发布求助
文献互助 智能选刊 最新文献

Cancer discovery最新文献

筛选
英文 中文
A Physical Framework to Control Cancer Cell Heterogeneity and Plasticity. 控制癌细胞异质性和可塑性的物理框架。
IF 28.2 1区 医学
Cancer discovery Pub Date : 2026-04-01 DOI: 10.1158/2159-8290.cd-26-0083
Hadrien De Blander,Jean-Christophe Marine
{"title":"A Physical Framework to Control Cancer Cell Heterogeneity and Plasticity.","authors":"Hadrien De Blander,Jean-Christophe Marine","doi":"10.1158/2159-8290.cd-26-0083","DOIUrl":"https://doi.org/10.1158/2159-8290.cd-26-0083","url":null,"abstract":"We propose a physics-based framework in which cancer cell state is defined by position and velocity in a continuous space of directly measurable physical variables-cell surface area (S) and volume (V)-and motion through S-V space as an interpretable proxy for plasticity. Therapy generates S-V vector fields that govern trajectories, enabling the design of drug combinations to steer heterogeneous cell populations toward nonviable states, offering a predictive and physically interpretable alternative to therapies directed against oncogenic mutations and/or predefined cell subpopulations.","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":"46 1","pages":"637-643"},"PeriodicalIF":28.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147583946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fiber: A New Myeloma Prevention Approach with Abundant Positive Effects. 纤维：一种新的预防骨髓瘤的方法，具有丰富的积极作用。
IF 28.2 1区 医学
Cancer discovery Pub Date : 2026-04-01 DOI: 10.1158/2159-8290.cd-26-0152
Heather Fairfield,Michaela R Reagan
{"title":"Fiber: A New Myeloma Prevention Approach with Abundant Positive Effects.","authors":"Heather Fairfield,Michaela R Reagan","doi":"10.1158/2159-8290.cd-26-0152","DOIUrl":"https://doi.org/10.1158/2159-8290.cd-26-0152","url":null,"abstract":"In a recent study by Shah, Cogrossi, and colleagues, patients with overweight/obesity and pre-myeloma diseases (monoclonal gammopathy of undetermined significance or smoldering myeloma) were mailed 12 weeks of high-fiber meals, provided with nutritional counseling, and required to track their food intake and weight. The intervention was well tolerated and improved quality of life, metabolic health, gut microbiome composition, and immune system function while supporting stable or improved multiple myeloma disease trajectories. See related article by Shah et al., p. 697.","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":"24 1","pages":"623-625"},"PeriodicalIF":28.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147583933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor-Brain Communication Mediates Immune Escape of Lung Cancer. 肿瘤-脑通讯介导肺癌的免疫逃逸
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-04-01 DOI: 10.1158/2159-8290.CD-RW2026-026
{"title":"Tumor-Brain Communication Mediates Immune Escape of Lung Cancer.","authors":"","doi":"10.1158/2159-8290.CD-RW2026-026","DOIUrl":"10.1158/2159-8290.CD-RW2026-026","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147289342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disrupting MYC RNA Interactions Promotes Tumor Regression. 破坏MYC RNA相互作用促进肿瘤消退。
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-04-01 DOI: 10.1158/2159-8290.CD-RW2026-019
{"title":"Disrupting MYC RNA Interactions Promotes Tumor Regression.","authors":"","doi":"10.1158/2159-8290.CD-RW2026-019","DOIUrl":"10.1158/2159-8290.CD-RW2026-019","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precision, Partnership, Purpose: Advancing Cancer Science to Save Lives Globally. 精准、合作、目标：推进癌症科学，拯救全球生命。
IF 28.2 1区 医学
Cancer discovery Pub Date : 2026-04-01 DOI: 10.1158/2159-8290.cd-26-0411
Lillian L Siu
{"title":"Precision, Partnership, Purpose: Advancing Cancer Science to Save Lives Globally.","authors":"Lillian L Siu","doi":"10.1158/2159-8290.cd-26-0411","DOIUrl":"https://doi.org/10.1158/2159-8290.cd-26-0411","url":null,"abstract":"Increasing knowledge in molecular biology, enabled by multiomic technologies, data science, and global collaboration, extends cancer research beyond advanced disease settings toward earlier detection, interception, and more effective therapies. Through partnership, workforce development, and a commitment to equity and trust in science, discovery can be catalyzed into meaningful patient impact.","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":"1 1","pages":"629-632"},"PeriodicalIF":28.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147583939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Restricting Itaconate Suppresses ZFTA-RELA Ependymoma Growth. 限制衣康酸抑制zfa - rela室管膜瘤生长。
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-04-01 DOI: 10.1158/2159-8290.CD-RW2026-025
