Journal of otology最新文献

{"title":"The advancements in understanding the pathogenesis of ear fullness.","authors":"Shimin Zong, Wenting Yu, Xuan Yu, Ting Li, Wei Tang, Tianyi Liu, Hongjun Xiao","doi":"10.26599/JOTO.2025.9540012","DOIUrl":"10.26599/JOTO.2025.9540012","url":null,"abstract":"<p><p>The sensation of ear fullness is a prevalent symptom encountered in clinical practice at ear clinics. It can manifest in various conditions, including external auditory canal diseases, middle ear diseases, inner ear diseases, as well as non-ear related disorders such as autonomic nervous dysfunction and temporomandibular joint dysfunction. Despite extensive research efforts, the underlying mechanism of ear fullness remains complex and not fully elucidated. Furthermore, the mechanism of ear fullness varies depending on the specific anatomical site and associated disease pathology. In this article, we have conducted a comprehensive literature review to explore the mechanisms underlying ear fullness across different sites of the auditory conduction pathway. By focusing on these lesions and their correlation with ear fullness, we aim to provide an updated understanding on the etiology, diagnosis, and therapy for ear fullness-related diseases.</p>","PeriodicalId":94336,"journal":{"name":"Journal of otology","volume":"20 2","pages":"72-81"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern aspects of diagnosing purulent pathology of the ear (Review of cases of middle ear cholesteatoma using non-EPI DWI MRI).","authors":"Asel Imangalieva, Dina Kussainova, Otabek Tajibaev, Segizbayeva Aliya","doi":"10.26599/JOTO.2025.9540017","DOIUrl":"10.26599/JOTO.2025.9540017","url":null,"abstract":"<p><p>Chronic suppurative otitis media (CSOM) is a prevalent condition in otolaryngology with significant medical and social implications, including hearing loss and severe intracranial complications. This article discusses the challenges in diagnosing cholesteatoma, a common complication of CSOM, particularly when using computed tomography (CT) and magnetic resonance imaging (MRI). We present three clinical cases where MRI, particularly in the non-EPI diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) modes, effectively identified the presence and extent of cholesteatoma that CT could not reliably distinguish due to overlapping features with other soft tissue formations. The high sensitivity of MRI, highlight its value in both primary diagnosis and assessment of recurrence. Our findings advocate for the incorporation of MRI into the diagnostic protocols for CSOM in the Republic of Kazakhstan, emphasizing the need for reliable epidemiological data to inform future research and prevent potential intracranial complications.</p>","PeriodicalId":94336,"journal":{"name":"Journal of otology","volume":"20 2","pages":"117-122"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Consanguineous Marriage on Hearing and Language Disorders: Study Among a Group of Egyptian Children.","authors":"Sherien A Nasser, Fatma Hussein, Heba Tallah Sherif Abd El Hady, Nagwa A Meguid","doi":"10.26599/JOTO.2025.9540016","DOIUrl":"10.26599/JOTO.2025.9540016","url":null,"abstract":"<p><strong>Background: </strong>Even though various research has demonstrated the connection between consanguinity and health issues, consanguineous marriage still common in Egypt with high prevalence rate 35.3%, 23.5% in semi-urban and 17.7% in urban areas.</p><p><strong>Methods: </strong>This study was conducted on 434 native Arabic-speaking Egyptians children (3-10 years) who visited Special Needs Clinic at National Research Centre, among one year presenting with a hearing or /and language problem. They were subjected to psychometric assessment, Conners' Parent Rating Scales-Revised, Autism Diagnostic Interview Revised, Childhood Autism Rating Scale, audiological assessment, and Arabic Preschool Language Scale-4. Participants were classified into 6 subgroups according to the cause of language delay. We estimated the frequency and degree of consanguinity in each group and the association between consanguinity and hearing and language problems.</p><p><strong>Results: </strong>The prevalence of the consanguineous marriage in all participants (n=434) was 31.6 % with the mean inbreeding coefficient of 0.01208. First cousins' marriages were the most common type of consanguineous marriages (50.3% of consanguineous marriages). Among all participants in the 6 subgroups (n =434), language delay secondary to cognitive delay showed the highest percentage of consanguineous marriages (35%) followed by autism spectrum disorder (32.8%). No significant association between consanguinity and language problems. Among the 78 participants with sensorineural hearing loss, 35.9% of consanguineous couples (no.