Cancer discovery最新文献

{"title":"Transmissible Cancer Discovered in Catfish","authors":"","doi":"10.1158/2159-8290.cd-nw2026-0082","DOIUrl":"https://doi.org/10.1158/2159-8290.cd-nw2026-0082","url":null,"abstract":": Researchers have discovered that black splotches on brown bullhead catfish in lakes in New England and Canada are likely caused by a transmissible cancer, the first one found in fish. The discovery raises questions about the cancer’s origin, how it might spread, and how widespread the phenomenon might be—and could offer insights into cancer biology more broadly.","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":"54 1","pages":""},"PeriodicalIF":28.2,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148675309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Follicular Lymphoma Transformation is Characterized by Cytokine-associated Remodeling of Stromal and Macrophage Compartments","authors":"Nicholas J. Haradhvala, Stephanie Pei Tung Yiu, Laura Beckmann, Sam Sadigh, Zachary Leibowitz, Erik Landolsi, Santiago Rivero, Stephanie L. Deng, Sabrina Hu, Mingzeng Zhang, Daniel Filip, Amber Pospistle, Yao Yu Yeo, Katie Maurer, Johan Gustafsson, Kai Stewart, Vignesh Shanmugam, McKayla Van Orden, Wesley S. Lu, Shuqiang Li, Kenneth J. Livak, Huaying Qiu, Ankit Basak, Alex K. Shalek, Brian P. Danysh, Mikaela McDonough, Satyen H. Gohil, Yue Ren, Yinglu Zhou, Donna S. Neuberg, Svitlana Tyekucheva, Scott J. Rodig, Eric D. Jacobsen, Marek Mraz, Mark A. Murakami, Habibe Kurt, Catherine J. Wu, Gad Getz, Sizun Jiang, Erin M. Parry","doi":"10.1158/2159-8290.cd-25-1104","DOIUrl":"https://doi.org/10.1158/2159-8290.cd-25-1104","url":null,"abstract":"Across cancer, one of the most frequent examples of histologic transformation is the evolution of follicular lymphoma (FL) to an aggressive large cell lymphoma. Despite recent progress, understanding of the molecular and cellular underpinnings of transformation remains incomplete. Here, we dissect the interplay of tumor and microenvironment cell populations across transformation through a multimodal investigation of 95 FL and transformed FL (tFL) samples, including single-cell and bulk RNA-sequencing alongside spatial transcriptomics and proteomics, and validate findings across independent FL-tFL pairs. Upon transformation, fibroblasts and GPNMB+ macrophages increase while lymph-node organizing follicular dendritic and CCL21+ fibroblastic reticular cells were lost, resulting in an altered spatial distribution of cytokines that impacts T cell infiltration and macrophage differentiation and function. Secreted stromal and macrophage signals were further evident by non-invasive plasma proteomics. Taken together, our data reveal expansion of macrophages and fibroblasts as key features of transformation with potential diagnostic and therapeutic implications.","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":"35 1","pages":""},"PeriodicalIF":28.2,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148675315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomics of Subsequent Neoplasms in Childhood Cancer Survivors.","authors":"Eline J M Bertrums, Ruben van Boxtel","doi":"10.1158/2159-8290.CD-26-1036","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-26-1036","url":null,"abstract":"<p><p>Brady and colleagues investigated the mutational consequences of cancer treatment on the genomes of 160 childhood cancer survivors who developed a subsequent neoplasm (SN). Their research aids in directing the next steps toward the prevention of SNs. See related article by Brady et al., p. 1590.</p>","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":"16 8","pages":"1483-1485"},"PeriodicalIF":29.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The KRASG12D Inhibitor Pipeline Grows.","authors":"","doi":"10.1158/2159-8290.CD-NW2026-0069","DOIUrl":"10.1158/2159-8290.CD-NW2026-0069","url":null,"abstract":"<p><p>At this year's ASCO Annual Meeting, investigators also presented encouraging early clinical data for several KRASG12D-selective inhibitors, including RNK08594, GFH375, and DN022150, suggesting that this type of drug could play a role in the treatment of several solid tumors, such as pancreatic ductal adenocarcinoma and non-small cell lung cancer.</p>","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":29.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type II JAK2 Inhibitor Gets Off to a Strong Start.","authors":"","doi":"10.1158/2159-8290.CD-NW2026-0074","DOIUrl":"10.1158/2159-8290.CD-NW2026-0074","url":null,"abstract":"<p><p>AJ1-11095, a type II JAK2 inhibitor being developed for myelofibrosis, led to impressive clinical responses in a recent phase I study, suggesting that the drug, and perhaps the rest of its still-investigational class, could prove better than currently approved type I JAK2 inhibitors.</p>","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":29.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Outstanding\" ADC Candidates Emerge for SCLC, Other Cancers.","authors":"","doi":"10.1158/2159-8290.CD-NW2026-0066","DOIUrl":"10.1158/2159-8290.CD-NW2026-0066","url":null,"abstract":"<p><p>The treatment arsenal for small cell lung cancer could soon include antibody-drug conjugates, with early data from three phase I studies indicating robust response rates to CD56-targeting DXC006, DLL-3-targeting BL-M14D1, and B7-H3-targeting SYS6043. The latter also appears active in other tumor types, including ovarian and breast cancers. As well, phase II findings on a fourth ADC candidate, HER2-targeting trastuzumab brengitecan, suggest its strong efficacy in platinum-resistant ovarian cancer.