Endocrine, metabolic & immune disorders drug targets最新文献

{"title":"Evaluation of Betatrophin, Chemerin, and Kisspeptin Levels in Acromegaly Patients.","authors":"Dondu Aysegul Cayan, Senay Topsakal, Esin Avci","doi":"10.2174/0118715303375180250312035323","DOIUrl":"https://doi.org/10.2174/0118715303375180250312035323","url":null,"abstract":"<p><strong>Background: </strong>Acromegaly is a chronic disorder characterized by excessive growth hormone (GH) secretion from pituitary somatotroph cells, resulting in metabolic complications and increased morbidity. Elevated levels of GH and insulin-like growth factor 1 (IGF-1) contribute to various metabolic and morphological abnormalities. Betatrophin, produced in the liver and adipose tissue, plays a significant role in regulating glucose and lipid metabolism. Chemerin, an adipokine, influences insulin sensitivity, lipid metabolism, and inflammation. Additionally, kisspeptin, a neuropeptide, stimulates the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) through the hypothalamic-pituitary-gonadal axis.</p><p><strong>Objective: </strong>This study aimed to investigate the levels of betatrophin, chemerin, and kisspeptin in acromegaly patients and their potential relationship with dyslipidemia and diabetes.</p><p><strong>Methods: </strong>This study included 40 patients diagnosed with acromegaly and 40 healthy controls. GH and IGF-1 levels were measured, and venous blood samples were analyzed for betatrophin, chemerin, and kisspeptin levels using ELISA.</p><p><strong>Results: </strong>The analysis revealed no significant difference in betatrophin levels between acromegaly patients and controls (p>0.05). However, significantly lower levels of chemerin and kisspeptin were observed in patients with acromegaly (p<0.001). Furthermore, a significant correlation was identified between IGF-1 and kisspeptin levels, indicating a potential pathway for future research in diagnostics and therapy.</p><p><strong>Conclusion: </strong>This study highlights the altered levels of chemerin and kisspeptin in acromegaly patients, suggesting their involvement in metabolic dysregulation associated with the condition. Further investigation into the correlation between IGF-1 and kisspeptin could provide insights into developing targeted therapeutic strategies.</p>","PeriodicalId":94316,"journal":{"name":"Endocrine, metabolic & immune disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic Ketoacidosis: Considerations and Residual Controversies in Management After the 2024 ADA, EASD, JBDS, AACE, and DST Joint Consensus.","authors":"A Ciafardini, W Vena, N Betella, S Pigni, M Mirani, V M Altieri, G Mazziotti, A G Lania, A C Bossi","doi":"10.2174/0118715303374972250407065308","DOIUrl":"https://doi.org/10.2174/0118715303374972250407065308","url":null,"abstract":"<p><p>Diabetic ketoacidosis (DKA) is the most serious and life-threatening complication of Diabetes Mellitus (DM), characterized by the triad of hyperglycemia, ketonemia, and anion gap metabolic acidosis. DKA is more common in young people with type 1 diabetes (T1D) but can also occur in patients with type 2 diabetes (T2D) and in pregnant women with pregestational T1D or T2D or gestational DM. Moreover, DKA may be a rare complication of immune check-point inhibitor therapy. Euglycemic DKA (eDKA) is a variant of DKA with normal or minimally elevated serum glucose associated with using sodium-glucose cotransporter-2 (SGLT2) inhibitors, a class of anti-hyperglycemic medications. Prompt identification of DKA in the emergency setting is mandatory, and the management of its critical aspects and its possible underlying precipitating factors are often life-changing choices for patients. Despite diagnostic and therapeutic improvements, DKA still stands as one of the main causes of morbidity and mortality in DM individuals. Recently, an inter-society consensus report has been published to provide up-to-date knowledge on DKA. Nevertheless, controversies concerning the clinical management of this acute complication of DM remain to be unfolded and high-quality evidence is lacking in concern to solve such critical aspects. This narrative review aims to explore and discuss DKA, its epidemiology, pathogenesis, diagnosis, clinical onset, and treatment, highlighting some of the main remaining open controversies.</p>","PeriodicalId":94316,"journal":{"name":"Endocrine, metabolic & immune disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Genetic Link between Irritable Bowel Syndrome and Polycystic Ovary Syndrome: Bidirectional Mendelian Randomization and Machine Learning Approaches.","authors":"Ziwei Gao, Zhenglin Mei, Yujun Zhang, Siyao Lv, Jingru Song, Wei Ye","doi":"10.2174/0118715303363459250317084005","DOIUrl":"https://doi.org/10.2174/0118715303363459250317084005","url":null,"abstract":"<p><strong>Background: </strong>Research has shown a certain correlation between polycystic ovary syndrome (PCOS) and irritable bowel syndrome (IBS). The study aims to determine the directionality and underlying biological processes influencing the relationship between these two disorders.