World journal of methodology最新文献_第3页

Point-of-care ultrasound in nephrology: A private practice viewpoint. 点护理超声在肾脏病：私人执业的观点。

World journal of methodology Pub Date : 2024-12-20 DOI: 10.5662/wjm.v14.i4.95685

Rajiv Sinanan, Afsheen Moshtaghi, Abhilash Koratala

{"title":"Point-of-care ultrasound in nephrology: A private practice viewpoint.","authors":"Rajiv Sinanan, Afsheen Moshtaghi, Abhilash Koratala","doi":"10.5662/wjm.v14.i4.95685","DOIUrl":"10.5662/wjm.v14.i4.95685","url":null,"abstract":"Point-of-care ultrasound (POCUS) is a limited ultrasound examination performed by the clinician at the bedside, emerging as a complement to physical examination across various medical specialties. In the field of nephrology, its integration has been gradual, primarily limited to guiding procedures like temporary dialysis catheter placement or, in some cases, diagnostic kidney ultrasounds. In reality, the assessment of hemodynamic status at the bedside holds immense value for nephrologists, yet there exists limited awareness among practitioners regarding its implementation. While there is a growing trend towards incorporating multi-organ POCUS training in fellowship programs, private practice nephrologists remain relatively uninformed. This discussion explores the untapped potential of POCUS as a valuable diagnostic tool in everyday nephrology practice, demonstrating its effectiveness in diverse clinical settings, ranging from medical wards to outpatient dialysis units. Additionally, we delve into the challenges hindering its widespread adoption and consider the future trajectory of this innovative approach.","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"14 4","pages":"95685"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remission of type 2 diabetes mellitus: Emerging concepts and proposed diagnostic criteria. 2型糖尿病的缓解：新兴概念和建议的诊断标准。

World journal of methodology Pub Date : 2024-12-20 DOI: 10.5662/wjm.v14.i4.95210

Arkiath Veettil Raveendran

引用次数: 0

Diabetic retinopathy: A review on its pathophysiology and novel treatment modalities. 糖尿病视网膜病变：病理生理学和新的治疗方式的综述。

World journal of methodology Pub Date : 2024-12-20 DOI: 10.5662/wjm.v14.i4.95881

Arvind Kumar Morya, Prasanna Venkatesh Ramesh, Prateek Nishant, Kirandeep Kaur, Bharat Gurnani, Aarti Heda, Sarika Salodia

引用次数: 0

Role of molecular imaging in prognosis, diagnosis, and treatment of gastrointestinal cancers: An update on new therapeutic methods. 分子影像学在胃肠道肿瘤预后、诊断和治疗中的作用：新治疗方法的最新进展。

World journal of methodology Pub Date : 2024-12-20 DOI: 10.5662/wjm.v14.i4.93461

Mobina Fathi, Hayder Jasim Taher, Sabah Jassim Al-Rubiae, Shirin Yaghoobpoor, Ashkan Bahrami, Reza Eshraghi, Hossein Sadri, Mahsa Asadi Anar, Ali Gholamrezanezhad

{"title":"Role of molecular imaging in prognosis, diagnosis, and treatment of gastrointestinal cancers: An update on new therapeutic methods.","authors":"Mobina Fathi, Hayder Jasim Taher, Sabah Jassim Al-Rubiae, Shirin Yaghoobpoor, Ashkan Bahrami, Reza Eshraghi, Hossein Sadri, Mahsa Asadi Anar, Ali Gholamrezanezhad","doi":"10.5662/wjm.v14.i4.93461","DOIUrl":"10.5662/wjm.v14.i4.93461","url":null,"abstract":"One of the leading causes of cancer-related death is gastrointestinal cancer, which has a significant morbidity and mortality rate. Although preoperative risk assessment is essential for directing patient care, its biological behavior cannot be accurately predicted by conventional imaging investigations. Potential pathophysiological information in anatomical imaging that cannot be visually identified can now be converted into high-dimensional quantitative image features thanks to the developing discipline of molecular imaging. In order to enable molecular tissue profile in vivo, molecular imaging has most recently been utilized to phenotype the expression of single receptors and targets of biological therapy. It is expected that molecular imaging will become increasingly important in the near future, driven by the expanding range of biological therapies for cancer. With this live molecular fingerprinting, molecular imaging can be utilized to drive expression-tailored customized therapy. The technical aspects of molecular imaging are first briefly discussed in this review, followed by an examination of the most recent research on the diagnosis, prognosis, and potential future clinical methods of molecular imaging for GI tract malignancies.","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"14 4","pages":"93461"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relation between dysbiosis and inborn errors of immunity. 生态失调与先天免疫缺陷的关系。

