Current drug delivery最新文献

{"title":"Applications of Biodegradable Polymeric Nanomaterials as Drug Delivery Systems.","authors":"Han Bao, Ning Wang, Jia Guo, Xiangjun Han","doi":"10.2174/0115672018392176250722113903","DOIUrl":"https://doi.org/10.2174/0115672018392176250722113903","url":null,"abstract":"<p><p>There are a variety of biodegradable polymers, including natural polysaccharides, proteins, nucleic acids, etc., in animals and plants, as well as some polymers that are synthesized by microorganisms, such as poly(3-hydroxybutyrate-co-3-hydroxyhexanoate). At present, the most common polymers are those that are artificially synthesized, such as polyethylene glycol, polylactic acid, and polycaprolactone. These polymers can degrade via hydrolytic and enzymatic processes in the body into low-molecular-weight products that are then reabsorbed or excreted, making them the most suitable materials for the synthesis of biodegradable nanoparticles. Biodegradable polymers can react with other substances to form nanocomposites, which have superior biocompatibility, degradability, and safety. Biodegradable polymer-based nanocomposites exhibit targeting capabilities, including passive (enhanced permeability and retention effect), active (ligand-receptor interactions), tumor microenvironment-responsive, and external stimulus-responsive (e.g., magnetic, electric, and lightdriven) targeting. In addition, synthesized biodegradable nanomaterials can alter the solubility of the loaded drug and improve its bioavailability. Thus, these materials have been widely used in drug delivery systems. This review aimed to summarize the recent advances in biodegradable polymeric nanomaterials for biomedical drug delivery, analyze their design advantages and clinical translation potential, and explore their future prospects and challenges in precision therapy and targeted delivery.</p>","PeriodicalId":94287,"journal":{"name":"Current drug delivery","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in Nanocarrier Production Techniques and Methods for Enhanced Targeted Delivery of Drug: A Comprehensive Review.","authors":"Atish Kumar S Mundada, Lokesh P Kothari, Kuldeep Vinchurkar, Saloni Yadav, Arprita Malhan, Mridul Guleria, Sudarshan Singh","doi":"10.2174/0115672018379860250722161458","DOIUrl":"https://doi.org/10.2174/0115672018379860250722161458","url":null,"abstract":"<p><p>Nanotechnology has transformed drug delivery systems, leading to the creation of various nanocarriers that offer significant advantages over traditional methods. This review explores key techniques and methods for producing nanocarriers like liposomes, niosomes, dendrimers, nanocapsules, carbon nanotubes, polymeric micelles, and solid lipid nanoparticles. Operating within the nanoscale range (1-100 nm), these nanocarriers enhance drug efficacy, reduce side effects, and improve bioavailability. Liposomes are generated using methods, such as the Bangham procedure, solvent injection, and microfluidic channels. Nanocarriers have become fundamental to sophisticated drug delivery systems, providing improved precision, regulated release, and targeted therapeutic administration. Innovative methods, such as microfluidics and nanoprecipitation, have enhanced the scalability and consistency of nanocarriers, while progress in surface engineering, including ligand conjugation and stimuli-responsive coatings, facilitates improved targeting and controlled drug release. The advancement of biocompatible and biodegradable nanomaterials, including polymeric nanoparticles, liposomes, and dendrimers, has broadened the clinical utility of nanocarriers, especially in oncology, neurology, and gene therapy. This review underscores the versatility and potential of these nanocarriers in advancing drug delivery, emphasizing their capacity for targeted, efficient, and controlled therapeutic interventions.</p>","PeriodicalId":94287,"journal":{"name":"Current drug delivery","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer Cell-Coated PLGA Nanoparticles Loaded with Sorafenib and Spions for Hepatocellular Carcinoma Theranostics.","authors":"Qixiong Lin, Yanyan Wen, Yueyou Peng, Tianfeng Shi, Kunkun Liu, Qiufeng Yu, Wei Tian, Yanfeng Meng","doi":"10.2174/0115672018377065250717004240","DOIUrl":"https://doi.org/10.2174/0115672018377065250717004240","url":null,"abstract":"<p><strong>Introduction: </strong>Hepatocellular carcinoma (HCC) is the sixth most common malignant cancer worldwide, but the chemotherapy drugs used in the treatment of HCC patients have limited efficacy and cause severe side effects. To improve HCC treatment outcomes, a cancer cell membrane (CCM)-coated biomimetic nanodelivery system was designed to achieve enhanced anti-HCC effects.