</p><p><strong>Methods: </strong>We explored the causal relationship between IBS and PCOS by conducting a comprehensive bidirectional Mendelian randomization (MR) analysis using five different methods and conducted robustness assessments. We extracted differentially expressed genes from the IBS and PCOS datasets for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. Additionally, we developed a protein-protein interaction (PPI) network and applied the Least Absolute Shrinkage and Selection Operator (LASSO) and Support Vector Machine (SVM) methodologies to pinpoint key diagnostic markers. Diagnostic efficacy was further assessed through Receiver Operating Characteristic (ROC) curve analysis for selected genes. Finally, single-sample gene set enrichment analysis (ssGSEA) was carried out to examine immune cell infiltration in IBS and PCOS.</p><p><strong>Results: </strong>MR analysis identified a causal effect of PCOS on IBS (IVW, OR = 1.034, 95% CI: 1.003-1.065, P = 0.029). Conversely, no relationship between IBS and PCOS was observed in the reverse analysis. Furthermore, integrative bioinformatics and machine learning analyses identified CD14 and CASP1 as key diagnostic biomarkers for both IBS and PCOS, which were significantly associated with immune cell infiltration.</p><p><strong>Conclusion: </strong>MR analysis has demonstrated a significant positive causal relationship between PCOS and IBS, though the reverse causality from IBS to PCOS appeared non-significant. The genes CD14 and CASP1 emerged as potential shared diagnostic markers between these two conditions.</p>","PeriodicalId":94316,"journal":{"name":"Endocrine, metabolic & immune disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Hub Neutrophil Coexpressed Genes in Acute Pancreatitis via Machine Learning.","authors":"Yuting Guan, Zudong Xu, Liuling Liang, Wentao Deng, Zhilin Qin, Jiaming Yang, Shanyu Qin","doi":"10.2174/0118715303375487250225114210","DOIUrl":"https://doi.org/10.2174/0118715303375487250225114210","url":null,"abstract":"<p><strong>Background: </strong>Acute pancreatitis (AP) is a disease with high morbidity and mortality. Neutrophils are highly correlated with the occurrence and severity of the inflammatory response in AP. However, the mechanism by which neutrophils act on AP is currently unclear. We aimed to target genes coexpressed with neutrophils to identify new possibilities for diagnosing and treating AP.</p><p><strong>Methods: </strong>We analyzed the differences in immune infiltration in AP and the differential expression of neutrophil-coexpressed genes. Then, models were built through various machine learning methods, and the hub neutrophil coexpressed genes were identified. Receiver operating characteristic (ROC) curves were used for validation, and the relationships between the hub neutrophil coexpressed genes and immune infiltration were explored. GSEA and GSVA were used to investigate the biological functions of genes. Finally, we explored the miRNAs and lncRNAs associated with the hub neutrophil coexpressed genes.</p><p><strong>Results: </strong>Neutrophil infiltration varied significantly in samples from patients with AP. RGS2, AHNAK, and OGT were identified as hub neutrophil coexpressed genes by taking intersections of genes involved in the machine learning approach. The hub neutrophil coexpressed genes are closely associated with a variety of immune cells. GSVA revealed that the hub neutrophil coexpressed genes are differentially expressed in multiple immune- and inflammation-related pathways. These findings suggest that these genes may influence AP progression through these pathways.</p><p><strong>Conclusions: </strong>In this study, genes coexpressed with neutrophils in AP were identified, and their biological functions were investigated. These findings may provide more effective therapeutic strategies for the prediction, prevention, and personalized treatment of patients with AP.</p>","PeriodicalId":94316,"journal":{"name":"Endocrine, metabolic & immune disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human-like Skin Tissue Graft Generated Using Human UmbilicalCordBlood Mesenchymal Stem Cells and Acellular Amniotic Membrane: A New Approach in Reconstructive Medicine.","authors":"Binh Thanh Nguyen, Thao Duy Huynh, Hoa Khanh Nguyen, Huong Kc Hoang, Thuy Thanh Thi Tran, Hien Ngoc Nhan, Hien Thu Thi Nguyen, Quan Minh Thai Ngo, Kiet Tuan Nguyen, Francesco Inchingolo, Luigi Santacroce, Kieu Cd Nguyen, Ciro Gargiulo Isacco","doi":"10.2174/0118715303370737250324063647","DOIUrl":"https://doi.org/10.2174/0118715303370737250324063647","url":null,"abstract":"<p><strong>Background: </strong>Due to its outstanding biological properties, the Human Amniotic Membrane (HAM) has been a topic of medical research for many years to treat, repair, and regenerate damages related to the epithelial surface, corneal epithelial, orthopedic, and infected body parts. The HAM shows crucial anti-inflammatory, anti-bacterial, and anti-viral properties and immunomodulating qualities. Therefore, the HAM is one of the most used natural biomaterials in tissue engineering to generate bio-scaffolds.