World journal of methodology最新文献

{"title":"Visualizing medicine: The case for implementing graphical abstracts in clinical reporting.","authors":"Naveen Jeyaraman, Madhan Jeyaraman, Swaminathan Ramasubramanian, Sangeetha Balaji, Arulkumar Nallakumarasamy","doi":"10.5662/wjm.v15.i2.95966","DOIUrl":"10.5662/wjm.v15.i2.95966","url":null,"abstract":"<p><p>Graphical abstracts (GAs) are emerging as a pivotal tool in medical literature, enhancing the dissemination and comprehension of complex clinical data through visual summaries. This editorial highlights the significant advantages of GAs, including improved clarity, increased reader engagement, and enhanced visibility of research findings. By transforming intricate scientific data into accessible visual formats, these abstracts facilitate quick and effective knowledge transfer, crucial in clinical decision-making and patient care. However, challenges such as potential data misrepresentation due to oversimplification, the skill gap in graphic design among researchers, and the lack of standardized creation guidelines pose barriers to their widespread adoption. Additionally, while software such as Adobe Illustrator, BioRender, and Canva are commonly employed to create these visuals, not all researchers may be proficient in their use. To address these issues, we recommend that academic journals establish clear guidelines and provide necessary design training to researchers. This proactive approach will ensure the creation of high-quality GAs, promote their standardization, and expand their use in clinical reporting, ultimately benefiting the medical community and improving healthcare outcomes.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"15 2","pages":"95966"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors for acute central retinal artery occlusion treated with hyperbaric oxygen: The Hong Kong study report number five.","authors":"Sunny Chi Lik Au, Steffi Shing Yee Chong","doi":"10.5662/wjm.v15.i2.96777","DOIUrl":"10.5662/wjm.v15.i2.96777","url":null,"abstract":"<p><strong>Background: </strong>Central retinal artery occlusion (CRAO) is a potentially blinding disease, and hyperbaric oxygen therapy (HBOT) is becoming increasingly popular with the support of scientific evidence. Despite the presence of various acute management measures, there is no clear evidence on the gold standard treatment for CRAO.</p><p><strong>Aim: </strong>To identify factors and imaging parameters associated with good visual outcome, which guide ophthalmologists in the triage of CRAO patients for HBOT.</p><p><strong>Methods: </strong>Patients who suffered from CRAO and had a symptom onset ≤ 6 h were recruited for a course of HBOT in a tertiary hospital after failing bedside treatment. Patient demographics, onset time, CRAO eye parameters, and past medical history were prospectively collected. Visual outcomes after HBOT were also analyzed.</p><p><strong>Results: </strong>A total of 26 patients were included; the female-to-male ratio was 1:1.6, and the mean age was 67.5 years ± 13.3 years (range 44-89 years). The mean duration of follow-up and mean visual acuity (VA) improvement were 10.0 mo ± 5.3 mo and 0.48 logarithm of minimal angle of resolution (logMAR) ± 0.57 logMAR (approximately 9 letters in ETDRS) (<i>P</i> = 0.0001, <i>Z</i> = -3.67), respectively. The 1 mm zone of central macular thickness (CMT) on optical coherence tomography was not associated with VA changes (<i>P</i> = 0.119); however, the 1-to-3 mm circular rim of CMT was fairly associated (<i>P</i> = 0.02, Spearman's coefficient = 0.45). Complete retinal perfusion time during fundus fluorescein angiography (FFA) was moderately associated (<i>P</i> = 0.01, Spearman's coefficient = 0.58) with visual outcome.</p><p><strong>Conclusion: </strong>A thinner 1-to-3 mm circular rim of CMT, but not the central 1 mm zone, is associated with better visual outcome. A shorter perfusion delay on FFA is also associated with better visual outcome.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"15 2","pages":"96777"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnification: The game changer in dentistry.","authors":"Sachin Chauhan, Radha Chauhan, Prashant Bhasin, Meenu Bhasin","doi":"10.5662/wjm.v15.i2.100937","DOIUrl":"10.5662/wjm.v15.i2.100937","url":null,"abstract":"<p><p>During dental examinations and treatments, many dentists are using magnification to improve their vision. The dental operating microscope serves as the most effective tool for this purpose, enhancing the quality, longevity, and outcome of clinical work. This review will explore the latest research and data on the importance of magnification devices in dentistry, including diagnostic methods, treatment options and ergonomics in specialities such as restorative dentistry, endodontics, pedodontics, periodontics, and prosthodontics. This review aims to provide insights into the optimal magnification for different clinical situations, the specific benefits of dental operating microscopes for each dental branch, and their limitations.