''Clinical Management of Acute Mastoiditis in a Pediatric Patient with Leukocyte Adhesion Deficiency''.

Abstract

Leukocyte adhesion deficiency type-1 is frequently associated with otorhinolaryngological manifestations, most notably a high prevalence of otitis media. Although multiple case reports have documented an increased prevalence of acute otitis media and mastoiditis in patients with LAD-1, no clinical or experimental studies have fully elucidated the pathophysiological mechanisms underlying this association. Despite guideline recommendations for urgent antibiotic therapy in immunocompromised patients with acute otitis media, a standardized treatment protocol for its complications remains lacking. Moreover, no established consensus exists regarding the optimal therapeutic approach for Leukocyte adhesion deficiency type-1 associated cases. This report contributes to the scarce literature on acute mastoiditis in LAD-1 and underscores the need for a tailored, multidisciplinary approach. In the absence of standardized treatment protocols, further research is crucial to refine management strategies and improve outcomes in immunocompromised patients with acute otitis media complications.