</p><p><strong>Objective: </strong>This study used HAM as a raw material to produce a collagen membrane that fully meets the criteria for creating a bioscaffold with suitable mechanical strength and limited risk of graft rejection. This collagen membrane would be a bioscaffold to carry Human Umbilical Cord Blood Mesenchymal Stem Cells (hUCB-MSCs) to generate human epithelial-like cell sheets. Shortly, these cell sheets can repair and regenerate the epithelial layer in trauma cases, severe damage from accidents, burns, and other post-operational conditions.</p><p><strong>Methods: </strong>Among the varieties of stem cells currently being researched, MSCs are the most studied and applied due to their outstanding bio-qualities and regenerative features. We used International Society for Cells and Gene Therapy (ISCT) standards to identify and characterize the hUCB-MSCs obtained from a donor's umbilical cord blood who provided consent. We used an inverted phase contrast microscope to evaluate morphological changes and epithelial stratification of cultured growing cells on the collagen scaffold. Further, staining techniques, such as H&E and Trichrome, were used to assess the morphology and structure of the new epithelial construct; histochemical staining with p63 and ck 1/10 markers was used to evaluate the cellular characteristics and specific traits. Transmission electron microscopy was used to validate cell junctions.</p><p><strong>Results: </strong>This study successfully obtained human epithelial-like cell sheets with multiple cell layers, morphology, and characteristics comparable to human epithelial tissue.</p><p><strong>Conclusion: </strong>The results of this study will constitute a potential alternative to autologous skin grafting in heavy skin loss and deep lesions.</p>","PeriodicalId":94316,"journal":{"name":"Endocrine, metabolic & immune disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Effects of Propolis on Oral Mucositis in Patients Undergoing Chemotherapy: A Systematic Review and Meta-Analysis.","authors":"Yun-Chen Chang, Annamaria Porreca, Raffaella Massafra, Gen-Min Lin, Elsa Vitale","doi":"10.2174/0118715303356011250307070928","DOIUrl":"https://doi.org/10.2174/0118715303356011250307070928","url":null,"abstract":"<p><strong>Introduction: </strong>Oral mucositis (OM) refers to an erythematous, shared, and painful complication resulting from chemotherapy or radiotherapy.</p><p><strong>Aim: </strong>This study aimed to discuss OM in chemotherapy patients and the use of propolis in medicine inside the hospital and before preparing for or during chemotherapy.</p><p><strong>Methods: </strong>A comprehensive literature search was performed across three databases, adhering strictly to the inclusion criteria of randomized controlled trials (RCTs) to maintain research integrity and relevance. The methodological approach was guided by the PRISMA guidelines to ensure systematic rigor and transparency in reporting. To evaluate the quality of the included studies, the Evidence- Based Nursing (EBN) approach specific to randomized trials was employed. Meta-analytical procedures were conducted using a fixed random-effects model, allowing for the synthesis of evidence across studies with the calculation of odds ratios to quantify treatment effects.</p><p><strong>Results: </strong>The meta-analysis incorporated seven studies assessing the efficacy of propolis in the treatment of oral mucositis among patients undergoing chemotherapy. The results demonstrated a marked improvement in the condition of patients receiving propolis, with a statistically significant odd ratio (OR) of 0.35 (95% confidence interval [CI]: 0.18-0.70; P = 0.003). However, the analysis did present some asymmetry (z = -1.5970, P = 0.1103) with a limit estimation of b = 0.3653 [CI: -0.7395, 1.4702], indicating a potential trend towards the effectiveness of propolis, though these results did not achieve statistical significance.</p><p><strong>Conclusion: </strong>The present findings suggest a promising but not yet definitively proven benefit of propolis in managing oral mucositis.