Canadian Veterinary Journal-revue Veterinaire Canadienne最新文献

{"title":"Dexmedetomidine constant-rate infusion with additional partial intravenous anesthesia for a dog undergoing partial pancreatectomy for an insulinoma.","authors":"Anna R P Henderson, Tainor Tisotti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Alpha-2 adrenergic agonist use in the anesthetic management of dogs undergoing partial pancreatectomy has been reported, but only as single-bolus administration of medetomidine in the premedication or low-dose constant-rate infusion (CRI) of dexmedetomidine, without other systemic analgesic drugs. A 10-year-old Boston terrier diagnosed with an insulinoma was presented to the Ontario Veterinary College Health Sciences Centre (Guelph, Ontario). The anesthetic management for partial pancreatectomy included a high-dose dexmedetomidine CRI (4 μg/kg per hour) as well as lidocaine and fentanyl CRIs for additional analgesia and minimum alveolar concentration reduction. A low-dose norepinephrine CRI was used to maintain blood pressure and improve cardiac output. Overall, blood glucose concentration was controlled, no adverse effects were detected, and the dog did not develop pancreatitis postoperatively. Anesthetic management with a high-dose dexmedetomidine CRI along with other systemic analgesia has apparently not been reported for dogs presented for partial pancreatectomy due to insulinoma. Key clinical message: A high-dose dexmedetomidine CRI along with other systemic analgesia was successfully used to manage a dog undergoing partial pancreatectomy for an insulinoma.</p>","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 7","pages":"728-733"},"PeriodicalIF":1.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Top 4 ways to trim expenses.","authors":"Darren Osborne, Amy Noonan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 7","pages":"814-817"},"PeriodicalIF":1.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term management of mandibular osteosarcoma in a dog using toceranib after hemimandibulectomy.","authors":"Hwi Park, Soo-Jin Yu, Ae-Lin Jeong, Hun-Young Yoon, Kieun Bae, Kyong-Ah Yoon, Jung-Hyun Kim","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 6-year-old castrated male golden retriever dog weighing 32.6 kg was presented for chemotherapy after hemimandibulectomy due to mandibular osteosarcoma. Considering the incomplete surgical excision and metastatic potential, adjuvant chemotherapy was considered. Oral toceranib (2.76 mg/kg, PO, q48h) was initiated after a nodule was palpated at the surgical site 4 wk following hemimandibulectomy. During treatment, the drug dose was decreased due to mildly increased creatinine levels. However, after 1 mo, the dose was increased because creatinine had decreased to previous values. The animal experienced vomiting and diarrhea 7 mo after toceranib initiation; therefore, the drug was stopped for 1 wk. After that point, except for mild neutropenia, no other clinicopathological abnormalities, clinical signs, recurrence, or metastasis occurred. The toceranib therapy provided a durable disease-free interval in this case. Therefore, oral toceranib therapy can be an option for adjuvant chemotherapy for canine mandibular osteosarcoma. Key clinical message: In this case, which was characterized by the overexpression of various receptor tyrosine kinase genes, oral toceranib administration provided a durable disease-free interval in a dog. Further studies are warranted to evaluate the general application of toceranib for the management of canine mandibular osteosarcoma.</p>","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 7","pages":"747-754"},"PeriodicalIF":1.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Informant discrepancy between caretakers in history reporting in veterinary dermatology.","authors":"Joseph Cordonier, Tyler Udenberg, Vincent Defalque, Jay Korbelik, Ljubomir Miljacic, Nayak Polissar","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Collection of medical history is essential for making informed clinical decisions in veterinary medicine. In veterinary dermatology, historical patterns may alter a clinician's diagnostic and therapeutic recommendations. Veterinary patient reporting has similarities to reporting in human pediatric medicine, in which clinician history is collected from caretakers instead of patients themselves. Informant discrepancy between medical histories taken from co-parents has been observed in human pediatric medicine but has not been assessed in veterinary medicine.</p><p><strong>Objective: </strong>The objective of this questionnaire-based, prospective, descriptive study was to investigate informant agreement among caretakers of veterinary dermatology patients.</p><p><strong>Participants and procedure: </strong>A caretaker history questionnaire was designed to assess the primary concern of the caretaker, seasonality and duration of clinical signs, pruritus score, areas of the body affected, dietary history, and medication history. At initial dermatology consultations, caretakers completed the questionnaire in separate rooms, as anonymized pairs. Agreement proportion was analyzed by calculating the proportion of pairs, among all pairs, in which both caretakers agreed.</p><p><strong>Results: </strong>Fifty-three paired responses (106 caretakers) volunteered for the study. Agreement was highest for histories of gastrointestinal signs (94.1%), skin disease exacerbation by diet (84.3%), and duration of disease (80.4%). Caretakers reported pruritus visual analogue scores within 2 score units of one another for 61.5% of patients. \"Individual affected body part\" agreement and \"individual protein consumed\" agreement proportions were 53.5 and 55.7%, respectively. The lowest agreement was seen for seasonality of disease (38.5%) and individual medication use (38.7%).</p><p><strong>Conclusion and clinical relevance: </strong>Our findings supported the concept that informant discrepancy exists between caretaker histories reported in veterinary dermatology, suggesting that all caretakers' histories should be taken into consideration.</p>","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 7","pages":"781-788"},"PeriodicalIF":1.