FABP4-tastic胰腺星状细胞对KITL进行加热以维持固有的微环境肿瘤抑制。

IF 29.7 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2025-04-30 DOI:10.1158/2159-8290.cd-25-0212

Aleksandr Dolskii,Edna Cukierman

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引用次数: 0

摘要

Oñate和同事证明，KITL在胰腺星状细胞中的表达对于维持胰腺微环境固有的肿瘤抑制功能至关重要，其缺失会导致胰腺癌的发展。这一关键发现不仅加强了自然微环境肿瘤抑制的百年假设，而且强调了一个有希望的治疗途径，即恢复KITL表达可以重建胰腺驻留纤维母细胞的肿瘤抑制功能。参见Oñate等人的相关文章，第XX页。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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FABP4-tastic Pancreatic Stellate Cells Coddle KITL to Uphold Inherent Microenvironmental Tumor Suppression.

Oñate and colleagues demonstrate that KITL expression in pancreatic stellate cells is crucial for maintaining the inherent tumor-suppressive function of the pancreatic microenvironment, and its loss enables pancreatic cancer development. This pivotal discovery not only reinforces the century-old hypothesis of natural microenvironmental tumor suppression but also highlights a promising therapeutic avenue whereby restoring KITL expression could reestablish the tumor-suppressive functions of pancreas-resident fibroblastic cells. See related article by Oñate et al., p. XX.

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来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.