Current Alzheimer research最新文献_第8页

Antipsychotics in Alzheimer's Disease: Current Status and Therapeutic Alternatives. 阿尔茨海默病中的抗精神病药物：抗精神病药物在阿尔茨海默病中的应用：现状与治疗替代方案》（Current Status and Therapeutic Alternatives.

Current Alzheimer research Pub Date : 2023-01-01 DOI: 10.2174/0115672050287534240215052417

Maria Paula Maziero, Natalia P Rocha, Antonio L Teixeira

引用次数: 0

Accuracy of Telephone-Based Cognitive Screening Tests: Systematic Review and Meta-Analysis 基于电话的认知筛选测试的准确性：系统回顾与元分析

Current Alzheimer research Pub Date : 2020-04-01 DOI: 10.2174/15672050mta3qnjgj4

E. Elliott

引用次数: 6

Withdrawn: Biomarkers in Alzheimer's Disease-Recent Update. 撤回：阿尔茨海默病的生物标志物--近期更新。

Current Alzheimer research Pub Date : 2017-02-20

引用次数: 0

PERK-opathies: An Endoplasmic Reticulum Stress Mechanism Underlying Neurodegeneration. PERK病：神经变性的内质网应激机制。

Current Alzheimer research Pub Date : 2016-01-01 DOI: 10.2174/1567205013666151218145431

Michelle C Bell, Shelby E Meier, Alexandria L Ingram, Jose F Abisambra

{"title":"PERK-opathies: An Endoplasmic Reticulum Stress Mechanism Underlying Neurodegeneration.","authors":"Michelle C Bell, Shelby E Meier, Alexandria L Ingram, Jose F Abisambra","doi":"10.2174/1567205013666151218145431","DOIUrl":"https://doi.org/10.2174/1567205013666151218145431","url":null,"abstract":"<p><p>The unfolded protein response (UPR) plays a vital role in maintaining cell homeostasis as a consequence of endoplasmic reticulum (ER) stress. However, prolonged UPR activity leads to cell death. This time-dependent dual functionality of the UPR represents the adaptive and cytotoxic pathways that result from ER stress. Chronic UPR activation in systemic and neurodegenerative diseases has been identified as an early sign of cellular dyshomeostasis. The Protein Kinase R-like ER Kinase (PERK) pathway is one of three major branches in the UPR, and it is the only one to modulate protein synthesis as an adaptive response. The specific identification of prolonged PERK activity has been correlated with the progression of disorders such as diabetes, Alzheimer's disease, and cancer, suggesting that PERK plays a role in the pathology of these disorders. For the first time, the term \"PERK-opathies\" is used to group these diseases in which PERK mediates detriment to the cell culminating in chronic disorders. This article reviews the literature documenting links between systemic disorders with the UPR, but with a specific emphasis on the PERK pathway. Then, articles reporting links between the UPR, and more specifically PERK, and neurodegenerative disorders are presented. Finally, a therapeutic perspective is discussed, where PERK interventions could be potential remedies for cellular dysfunction in chronic neurodegenerative disorders. </p>","PeriodicalId":94309,"journal":{"name":"Current Alzheimer research","volume":"13 2","pages":"150-63"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542591/pdf/nihms-1025111.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 54