Global Trends in Research of Intestinal Cells and Type 2 Diabetes Mellitus: A Bibliometric and Visualized Analysis from 2004 to 2023.

Abstract

Background: As a systemic metabolic disease, type 2 diabetes has gradually become a disease that seriously threatens human health and quality of life worldwide. Many studies have shown that its pathogenesis and treatment are closely related to intestinal cells. However, the research in this field lacks relevant bibliometric analysis. This study aims to review the knowledge structure and research hot spots on intestinal cells and type 2 diabetes and provide a new direction for its future research through bibliometric methods and visual knowledge maps.

Methods: Using the Web of Science Core Collection (WoSCC) database, we searched the related literature on intestinal cells and type 2 diabetes from 2004 to 2023, and made bibliometric analysis through VOSviewer, CiteSpace, the "Bibliometrix" R package, and Scimago Graphica. Combined with Bradford's Law, Price's Law, Lotka's Law, and Zipf's law, bibliometrics analysis was conducted on publication time, author, country/region, keywords, journals, and references related to publications in this field.

Results: A total of 394 articles were included from 51 countries, led by the United States and China. In the past 20 years, the publication of relevant literature has shown a steady growth trend. These articles are from 2486 authors. Among them, Ti-dong Shan and Tao Yu from China have published the most literature, the University of Toronto is the main research institution, the Journal of Biological Chemistry is the journal with the most common citations, and the most prominently cited article is Sugar absorption in the industry: the role of GLUT2.

Conclusion: This study is the first bibliometric analysis that comprehensively summarizes the research trends and hot spots of intestinal cells and type 2 diabetes. This information determines the research hot spots and research frontiers in this field. The hot spots of research are "intestinal epithelial cells", "GLP-1", "SGLT-1", "GLUT2", and "intestinal endocrine cell", while "intestinal epithelial stem cells", "short-chain fatty acid", "bile acid" and "bariatric surgery" may be the focus of future research, which helps clinicians better understand the relationship between intestinal cells and type 2 diabetes, and provides a reference direction for future scholars in this field.