{"title":"Enrofloxacin-associated ocular disease in cats: A scoping review.","authors":"J Scott Weese, Heather E Weese","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Ocular effects, most notably retinal degeneration, have been linked to enrofloxacin use in cats. However, data have been limited and there is a need for formal evidence synthesis to better understand and characterize these potentially life-altering adverse events.</p><p><strong>Objective: </strong>The objective was to describe data regarding ocular adverse events associated with enrofloxacin administration in cats and to identify information gaps.</p><p><strong>Procedure: </strong>A scoping review was conducted, searching the MEDLINE (<i>via</i> the Ovid platform), Web of Science, and CAB Abstracts bibliographic databases.</p><p><strong>Results: </strong>Six references passed title and abstract screening, then full text screening: 1 case series (<i>n</i> = 17 cases), 3 single case reports, 1 conference research abstract (<i>n</i> = 2 cases), and 1 pharmacovigilance summary publication. There were reports of enrofloxacin-associated adverse ocular events in 163 cats. Loss of vision, mydriasis, and altered pupillary light responses were most commonly reported. Increased tapetal reflectivity, retinal vessel attenuation, and retinal degeneration were the most common abnormalities on ophthalmological examination. Most cats had permanent blindness or altered vision. Most cats had received doses well in excess of the current label recommendation, but 15/103 (14%) cats for which dosing data were available were reported to have received ≤ 5 mg/kg per day.</p><p><strong>Conclusion and clinical relevance: </strong>Suspected enrofloxacin-associated ocular disease in cats typically resulted in long-term blindness or visual deficits, but full recovery occurred in a subset. Inadequate data were available to assess potential risk factors (<i>e.g.</i>, age, dose). Although a dose of ≤ 5 mg/kg per day will likely reduce the likelihood of adverse events, these data indicated that ocular disease was still possible at that dosage.</p>","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 12","pages":"1326-1333"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Let's celebrate the good and positive things about veterinary medicine and veterinarians!","authors":"John Kastelic, Tim Ogilvie","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 12","pages":"1257-1258"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146045860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Case of primary digital embryonal rhabdomyosarcoma in a cat.","authors":"Seongwon Heo, Chaewon Shin, Hayoung Ryu, Seulgi Hwang, Il-Hwa Hong, Dong-In Jung, DoHyeon Yu, Hyeona Bae","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An 11-year-old Turkish angora cat was presented with a mass in the right forelimb phalangeal region. Two years earlier, the cat had undergone surgical resection of a dorsal interscapular mass. Before initiating anticancer therapy, surgical incisional biopsy of a phalangeal region mass was done, followed by histopathologic and immunohistochemical analyses. The tumor cells demonstrated positive immunohistochemical labelling for desmin, vimentin, and myoblast determination protein 1, supporting a diagnosis of rhabdomyosarcoma (RMS). Histologic features were consistent with an embryonal subtype of RMS. Accordingly, a right forelimb amputation was completed. To our knowledge, this is the first reported case of a digital RMS in a cat. Because RMS is a rare tumor in cats, it is essential to study the clinical presentation, hematologic and serologic changes, treatment responses, and prognosis. Suitably, this case report provides valuable insight into the management of similar cases in cats. Key clinical message: This first reported case of digital RMS in a cat highlights the importance of studying the clinical presentation and treatment of RMS in feline patients.</p>","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 12","pages":"1286-1291"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Volunteering for One Health - How Veterinarians Without Borders leverages volunteer-sending programs to strengthen systems globally.","authors":"Megan Sylka","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 12","pages":"1346-1349"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case of feline gastrointestinal eosinophilic sclerosing fibroplasia extending to the liver and jejunal lymph nodes.","authors":"Margherita Orlandi, Francesca Parisi, Francesca Abramo, Caterina Puccinelli, Verena Habermaaß, Giulia Mennuni, Veronica Marchetti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An 8-year-old neutered male domestic shorthair cat with a history of persistent diarrhea and a previous diagnosis of feline gastrointestinal eosinophilic sclerosing fibroplasia in the jejunum was presented to our hospital. Abdominal ultrasound examination revealed a hepatic lesion with a diffuse altered echostructure. Histopathologic analysis confirmed the diagnosis of hepatic feline eosinophilic sclerosing fibroplasia (FESF), marked by multinodular lesions with abundant inflammatory cell infiltrates. Despite treatment with corticosteroids and supportive care, the cat was euthanized 15 d after diagnosis due to the deterioration of its health status. This report aims to highlight the necessity to include FESF within differential diagnoses when diagnosing liver masses in cats, particularly those with previous gastrointestinal involvement. It emphasizes the need for histopathologic confirmation and highlights the challenges in diagnosing this condition, especially regarding its multifocal nature and potential misdiagnosis as tumors. With only 2 documented cases of liver involvement available, the prognosis for hepatic FESF remains unclear, warranting further investigation to establish definitive therapeutic guidelines. Key clinical message: Feline eosinophilic sclerosing fibroplasia should be considered as a differential diagnosis for cats presented with liver masses. The diagnosis relies on careful history-taking and clinical examination, mainly in the presence of a previous gastrointestinal mass. Histopathologic evidence is essential for a definitive diagnosis.