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"15 2","pages":"100937"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Musculoskeletal disorders in nursing staff.","authors":"Agapi Kolovou, Asterios N Gkougkoulias, Nikolaos Stefanou, Elena Manuela Samaila, Maria Tsekoura, Marianna Vlychou, Charalampos Matzaroglou, Zoe H Dailiana","doi":"10.5662/wjm.v15.i2.98043","DOIUrl":"10.5662/wjm.v15.i2.98043","url":null,"abstract":"<p><p>Nursing staff provides patient care in an occupational environment that often imposes challenges that affect significantly the musculoskeletal system. Work-related musculoskeletal disorders are common in nursing stuff and have a negative impact in their professional and daily activities. In the current editorial, the duties of nursing staff, the types of musculoskeletal disorders, the predisposing factors (including factors related to professional tasks/ergonomics and to working schedules, psychological, social and individual factors) and their impact on working ability and quality of life nursing staff are summarized and preventive measures are proposed.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"15 2","pages":"98043"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticonvulsant potential of rosuvastatin in combination with carbamazepine and valproate in animal models of epilepsy.","authors":"Vandana Tayal, Akash Mandal, Ijasul Haque M, Akhilesh Mishra, Bhupinder S Kalra, Vandana Roy","doi":"10.5662/wjm.v15.i2.99580","DOIUrl":"10.5662/wjm.v15.i2.99580","url":null,"abstract":"<p><strong>Background: </strong>Epilepsy impacts millions of people, with many not responding to existing treatments. Some evidence links neuroinflammatory processes to epilepsy. Statins exhibit anti-inflammatory and neuroprotective properties, potentially offering antiepileptic effects.</p><p><strong>Aim: </strong>To evaluate the anticonvulsant effects of rosuvastatin in animal models of epilepsy.</p><p><strong>Methods: </strong>Ninety-six albino mice were divided into 16 groups. In the maximal electroshock seizure (MES) model, eight groups received intraperitoneal vehicle, carbamazepine, rosuvastatin, or a combination. Outcomes measured included seizure protection [tonic hind limb extension (THLE)], duration of THLE, seizure duration, and mortality. In the pentylenetetrazol (PTZ) model, eight groups were pretreated with vehicle, valproate, rosuvastatin, or a combination, with outcomes measured as seizure latency, seizure duration, and mortality.</p><p><strong>Results: </strong>In the MES model, rosuvastatin exhibited protection against THLE in a small percentage of mice. Rosuvastatin shortens the duration of THLE in a dose-dependent manner. However, none of these were statistically significant compared to the control group. The combination of rosuvastatin 10 mg/kg with carbamazepine 4 mg/kg resulted in a significant reduction in seizure duration compared to the control group, better than carbamazepine alone at 4 mg/kg and 6 mg/kg. In the PTZ model, rosuvastatin alone showed no significant effects on latency, duration of seizure, or mortality. However, rosuvastatin 10 mg/kg combined with valproate 100 mg/kg significantly delayed the onset of seizures, seizure duration and mortality percentage, better than valproate alone at 100 mg/kg.</p><p><strong>Conclusion: </strong>Rosuvastatin enhanced the anticonvulsant effects of carbamazepine and valproate. Further studies are required to explore the antiepileptic potential of rosuvastatin at various doses, durations, dosage forms, routes and models.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"15 2","pages":"99580"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the outcomes of diabetic vitrectomy with pharmacological adjuvants.","authors":"Chun-Yao Cheng, Wen-Rui Hao, Tzu-Hurng Cheng","doi":"10.5662/wjm.v15.i2.98912","DOIUrl":"10.5662/wjm.v15.i2.98912","url":null,"abstract":"<p><p>This editorial offers insights from a minireview by Venkatesh <i>et al</i>, who explored pharmacological adjuvants for diabetic vitrectomy. Specifically, they synthesized current knowledge and evaluated the efficacy of various adjunctive therapies in improving the outcomes of diabetic retinopathy and managing associated complications. Herein, we highlight the key roles of pharmacological adjuvants in optimizing surgical techniques, minimizing intraoperative challenges, and enhancing postoperative recovery. We further discuss the potential implications of this approach for clinical practice and future research directions in this evolving field. Overall, this editorial underscores the importance of incorporating pharmacological adjuvants into standard diabetic vitrectomy care to improve surgical outcomes and thus patients' quality of life.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"15 2","pages":"98912"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Wharton's jelly-derived stem cell therapy in autism: Insights from a case study.","authors":"Muzamil Akhtar, Abdulqadir J Nashwan","doi":"10.5662/wjm.v15.i2.100074","DOIUrl":"10.5662/wjm.v15.i2.100074","url":null,"abstract":"<p><p>Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder affecting over 2% of the global population, marked by social communication deficits and repetitive behaviors. Kabatas <i>et al</i> explored the efficacy and safety of Wharton's jelly-derived mesenchymal stem cell (WJ-MSC) therapy in a 4-year-old child with ASD. Using the childhood autism rating scale and Denver II developmental screening test, significant improvements were seen after six WJ-MSC sessions, with no adverse events over 2 years. Despite promising results, the study's single-case design limits generalizability. Larger, multi-center trials are needed to validate the findings and assess long-term effects of WJ-MSC therapy in ASD.