= 28 cases) were reported versus 64.1 % of non-consanguineous couples (no.= 50 cases).</p><p><strong>Conclusions: </strong>The Frequency of consanguineous marriages in our participants was 31.6 % which was close to that reported in Egyptian population. Absence of significant association between consanguinity and language problems warrants further investigation and point to the role of genetic - environment interplay in cases of language delay.</p>","PeriodicalId":94336,"journal":{"name":"Journal of otology","volume":"20 2","pages":"110-116"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternative Modalities for Temporal Bone Training in Otolaryngology: A Systematic Review.","authors":"Quan Lu, John Wenger, Anita Jeyakumar","doi":"10.26599/JOTO.2025.9540015","DOIUrl":"10.26599/JOTO.2025.9540015","url":null,"abstract":"<p><strong>Objective: </strong>Critically appraise the current state of alternate temporal bone training techniques (virtual reality (VR) simulation, 3D-printed models, and mental practice (MP)) compared to traditional and cadaver methods. Databases Reviewed: PubMed, Cochrane, Web of Science.</p><p><strong>Methods: </strong>Search terms utilized \"temporal bone training\", \"temporal bone surgical modalities\", and \"training modalities temporal bone surgery\" with \"3D\", \"rapid prototyp*\", \"stereolithography\", \"additive manufact*\", \"plaster\", \"VR\", \"virtual reality\", \"animal model\", \"animal temporal bone\", and \"synthetic\" with \"AND\" for all literature. Exclusion criteria: non-ENT, non-English, and did not compare against alternative/traditional methods.</p><p><strong>Results: </strong>10 studies were included with 322 participants (83.9% ENT residents and 16.1% medical students). Costs include the FDM printer ($300), materials ($5/3D model), and <$5,000 for freeware simulator hardware. The Welling scale was used in 50% of studies. Alternate methods produced comparable or improved assessment scores to traditional and cadaver methods. Injuries were reported in three VR studies, with two reported significantly lower injury scores in the intervention groups. Time to completion was not significantly different in four VR studies, except for one finding that the time to visualize the incus was significantly lower in the intervention group. Performance after MP was not statistically different.</p><p><strong>Conclusion: </strong>More data are needed to assess whether the alternate methods are comparable to cadaveric dissection in temporal bone training. 3D models and VR simulation demonstrate promising potential for novel trainees to acquire the basic skills and produce performance comparable to or significantly better than traditional methods of lectures, textbooks, CT images, and operative videos.</p>","PeriodicalId":94336,"journal":{"name":"Journal of otology","volume":"20 2","pages":"103-109"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between MatriX and mAXIS titanium prosthesis in stapedotomy: prospective study and review of the literature.","authors":"Angelo Immordino, Pollarolo Marco, Francesco Lorusso, Federico Sireci, Palmira Immordino, Salvatore Gallina, Francesco Dispenza","doi":"10.26599/JOTO.2025.9540014","DOIUrl":"10.26599/JOTO.2025.9540014","url":null,"abstract":"<p><strong>Background: </strong>Stapes prostheses play a crucial role in improving auditory performance and facilitating the patient's reintegration into social life. However, determining the ideal characteristics of a prosthesis and identifying the best commercially available option remain challenging. This study aims to compare the outcomes of two different types of prostheses: the MatriX Stapes Prosthesis and the new mAXIS Stapes Prosthesis.</p><p><strong>Methods: </strong>A prospective study was conducted on patients diagnosed with suspected otosclerosis who underwent stapedotomy, receiving either the MatriX or mAXIS prosthesis randomly during surgery. Postoperative follow-ups were conducted for at least one year. Audiometric evaluations were analyzed using statistical tests. Additionally, a systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement.</p><p><strong>Results: </strong>The prospective study included 84 patients, divided into two groups (G1: MatriX, G2: mAXIS). The auditory results were satisfactory for both prostheses, demonstrating their effectiveness in improving hearing thresholds. We observed a gain for air conduction threshold of 26.2 dB vs 21.2 dB with an ABG closure of 20.7 dB vs and 21.2 dB in G1 and G2 respectively. The literature review encompassed 15 studies, revealing overall positive outcomes with different prosthetic materials.