</p><p><strong>Methods: </strong>Poly (lactic-co-glycolic acid) (PLGA) was used to carry both sorafenib, which is used to treat advanced HCC, and superparamagnetic iron oxide nanoparticles (SPIONs). The prepared nanoparticles (NPs) were coated with Huh-7 cell membranes to obtain biomimetic nanoparticles (SFINPs@CCM). The physicochemical properties of SFINPS@CCM were then characterized, and the drug loading efficiency, release rate, transverse relaxation rate for MRI, fluorescence targeting ability, and anti-HCC ability were evaluated.</p><p><strong>Results: </strong>The SFINPS@CCM were successfully prepared. The loading efficiency of sorafenib in the SFINPs was 88.24%. The cumulative amount of sorafenib released from the SFINPs@CCM at 72 h was 72.96%. In vitro magnetic resonance imaging (MRI) showed the transverse relaxation rate was 25.448 mM-1 s-1. Meanwhile, the fluorescent tracing verified the homologous targeting ability of SFINPs@CCM to Huh-7 cells. The cytotoxicity of SFINPS@CCM was 29.48±5.74%, which was significantly higher than that of the SFINPs.</p><p><strong>Discussion: </strong>The study indicates that the SFINPs@CCM system achieves efficient drug delivery and enhances anti-HCC efficacy. While the results are encouraging, further research is needed to confirm broader applicability.</p><p><strong>Conclusion: </strong>The biomimetic nanodelivery system exhibits good targeting and excellent therapeutic effects, laying a technical foundation for preclinical studies.</p>","PeriodicalId":94287,"journal":{"name":"Current drug delivery","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin-Embedded Hydrogels: A Promising Approach for Accelerating Healing in Diabetic Ulcers.","authors":"Jiaru Zhou, Xiangmei Liu, Tianyu Tang, Jiawei Liang, Huashen He, Yingyao Luo, Yanhua Guo, Peining Li, Junfeng Ban, Yan Zhang","doi":"10.2174/0115672018384803250713182036","DOIUrl":"https://doi.org/10.2174/0115672018384803250713182036","url":null,"abstract":"<p><strong>Introduction: </strong>Difficulty in wound healing is a significant worldwide clinical challenge with serious health consequences and even life-threatening consequences. We designed an acrylic hydrogel loaded with metformin and investigated its mechanism of action in promoting wound repair.</p><p><strong>Methods: </strong>In this study, we obtained self-assembled metformin hydrogels (SAMHs) delivery system using acrylic acid (AA) as matrix and ammonium persulfate (APS) as initiator, and evaluated the appearance, water vapor transmission rate, swelling properties, mechanical properties, and bioactivities of the SAMHs, and finally assessed the potential of the SAMHs for the treatment of chronic wounds in a diabetic rat wound model.</p><p><strong>Results: </strong>SAMHs were colorless and transparent in appearance, with a water vapor transmission rate of 3530 g·m-2·day-1, a dissolution rate of 504%, a Young's modulus of 34 Kpa, and an elongation at break of 595.7%.The drug loading capacity of SAMHs was 0.8±0.04 mg·g-1 and the cumulative release amounted to 71.67±2.03%. In vivo experiments showed that on day 14, the SAMHs group achieved a wound healing rate of 96.74%, with complete epithelialization, a collagen fiber content of 75.10%, elevated VEGF expression, and a TNF-α level of 162.62 pg·mL⁻¹, all of which exhibited significant differences compared to the control group.</p><p><strong>Discussion: </strong>SAMHs exhibit excellent performance in several aspects, achieving slow drug release and promoting wound repair. In addition, SAMHs are simple and low-cost to prepare, which is expected to bring more cost-effective treatment options for diabetic patients. However, antimicrobial properties and clinical trial data are lacking in this study, and their applicability in complex wounds requires further validation.</p><p><strong>Conclusion: </strong>The hydrogel we prepared has excellent properties, is suitable for use in chronic wounds and promotes wound healing in diabetic rats and is an effective therapeutic strategy for chronic wounds.</p>","PeriodicalId":94287,"journal":{"name":"Current drug delivery","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart Nanofibers in Wound Healing: Exploring Novel Combinations and Applications.","authors":"Badriyah Shadid Alotaibi, Madiha Khan, Nihal Abdalla Ibrahim, Abida Kalsoom Khan, Rabia Liaqat, Munaza Ijaz","doi":"10.2174/0115672018376778250616113903","DOIUrl":"https://doi.org/10.2174/0115672018376778250616113903","url":null,"abstract":"<p><p>Due to certain limitations of traditional therapies, millions of people all over the world suffering from chronic wounds are exploring new treatments. As single-layer nanofibers cannot meet different wound surface needs, multifunctional nanofibers with drug combinations surpass the limitation of conventional drug-polymer combinations. Traditional wound therapies have several limitations, prompting the search for more effective alternatives, particularly for chronic wounds. Singlelayer nanofibers often fail to meet diverse wound-healing needs, whereas multifunctional nanofibers, incorporating drug combinations, overcome these limitations. Polymers, widely used in nanofiber