World journal of methodology Pub Date : 2024-12-20 DOI: 10.5662/wjm.v14.i4.96380

Öner Özdemir

{"title":"Relation between dysbiosis and inborn errors of immunity.","authors":"Öner Özdemir","doi":"10.5662/wjm.v14.i4.96380","DOIUrl":"10.5662/wjm.v14.i4.96380","url":null,"abstract":"Inborn errors of immunity (IEI) disorders, formerly primary immune deficiency diseases, are a heterogeneous group of disorders with variable hereditary transitions, clinical manifestations, complications and varying disease severity. Many of the clinical symptoms, signs and complications in IEI patients can be attributed to inflammatory and immune dysregulatory processes due to loss of microbial diversity (dysbiosis). For example, in common variable immunodeficiency patients, the diversity of bacteria, but not fungi, in the gut microbiota has been found to be reduced and significantly altered. Again, this was associated with a more severe disease phenotype. Compromise of the STAT3/Th17 pathway in hyper-IgE syndrome may lead to dysbiosis of the oral microbiota in these patients, causing Candida albicans to switch from commensal to pathogenic. Modification of the microbiota can be used as a therapeutic approach in patients with IEI. Prebiotics, probiotics, postbiotics and fecal microbiota transplantation can be used to restore the balance of the gut microbiota and reduce pathogenicity in IEI patients. Clinical trials are currently underway to understand the impact of this dysbiosis on the phenotype of IEI diseases and its role in their treatment.","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"14 4","pages":"96380"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence and robotics in regional anesthesia. 人工智能和机器人在区域麻醉中的应用。

World journal of methodology Pub Date : 2024-12-20 DOI: 10.5662/wjm.v14.i4.95762

Nitin Choudhary, Anju Gupta, Nishkarsh Gupta

引用次数: 0

Exploring the limited use of transdermal medications in psychiatry: Challenges and potential solutions. 探索精神病学中透皮药物的有限使用：挑战和潜在的解决方案。

World journal of methodology Pub Date : 2024-12-20 DOI: 10.5662/wjm.v14.i4.96145

Mandeep Kaur, Meera Patel, Elizabeth Monis

引用次数: 0

Mental health in the virtual world: Are we ready for the metaverse era? 虚拟世界中的心理健康：我们准备好迎接虚拟世界时代了吗？

World journal of methodology Pub Date : 2024-12-20 DOI: 10.5662/wjm.v14.i4.95064

Tuffy Mamede, Patrícia Lordêlo

{"title":"Mental health in the virtual world: Are we ready for the metaverse era?","authors":"Tuffy Mamede, Patrícia Lordêlo","doi":"10.5662/wjm.v14.i4.95064","DOIUrl":"10.5662/wjm.v14.i4.95064","url":null,"abstract":"The advent of the metaverse, including virtual reality, augmented reality, and artificial intelligence, is an undeniable issue that health care scientists need to update. It influences all fields of knowledge, interpersonal relationships, and health. Regarding mental health since the post-coronavirus disease 2019 pandemic, it is necessary to consider and understand the potential, possibilities, weaknesses, and consequences arising from and provided by this new scenario. Due to the increasing need for mental health monitoring and care, mental health treatments require in-depth training and preparation to achieve the maximum use of the metaverse advantages and possibilities. Currently, very little is known about the effectiveness of remote mental health treatment, but it is certainly suggested that accessibility and the characteristics associated with the use of metaverse technologies may represent new horizons for accessibility and approach tools, as long as more studies are carried out and more evidence is collected to develop accurate guidelines, safe training, solve ethical concerns, and overcome limitations.","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"14 4","pages":"95064"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological adjuvants for diabetic vitrectomy surgery. 糖尿病玻璃体切除术的药物佐剂。