</p>","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":29.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148175486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Counterintuitive Approach to Cancer Therapy.","authors":"René Bernards","doi":"10.1158/2159-8290.CD-26-1039","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-26-1039","url":null,"abstract":"<p><p>Ever since immune checkpoint blockade showed activity in the treatment of cancer, the search has been on for combination regimens that make this therapy more effective. In this issue, Blagg and colleagues describe an unorthodox approach to increasing the effectiveness of cancer immunotherapy. See related article by Blagg et al., p. 1649.</p>","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":"16 8","pages":"1486-1488"},"PeriodicalIF":29.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modular Platform Curbs CAR T-Cell Exhaustion by Tuning Receptor Shedding.","authors":"","doi":"10.1158/2159-8290.CD-RW2026-059","DOIUrl":"10.1158/2159-8290.CD-RW2026-059","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":29.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148223273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Same-Slide Spatial Multiomics Integration with IN-DEPTH Reveals Tumor Virus-Linked Spatial Reorganization of the Tumor Microenvironment.","authors":"Stephanie Pei Tung Yiu, Yuzhou Chang, Yao Yu Yeo, Huaying Qiu, Wenrui Wu, Hendrik A Michel, Xiaojie Jin, Rongting Huang, Shoko Kure, Lindsay Parmelee, Shuli Luo, Precious Cramer, Jia Le Lee, Yang Wang, Zhangxin Zhao, Jason Yeung, Nourhan El Ahmar, Berkay Simsek, Razan Mohanna, McKayla Van Orden, Wesley S Lu, Kenneth J Livak, Shuqiang Li, Ce Gao, Melinda Burgess, Colm Keane, Jahanbanoo Shahryari, Leandra G Kingsley, Reem N Al-Humadi, Sahar Nasr, Dingani Nkosi, Sam Sadigh, Philip Rock, Leonie Frauenfeld, Louisa Kaufmann, Bokai Zhu, Ankit Basak, Nagendra Dhanikonda, Chi Ngai Chan, Jordan Krull, Ye Won Cho, Chia-Yu Chen, Jonathan Brown, Hongbo Wang, Bo Zhao, Jia-Ying Joey Lee, Lit-Hsin Loo, David M Kim, Vassiliki A Boussiotis, Baochun Zhang, Kevin Wei, Alex K Shalek, Brooke E Howitt, Sabina Signoretti, Christian M Schürch, F Stephen Hodi, W Richard Burack, Scott J Rodig, Qin Ma, Sizun Jiang","doi":"10.1158/2159-8290.CD-25-0775","DOIUrl":"10.1158/2159-8290.CD-25-0775","url":null,"abstract":"<p><p>Spatial transcriptomics and proteomics have enabled profound insights into tissue organization, yet these technologies remain largely disparate, and emerging same-slide multiomics approaches are limited in plex, spatial resolution, signal retention, and integrative analytics. We introduce IN-situ DEtailed Phenotyping To High-resolution transcriptomics (IN-DEPTH), a streamlined, resource-efficient, commercially compatible workflow using single-cell spatial proteomics-derived imaging to guide transcriptomic capture on the same slide without RNA signal loss. To integrate modalities beyond niche-level mapping, we developed Spectral Graph Cross-Correlation (SGCC), a proteomic-transcriptomic framework resolving spatially coordinated functional state changes across interacting cell populations. Applied to diffuse large B-cell lymphoma (DLBCL), IN-DEPTH and SGCC enabled stepwise discovery from Epstein-Barr virus (EBV)-positive and EBV-negative tumor comparisons with single-cell resolution, revealing coordinated tumor-macrophage-CD4 T-cell remodeling, immunosuppressive C1Q macrophage enrichment, CD4 T-cell dysfunction, and a candidate IL27-STAT3 signaling axis. Collectively, IN-DEPTH enables scalable spatial multiomics to uncover clinically relevant microenvironmental mechanisms and toward robust spatial multimodal AI models.</p><p><strong>Significance: </strong>IN-DEPTH enables same-slide spatial multiomics across commercial platforms via a protein-first strategy preserving protein epitopes, RNA quality, and tissue integrity. Coupled with SGCC, it resolves coordinated spatial immune remodeling, revealing EBV/LMP1-driven C1Q macrophage polarization and CD4 T-cell dysfunction in DLBCL, with broad applicability to other diseases.</p>","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"1611-1648"},"PeriodicalIF":29.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13091187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare Fusions, Real Targets: Ultraprecision Oncology in Lung Cancer.","authors":"Xiuning Le, Jürgen Wolf","doi":"10.1158/2159-8290.CD-26-1062","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-26-1062","url":null,"abstract":"<p><p>Beyond established rare fusions, such as ALK and ROS1, emerging ultrarare fusions involving receptor tyrosine kinases or their ligands, including EGFR-SHC1, further guide us to uncover novel mechanisms of oncogenic activation and corresponding treatment strategies. Collectively, rare and ultrarare genomic events are driving precision oncology toward an increasingly individualized era of \"ultraprecision\" cancer therapy. See related article by Zheng et al., p. 1573.</p>","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":"16 8","pages":"1480-1482"},"PeriodicalIF":29.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}