Journal of clinical medicine research最新文献

{"title":"Dysmenorrhea and Absence of Restorative Sleep.","authors":"Keiko Takata, Kazuhiko Kotani, Hitoshi Umino","doi":"10.14740/jocmr6579","DOIUrl":"10.14740/jocmr6579","url":null,"abstract":"<p><strong>Background: </strong>Dysmenorrhea negatively affects daily functioning; however, its association with restorative sleep remains undetermined, while sleep-related health is a recent topic. This study investigated whether there is an association between dysmenorrhea severity and the absence of restorative sleep in women.</p><p><strong>Methods: </strong>This cross-sectional study included 2,752 women of 18-56 years of age who underwent health-screening. Dysmenorrhea was categorized as mild, moderate, or severe, based on self-reports. Restorative sleep was evaluated using a questionnaire regarding sufficient rest from sleep. Their associations were tested using a logistic regression analysis adjusted for confounders with odds ratio (OR) and 95% confidence interval (CI).</p><p><strong>Results: </strong>Restorative sleep was absent in 38.4% of this population. There was a significant association between severe dysmenorrhea and the absence of restorative sleep (adjusted OR 2.282, 95% CI 1.744-2.986; P < 0.001). There was also a significant association between moderate dysmenorrhea and the absence of restorative sleep (adjusted OR 1.241, 95% CI 1.049-1.467; P = 0.012).</p><p><strong>Conclusions: </strong>The results indicated a positive association between dysmenorrhea severity and the absence of restorative sleep in women. The evaluation of restorative sleep may be relevant to health checks in association with dysmenorrhea.</p>","PeriodicalId":94329,"journal":{"name":"Journal of clinical medicine research","volume":"18 7","pages":"449-455"},"PeriodicalIF":2.2,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian Rhythms in Colorectal Cancer: Recent Advances in Development and Treatment.","authors":"Yi Liu, Ting Wang, Rong Jun Zhu, Yu Li Zhang, Hua Sui","doi":"10.14740/jocmr6626","DOIUrl":"10.14740/jocmr6626","url":null,"abstract":"<p><p>The circadian clock orchestrates biological rhythms across species and is deeply involved in the physiological and biochemical processes underlying tumor initiation and progression. By regulating cell division, DNA repair, immune function, and hormonal balance, circadian rhythms interact closely with cancer, providing a theoretical foundation for the exploration of chronotherapy. Maintaining circadian homeostasis is therefore essential for cancer prevention and treatment. This review centers on the intricate relationship between circadian rhythms and malignancy, with a particular focus on the role of circadian disruption in tumorigenesis and malignant progression. A systematic literature search was performed across the PubMed, MEDLINE, and Scopus databases to screen original studies and review articles focusing on circadian regulation in colorectal cancer. This review delineates the tissue-specific effects of circadian clock signaling in colorectal malignancy and clarifies the correlation between circadian disruption and early tumorigenesis. Accumulated evidence is integrated into a comprehensive mechanistic framework covering metabolic reprogramming, tumor immunosuppression, and stromal remodeling. Additionally, current advances in harnessing circadian rhythms to refine preventive strategies and chronotherapeutic regimens for colorectal cancer are highlighted, with a concise discussion on the potential of traditional Chinese medicine in regulating biological rhythms to improve colorectal cancer clinical management.</p>","PeriodicalId":94329,"journal":{"name":"Journal of clinical medicine research","volume":"18 7","pages":"437-448"},"PeriodicalIF":2.2,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal Artery Occlusion and Incident Dementia in the All of Us Research Program: Detection Bias Calibration with Prespecified Negative-Control Outcomes.","authors":"Meet Popatbhai Kachhadia, Piyush Puri, Usmaan Topiwala, Juber D Shaikh, Gurnoor Gill, Shailesh Gupta, Michelle Byrus, Harshal A Sanghvi","doi":"10.14740/jocmr6628","DOIUrl":"10.14740/jocmr6628","url":null,"abstract":"<p><strong>Background: </strong>Retinal artery occlusion (RAO) shares vascular pathophysiology with cerebrovascular disease, and its relationship to incident dementia remains unsettled. Reported associations may reflect shared vascular pathology, differential ascertainment along the intensive workup pathways that RAO patients enter, or both. No prior study has calibrated RAO-dementia estimates against prespecified negative-control outcomes spanning distinct ascertainment pathways.