</p>","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 12","pages":"1297-1302"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146045809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Use of a Fogarty balloon catheter for management of distal nasolacrimal duct atresia in a standing sedated horse.","authors":"Simon Bourassi, Heather Jack, Agnieszka Florczyk","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 4-year-old Arabian cross paint mare was referred for evaluation of chronic mucopurulent discharge and epiphora of the left eye. Ophthalmic and radiographic evaluations confirmed distal nasolacrimal duct atresia with absence of the nasolacrimal orifice. Initial minimally invasive treatments, including guidewire-assisted catheterization and diode laser photoablation, were unsuccessful. Definitive treatment was achieved using a Fogarty arterial embolectomy catheter under standing sedation. Controlled balloon inflation and deflation enabled progressive dilation of the obstructed duct, and a surgical mucosal opening over the balloon permitted creation of a nasal orifice. A temporary stent was maintained for 4 wk, resulting in successful restoration of nasolacrimal drainage without recurrence of epiphora. Twelve months after catheter removal, no recurrence of ocular discharge was noted. This case report highlights a minimally invasive, effective technique for treating distal nasolacrimal duct atresia in horses when other neocanalization methods are unsuccessful. Key clinical message: A Fogarty catheter-assisted neocanalization offered a practical and effective option for restoring nasolacrimal duct patency in a horse with distal duct atresia and absence of the nasal orifice, providing a minimally invasive alternative when conventional methods failed.</p>","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 12","pages":"1273-1278"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nathan E N Erickson, Cheryl L Waldner, Michelle Sniatynski, Stacey Lacoste, Diego Moya, John A Ellis
{"title":"Comparing clinical and immunologic response efficacy of systemic prime <i>versus</i> mucosal prime and systemic boost vaccination of beef calves after coinfection with bovine respiratory syncytial virus and bovine parainfluenza virus type 3 at weaning.","authors":"Nathan E N Erickson, Cheryl L Waldner, Michelle Sniatynski, Stacey Lacoste, Diego Moya, John A Ellis","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>This study compared the efficacy of mucosal prime and systemic boost vaccination of young beef calves to the current industry standard of systemic prime in the presence of maternal antibodies.</p><p><strong>Animals: </strong>April-born commercial crossbred beef calves (N = 22) were enrolled as neonates with a mean body weight of 37.7 ± 5.3 kg.</p><p><strong>Procedure: </strong>At birth, 11 calves (PRB) were intranasally administered a commercial combination modified live virus [bovine herpesvirus type 1 (BoHV1), bovine respiratory syncytial virus (BRSV), bovine parainfluenza virus type 3 (BPIV3)] mucosal vaccine and 11 calves (INJ) remained unvaccinated. At ~39 ±2 d of age, all 22 calves were subcutaneously administered a combination modified live virus systemic vaccine (BoHV1, BRSV, BPIV3, and bovine viral diarrhea virus types 1 and 2). At weaning (159 ±2 d of age), calves were challenged by coinfection with BRSV and BPIV3 and monitored 8 d for health and immunologic outcomes.</p><p><strong>Results: </strong>The INJ group had an increased risk of greater group cumulative clinical scores on Day 8 and rectal temperature > 39.5°C on Days 7 and 8 post-challenge. The INJ calves had lower arterial oxygenation than the PRB on Day 6, indicating more severe lung pathology. Shedding of BRSV and BPIV3 was greater on Days 5 and 7 for INJ compared to PRB.</p><p><strong>Conclusion: </strong>Mucosal priming and systemic boosting resulted in fewer lung lesions and less shedding of virus post-viral challenge at weaning than systemic priming of young calves.</p><p><strong>Clinical relevance: </strong>Prime-boost vaccination optimizes immune development toward weaning.</p>","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 12","pages":"1315-1325"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prognosis for surgical intestinal resection in inflammatory bowel disease refractory to medical treatment in a dog.","authors":"Jeong-Ho Ha, Yunho Jeong, Ho-Hyun Kwak, Sooyoung Choi, Jin-Ok Ahn, Jin-Young Chung","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 14-year-old spayed female Maltese dog had been diagnosed with inflammatory bowel disease (IBD) <i>via</i> surgical biopsy and histopathologic findings. The dog had shown stable clinical control with prednisolone for 2 y but subsequently developed diarrhea, and serum albumin levels could not be adequately controlled. Despite titrating up the prednisolone dosage (1 mg/kg, PO, q12h), serum albumin concentration remained low and diarrhea persisted. Diagnostic imaging identified the underlying cause of the gastrointestinal signs as segmental eccentric small intestine wall thickening with homogenous hypoenhancement. A surgical resection of the affected segment was undertaken, primarily for histopathologic examination to identify the underlying cause rather than for therapeutic purposes. Postoperatively, medical management was continued, and the therapeutic response to medical therapy improved as the prednisolone was gradually tapered. Stable management was ultimately achieved at a prednisolone dosage of 0.25 mg/kg, PO, q24h, once. Key clinical message: In veterinary medicine, IBD is generally managed with medical therapy, and poor prognosis may occur if the clinical signs are not controlled. In certain cases, however, a surgical approach may offer benefits in the management of IBD. In the case reported herein, surgical resection was conducted on the segments of intestine with severe inflammation in a 14-year-old spayed female Maltese dog diagnosed with IBD that was not controlled by medical therapy. After surgery, the IBD was managed successfully with prednisolone.</p>","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 12","pages":"1303-1307"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}