Marina V Estevam, Samara Beretta, Nathalia F Smargiassi, Daniela C J Armani, Marjury C Maronezi, Paulo E Martinelli, Rosemeri O Vasconcelos, Gilson H Toniollo, Maricy Apparício
{"title":"Anencephaly and palatoschisis in 2 newborn puppies.","authors":"Marina V Estevam, Samara Beretta, Nathalia F Smargiassi, Daniela C J Armani, Marjury C Maronezi, Paulo E Martinelli, Rosemeri O Vasconcelos, Gilson H Toniollo, Maricy Apparício","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Anencephaly is a congenital condition characterized by incomplete brain development and malformations of cranial bones and cerebral hemispheres. Such defects arise from improper neural tube closure during embryogenesis. Although well documented in humans, they are infrequently reported in veterinary medicine. The etiology of anencephaly in dogs is not fully understood, but a strong genetic predisposition has been observed, particularly among brachycephalic breeds. In addition, studies in humans have implicated factors such as folic acid deficiency, hypervitaminosis A, and exposure to teratogens as potential contributors. Using diagnostic imaging techniques, including radiography and ultrasonography, it is possible to detect intrauterine modifications indicative of malformation. Unfortunately, there are no known corrections or treatments for anencephaly, and affected fetuses are typically stillborn or die within hours after birth. This case report presents observations of 2 neonatal puppies with anencephaly, acalvaria, exophthalmia, and palatoschisis, providing further insights into these puzzling brain malformations in canines. Key clinical message: The present report highlights the importance of prenatal monitoring for diagnosis of anencephaly in dogs. It describes radiographic and ultrasonographic findings and compares morphological changes in 2 affected puppies of different breeds and clinical histories.</p>","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 6","pages":"628-634"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel insights regarding field investigations of anthrax outbreaks.","authors":"Robert S Gainer, Martin E Hugh-Jones","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 6","pages":"682-684"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The most effective systemic treatment in cats with otodectic mange: A critically appraised topic.","authors":"Thibault Burnouf, Eric Guaguère","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Otodectic mange is one of the most common ectoparasitic diseases in cats and the most common cause of feline otitis externa. It is particularly prevalent in young cats between 3 and 6 mo of age and is a veterinary concern, especially in catteries, due to its highly contagious nature. Although there is a risk of overdiagnosis if based solely on cerumen, it is not difficult to identify <i>Otodectes cynotis</i> if there is a clinical suspicion in a young cat. Considering the variety of available acaricidal molecules, as well as the need to use the most effective treatment, the present article reviews evidence comparing various types of systemic treatment for otodectic mange in cats.</p><p><strong>Results: </strong>Isoxazolines (sarolaner, fluralaner, or esafoxolaner) or similar molecules such as tigolaner (a bispyrazole) and macrocyclic lactones (selamectin, eprinomectin, or moxidectin) can lead to parasitological cure and improvement of clinical signs associated with otodectic mange in cats, with rare, mainly cutaneous side effects with mild, autoresolving lesions.</p><p><strong>Conclusion: </strong>Similarities in the clinical and parasitological efficacy of these substances highlight the need for comparative studies that could allow identification of the most efficacious product.</p>","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 6","pages":"663-676"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Naomi E Crabtree, Ava M Capper, Laura H McKinnon, Kira L Epstein
{"title":"Perioperative factors and outcomes associated with antimicrobial therapy duration in horses undergoing exploratory celiotomy.","authors":"Naomi E Crabtree, Ava M Capper, Laura H McKinnon, Kira L Epstein","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The objective was to compare perioperative factors that may influence clinician decisions regarding antimicrobial therapy duration and outcomes in horses undergoing exploratory celiotomy.</p><p><strong>Animals: </strong>Horses > 1 mo of age undergoing exploratory celiotomy for colic that survived without repeat celiotomy for ≥ 5 d.</p><p><strong>Procedure: </strong>Retrospective cohort study. Cases were grouped by duration of antimicrobial therapy: G1, ≤ 24 h; G2, 1 to 3 d; G3, > 3 d. Admission, surgical, and postoperative data from the medical records and long-term outcome assessed <i>via</i> telephone follow-up were compared among groups.