</p><p><strong>Methods: </strong>Among 129,279 All of Us participants aged 50 years or older and free of prevalent dementia (controlled-tier release R2024Q3R9, OMOP common data model), strict RAO was defined by seven verified SNOMED concept identifiers (n = 339). Incident dementia required two or more codes at least 30 days apart (Wilkinson algorithm), with prespecified vascular and Alzheimer subtypes. Cox models used age as timescale with left truncation and time-varying exposure; 1:5 propensity-score matching was the primary confounder-adjusted analysis. Cataract, benign paroxysmal positional vertigo (BPPV), and inguinal hernia were prespecified negative controls for ophthalmology, neurology, and general-contact pathways.</p><p><strong>Results: </strong>There were 1,506 incident dementia events. RAO was not associated with all-cause dementia (unmatched hazard ratio (HR) 0.81, 95% confidence interval (CI) 0.40-1.64; matched HR 1.33, 95% CI 0.72-2.47; 10 exposed events). The vascular dementia estimate remained elevated but imprecise (unmatched HR 1.93, 95% CI 1.02-3.66; matched HR 1.81, 95% CI 0.66-4.94; 3 exposed events). Cataract was elevated (HR 1.87, 95% CI 1.45-2.42), whereas BPPV (HR 1.27, 95% CI 0.90-1.79) and hernia (HR 1.10, 95% CI 0.68-1.78) were not.</p><p><strong>Conclusions: </strong>We found no evidence that RAO is independently associated with incident dementia, replicating a large European null finding in a diverse United States cohort. The cohort was underpowered to exclude clinically meaningful effects, particularly for vascular dementia. Detection bias in this dataset was demonstrably pathway-specific, but same-pathway calibration accounts for only part of the residual vascular dementia estimate.</p>","PeriodicalId":94329,"journal":{"name":"Journal of clinical medicine research","volume":"18 7","pages":"489-495"},"PeriodicalIF":2.2,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differentiating Juvenile Idiopathic Arthritis From Acute Lymphoblastic Leukemia in Children: A Multidisciplinary Diagnostic Approach, Systematic Review and Meta-Analysis.","authors":"Heba M Reyad, Narmen Eltrafi, Walaa H Ali, Mohamed Abdelrazek, Marwa Khairy Abd Elwahab, Eiman Ibrahim, Seham Nabil Ramdan, Ahmed Akef, Jumana Ahmed Eid, Mohamed Hashem Youssef Abdou, Soad A Eltokhy, Sedeek Mosaid, Mona E Hashem, Iman Ahmed Kassem, Ramy Saleh Abdelghany","doi":"10.14740/jocmr6630","DOIUrl":"10.14740/jocmr6630","url":null,"abstract":"<p><strong>Background: </strong>Juvenile idiopathic arthritis (JIA) and acute lymphoblastic leukemia (ALL) share overlapping musculoskeletal presentations in pediatric patients, and the misclassification of ALL as JIA carries life-threatening consequences due to inappropriate initiation of corticosteroid or immunosuppressive therapy. A rigorous synthesis of contemporary evidence identifying the most reliable clinical and laboratory discriminators between these two conditions is long overdue. This systematic review and meta-analysis aimed to evaluate clinical, laboratory, and biomarker-based features that differentiate ALL from JIA in pediatric patients. The primary focus was on studies published between January 2021 and April 2026, while selectively incorporating seminal pre-2021 studies with major diagnostic relevance and extractable comparative data to strengthen quantitative synthesis.</p><p><strong>Methods: </strong>A comprehensive search of PubMed, EMBASE, Web of Science, CINAHL, and Cochrane Library was conducted using pre-specified search terms. Two independent reviewers screened titles, abstracts, and full texts. Methodological quality was assessed with the Newcastle-Ottawa Scale (NOS). Pooled odds ratios (ORs) were estimated under a random-effects model (DerSimonian-Laird), and heterogeneity was quantified using the I² statistic. Publication bias was evaluated with Egger regression and visual inspection of funnel plots.