hypophosphatemic rickets and further on gene sequencing she was found to have autosomal dominant hypophosphatemic rickets (HR). During her follow-up visits, her checkup and antenatal investigations were normal. Pregnancy acts as a stressor and patients with asymptomatic ADHR may present during pregnancy for the first time with the symptoms of HR. So, a high index of suspicion is required for patients reporting musculoskeletal pains in pregnancy. Early diagnosis can help the mother have a better pregnancy experience. Phosphate and vitamin D supplementation during pregnancy can help these women reduce musculoskeletal pain symptoms. Unfortunately, this patient had a spontaneous abortion in the second trimester. The overall prevalence of ADHR is less than 1 per 1,00,000 live births. Data in pregnancy with ADHR is also minimal due to the condition's rarity. Hence, more and more studies are required in pregnancy with this disease to come to any conclusion and to find any association of ADHR with pregnancy outcomes. Genetic counselling and the need for testing in newborns if symptomatic is also an essential factor to remember when coming across such antenatal patients.</p>","PeriodicalId":94346,"journal":{"name":"Nigerian medical journal : journal of the Nigeria Medical Association","volume":"65 6","pages":"1156-1159"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}