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Tracking the Dormant Cancer Boneprint 追踪潜伏的癌症骨印
IF 28.2 1区 医学
Cancer discovery Pub Date : 2026-04-01 DOI: 10.1158/2159-8290.cd-26-0163
Andreia M. Gonçalves, Ana Luísa Correia
{"title":"Tracking the Dormant Cancer Boneprint","authors":"Andreia M. Gonçalves, Ana Luísa Correia","doi":"10.1158/2159-8290.cd-26-0163","DOIUrl":"https://doi.org/10.1158/2159-8290.cd-26-0163","url":null,"abstract":"Summary: Cancer cells can repurpose a fundamental bone development program to escape therapy in a dormant state. This finding offers a way to detect cancer dormancy and assess recurrence risk using routine bone scans. See related article by Sreekumar et al., p. 781","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":"54 1","pages":""},"PeriodicalIF":28.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147586626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Occupation May Influence Risk of Cancer Mortality. 职业可能影响癌症死亡风险
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-04-01 DOI: 10.1158/2159-8290.CD-NW2026-0017
{"title":"Occupation May Influence Risk of Cancer Mortality.","authors":"","doi":"10.1158/2159-8290.CD-NW2026-0017","DOIUrl":"10.1158/2159-8290.CD-NW2026-0017","url":null,"abstract":"<p><p>Based on data from the U.S. National Center for Health Statistics, researchers have found that occupation may influence the risk of cancer mortality among working adults, ages 20 to 64. Broadly speaking, men working in construction and extraction-for instance, roofers and mining machine operators-and women working in transportation had the highest mortality rates. Numerous factors beyond carcinogen exposure, such as job stressors leading to tobacco and alcohol use, inconsistent income, and limited health-care access could explain why.</p>","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147289313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intra- Versus Extracellular Bacteria Dictate Tumor Immunity and Metastatic Recurrence. 细胞内与细胞外细菌决定肿瘤免疫和转移复发。
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-04-01 DOI: 10.1158/2159-8290.CD-RW2026-027
{"title":"Intra- Versus Extracellular Bacteria Dictate Tumor Immunity and Metastatic Recurrence.","authors":"","doi":"10.1158/2159-8290.CD-RW2026-027","DOIUrl":"10.1158/2159-8290.CD-RW2026-027","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Pan-Cancer Comparative and Integrative Analyses of Driver Alterations Using Japanese and International Genomic Databases. 更正：使用日本和国际基因组数据库对驱动改变的泛癌症比较和综合分析。
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-04-01 DOI: 10.1158/2159-8290.CD-26-0316
Sara Horie, Yuki Saito, Yasunori Kogure, Kota Mizuno, Yuta Ito, Mariko Tabata, Takanori Kanai, Koichi Murakami, Junji Koya, Keisuke Kataoka
{"title":"Correction: Pan-Cancer Comparative and Integrative Analyses of Driver Alterations Using Japanese and International Genomic Databases.","authors":"Sara Horie, Yuki Saito, Yasunori Kogure, Kota Mizuno, Yuta Ito, Mariko Tabata, Takanori Kanai, Koichi Murakami, Junji Koya, Keisuke Kataoka","doi":"10.1158/2159-8290.CD-26-0316","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-26-0316","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":"16 4","pages":"822"},"PeriodicalIF":33.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early-Life Mutagenesis and the Rise of Early-Onset Colorectal Cancer. 生命早期突变与早发性结直肠癌的增加。
IF 28.2 1区 医学
Cancer discovery Pub Date : 2026-04-01 DOI: 10.1158/2159-8290.cd-26-0166
Ludmil B Alexandrov,Paul Brennan,Michael R Stratton
{"title":"Early-Life Mutagenesis and the Rise of Early-Onset Colorectal Cancer.","authors":"Ludmil B Alexandrov,Paul Brennan,Michael R Stratton","doi":"10.1158/2159-8290.cd-26-0166","DOIUrl":"https://doi.org/10.1158/2159-8290.cd-26-0166","url":null,"abstract":"Colorectal cancer incidence is rising globally among individuals younger than 50 years and remains poorly explained by established risk factors. In this study, we advance the hypothesis that early-childhood exposure to mutagen-producing bacteria contributes to lifetime colorectal cancer risk by imprinting oncogenic mutations in the developing colorectal epithelium, thereby initiating tumorigenesis decades before clinical diagnosis and redefining early-onset colorectal cancer as a disease rooted in early-life mutagenic exposure.","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":"105 1","pages":"644-646"},"PeriodicalIF":28.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147583935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Seven Ps of Cancer Interception. 癌症拦截的七个p。