</p><p><strong>Results: </strong>Eighteen studies were included in the qualitative synthesis, of which 12 primary comparative studies contributed quantitative data to the meta-analysis, encompassing 5,198 pediatric patients across 12 countries. Thrombocytopenia (platelets < 100 × 10⁹/L) demonstrated the highest diagnostic weight, with a pooled OR of 108.4 (95% CI: 58.2-201.7; I² = 34.2%), followed closely by neutropenia (pooled OR = 103.6; 95% confidence interval (CI): 55.9-192.0; I² = 31.7%) and anemia (pooled OR = 57.4; 95% CI: 22.1-149.0; I² = 41.6%). Limb pain disproportionate to physical findings, nocturnal bone pain, hepatosplenomegaly, and elevated lactate dehydrogenase (LDH) were additional independent predictors. Novel biomarkers including S100A9 and S100A12 showed markedly reduced levels in ALL compared to JIA (area under the curve (AUC) = 0.91). No evidence of significant publication bias was detected.</p><p><strong>Conclusion: </strong>The triad of thrombocytopenia, neutropenia, and anemia constitutes the most powerful hematological screening strategy for distinguishing ALL from JIA in children presenting with arthropathy. Bone marrow aspiration should be pursued without hesitation when two or more cell lines are affected. Clinicians must resist initiating immunosuppressive therapy before excluding an underlying malignancy, particularly when pain is nocturnal, disproportionate to findings, or associated with weight loss and organomegaly.</p>","PeriodicalId":94329,"journal":{"name":"Journal of clinical medicine research","volume":"18 6","pages":"394-406"},"PeriodicalIF":2.2,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13375429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline Lactate Dehydrogenase Predicts Early Treatment Failure in Diffuse Large B-Cell Lymphoma Treated With R-CHOP: A Real-World Cohort Study.","authors":"Noorwati Sutandyo, Hilman Tadjoedin, Nia Novianti Siregar, Yuniar Harris Prayitno","doi":"10.14740/jocmr6583","DOIUrl":"10.14740/jocmr6583","url":null,"abstract":"<p><strong>Background: </strong>Early treatment failure following first-line R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) remains a major clinical problem in diffuse large B-cell lymphoma (DLBCL), particularly in real-world settings where late presentation and variable access to diagnostics may shape outcomes. We examined clinical and laboratory predictors of time-to-diagnosis associated with early treatment failure in an Indonesian referral-center cohort.</p><p><strong>Methods: </strong>We performed a retrospective observational cohort study at Dharmais National Cancer Center Hospital, Jakarta, including adults with DLBCL who initiated first-line R-CHOP between January 2019 and June 2024 and had evaluable baseline data and response assessment. Early treatment failure was defined as primary refractory disease (stable/progressive disease during or at the end of treatment, or a partial response at the end of treatment) or early recurrence occurring within ≤ 12 months following the attainment of complete response. Candidate predictors were analyzed using logistic regression; a prespecified multivariable model included age > 60 years, Eastern Cooperative Oncology Group (ECOG) performance status, Ann Arbor stage, anemia, and lactate dehydrogenase (LDH).</p><p><strong>Results: </strong>Among 372 patients diagnosed during the predefined study period, 105 with DLBCL were included in the final analytic cohort. Their mean age was 52.2 years and 54.3% were male. Early treatment failure occurred in 54/105 (51.4%): 45 (83.3%) primary refractory and nine (16.7%) early relapse. On univariate analysis, unfavorable ECOG, advanced stage, anemia, and elevated LDH were associated with early failure. In multivariable analysis, only elevated LDH remained independently associated (adjusted odds ratio (OR) 2.41, 95% confidence interval (CI) 1.01-5.79). Model discrimination was limited-to-modest (area under the curve (AUC) 0.646), indicating that baseline clinical variables alone were insufficient for strong individual-level prediction.