formulations, exhibit immunostimulatory, anti-inflammatory, and antimicrobial properties, enhancing the woundhealing process. However, due to a lack of certain biological properties, researchers have formed hybrid polymers, which are a combination of natural and synthetic polymers to meet wound healing requirements. Despite their advantages in biocompatibility and tunable mechanical properties, the clinical translation of polymer-based nanofibers faces challenges in regulatory approval and largescale production. Most studies are still limited to in vitro evaluations, and standardized in vivo models or human trials are necessary to validate their long-term efficacy. Additionally, to meet FDA and DRAP guidelines, these materials must undergo rigorous biodegradation and cytotoxicity assessments before clinical adoption. Owing to several bioactive components (e.g., vitamins, polyphenols) in structures of herbal extract, they have excellent anti-inflammatory, antimicrobial, and antioxidant properties. Nanofibrous scaffolds of herbal extracts are in prominence and can have a multi-target synergistic impact. Among several treatments for repairing wounds, growth factors have also been proven as an effective treatment for active healing. This review will provide the researchers with a holistic view of recently reported novel multifunctional nanofibers composed of different combinations of drugs, polymers, herbal extracts, growth factors, and biomolecules to promote wound healing. Although several multifunctional nanofibers have been prepared and shown excellent properties for wound healing therapy, still development of multifunctional nanofibers still needs to be focused on. In a nutshell, multifunctional nanofibers have become very famous in the wound healing process, and a better scale-up of these nanofibers in the coming era will result in commercialization, and products of these nanofibers will become more popular.</p>","PeriodicalId":94287,"journal":{"name":"Current drug delivery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"6D Printing and the Future of Personalized Medicine: A New Frontier in Drug Delivery.","authors":"Komal, Balak Das Kurmi, Raj Kumar Narang, Amandeep Singh","doi":"10.2174/0115672018411212250623034423","DOIUrl":"https://doi.org/10.2174/0115672018411212250623034423","url":null,"abstract":"","PeriodicalId":94287,"journal":{"name":"Current drug delivery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cefadroxil-Mupirocin Integrated Electrospun Nanofiber Films for Burn Wound Therapy.","authors":"Saman Rashid, Munaza Ijaz, Sana Rafique, Haya Yasin, Mahnoor Mushtaq, Abida Kalsoom Khan, Madiha Khan, Bushra Nasir, Ghulam Murtaza","doi":"10.2174/0115672018374558250607134659","DOIUrl":"10.2174/0115672018374558250607134659","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to fabricate dual drug-loaded nanofibrous films made from polyvinyl alcohol (PVA) and chitosan, incorporating cefadroxil and mupirocin to meet the critical needs of burn wound care.</p><p><strong>Methods: </strong>Electrospinning was utilized to fabricate cefadroxil- and mupirocin-loaded polyvinyl alcohol PVA/Chitosan nanofibers. Characterization of structural and morphological properties of these nanofibers was done through Fourier Transform IR Spectroscopy, Scanning Electron Microscopy, Thermal analysis by TGA, and XRD spectroscopy. The kinetic profiles of the drug release mechanisms were considered to determine the release of cefadroxil and mupirocin. Antibacterial activity was determined against the bacteria Staphylococcus aureus and Pseudomonas aeruginosa, while the wound healing efficacy was tested in a rabbit model using full-thickness wounds.</p><p><strong>Results: </strong>SEM analysis demonstrated the formation of uniform and smooth nanofibers possessing a well-defined morphology. FTIR spectroscopy confirmed the successful incorporation of cefadroxil and mupirocin into the PVA/Chitosan matrix. TGA analysis indicated the thermal stability of the nanofibers, while XRD results suggested that the drugs were either molecularly dispersed or in an amorphous state within the biopolymeric blend. Drug release studies showed distinct profiles, with an initial burst release followed by sustained drug release. Over 80% of mupirocin was released within the first 2 hours, while cefadroxil exhibited a cumulative release exceeding 60%. Antibacterial assays showed significant inhibition zones, with the largest being 20 mm against Staphylococcus aureus. In vivo studies utilizing a full-thickness rabbit wound model revealed that the drug-loaded nanofibers accelerated wound contraction, achieving approximately 90% closure by day 17, compared to less than 70% for the control.</p><p><strong>Conclusion: </strong>The study demonstrates that cefadroxil-mupirocin nanofiber films provide superior antibacterial activity and faster wound healing rates, highlighting their potential in advanced burn wound management.