</p><p><strong>Conclusions: </strong>The study revealed effective auditory improvement with both prostheses, yet no statistically significant differences in air-bone gap closure or average hearing gain. Titanium emerged as the preferred material due to its biocompatibility, lightweight nature, and stability under magnetic resonance imaging. The mAXIS prosthesis is introduced as a cost-effective alternative with favorable intraoperative features.</p>","PeriodicalId":94336,"journal":{"name":"Journal of otology","volume":"20 2","pages":"93-102"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Approach to Osteoradionecrosis of the Temporal Bone: Vascularized Obliteration with Gracilis Muscular Free Flap.","authors":"Saro-Buendía Miguel, Andresen-Lorca Belén, Pérez-García Alberto, Llópez Carratala Nacho, Carreres Polo Joan, Armengot Carceller Miguel, Perolada Valmaña Jose María","doi":"10.26599/JOTO.2025.9540018","DOIUrl":"10.26599/JOTO.2025.9540018","url":null,"abstract":"<p><p>Osteoradionecrosis of the temporal bone (ORN-TB) is usually controlled with conservative measures. However, a temporal bone resection may be required in unresponsive cases. The reconstruction of the resulting defects may be challenging because of the radiation damage to regional tissues. As a result, distant free flaps may be an optimal choice. For instance, the gracilis muscular free flap (GMFF) has consistent vascular anatomy and can be used to reconstruct small defects. We report three cases of uncontrolled ORN-TB requiring an extensive temporal bone resection followed by vascularized obliteration with a GMFF. The patients reported complete control of the main otologic symptoms (otorrhea, otalgia, and aural fullness) and optimal functional and aesthetic outcomes. Finally, the patients reported significant improvement in quality of life despite early postoperative complications. To our knowledge, the GMFF had not been used to obliterate temporal bone defects in patients with ORN-TB.</p>","PeriodicalId":94336,"journal":{"name":"Journal of otology","volume":"20 2","pages":"123-126"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report of a novel <i>GREB1L</i> gene mutation in a patient with branchio-oto-renal syndrome.","authors":"Sijing Chen, Zixuan Yang, Maoxin Wang, Cuiping Zhong","doi":"10.26599/JOTO.2025.9540011","DOIUrl":"10.26599/JOTO.2025.9540011","url":null,"abstract":"<p><p>Branchio-oto-renal (BOR) syndrome is an uncommon disorder inherited in an autosomal dominant manner. Its main clinical manifestations include branchial cleft cysts, anterior auricular fistula, hearing impairment, and kidney malformations. BOR syndrome is associated with heterozygous pathogenic variants including <i>EYA1</i>, <i>SIX1</i>, and <i>SIX5</i>. The study focused on a 13-year-old Chinese boy who presented with hearing impairment, renal malformations, and bony atresia of the right external auditory canal with microtia. The boy's clinical manifestations met the diagnostic criteria for BOR syndrome. Two of the boy's family members underwent clinical examination. However, neither displayed a phenotype associated with BOR syndrome. The boy and his two relatives provided blood samples for genomic DNA extraction, followed by Sanger sequencing. A novel mutation in the <i>GREB1L</i> gene was identified in the boy, but neither of his family members exhibited the same variant. Identifying a novel mutation in <i>GREB1L</i> offers valuable insights into the genotype-phenotype correlation of BOR syndrome, improving the precision of early diagnosis and promoting the advancement of personalized treatment strategies.</p>","PeriodicalId":94336,"journal":{"name":"Journal of otology","volume":"20 2","pages":"67-71"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Musicians Experience Early Aging in Speech Perception in Noise Abilities Compared to Musicians.","authors":"Kruthika S, Ajith Kumar Uppunda","doi":"10.26599/JOTO.2025.9540020","DOIUrl":"10.26599/JOTO.2025.9540020","url":null,"abstract":"<p><strong>Background: </strong>Research has shown that musicians outperform non-musicians in speech perception in noise (SPiN) tasks. However, it remains unclear whether the advantages of musical training are substantial enough to slow down the decline in SPiN performance associated with aging.</p><p><strong>Objectives: </strong>Therefore, we assessed SPiN performances in a continuum of age groups comprising musicians and non-musicians. The goal was to compare how the aging process affected SPiN performances of musicians and non-musicians.