World journal of methodology Pub Date : 2024-12-20 DOI: 10.5662/wjm.v14.i4.92246

Ramesh Venkatesh, Chaitra Jayadev, Vishma Prabhu, Priyanka Gandhi, Rupal Kathare, Naresh K Yadav, Ayushi Choudhary, Jay Chhablani

{"title":"Pharmacological adjuvants for diabetic vitrectomy surgery.","authors":"Ramesh Venkatesh, Chaitra Jayadev, Vishma Prabhu, Priyanka Gandhi, Rupal Kathare, Naresh K Yadav, Ayushi Choudhary, Jay Chhablani","doi":"10.5662/wjm.v14.i4.92246","DOIUrl":"10.5662/wjm.v14.i4.92246","url":null,"abstract":"Diabetic vitrectomy is a highly intricate surgical procedure performed during the advanced stages of diabetic retinopathy (DR). It is used to treat conditions such as tractional or combined retinal detachment, vitreous hemorrhage, and subhyaloid hemorrhage, which are all severe manifestations of proliferative DR. The results of the surgery are uncertain and variable. Vitreoretinal surgery has made significant progress since the early stages of vitrectomy. In the past ten years, advancements in intravitreal pharmacotherapy have emerged, offering new possibilities to improve the surgical results for our patients. Within the realm of medical terminology, an \"adjunct\" refers to a pharmaceutical or substance employed to aid or expedite the primary therapeutic intervention for a particular ailment. Their introduction has broadened the range of therapeutic choices that are accessible prior to, during, and following surgical procedures. This review article will specifically analyze the pharmacological adjuncts used in diabetic vitrectomy surgery, with a focus on their role in facilitating or aiding specific steps of the procedure. The implementation of this system of categorization offers benefits to the surgeon by allowing them to foresee potential difficulties that may occur during the surgical procedure and to choose the appropriate pharmacological agent to effectively tackle these challenges, thus enhancing surgical success rates.","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"14 4","pages":"92246"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maintenance of stem cell self-renewal by sex chromosomal zinc-finger transcription factors. 性染色体锌指转录因子对干细胞自我更新的维持作用。

World journal of methodology Pub Date : 2024-12-20 DOI: 10.5662/wjm.v14.i4.97664

Katsuhiro Kita, Celine Morkos, Kathleen Nolan

{"title":"Maintenance of stem cell self-renewal by sex chromosomal zinc-finger transcription factors.","authors":"Katsuhiro Kita, Celine Morkos, Kathleen Nolan","doi":"10.5662/wjm.v14.i4.97664","DOIUrl":"10.5662/wjm.v14.i4.97664","url":null,"abstract":"In this Editorial review, we would like to focus on a very recent discovery showing the global autosomal gene regulation by Y- and inactivated X-chromosomal transcription factors, zinc finger gene on the Y chromosome (ZFY) and zinc finger protein X-linked (ZFX). ZFX and ZFY are both zinc-finger proteins that encode general transcription factors abundant in hematopoietic and embryonic stem cells. Although both proteins are homologs, interestingly, the regulation of self-renewal by these transcriptional factors is almost exclusive to ZFX. This fact implies that there are some differential roles between ZFX and ZFY in regulating the maintenance of self-renewal activity in stem cells. Besides the maintenance of stemness, ZFX overexpression or mutations may be linked to certain cancers. Although cancers and stem cells are double-edged swords, there is no study showing the link between ZFX activity and the telomere. Thus, stemness or cancers with ZFX may be linked to other molecules, such as Oct4, Sox2, Klf4, and others. Based on very recent studies and a few lines of evidence in the past decade, it appears that the ZFX is linked to the canonical Wnt signaling, which is one possible mechanism to explain the role of ZFX in the self-renewal of stem cells.","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"14 4","pages":"97664"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0