</p><p><strong>Conclusion: </strong>In this real-world Indonesian DLBCL cohort, early treatment failure was frequent and was associated with elevated baseline LDH after adjustment. Given the limited-to-modest model discrimination and the retrospective single-center design, LDH should be interpreted as a practical warning marker for closer monitoring rather than a stand-alone predictor, and these findings require prospective validation.</p>","PeriodicalId":94329,"journal":{"name":"Journal of clinical medicine research","volume":"18 6","pages":"379-393"},"PeriodicalIF":2.2,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13375426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Facet Joint Effusion on Magnetic Resonance Imaging Is Associated With Dynamic Segmental Instability and Pain Severity in Degenerative Lumbar Spondylolisthesis.","authors":"Yu Lin Zhao, Hai Peng Si, Yong Guang Sun","doi":"10.14740/jocmr6572","DOIUrl":"10.14740/jocmr6572","url":null,"abstract":"<p><strong>Background: </strong>The aims of the study were to determine whether quantitatively measured facet joint effusion (FJE) on magnetic resonance imaging (MRI) is associated with dynamic segmental instability and greater pain severity in patients with degenerative lumbar spondylolisthesis (DLS), and to evaluate the diagnostic performance of FJE for identifying unstable segments.</p><p><strong>Methods: </strong>This retrospective single-center study reviewed 151 consecutive DLS patients treated at Qilu Hospital (Qingdao) between January 1, 2020 and June 30, 2024. The cohort included 31 men and 118 women (mean age 64.52 ± 9.76 years). Slipped levels comprised L3 (n = 7), L4 (n = 116), and L5 (n = 28). Patients with prior lumbar surgery, acute spinal trauma, tumor, ankylosing spondylitis, marked scoliosis, multilevel spondylolisthesis, or retrolisthesis were excluded. On axial T2-weighted MRI, the maximal unilateral and bilateral facet effusion thicknesses were measured in millimeters. Dynamic imaging was used to classify segments as stable or unstable. Pain was quantified using the Visual Analog Scale (VAS). Statistical analyses compared FJE presence and size between stable and unstable segments and assessed diagnostic accuracy (sensitivity, specificity, receiver operating characteristic area under the curve) and correlations with slip distance and VAS.</p><p><strong>Results: </strong>Seventy-two patients (47.7%) had dynamic segmental instability. FJE was present at 93.1% of unstable levels, with mean effusion thickness of 2.75 ± 0.89 mm, whereas stable levels showed a 26.6% FJE incidence and mean thickness of 1.25 ± 1.25 mm (P < 0.05). Using presence of FJE to identify instability yielded sensitivity 93.1% and specificity 73.4%. Among 88 patients with effusion ≥ 1.0 mm, 76.1% exhibited instability. Effusion thickness correlated linearly with the anteroposterior slip distance difference. Facet joint degeneration grade related nonlinearly to effusion width (increase from grade 1 to 2, decline at grade 3; P < 0.05). ROC AUCs for left and right effusion thickness were 0.9243 and 0.9296, respectively (P < 0.0001). Patients with effusion had higher VAS scores (4.30 ± 1.07 vs. 2.79 ± 0.68, P < 0.05).</p><p><strong>Conclusions: </strong>Millimeter-quantified FJE on MRI was strongly associated with dynamic segmental instability and greater pain severity in DLS. Quantitative FJE demonstrated high diagnostic accuracy and may serve as a practical imaging marker to identify unstable lumbar segments. Given the retrospective design, these results indicate association rather than causation and require prospective validation.</p>","PeriodicalId":94329,"journal":{"name":"Journal of clinical medicine research","volume":"18 6","pages":"369-378"},"PeriodicalIF":2.2,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13375413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Triglyceride-Glucose Index and Mortality Risk in Cardiovascular Disease Patients: A Meta-Analysis.","authors":"Ren Jie Wu, Jie Yu, Ying Zhao, Jie Han, Xing Liang Shi, Jia Bing Wang, Ming Wu Hu, Ting Li","doi":"10.14740/jocmr6567","DOIUrl":"10.14740/jocmr6567","url":null,"abstract":"<p><strong>Background: </strong>The triglyceride-glucose (TyG) index was proposed as a possible indicator with regard to projecting cardiovascular disease (CVD) outcomes. Nevertheless, its capacity to project outcomes in various CVD patient groups, particularly those without type 2 diabetes mellitus (T2DM), remains uncertain. This meta-analysis is intended to assess the relationship that exists between baseline TyG levels and mortality outcomes in hospitalized CVD patients while examining potential variations in this association across different subgroups.