</p>","PeriodicalId":94316,"journal":{"name":"Endocrine, metabolic & immune disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143805228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Scientific Trends in the Use Of Mesenchymal Stem Cells for the Treatment of Diabetes Mellitus from 2000 to 2023: A Bibliometric Study.","authors":"Zhenquan Sun, Yinghao Wang, Kexin Chen, Wen Zheng, Yang Wang, Mengxue Zhu, Min Yang, Xueyan Zhou","doi":"10.2174/0118715303348724250310082224","DOIUrl":"https://doi.org/10.2174/0118715303348724250310082224","url":null,"abstract":"<p><strong>Background: </strong>Diabetes mellitus is a chronic disease that seriously endangers human health, and mesenchymal stem cell [MSC] therapy is an emerging medical approach. Therefore, analyzing the effectiveness of MSCs in the literature is highly important for building relevant knowledge networks and promoting development in this field.</p><p><strong>Methods: </strong>The Web of Science database was selected as the source of literature, and all the literature on MSCs in diabetes from January 1, 2000, to October 18, 2023, was selected. After screening, CiteSpace and VOSviewer were imported into bibliometric software to construct the knowledge visualization map. Journal analysis, author analysis, country/region analysis, reference analysis, and keyword analysis were performed.</p><p><strong>Results: </strong>A total of 2912 articles and reviews were included. The number of articles on the use of MSCs for the treatment of diabetes is increasing annually. These publications originate mainly from 90 countries and 278 institutions, of which China and the United States were the top producers. We identified 15384 authors, with Liu Jiejie having the largest number of articles and Shapiro Amj being the most frequently co-cited. Stem Cell Res Ther was the most studied journal, and Diabetes was the most frequently cited journal. After analysis, the most common keywords were MSCs, diabetes mellitus, expression, transplantation, and differentiation.</p><p><strong>Conclusions: </strong>Research into MSC-based interventions for diabetes is booming. In the future, cooperation and connections between various countries and institutions should be strengthened. MSCinduced differentiation into insulin-producing cells, MSCs homing in vivo, the therapeutic effect of MSCs on diabetic nephropathy, and the therapeutic effect of exosomes secreted by MSCs constitute the current research hotspots and development trends for future research.</p>","PeriodicalId":94316,"journal":{"name":"Endocrine, metabolic & immune disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143805240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Gut-Brain Axis: Exploring the Neurogastrointestinal Interactions and Therapeutic Potentials in Autism Spectrum Disorder.","authors":"Manjeet Kumar, Sidharth Mehan, Tarun Sharma, Aakash Kumar, Zuber Khan, Arun Kumar Sharma, Nitish Kumar, Ghanshyam Das Gupta","doi":"10.2174/0118715303369166250325110016","DOIUrl":"https://doi.org/10.2174/0118715303369166250325110016","url":null,"abstract":"<p><p>This comprehensive review critically examines the gut-brain axis (GBA) and its implications in autism spectrum disorder (ASD). The GBA is a complex, bidirectional communication network that integrates the gastrointestinal tract, the central nervous system, and the gut microbiota. This axis is mediated through various physiological pathways, including the enteric nervous system (ENS), the vagus nerve, immune responses, and metabolic activities of gut microorganisms. ASD, a developmental disorder marked by social impairments and repetitive behaviors, presents with notable neurological irregularities. The review highlights the increased prevalence of gastrointestinal (GI) disturbances in individuals with ASD, suggesting a potential link between GI symptoms and the severity of ASD-related behaviors. This correlation is supported by evidence of altered gut microbiota composition in ASD, indicating significant interactions between the gut environment and neurological health. Moreover, the pathophysiology of ASD is explored with an emphasis on genetic and environmental contributions to neurodevelopmental impairments. Key topics include synaptic dysfunction, the roles of neurotransmitters like GABA and serotonin, and the impact of gut-brain interactions on ASD progression. Specifically, this review addresses how gut microbiota may influence metabolic alterations, immune dysregulation, oxidative stress, mitochondrial function, and neurotransmitter production in ASD. Emerging research on microbiome-based therapies for ASD is discussed, focusing on the potential of probiotics, prebiotics, and faecal microbiota transplantation (FMT) as novel interventions. Ethical considerations in this burgeoning field are also considered, highlighting the necessity for rigorous scientific inquiry and ethical oversight. The review advocates for a multidisciplinary approach to understanding and addressing the complexities of ASD. By integrating insights from genetics, neuroscience, psychology, and gastroenterology, a more comprehensive understanding of the role of GBA in ASD can be achieved. This interdisciplinary perspective is crucial for developing effective, individualized treatments and improving the quality of life for individuals with ASD.