成年猫硝基呋喃妥因继发的周围多神经病变。

IF 0.9 4区 农林科学 Q3 VETERINARY SCIENCES
Dezirae Leger, Yasmine Messiaen, Kathleen Linn
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引用次数: 0

摘要

一只6岁阉割的雄性家养短毛猫因其5天的后肢蹲姿行走史而被转诊。在转诊之前,猫已经从会阴尿道造口手术中恢复过来,之前有6周的复发性尿路感染,在此期间有3次尿路阻塞。猫在会阴尿道造口手术前仅给予兽医处方的呋喃妥因(4 mg/kg, q8h)治疗1 d。重新注射呋喃妥因两天后,猫开始表现出后肢蜷缩的姿势。在出现后肢蹲姿时,猫被给予呋喃妥因(4 mg/kg, q8h)共6 d(术前1 d,家中5 d,两次兽医就诊之间);然而,在两次访问期间,医院都没有给药)。两后肢均出现无共济失调的活动截瘫,髌骨反射减少,内侧(手指2)退缩反射减少,与影响股神经的周围多神经病变一致。胸椎和腰椎的计算机断层扫描未见与临床症状相符的异常。假定诊断为呋喃妥因给药后继发的周围多神经病变。关键的临床信息:虽然周围多神经病变是呋喃妥因的副作用之一,但仅在人类中有孤立的报道,据作者所知,在伴侣动物中没有报告病例。本病例报告的重点是在伴侣动物中与呋喃妥因施用相关的最小报道的神经系统副作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Peripheral polyneuropathy secondary to nitrofurantoin administration in an adult cat.

A 6-year-old castrated male domestic shorthair cat was referred because of a 5-day history of walking with a crouched hindlimb stance. Before referral, the cat had been recovering from perineal urethrostomy surgery, preceded by 6 wk of recurrent urinary tract infections, with 3 urinary blockages during that interval. The cat was being managed on nitrofurantoin (4 mg/kg, q8h), prescribed by the referring veterinarian and administered for only 1 d before the perineal urethrostomy surgery. Two days after the nitrofurantoin was restarted, the cat began displaying the crouched hindlimb stance. At the time of presentation for the crouched hindlimb stance, the cat had been administered nitrofurantoin (4 mg/kg, q8h) for a total of 6 d (1 d before the surgery and 5 d at home in between the 2 veterinary visits; however, the medication was not administered in hospital during either visit). Ambulatory paraparesis with no ataxia, decreased patellar reflexes, and decreased medial (digit 2) withdrawal reflexes were present in both hind limbs, consistent with a peripheral polyneuropathy affecting the femoral nerves. Computed tomographic imaging of the thoracic and lumbar spine showed no abnormalities compatible with the clinical signs. A presumptive diagnosis of peripheral polyneuropathy secondary to nitrofurantoin administration was made. Key clinical message: Although peripheral polyneuropathy is a reported side effect of nitrofurantoin, there are only isolated reports of its occurrence in humans and, to the authors' knowledge, no reported cases in companion animals. This case report focuses on the minimally reported neurologic side effects associated with nitrofurantoin administration in companion animals.

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来源期刊
CiteScore
1.20
自引率
10.00%
发文量
177
审稿时长
12-24 weeks
期刊介绍: The Canadian Veterinary Journal (CVJ) provides a forum for the discussion of all matters relevant to the veterinary profession. The mission of the Journal is to educate by informing readers of progress in clinical veterinary medicine, clinical veterinary research, and related fields of endeavor. The key objective of The CVJ is to promote the art and science of veterinary medicine and the betterment of animal health. A report suggesting that animals have been unnecessarily subjected to adverse, stressful, or harsh conditions or treatments will not be processed for publication. Experimental studies using animals will only be considered for publication if the studies have been approved by an institutional animal care committee, or equivalent, and the guidelines of the Canadian Council on Animal Care, or equivalent, have been followed by the author(s).
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