</p><p><strong>Methods: </strong>The authors systematically searched the Embase, PubMed and Web of Science databases for studies evaluating the connection between TyG levels and mortality outcomes in CVD patients. Seventeen studies, including a total of 26,464 participants, were included. The primary findings analyzed were all-cause mortality and cardiovascular mortality. Stratified and sensitivity analyses were performed to evaluate the robustness and generalizability of the findings.</p><p><strong>Results: </strong>Elevated TyG levels were significantly associated with higher risks of both all-cause mortality (hazard ratio (HR) = 1.43; 95% CI, 1.27-1.62; P < 0.001) and cardiovascular mortality (HR = 1.62; 95% CI, 1.33-1.97; P < 0.001) in patients with acute and chronic CVD. However, this association was not significant in patients without T2DM. Dose-response meta-analysis indicated a linear increase in all-cause mortality risk with higher TyG levels. Sensitivity analyses confirmed the robustness of the results, and no significant publication bias was detected.</p><p><strong>Conclusions: </strong>TyG could potentially predict mortality risk in CVD patients, particularly within the Asian population. Additional high-quality, large-scale studies across diverse ethnic groups (such as Caucasians) are needed to validate these results' global generalizability.</p>","PeriodicalId":94329,"journal":{"name":"Journal of clinical medicine research","volume":"18 6","pages":"407-419"},"PeriodicalIF":2.2,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13375415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetus-in-Fetu: A PRISMA-Informed Narrative Review With an Illustrative Prenatal Case.","authors":"Agata Leszczynska-Wierzba, Michal Buczynski, Aleksandra Jasinska, Katarzyna Luterek, Denis Aduku, Aleksandra Slowakiewicz, Katarzyna Balcerak, Katarzyna Zapalowicz, Dariusz Madajczak, Beata Borek-Dzieciol, Bozena Kociszewska-Najman, Arkadiusz Krzyzanowski, Przemyslaw Kosinski, Wiku Andonotopo, Muhammad Adrianes Bachnas","doi":"10.14740/jocmr6423","DOIUrl":"10.14740/jocmr6423","url":null,"abstract":"<p><p>Fetus-in-fetu (FIF) is an uncommon congenital anomaly arising from aberrant monozygotic twinning, in which a malformed parasitic twin becomes incorporated within the body of the host. Despite its rarity, FIF remains clinically relevant because it is frequently misdiagnosed as a teratoma, particularly when detected outside the neonatal period or at atypical anatomical sites. This review present a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-informed narrative synthesis of the human literature on FIF, integrating embryological concepts, diagnostic imaging features, genetic observations, and surgical management. A systematic search of major electronic databases identified 45 publications meeting predefined eligibility criteria. From these, 25 core studies were selected for in-depth narrative analysis based on diagnostic confirmation, methodological clarity, and avoidance of overlapping case reports. To contextualize the literature, a previously unreported human case of FIF associated with omphalocele and complex congenital cardiac anomalies was also described, illustrating current prenatal diagnostic pathways and multidisciplinary postnatal care. Across reported cases, FIF is most often diagnosed in infancy and is typically benign following complete surgical excision. Distinguishing FIF from mature teratoma relies on recognition of organized axial structures, symmetry, and shared monozygotic genetic identity. Although malignant transformation is rare, incomplete resection and immature tissue components warrant long-term surveillance. Improved prenatal imaging has enhanced early recognition of FIF, yet its developmental mechanisms remain incompletely understood. Future progress will likely depend on coordinated clinical reporting and translational research addressing early embryonic asymmetry, diagnostic refinement, and evidence-based follow-up strategies.