World journal of nephrology最新文献

{"title":"Renal tubular acidosis: Varied aetiologies and clinical presentations: Three case reports.","authors":"Akhila Bhandarkar, Anwitha Varmudy, Hiya Boro, Sowrabha Bhat","doi":"10.5527/wjn.v14.i2.104760","DOIUrl":"10.5527/wjn.v14.i2.104760","url":null,"abstract":"<p><strong>Background: </strong>Renal tubular acidosis (RTA) refers to a group of kidney disorders characterized by defective acid excretion or bicarbonate reabsorption, leading to metabolic acidosis. This case series presents three cases of RTA with distinct etiologies and clinical manifestations. These cases emphasize the necessity of a comprehensive evaluation of RTA, considering both renal and systemic origins.</p><p><strong>Case summary: </strong>The first case describes a female patient with osteopetrosis-related RTA, diagnosed with Guibaud-Vainsel syndrome, emphasizing the importance of genetic assessment. The second case delineates RTA secondary to focal segmental glomerulosclerosis, associating tubular dysfunction with glomerular pathology. In the first two cases whole exome sequencing confirmed genetic diagnosis. The third case illuminates RTA as a complication of Graves' disease, highlighting autoimmune implications.</p><p><strong>Conclusion: </strong>These cases underscore the interdisciplinary approach essential in RTA management. Understanding the diverse pathophysiology of RTA aids in tailored therapeutic strategies and improved patient outcomes.</p>","PeriodicalId":94272,"journal":{"name":"World journal of nephrology","volume":"14 2","pages":"104760"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sucroferric oxyhydroxide monotherapy for hyperphosphatemia in Indian chronic kidney disease patients undergoing hemodialysis: A phase IV, single-arm, open-label study.","authors":"M R Niranjan, Sanjay Srinivasa, Vibhanshu Gupta, Anil K Bhalla, Ankush Gaikwad, Prajakta Wangikar, Sachin Suryawanshi, Priti Gajbe","doi":"10.5527/wjn.v14.i2.100117","DOIUrl":"10.5527/wjn.v14.i2.100117","url":null,"abstract":"<p><strong>Background: </strong>Hyperphosphatemia (HP) is a common complication in an advanced stage of chronic kidney disease (CKD) and is associated with cardiovascular issues, metabolic bone abnormalities and worsening of secondary hyperparathyroidism. Most patients on dialysis require phosphate binders to control HP. Sucroferric oxyhydroxide (SO) (Dynulta^™) is a calcium-free, polynuclear iron (III) based oral phosphate binder, for the treatment of HP. In this phase IV, open-label, single-arm, multi-center, 12-week, SOLO CKD study evaluated efficacy and safety of Dynulta^™ in Indian CKD patients undergoing hemodialysis.</p><p><strong>Aim: </strong>To investigate the efficacy, safety and tolerability of SO Chewable Tablet (Dynulta^™) in patients with CKD on hemodialysis.</p><p><strong>Methods: </strong>Hyperphosphatemic patients on hemodialysis and fulfilling eligibility criteria were included in the study for at least 12 weeks and received SO 1500 mg chewable tablet per day. The key endpoint was change in mean serum phosphorus levels after 12 weeks. Data were analysed using analysis of variance, Paired test, Wilcoxon test, and post-hoc comparisons, with <i>P</i> < 0.05 considered statistically significant, using Graph Pad software.</p><p><strong>Results: </strong>A total of 114 patients were enrolled and 94 patients completed the study. The mean ± SD serum phosphorous level was reduced from 7.62 mg/dL ± 2.02 mg/dL at baseline to 5.13 mg/dL ± 1.88 mg/dL after 12 weeks of treatment. At each follow-up visit, the reduction in mean serum phosphorous levels was statistically significant (<i>P</i> value < 0.05) compared to baseline, confirming the efficacy of SO. A total of 33.33% of patients experienced adverse events (AEs). The most frequently reported AEs were pyrexia, nasopharyngitis and headache, which were considered unlikely to be related to the study drug treatment. No serious AEs was reported during the study period and no patients discontinued treatment due to AEs.</p><p><strong>Conclusion: </strong>This first real-world study in Indian CKD patients on hemodialysis shows SO as a safe, and effective monotherapy for HP, though its small sample size limits generalizability.