</p><p><strong>Method: </strong>A cross-sectional descriptive mixed design was used, involving 150 participants divided into 75 musicians and 75 non-musicians. Each age group (10-19, 20-29, 30-39, 40-49, and 50-59) consisted of 15 musicians and 15 non-musicians. Six Kannada sentence lists were combined with four-talker babble. At +5, 0, and -5 dB signal-to-noise ratios (SNRs), the percent correct Speech Identification Scores were calculated.</p><p><strong>Results: </strong>The repeated measure ANOVA (RM ANOVA) revealed significant main effects and interaction effects between SNR, musicianship, and age groups (p < 0.05). A small to large effect size was noted (η_p ²= 0.05 to 0.17). A significant interaction effect and follow-up post hoc tests showed that SPiN abilities deteriorated more rapidly with increasing age in non-musicians compared to musicians, especially at difficult SNRs.</p><p><strong>Conclusions: </strong>Musicians had better SPiN abilities than non-musicians across all age groups. Also, age-related deterioration in SPiN abilities was faster in non-musicians compared to musicians.</p>","PeriodicalId":94336,"journal":{"name":"Journal of otology","volume":"20 2","pages":"133-140"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"''Clinical Management of Acute Mastoiditis in a Pediatric Patient with Leukocyte Adhesion Deficiency''.","authors":"Allahverdi Aghayev, Alparslan Gonul, Hazan Basak","doi":"10.26599/JOTO.2025.9540019","DOIUrl":"10.26599/JOTO.2025.9540019","url":null,"abstract":"<p><p>Leukocyte adhesion deficiency type-1 is frequently associated with otorhinolaryngological manifestations, most notably a high prevalence of otitis media. Although multiple case reports have documented an increased prevalence of acute otitis media and mastoiditis in patients with LAD-1, no clinical or experimental studies have fully elucidated the pathophysiological mechanisms underlying this association. Despite guideline recommendations for urgent antibiotic therapy in immunocompromised patients with acute otitis media, a standardized treatment protocol for its complications remains lacking. Moreover, no established consensus exists regarding the optimal therapeutic approach for Leukocyte adhesion deficiency type-1 associated cases. This report contributes to the scarce literature on acute mastoiditis in LAD-1 and underscores the need for a tailored, multidisciplinary approach. In the absence of standardized treatment protocols, further research is crucial to refine management strategies and improve outcomes in immunocompromised patients with acute otitis media complications.</p>","PeriodicalId":94336,"journal":{"name":"Journal of otology","volume":"20 2","pages":"127-132"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial and Audiological Characteristics in Misophonia: An Interdisciplinary Comparison Study of Adults with Misophonia to Healthy Controls.","authors":"Mercedes G Woolley, Hailey E Johnson, Emily M Bowers, Doris Velasquez, Julie M Petersen, Karen Muñoz, Michael P Twohig","doi":"10.26599/JOTO.2025.9540013","DOIUrl":"10.26599/JOTO.2025.9540013","url":null,"abstract":"<p><p>Despite the increasing investigation into misophonia, its classification remains debated due to symptom overlap with audiological and psychological conditions, as well as methodological limitations in existing studies. In the present study, we compared a clinical sample of adults seeking treatment for misophonia with a non-treatment-seeking sample of age- and gender-matched healthy controls. In these two samples, we examined the psychological and audiological features of misophonia by assessing key psychological processes (anger, disgust, OCD symptoms, anxiety, depression, stress, well-being, and psychological inflexibility) and audiological features (hearing, hyperacusis, and tinnitus). We found that individuals with misophonia exhibit higher levels of psychological inflexibility and stress compared to healthy controls. Audiological comparisons indicated that hyperacusis is more prevalent in the misophonia group, with significantly more impairment in social and occupational functioning. There were no differences between groups on an objective assessment of hearing, although self-report measures indicated that individuals with misophonia may have greater difficulty with auditory processing. These findings suggest that misophonia is a complex disorder marked by transdiagnostic psychological characteristics and sound sensitivities. Our results underscore the need for interdisciplinary assessment and treatment approaches that incorporate psychosocial and audiological perspectives.</p>","PeriodicalId":94336,"journal":{"name":"Journal of otology","volume":"20 2","pages":"82-92"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}