</p>","PeriodicalId":94329,"journal":{"name":"Journal of clinical medicine research","volume":"18 6","pages":"353-368"},"PeriodicalIF":2.2,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13375432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidized High-Density Lipoprotein and Cardiovascular Risk in Rheumatoid Arthritis.","authors":"Linda Scharow, Susann Patschan, Nikolaos Pagonas, Meike Hoffmeister, Inga Claus, Emily Deichsler, Werner Dammermann, Oliver Ritter, Daniel Patschan","doi":"10.14740/jocmr6494","DOIUrl":"10.14740/jocmr6494","url":null,"abstract":"<p><strong>Background: </strong>Patients with rheumatoid arthritis (RA) have a disproportionately increased cardiovascular risk (CVR). Serological CVR predictors that capture this disease-associated risk increase are currently not available. Elevated levels of oxidized high-density lipoprotein (oxHDL) have been associated with coronary artery disease and atrial fibrillation. The aim of this study was to evaluate the suitability of oxHDL as a CVR predictor in RA.</p><p><strong>Methods: </strong>An observational cross-sectional study was conducted in patients with confirmed RA undergoing variable disease-modifying anti-rheumatic drug (DMARD) therapy. Anamnestic, clinical, and laboratory surrogate markers of cardiovascular morbidity and disease activity were collected. Th quantification of oxHDL was conducted using a fluorometric biochemical cell-free assay.</p><p><strong>Results: </strong>A total of 200 RA patients were included in the study. oxHDL showed significant correlations with the following variables: body mass index (BMI) (positive), total cholesterol, and average daily prednisolone dose (both negative). Overweight and hypertensive individuals exhibited higher levels of oxHDL. Additionally, oxHDL correlated positively with the number of tender small joints.</p><p><strong>Conclusion: </strong>oxHDL is associated with distinct CVR indicators in RA. Both prospective and follow-up data are needed to definitively evaluate the role of oxHDL in CVR assessment in RA.</p>","PeriodicalId":94329,"journal":{"name":"Journal of clinical medicine research","volume":"18 5","pages":"283-291"},"PeriodicalIF":2.2,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13278688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148298198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative and Long-Term Outcomes of T-Shaped Esophagojejunostomy After Laparoscopic Total Gastrectomy for Gastric Cancer.","authors":"Van-Huong Nguyen, Van-Chien Dinh, Van-Thuong Pham, Van-Quyet Ha, Ba-Thai Nguyen, Dinh-Hieu Nguyen, Minh-Tung Do","doi":"10.14740/jocmr6549","DOIUrl":"10.14740/jocmr6549","url":null,"abstract":"<p><strong>Background: </strong>Intracorporeal esophagojejunostomy remains a technically challenging step in totally laparoscopic total gastrectomy (TLTG), and long-term outcome data for modified linear-stapled techniques are limited.</p><p><strong>Methods: </strong>We conducted an observational study including 167 consecutive patients who underwent TLTG with D2 lymphadenectomy and intracorporeal T-shaped functional end-to-end esophagojejunostomy between July 2017 and July 2025. Perioperative outcomes, postoperative complications, and long-term oncologic outcomes were analyzed.</p><p><strong>Results: </strong>All procedures were completed laparoscopically without conversion to open surgery. No anastomotic leakage occurred. Overall postoperative morbidity was 2.4%, and no postoperative mortality was observed. The mean follow-up duration was 44.1 ± 20.0 months, with complete survival follow-up. The 5-year overall survival rate was 41.8%.</p><p><strong>Conclusions: </strong>T-shaped functional end-to-end esophagojejunostomy after TLTG is safe and reproducible, with low anastomotic-related morbidity and acceptable long-term oncologic outcomes. These findings provide real-world evidence supporting standardized intracorporeal reconstruction following total gastrectomy.</p>","PeriodicalId":94329,"journal":{"name":"Journal of clinical medicine research","volume":"18 5","pages":"336-342"},"PeriodicalIF":2.2,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13278692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148298189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}