</p>","PeriodicalId":94272,"journal":{"name":"World journal of nephrology","volume":"14 2","pages":"100117"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the pathophysiology and treatment of focal segmental glomerulosclerosis: The importance of a timely and tailored approach.","authors":"Guido Gembillo, Concetto Sessa, Domenico Santoro","doi":"10.5527/wjn.v14.i2.103039","DOIUrl":"10.5527/wjn.v14.i2.103039","url":null,"abstract":"<p><p>Focal segmental glomerulosclerosis (FSGS) is a histological pattern of glomerular damage that significantly contributes to chronic kidney disease and end-stage renal disease. Its incidence is rising globally, necessitating timely and personalized management strategies. This paper aims to provide an updated overview of the pathophysiology, diagnosis, and therapeutic strategies for FSGS, emphasizing the importance of early interventions and tailored treatments. This editorial synthesizes key findings from recent literature to highlight advancements in understanding and managing FSGS. Emerging evidence supports the role of targeted therapies and personalized approaches in improving outcomes for FSGS patients. Advances include novel biomarkers, genetic testing, and innovative therapeutics such as transient receptor potential ion channel blockers and antisense oligonucleotides for apolipoprotein 1-related FSGS. Effective management of FSGS requires a combination of timely diagnosis, evidence-based therapeutic strategies, and ongoing research to optimize patient outcomes and address gaps in the current understanding of the disease.</p>","PeriodicalId":94272,"journal":{"name":"World journal of nephrology","volume":"14 2","pages":"103039"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Essential role of kidney biopsy in diagnosing glomerular diseases amidst evolving biomarkers.","authors":"Fernando M Gonzalez, Ricardo Valjalo","doi":"10.5527/wjn.v14.i2.103756","DOIUrl":"10.5527/wjn.v14.i2.103756","url":null,"abstract":"<p><p>The discussion on renal biopsies and biomarkers highlights the essential aspects of nephrology. Although novel diagnostic biomarkers are emerging, renal biopsy remains critical for accurate diagnosis and treatment owing to the lack of sufficiently validated biomarkers with high sensitivity and specificity. Puspitasari <i>et al</i> highlighted the significant changes in renal biopsy indications and histological outcomes before and after the coronavirus disease 2019 (COVID-19) pandemic, reflecting the complex interactions between clinical workflows, public health issues, and patient demographics. Although biomarkers are increasingly utilized in nephrology, their importance remains balanced with traditional practices. Advancements in precision medicine are exemplified by tests like plasma anti-phospholipase A2 receptor levels. However, the COVID-19 pandemic revealed significant vulnerabilities in nephrology services, emphasizing the necessity for adaptable and robust healthcare strategies to manage chronic conditions during global crises. In conclusion, while biomarkers are poised to assume a more prominent role in nephrology, the significance of renal biopsies and thorough histopathological analysis remains paramount in understanding complex disease processes and guiding personalized patient management. The ongoing integration of traditional diagnostic approaches with innovative biomarker strategies promises to improve patient care and long-term health outcomes.</p>","PeriodicalId":94272,"journal":{"name":"World journal of nephrology","volume":"14 2","pages":"103756"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the controversial link between pediatric obesity and graft survival in kidney transplantation.","authors":"Brooke Stanicki, Dante A Puntiel, Benjamin Peticca, Nicolas Egan, Tomas M Prudencio, Samuel G Robinson, Sunil S Karhadkar","doi":"10.5527/wjn.v14.i2.101961","DOIUrl":"10.5527/wjn.v14.i2.101961","url":null,"abstract":"<p><strong>Background: </strong>Childhood obesity is a significant public health concern, particularly amongst children with chronic kidney disease requiring kidney transplant (KT). Obesity, defined as a body mass index (BMI) of 30 kg/m² or greater, is prevalent in this population and is associated with disease progression. While BMI influences adult KT eligibility, its impact on pediatric transplant outcomes remains unclear. This study investigates the effect of BMI on graft survival and patient outcomes, addressing gaps in the literature and examining disparities across BMI classifications.</p><p><strong>Aim: </strong>To assess the impact of BMI classifications on graft and patient survival following KT.