{"title":"Restricting Itaconate Suppresses ZFTA-RELA Ependymoma Growth.","authors":"","doi":"10.1158/2159-8290.CD-RW2026-025","DOIUrl":"10.1158/2159-8290.CD-RW2026-025","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147289277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bringing AI to Cancer's Regulatory Genome. 将人工智能引入癌症调控基因组。
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-04-01 DOI: 10.1158/2159-8290.CD-NW2026-0011
{"title":"Bringing AI to Cancer's Regulatory Genome.","authors":"","doi":"10.1158/2159-8290.CD-NW2026-0011","DOIUrl":"10.1158/2159-8290.CD-NW2026-0011","url":null,"abstract":"<p><p>A new AI model that predicts how noncoding DNA mutations alter gene regulation is helping cancer researchers identify which genetic changes drive tumor initiation and progression. Early studies show how AlphaGenome can unify multiple layers of genomic regulation into a single framework, accelerating the discovery of cancer-relevant mutations that previously required years of experimental work to decipher.</p>","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neoantigen Vaccine Spurs Broad Immune Responses. 新抗原疫苗刺激广泛的免疫反应。
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-04-01 DOI: 10.1158/2159-8290.CD-NW2026-0012
{"title":"Neoantigen Vaccine Spurs Broad Immune Responses.","authors":"","doi":"10.1158/2159-8290.CD-NW2026-0012","DOIUrl":"10.1158/2159-8290.CD-NW2026-0012","url":null,"abstract":"<p><p>A neoantigen vaccine against 209 frameshift peptides elicited strong, broad, and long-lasting immunity in people with Lynch syndrome in a phase Ib/II study, offering a novel approach for preventing the range of cancers these individuals are at an elevated risk of developing.</p>","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genotype-to-Phenotype Mapping of Somatic Clonal Mosaicism via Single-Cell Co-Capture of DNA Mutations and mRNA Transcripts. 通过单细胞DNA突变和mRNA转录物的共同捕获体细胞克隆嵌合体的基因型-表型定位。
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-04-01 DOI: 10.1158/2159-8290.CD-24-0853
Dennis J Yuan, John Zinno, Theo Botella, Dalia Dhingra, Shu Wang, Allegra G Hawkins, Ariel Swett, Jesus Sotelo, Ramya Raviram, Clayton Hughes, Catherine Potenski, Katharine D Godfrey, Kara M Ainsworth, Shuzhen Xu, Jianwen Que, Julian A Abrams, Akira Yokoyama, Nobuyuki Kakiuchi, Seishi Ogawa, Dan A Landau
{"title":"Genotype-to-Phenotype Mapping of Somatic Clonal Mosaicism via Single-Cell Co-Capture of DNA Mutations and mRNA Transcripts.","authors":"Dennis J Yuan, John Zinno, Theo Botella, Dalia Dhingra, Shu Wang, Allegra G Hawkins, Ariel Swett, Jesus Sotelo, Ramya Raviram, Clayton Hughes, Catherine Potenski, Katharine D Godfrey, Kara M Ainsworth, Shuzhen Xu, Jianwen Que, Julian A Abrams, Akira Yokoyama, Nobuyuki Kakiuchi, Seishi Ogawa, Dan A Landau","doi":"10.1158/2159-8290.CD-24-0853","DOIUrl":"10.1158/2159-8290.CD-24-0853","url":null,"abstract":"<p><p>Somatic mosaicism is pervasively observed in human aging, with clonal expansions of cells harboring mutations in recurrently mutated driver genes. Bulk sequencing of tissues captures mutation frequencies but cannot reconstruct clonal architectures nor delineate how driver mutations affect cellular phenotypes. We developed single-cell genotype-to-phenotype sequencing (scG2P) for high-throughput, highly multiplexed, joint capture of genotyping of mutation hotspots and mRNA markers. We applied scG2P to aged esophagus samples from six individuals and observed large numbers of clones with a single driver event, accompanied by rare clones with two driver mutations. NOTCH1 mutants dominate the clonal landscape and are linked to stunted epithelial differentiation, whereas TP53 mutants promote clonal expansion through both differentiation biases and increased cell cycling. Thus, joint single-cell highly multiplexed capture of somatic mutations and mRNA transcripts enables high-resolution reconstruction of clonal architecture and associated phenotypes in solid tissue somatic mosaicism.</p><p><strong>Significance: </strong>Joint single-cell capture of somatic mutations and mRNA transcripts reconstructs clonal architecture and associated phenotypes of the phenotypically normal esophagus, providing the first single-cell genotype-phenotype map of this clonally mosaic tissue to accelerate our understanding of human somatic evolution in solid tissues and provide a window into early cancerous states.</p>","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"721-739"},"PeriodicalIF":33.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12874418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategy to Analyze Urine Tumor DNA Predicts Outcomes in Bladder Cancer. 分析尿液肿瘤DNA预测膀胱癌预后的策略。
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-04-01 DOI: 10.1158/2159-8290.CD-RW2026-021
{"title":"Strategy to Analyze Urine Tumor DNA Predicts Outcomes in Bladder Cancer.","authors":"","doi":"10.1158/2159-8290.CD-RW2026-021","DOIUrl":"10.1158/2159-8290.CD-RW2026-021","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书