</p>","PeriodicalId":94287,"journal":{"name":"Current drug delivery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Targeting Using Nanocolloids for the Management of Multiple Sclerosis.","authors":"Smita Jain, Kaisar Raza","doi":"10.2174/0115672018330624241125060045","DOIUrl":"10.2174/0115672018330624241125060045","url":null,"abstract":"<p><p>Multiple sclerosis (MS) causes sensory and motor deficiencies by breaking the myelin sheath, which inhibits electrical impulses from reaching affected neurons. The blood-brain barrier (BBB) and unanticipated side effects from inadequate targeting are major hurdles to MS treatment. Nanomedicines are being used to deliver therapeutic chemicals to lesions in order to address the limitations of existing MS therapy approaches. Nano-based therapies with deep BBB penetration and selective targeting have shown promising results, emerging as a possible therapy strategy for MS with improved therapeutic effects. This review will suggest the latest developments in nano-colloidsbased therapy for treating MS by evaluating their advantages and disadvantages.</p>","PeriodicalId":94287,"journal":{"name":"Current drug delivery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type IV Collagen-Targeting Nanoparticles for Efficient Delivery to the Renal Interstitium in Fibrotic Kidneys.","authors":"Yuki Nakamura, Kohei Togami, Sumio Chono","doi":"10.2174/0115672018377505250523040529","DOIUrl":"https://doi.org/10.2174/0115672018377505250523040529","url":null,"abstract":"<p><strong>Introduction: </strong>Renal fibrosis is widely recognized as the final common pathway in chronic kidney disease (CKD) progression, culminating in end-stage renal failure, and is characterized by excessive extracellular matrix (ECM) accumulation by renal myofibroblasts within the renal interstitium, ultimately leading to functional decline. In this study, to establish an effective drug delivery system targeting fibrotic lesions in the renal interstitium, we developed nanoparticles modified with short-chain peptides that bind type IV collagen (Col IV), a distinct ECM component predominantly remodeled in fibrosis.</p><p><strong>Methods: </strong>Col IV-targeting nanoparticles were intravenously administered to a unilateral ureteral obstruction (UUO) rat model of renal fibrosis. The distribution of these nanoparticles to the renal interstitium was examined via fluorescence-based ex vivo imaging and analysis of frozen kidney tissue sections. Additionally, we assessed cellular uptake in renal fibroblasts (NRK-49F), with or without transforming growth factor-beta 1 (TGF-β1) stimulation, using flow cytometry.</p><p><strong>Results: </strong>Both Col IV-targeting and non-targeting nanoparticles exhibited increased distribution in the fibrotic renal interstitium compared to healthy renal tissue. Moreover, the Col IV-targeting nanoparticles localized more extensively in the fibrotic interstitium than their non-targeting counterparts. In vitro, Col IV-targeting nanoparticles also showed significantly higher accumulation in NRK-49F cells, irrespective of TGF-β1 stimulation, compared to non-targeting nanoparticles.</p><p><strong>Conclusion: </strong>We successfully fabricated and evaluated Col IV-targeting nanoparticles as a potential drug delivery platform. In a UUO-induced renal fibrosis model, these nanoparticles efficiently migrated to the fibrotic renal interstitium, and in vitro experiments using NRK-49F cells demonstrated enhanced uptake by renal fibroblasts and myofibroblasts, central mediators of ECM deposition in fibrotic progression. These findings suggest that Col IV-targeting nanoparticles may serve as an effective drug carrier for delivering antifibrotic therapies, potentially mitigating CKD progression.</p>","PeriodicalId":94287,"journal":{"name":"Current drug delivery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Assembly Peptide Hydrogel and its Application in the Biomedical Field.","authors":"Libo Yuan, Yu Zhang, Yulu Shuai","doi":"10.2174/0115672018363733250227071908","DOIUrl":"https://doi.org/10.2174/0115672018363733250227071908","url":null,"abstract":"<p><p>With the continuous development of material science, many new biomaterials have emerged. Peptides have a strong supramolecular self-assembly ability and can form hydrogels through a self-assembly process. These self-assembled peptide hydrogels have the advantages of excellent biocompatibility, tunability, and degradability, and are suitable for biomedical fields. This paper reviews the mechanisms and characteristics of peptide gel formation, outlines the various factors affecting peptide gelation, and the applications of peptide hydrogels in drug delivery, tissue engineering, and wound healing. Finally, challenges encountered in self-assembled peptide gels and prospects for their application are highlighted.</p>","PeriodicalId":94287,"journal":{"name":"Current drug delivery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}