</p><p><strong>Methods: </strong>A retrospective cohort study analyzed 23081 pediatric transplant recipients from the Standard Transplant Analysis and Research database (1987-2022). Patients were grouped into six BMI categories: Underweight, healthy weight, overweight, and Class 1, 2, and 3 obesity. Data were analyzed using one-way way analysis of variance, Kruskal-Wallis tests, Chi-squared tests, Kaplan-Meier survival analysis with log-rank tests, and Cox proportional hazard regressions. Statistical significance was set at <i>P</i> < 0.05.</p><p><strong>Results: </strong>Class 3 obese recipients had lower 1-year graft survival (88.7%) compared to healthy-weight recipients (93.1%, <i>P</i> = 0.012). Underweight recipients had lower 10-year patient survival (81.3%, <i>P</i> < 0.05) than healthy-weight recipients. Class 2 and 3 obese recipients had the lowest 5-year graft survival (67.8% and 68.3%, <i>P</i> = 0.013) and Class 2 obesity had the lowest 10-year graft survival (40.7%). Cox regression identified increases in BMI category as an independent predictor of graft failure [hazard ratio (HR) = 1.091, <i>P</i> < 0.001] and mortality (HR = 1.079, <i>P</i> = 0.008). Obese patients experienced longer cold ischemia times (11.6 and 13.1 hours <i>vs</i> 10.2 hours, <i>P</i> < 0.001). Class 3 obesity had the highest proportion of Black recipients (26.2% <i>vs</i> 17.9%, <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Severe obesity and underweight status are associated with poorer long-term outcomes in pediatric KT recipients, emphasizing the need for nuanced transplant eligibility criteria addressing obesity-related risks and socioeconomic disparities.</p>","PeriodicalId":94272,"journal":{"name":"World journal of nephrology","volume":"14 2","pages":"101961"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of chronic kidney disease and associated factors at Wolkite University Specialized Hospital: A cross-sectional study.","authors":"Bisrat Fikadu Habtu, Fanta Obsa, Waqtola Cheneke, Sintayehu Asaye, Ahmed Nuru, Zuber Hajikelil","doi":"10.5527/wjn.v14.i2.100896","DOIUrl":"10.5527/wjn.v14.i2.100896","url":null,"abstract":"<p><strong>Background: </strong>Kidney is the vital organ that plays a great role in maintaining an optimal internal environment. The normal kidney function can be altered by physical injury or disease. Currently, chronic kidney disease (CKD) is an increasing major health problem worldwide. In 2017, it was ranked as the 12^th leading cause of death and is expected to rise to the 5^th ranked cause of death by 2040. Therefore, early detection, increasing patients' awareness and treatment of CKD are required to hold the problem. However, despite its higher prevalence of hospitalized morbidity and mortality, little is known about the magnitude and associated factor of CKD in the Ethiopian context. Hence this study aimed to determine the magnitude of CKD and associated factors at Wolkite University Specialized Hospital (WKUSTH), South West Ethiopia.</p><p><strong>Aim: </strong>To determine the magnitude, and associated factors of CKD in WKUSTH, Ethiopia.</p><p><strong>Methods: </strong>Institutional based cross-sectional study with secondary data was conducted from November 15, 2021 to February 28, 2022 at WKUSTH. Three hundred forty five (345) participants were selected by a convenient sampling technique. Creatinine and urea were measured using cobas311 fully automated chemistry analyzer and estimated glomerular filtration rate (eGFR) was calculated using CKD epidemiology collaboration formula. Socio-demographic and clinical data were collected by using a pretested questionnaire. Data were coded and entered into EpiData 3.1 version and exported to STATA version 14 for analysis. Bivariate analysis was used to screen candidate variables for multivariate analysis. In the multivariate analysis a <i>P</i> value < 0.05 were considered statistically significant.</p><p><strong>Results: </strong>The magnitude of CKD by impaired eGFR were 54 (15.7%) (95%CI: 0.116-0.194). In multivariable analysis, older age [adjusted odds ratio (AOR) = 5.91, 95%CI: 2.41-14.47)], hypertension (AOR =10.41, 95%CI: 4.55-23.81), diabetes mellitus (AOR = 5.90, 95%CI: 2.14-16.23), high body mass index (AOR = 3.0, 95%CI: 1.30-7.27), and anemia (AOR = 2.94, 95%CI: 1.26-6.88) were independently associated with CKD.