</p>","PeriodicalId":94316,"journal":{"name":"Endocrine, metabolic & immune disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Ischial Tubercle Pressure Sore with Secondary Periperineal Necrotizing Fasciitis.","authors":"Peiqi Wang, Yiyang Liu, Junhua Wang, Qiaofeng Guo, Xiang Wang","doi":"10.2174/0118715303385272250320042418","DOIUrl":"https://doi.org/10.2174/0118715303385272250320042418","url":null,"abstract":"<p><strong>Background: </strong>Perineal necrotizing fasciitis, or Fournier's gangrene, is a rare but rapidly progressing condition characterized by fascial necrosis. It is a severe, potentially life-threatening infection requiring prompt diagnosis and standardized treatment to optimize patient outcomes.</p><p><strong>Case presentation: </strong>A 48-year-old woman with poorly controlled type 2 diabetes developed necrotizing fasciitis of the right perineum secondary to an ischial tuberosity pressure ulcer. She had a prior spinal cord injury resulting in sensory dysfunction in the lower limbs, which masked significant pain. Management included surgical debridement, open wound care, antimicrobial therapy, and a free skin graft for wound closure.</p><p><strong>Conclusion: </strong>Effective treatment of necrotizing fasciitis relies on aggressive debridement and appropriate antimicrobial therapy. This case highlights the importance of early recognition and intervention to improve clinical diagnostic and management strategies.</p>","PeriodicalId":94316,"journal":{"name":"Endocrine, metabolic & immune disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Trends in Research of Intestinal Cells and Type 2 Diabetes Mellitus: A Bibliometric and Visualized Analysis from 2004 to 2023.","authors":"Zhaoyang Li, Shuang Zhang, Rufan Cao, Bo Wu, Kangning Han, Wenhui Yang, Shiyao Chen, Xinyu Zhang, Xiaochun Han, Liangqing Guo","doi":"10.2174/0118715303353611250312043509","DOIUrl":"https://doi.org/10.2174/0118715303353611250312043509","url":null,"abstract":"<p><strong>Background: </strong>As a systemic metabolic disease, type 2 diabetes has gradually become a disease that seriously threatens human health and quality of life worldwide. Many studies have shown that its pathogenesis and treatment are closely related to intestinal cells. However, the research in this field lacks relevant bibliometric analysis. This study aims to review the knowledge structure and research hot spots on intestinal cells and type 2 diabetes and provide a new direction for its future research through bibliometric methods and visual knowledge maps.</p><p><strong>Methods: </strong>Using the Web of Science Core Collection (WoSCC) database, we searched the related literature on intestinal cells and type 2 diabetes from 2004 to 2023, and made bibliometric analysis through VOSviewer, CiteSpace, the \"Bibliometrix\" R package, and Scimago Graphica. Combined with Bradford's Law, Price's Law, Lotka's Law, and Zipf's law, bibliometrics analysis was conducted on publication time, author, country/region, keywords, journals, and references related to publications in this field.</p><p><strong>Results: </strong>A total of 394 articles were included from 51 countries, led by the United States and China. In the past 20 years, the publication of relevant literature has shown a steady growth trend. These articles are from 2486 authors. Among them, Ti-dong Shan and Tao Yu from China have published the most literature, the University of Toronto is the main research institution, the Journal of Biological Chemistry is the journal with the most common citations, and the most prominently cited article is Sugar absorption in the industry: the role of GLUT2.</p><p><strong>Conclusion: </strong>This study is the first bibliometric analysis that comprehensively summarizes the research trends and hot spots of intestinal cells and type 2 diabetes. This information determines the research hot spots and research frontiers in this field. The hot spots of research are \"intestinal epithelial cells\", \"GLP-1\", \"SGLT-1\", \"GLUT2\", and \"intestinal endocrine cell\", while \"intestinal epithelial stem cells\", \"short-chain fatty acid\", \"bile acid\" and \"bariatric surgery\" may be the focus of future research, which helps clinicians better understand the relationship between intestinal cells and type 2 diabetes, and provides a reference direction for future scholars in this field.</p>","PeriodicalId":94316,"journal":{"name":"Endocrine, metabolic & immune disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}