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anencephaly and palatoschisis in 2 newborn puppies.","authors":"Marina V Estevam, Samara Beretta, Nathalia F Smargiassi, Daniela C J Armani, Marjury C Maronezi, Paulo E Martinelli, Rosemeri O Vasconcelos, Gilson H Toniollo, Maricy Apparício","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Anencephaly is a congenital condition characterized by incomplete brain development and malformations of cranial bones and cerebral hemispheres. Such defects arise from improper neural tube closure during embryogenesis. Although well documented in humans, they are infrequently reported in veterinary medicine. The etiology of anencephaly in dogs is not fully understood, but a strong genetic predisposition has been observed, particularly among brachycephalic breeds. In addition, studies in humans have implicated factors such as folic acid deficiency, hypervitaminosis A, and exposure to teratogens as potential contributors. Using diagnostic imaging techniques, including radiography and ultrasonography, it is possible to detect intrauterine modifications indicative of malformation. Unfortunately, there are no known corrections or treatments for anencephaly, and affected fetuses are typically stillborn or die within hours after birth. This case report presents observations of 2 neonatal puppies with anencephaly, acalvaria, exophthalmia, and palatoschisis, providing further insights into these puzzling brain malformations in canines. Key clinical message: The present report highlights the importance of prenatal monitoring for diagnosis of anencephaly in dogs. It describes radiographic and ultrasonographic findings and compares morphological changes in 2 affected puppies of different breeds and clinical histories.</p>","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 6","pages":"628-634"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To all the dogs I've loved before.","authors":"Fiona Emdin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 6","pages":"687-692"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two years of food animal matters.","authors":"Robert Tremblay","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 6","pages":"693-696"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel insights regarding field investigations of anthrax outbreaks.","authors":"Robert S Gainer, Martin E Hugh-Jones","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 6","pages":"682-684"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The most effective systemic treatment in cats with otodectic mange: A critically appraised topic.","authors":"Thibault Burnouf, Eric Guaguère","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Otodectic mange is one of the most common ectoparasitic diseases in cats and the most common cause of feline otitis externa. It is particularly prevalent in young cats between 3 and 6 mo of age and is a veterinary concern, especially in catteries, due to its highly contagious nature. Although there is a risk of overdiagnosis if based solely on cerumen, it is not difficult to identify <i>Otodectes cynotis</i> if there is a clinical suspicion in a young cat. Considering the variety of available acaricidal molecules, as well as the need to use the most effective treatment, the present article reviews evidence comparing various types of systemic treatment for otodectic mange in cats.</p><p><strong>Results: </strong>Isoxazolines (sarolaner, fluralaner, or esafoxolaner) or similar molecules such as tigolaner (a bispyrazole) and macrocyclic lactones (selamectin, eprinomectin, or moxidectin) can lead to parasitological cure and improvement of clinical signs associated with otodectic mange in cats, with rare, mainly cutaneous side effects with mild, autoresolving lesions.</p><p><strong>Conclusion: </strong>Similarities in the clinical and parasitological efficacy of these substances highlight the need for comparative studies that could allow identification of the most efficacious product.</p>","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 6","pages":"663-676"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative factors and outcomes associated with antimicrobial therapy duration in horses undergoing exploratory celiotomy.","authors":"Naomi E Crabtree, Ava M Capper, Laura H McKinnon, Kira L Epstein","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The objective was to compare perioperative factors that may influence clinician decisions regarding antimicrobial therapy duration and outcomes in horses undergoing exploratory celiotomy.</p><p><strong>Animals: </strong>Horses > 1 mo of age undergoing exploratory celiotomy for colic that survived without repeat celiotomy for ≥ 5 d.</p><p><strong>Procedure: </strong>Retrospective cohort study. Cases were grouped by duration of antimicrobial therapy: G1, ≤ 24 h; G2, 1 to 3 d; G3, > 3 d. Admission, surgical, and postoperative data from the medical records and long-term outcome assessed <i>via</i> telephone follow-up were compared among groups.</p><p><strong>Results: </strong>In total, 187 horses (67, 52, and 68 for G1, G2, and G3, respectively) were included. Differences in proportions of horses with strangulating lesions (29.9, 46.2, and 52.9%), undergoing enterotomy (23.9, 61.5, and 52.9%), and treated with resection/anastomosis (11.9, 28.9, and 39.7%) were identified (<i>P</i> = 0.02, <i>P</i> < 0.0001, and <i>P</i> = 0.001). Overall incisional infection rate in hospital was 12.8%, with no difference among groups (10.4, 13.5, and 14.7%; <i>P</i> = 0.80). Differences in proportions of horses with gastrointestinal (29.9, 42.3, and 55.9%; <i>P</i> = 0.009) and other inflammatory/infectious (13.4, 33.1, and 36.8%; <i>P</i> = 0.007) postoperative complications were identified. There was no difference among groups in survival to discharge (97.0, 96.2, and 89.7%; <i>P</i> = 0.20). Horses in G3 had increased duration of hospitalization [11 d (5 to 48 d)] <i>versus</i> G1 [8 d (5 to 63 d)] (<i>P</i> < 0.0001). Cost of hospitalization was higher for horses in G3 [$9410 ($3790 to $29 240)] than for those in G2 [$7340 ($1860 to $15 260)], which was higher than for those in G1 [$5330 ($3280 to $17 140)] (<i>P</i> < 0.0001).</p><p><strong>Conclusion: </strong>Antimicrobials were used for a longer duration in horses with more compromised bowel, after surgical procedures that entered intestine, and in cases with a variety of postoperative complications. Of note, incisional infection was a complication not associated with duration of therapy. Limited case numbers in some subgroups reduced statistical power, and findings should be interpreted accordingly.</p><p><strong>Clinical relevance: </strong>Operative and postoperative factors associated with longer duration of antimicrobial use in this study have been previously identified to influence clinical decision-making regarding the duration of antimicrobial therapy. However, the similar rate of incisional infection among groups suggests that this risk should minimally influence clinicians when deciding upon the duration of therapy. This study highlighted that further prospective, blinded studies are required to determine the risks and benefits of antimicrobial use in the postoperative period.</p>","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 6","pages":"653-662"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}