</p><p><strong>Conclusion: </strong>The magnitude of CKD among adult patients admitted to WKUSTH was high. Hence, researchers need to do a population-based study and longitudinal study on the magnitude of CKD, associated factors. Estimation of GFR for all hospitalized patients might help to early detection of CKD and prevent complications.</p>","PeriodicalId":94272,"journal":{"name":"World journal of nephrology","volume":"14 2","pages":"100896"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified National Early Warning Score 2, a reliable early warning system for predicting treatment outcomes in patients with emphysematous pyelonephritis.","authors":"Sriram Krishnamoorthy, Gayathri Thiruvengadam, Hariharasudhan Sekar, Velmurugan Palaniyandi, Srinivasan Ramadurai, Senthil Narayanasamy","doi":"10.5527/wjn.v14.i2.103035","DOIUrl":"10.5527/wjn.v14.i2.103035","url":null,"abstract":"<p><strong>Background: </strong>Emphysematous pyelonephritis (EPN) is a life-threatening necrotizing renal parenchyma infection characterized by gas formation due to severe bacterial infection, predominantly affecting diabetic and immunocompromised patients. It carries high morbidity and mortality, requiring early diagnosis and timely intervention. Various prognostic scoring systems help in triaging critically ill patients. The National Early Warning Score 2 (NEWS 2) scoring system is a widely used physiological assessment tool that evaluates clinical deterioration based on vital parameters, but its standard form lacks specificity for risk stratification in EPN, necessitating modifications to improve treatment decision-making and prognostic accuracy in this critical condition.</p><p><strong>Aim: </strong>To highlight the need to modify the NEWS 2 score to enable more intense monitoring and better treatment outcomes.</p><p><strong>Methods: </strong>This prospective study was done on all EPN patients admitted to our hospital over the past 12 years. A weighted average risk-stratification index was calculated for each of the three groups, mortality risk was calculated for each of the NEWS 2 scores, and the need for intervention for each of the three groups was calculated. The NEWS 2 score was subsequently modified with 0-6, 7-14 and 15-20 scores included in groups 1, 2 and 3, respectively.</p><p><strong>Results: </strong>A total of 171 patients with EPN were included in the study, with a predominant association with diabetes (90.6%) and a female-to-male ratio of 1.5:1. The combined prognostic scoring of the three groups was 10.7, 13.0, and 21.9, respectively (<i>P</i> < 0.01). All patients managed conservatively belonged to group 1 (<i>P</i> < 0.01). Eight patients underwent early nephrectomy, with six from group 3 (<i>P</i> < 0.01). Overall mortality was 8 (4.7%), with seven from group 3 (87.5%). The cutoff NEWS 2 score for mortality was identified to be 15, with a sensitivity of 87.5%, specificity of 96.9%, and an overall accuracy rate of 96.5%. The area under the curve to predict mortality based on the NEWS 2 score was 0.98, with a confidence interval of (0.97, 1.0) and <i>P</i> < 0.001.</p><p><strong>Conclusion: </strong>Modified NEWS 2 (mNEWS 2) score dramatically aids in the appropriate assessment of treatment-related outcomes. MNEWS 2 scores should become the practice standard to reduce the morbidity and mortality associated with this dreaded illness.</p>","PeriodicalId":94272,"journal":{"name":"World journal of nephrology","volume":"14 2","pages":"103035"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radial artery deviation and reimplantation technique <i>vs</i> classical technique in arterio-venous fistula: A randomised control trial.","authors":"Shakti S Sarangi, Shashank Kumar, Deepak P Bhirud, Mahendra Singh, Shiv C Navriya, Gautam Ram Choudhary, Arjun Singh Sandhu","doi":"10.5527/wjn.v14.i2.100092","DOIUrl":"10.5527/wjn.v14.i2.100092","url":null,"abstract":"<p><strong>Background: </strong>Surgically created arterio-venous fistulas (AVFs) are the gold standard for haemodialysis access for patients with end-stage renal disease. Standard practice of AVF creation involves selecting the non-dominant upper limb and starting with most distally with radio-cephalic arterio-venous fistula. The primary patency rate of radio-cephalic arterio-venous fistula varies from 20%-25%. It has been suggested the neointimal hyperplasia at the mobilized venous segment causes stenosis of the anastomosis. Therefore, the radial artery deviation and reimplantation (RADAR) technique, in which the vein is minimally mobilized, should result in a higher success rate.