</p><p><strong>Results: </strong>In total, 187 horses (67, 52, and 68 for G1, G2, and G3, respectively) were included. Differences in proportions of horses with strangulating lesions (29.9, 46.2, and 52.9%), undergoing enterotomy (23.9, 61.5, and 52.9%), and treated with resection/anastomosis (11.9, 28.9, and 39.7%) were identified (<i>P</i> = 0.02, <i>P</i> < 0.0001, and <i>P</i> = 0.001). Overall incisional infection rate in hospital was 12.8%, with no difference among groups (10.4, 13.5, and 14.7%; <i>P</i> = 0.80). Differences in proportions of horses with gastrointestinal (29.9, 42.3, and 55.9%; <i>P</i> = 0.009) and other inflammatory/infectious (13.4, 33.1, and 36.8%; <i>P</i> = 0.007) postoperative complications were identified. There was no difference among groups in survival to discharge (97.0, 96.2, and 89.7%; <i>P</i> = 0.20). Horses in G3 had increased duration of hospitalization [11 d (5 to 48 d)] <i>versus</i> G1 [8 d (5 to 63 d)] (<i>P</i> < 0.0001). Cost of hospitalization was higher for horses in G3 [$9410 ($3790 to $29 240)] than for those in G2 [$7340 ($1860 to $15 260)], which was higher than for those in G1 [$5330 ($3280 to $17 140)] (<i>P</i> < 0.0001).</p><p><strong>Conclusion: </strong>Antimicrobials were used for a longer duration in horses with more compromised bowel, after surgical procedures that entered intestine, and in cases with a variety of postoperative complications. Of note, incisional infection was a complication not associated with duration of therapy. Limited case numbers in some subgroups reduced statistical power, and findings should be interpreted accordingly.</p><p><strong>Clinical relevance: </strong>Operative and postoperative factors associated with longer duration of antimicrobial use in this study have been previously identified to influence clinical decision-making regarding the duration of antimicrobial therapy. However, the similar rate of incisional infection among groups suggests that this risk should minimally influence clinicians when deciding upon the duration of therapy. This study highlighted that further prospective, blinded studies are required to determine the risks and benefits of antimicrobial use in the postoperative period.</p>","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 6","pages":"653-662"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tracheal squamous cell carcinoma treated with tracheal resection and anastomosis in a dog.","authors":"Wayne Tsang, Kevin Choy, Kent Vince","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 9-year-old spayed female Labrador retriever was presented with intermittent expiratory cough and dyspnea unresponsive to prednisone and amoxicillin/clavulanic acid. Radiographic and computed tomographic examinations identified a localized dorsal intraluminal tracheal wall mass without detectable locoregional metastasis, leading to surgical resection and anastomosis of the affected tracheal segment. Histopathological analysis confirmed the mass as squamous cell carcinoma (SCC) with clear lateral and deep skeletal muscle margins. Monitoring after surgery, rather than adjuvant therapy, was elected by the dog's owner. The dog recovered with no complications noted and was in a state of clinical remission at the final in-hospital evaluation (3 mo after surgery). This case represents the second documented instance of canine tracheal SCC treated successfully with surgery. It underscores the potential for surgical intervention as a viable treatment option, potentially improving prognosis and survival outcomes in dogs affected by tracheal SCC. Regular evaluations and serial imaging examinations are recommended to monitor for recurrence and ensure long-term clinical remission. Key clinical message: This case marks the first documented tracheal resection and anastomosis as treatment for canine tracheal SCC and only the second reported tracheal SCC in a dog. Despite the typical negative outcomes associated with this SCC, the dog in this report achieved clinical remission without the need for chemotherapy or radiation therapy. Surgical intervention may be a viable treatment option for tracheal SCC, potentially improving prognosis and survival outcomes in affected dogs.</p>","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 6","pages":"622-627"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An update on <i>The Canadian Veterinary Journal (The CVJ)</i>.","authors":"John Kastelic, Tim Ogilvie, Kelly Gray-Sabourin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 6","pages":"589-591"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Suspected clinical methemoglobinemia associated with administration of hydrogen peroxide 3% in a dog treated for acute ibuprofen ingestion.","authors":"Dominique Dominguez, Rebecca Walton","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An 8-month-old intact male golden retriever dog was presented to the emergency department of a large private-practice specialty hospital. The dog had become cyanotic and collapsed following administration (orogastric tube) of 1.4 mL/kg of hydrogen peroxide 3% to induce emesis for ibuprofen ingestion. The dog had severe methemoglobinemia (33%; reference range: 0.3 to 1.5%) and developed anemia. The methemoglobinemia resolved after 24 h of hospitalization with supportive care. Results from assessment with high-performance liquid chromatography/tandem mass spectrometry were consistent with ibuprofen ingestion, with no acetaminophen detected. Key clinical message: This case demonstrated methemoglobinemia in a dog following both ibuprofen ingestion and hydrogen peroxide 3% administration.</p>","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 6","pages":"617-621"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}