IF 28.2 1区 医学
Cancer discovery Pub Date : 2026-04-01 DOI: 10.1158/2159-8290.cd-25-2061
Dimitrios N Sidiropoulos,Neeha Zaidi,Mark Yarchoan,Elizabeth M Jaffee
{"title":"The Seven Ps of Cancer Interception.","authors":"Dimitrios N Sidiropoulos,Neeha Zaidi,Mark Yarchoan,Elizabeth M Jaffee","doi":"10.1158/2159-8290.cd-25-2061","DOIUrl":"https://doi.org/10.1158/2159-8290.cd-25-2061","url":null,"abstract":"Advances in technology, clinical innovation, cross-sector collaboration, and active societal engagement are converging to shift cancer from an unexpected and lethal disease to a condition that can be detected early, intercepted effectively, and ultimately prevented. Framed around seven core principles: purpose, prevalence, potential, precision, practicality, partnership, and persistence, this commentary highlights how strategic alignment across these dimensions can catalyze progress toward global cancer interception.","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":"7 1","pages":"651-655"},"PeriodicalIF":28.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147583937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IFNγ Prevents Outgrowth of Metastasis-Promoting Lymphatic Vessels. IFNγ阻止促进转移的淋巴管的生长。
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-04-01 DOI: 10.1158/2159-8290.CD-RW2026-022
{"title":"IFNγ Prevents Outgrowth of Metastasis-Promoting Lymphatic Vessels.","authors":"","doi":"10.1158/2159-8290.CD-RW2026-022","DOIUrl":"10.1158/2159-8290.CD-RW2026-022","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147289329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights on Future Directions in Cancer Research from the 2026 AACR NextGen Stars. 2026年AACR下一代明星对未来癌症研究方向的见解。
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-04-01 DOI: 10.1158/2159-8290.CD-26-0284
CheukMan Cherie Au, Daniel D Azorín, Jian Carrot-Zhang, Steven M Corsello, Alvaro Curiel-Garcia, William Freed-Pastor, Adam J Grippin, Long Chi Nguyen, Ray Pillai, Amulya Sreekumar, Daniel J Zabransky
{"title":"Insights on Future Directions in Cancer Research from the 2026 AACR NextGen Stars.","authors":"CheukMan Cherie Au, Daniel D Azorín, Jian Carrot-Zhang, Steven M Corsello, Alvaro Curiel-Garcia, William Freed-Pastor, Adam J Grippin, Long Chi Nguyen, Ray Pillai, Amulya Sreekumar, Daniel J Zabransky","doi":"10.1158/2159-8290.CD-26-0284","DOIUrl":"10.1158/2159-8290.CD-26-0284","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":"16 4","pages":"670-676"},"PeriodicalIF":33.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensory Neurons Drive a Fibrotic Immune Microenvironment in Breast Cancer. 感觉神经元驱动乳腺癌纤维化免疫微环境。
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-04-01 DOI: 10.1158/2159-8290.CD-RW2026-020
{"title":"Sensory Neurons Drive a Fibrotic Immune Microenvironment in Breast Cancer.","authors":"","doi":"10.1158/2159-8290.CD-RW2026-020","DOIUrl":"10.1158/2159-8290.CD-RW2026-020","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modest Funding Increases "a Step in the Right Direction" for NIH, NCI. 适度的资助增加了NIH、NCI“正确方向上的一步”。
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-04-01 DOI: 10.1158/2159-8290.CD-NW2026-0021
{"title":"Modest Funding Increases \"a Step in the Right Direction\" for NIH, NCI.","authors":"","doi":"10.1158/2159-8290.CD-NW2026-0021","DOIUrl":"10.1158/2159-8290.CD-NW2026-0021","url":null,"abstract":"<p><p>The FY2026 appropriations bill signed into law includes $47.22 billion for the NIH, a $216 million increase over FY2025, and $7.4 billion for the NCI, a $128 million boost. This is a reverse from the steep cuts that were proposed by the White House, but the modest increases do not keep pace with biomedical inflation. In addition, the proposed 15% on indirect costs was blocked, while forward funding provisions that pay a multiyear grant all at once are included.</p>","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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