</p><p><strong>Aim: </strong>To compare the RADAR technique with classical technique in creation of AVF including: (1) Success rate; (2) Time to maturation; (3) Duration of surgery; and (4) Complication rate.</p><p><strong>Methods: </strong>In our study we recruited 94 patients in two randomized groups and performed the AVF by the classical method or the RADAR method.</p><p><strong>Results: </strong>The RADAR group had higher primary success rate (<i>P</i> = 0.007), less rate of complications (<i>P</i> = 0.04), shorter duration of surgery (<i>P</i> = 0.00) and early time to maturation (0.001) when compared with the classical group. The RADAR procedure is a safe and a more efficient alternative to the current classical method of AVF creation. Longer duration of follow-up is required to assess the long-term outcomes in the future.</p><p><strong>Conclusion: </strong>The RADAR procedure is a safe and more efficient alternative to the current classical method of AVF creation. Longer duration of follow-up is required to assess the long-term outcomes in the future.</p>","PeriodicalId":94272,"journal":{"name":"World journal of nephrology","volume":"14 2","pages":"100092"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-nuclear cytoplasmic antibody-associated vasculitis and kidney cancer: A mini review.","authors":"Samuel Wilding, Henry H L Wu, Nina Brown, Rajkumar Chinnadurai","doi":"10.5527/wjn.v14.i2.105166","DOIUrl":"10.5527/wjn.v14.i2.105166","url":null,"abstract":"<p><p>This mini review explores the links between anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) and kidney cancer. Several studies suggest an increased incidence of cancer for patients with AAV. Different cancer types have shown different standardized incidence ratios (SIRs) in association with AAV. The SIRs of kidney cancer were found to be between 1.7 and 3.3 as per three retrospective data analyses. This association is likely multifactorial, with increased de novo cancer risks associated with inflammatory diseases; carcinogenic therapies such as cyclophosphamide; and reduced immune surveillance of neoplastic cells in immunocompromised individuals. Some studies have proposed that cancers, including kidney cancer, could be a potential trigger for AAV. Due to variability in SIRs and a lack of multicenter studies looking specifically into the incidence of kidney cancer at AAV diagnosis and on follow-up post initiation of AAV treatment, there remains a lack of evidence to support formal screening for kidney cancer in the AAV patient cohort. Greater awareness on the increased risk of cancer in AAV patients, prompt urological assessment of \"red flag\" symptoms of kidney cancer, and smoking cessation advice to reduce cancer risk should be standard of care for patients with AAV.</p>","PeriodicalId":94272,"journal":{"name":"World journal of nephrology","volume":"14 2","pages":"105166"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Point-of-care ultrasonography in nephrology: Growing applications, misconceptions and future outlook.","authors":"Hugo Diniz, Filipa Ferreira, Abhilash Koratala","doi":"10.5527/wjn.v14.i2.105374","DOIUrl":"10.5527/wjn.v14.i2.105374","url":null,"abstract":"<p><p>Ultrasound has long been an essential tool in nephrology, traditionally used for procedures like vascular access and kidney biopsies. Point-of-care ultrasonography (POCUS), a rapidly evolving bedside technology, is now gaining momentum in nephrology by providing real-time imaging to enhance physical examination findings. Unlike comprehensive radiology-performed ultrasound, POCUS focuses on specific clinical questions, providing immediate and actionable insights. This narrative review examines the philosophy behind POCUS, its expanding applications in nephrology, and its impact on patient care, including its role in diagnosing obstructive uropathy, guiding fluid management, and evaluating hemodynamics in cardiorenal syndrome. Additionally, the review addresses barriers to widespread adoption, such as the need for structured training, competency validation, and interdisciplinary cooperation. By integrating POCUS into routine practice, nephrologists can refine diagnostic accuracy, improve patient outcomes, and strengthen the role of bedside medicine.</p>","PeriodicalId":94272,"journal":{"name":"World journal of nephrology","volume":"14 2","pages":"105374"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}