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"15 2","pages":"100074"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategic insights of telehealth platforms and strengths, weaknesses, opportunities, and threats analysis of Amazon's clinical endeavors.","authors":"Harpreet Grewal, Gagandeep Dhillon, Venkata Buddhavarapu, Ram Kishun Verma, Ripudaman Singh Munjal, Pranjal Sharma, Gurmanpreet Sidhu, Rahul Kashyap, Salim Surani","doi":"10.5662/wjm.v15.i2.98513","DOIUrl":"10.5662/wjm.v15.i2.98513","url":null,"abstract":"<p><strong>Background: </strong>The adoption of telehealth services surged after the coronavirus disease 2019 pandemic, revolutionizing traditional healthcare delivery models. Amazon Clinic's recent nationwide launch marks a significant milestone in this trend. This study aims to offer a strengths, weaknesses, opportunities, and threats (SWOT) analysis of Amazon Clinic and compare its features with leading virtual healthcare platforms.</p><p><strong>Aim: </strong>To evaluate Amazon Clinic's telehealth services through a SWOT analysis and compare its features with other leading virtual healthcare platforms.</p><p><strong>Methods: </strong>The initial search terms included were, amazon clinic odds ratio (OR) amwell OR Teladoc OR Walmart virtual health service OR CVS minute clinic OR CirrusMD OR brightside health, from 2000 to 2023. This search yielded 111 articles, from which duplicates were removed, and unrelated titles were filtered out. Eight articles were retained for a final review, including comparative studies, usability research, retrospective analyses, observational studies, and review articles. The data was organized and analyzed using Rayyan software and summarized in a table and PRISMA flowcharts.</p><p><strong>Results: </strong>The review included eight articles focusing on various aspects of telehealth. Comparative studies highlighted differences between Teladoc and traditional physician offices, noting lower diagnostic imaging orders and antibiotic prescriptions for Teladoc. User demographics for Teladoc showed younger, less engaged patients. Usability studies emphasized the importance of website design for telemedicine adoption. Tele-mental health platforms like Brightside showed superior outcomes in treating depression compared to traditional methods. Telemedicine for specialized fields like skin reconstruction demonstrated cost efficiency and reduced waiting times. The SWOT analysis identified Amazon Clinic's strengths, such as its vast consumer base and transparent pricing, and weaknesses like the lack of pediatric care. Opportunities included potential partnerships and service expansions, while threats involved competition and regulatory challenges.</p><p><strong>Conclusion: </strong>Amazon Clinic's entry into the telehealth sector represents a significant development with various strengths and opportunities. However, it faces challenges from established healthcare providers and regulatory landscapes. The future success of Amazon Clinic will depend on strategic collaborations, addressing service gaps, and navigating competition and regulations. Telemedicine's impact will hinge on its ability to effectively leverage these opportunities and overcome inherent challenges in the ever-evolving healthcare landscape.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"15 2","pages":"98513"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunohistochemical expression of matrix metalloproteinase-9 and 13 in oral squamous cell carcinoma and their role in predicting lymph node metastasis.","authors":"Bhari Sharanesha Manjunatha, Keshav T Handge, Vandana Sandeep Shah, Yasser Eid Al-Thobaiti, Deepak Gowda Sadashivappa Pateel","doi":"10.5662/wjm.v15.i2.94514","DOIUrl":"10.5662/wjm.v15.i2.94514","url":null,"abstract":"<p><strong>Background: </strong>One of the main characteristics of oral squamous cell carcinoma (OSCC) is that it metastasizes to cervical lymph nodes frequently with a high degree of local invasiveness. A primary feature of malignant tumors is their penetration of neighboring tissues, such as lymphatic and blood arteries, due to the tumor cells' capacity to break down the extracellular matrix (ECM). Matrix metalloproteinases (MMPs) constitute a family of proteolytic enzymes that facilitate tissue remodeling and the degradation of the ECM. MMP-9 and MMP-13 belong to the group of extracellular matrix degrading enzymes and their expression has been studied in OSCC because of their specific functions. MMP-13, a collagenase family member, is thought to play an essential role in the MMP activation cascade by breaking down the fibrillar collagens, whereas MMP-9 is thought to accelerate the growth of tumors. Elevated MMP-13 expression has been associated with tumor behavior and patient prognosis in a number of malignant cases.</p><p><strong>Aim: </strong>To assess the immunohistochemical expression of MMP-9 and MMP-13 in OSCC.</p><p><strong>Methods: </strong>A total of 40 cases with histologically confirmed OSCC by incisional biopsy were included in this cross-sectional retrospective study. The protocols for both MMP-9 and MMP-13 immunohistochemical staining were performed according to the manufacturer's recommendations along with the normal gingival epithelium as a positive control. All the observations were recorded and Pearson's <i>χ</i>² test with Fisher exact test was used for statistical analysis.</p><p><strong>Results: </strong>Our study showed no significant correlation between MMP-9 and MMP-13 staining intensity and tumor size. The majority of the patients were in advanced TNM stages (III and IV), and showed intense expression of MMP-9 and MMP-13.</p><p><strong>Conclusion: </strong>The present study suggests that both MMP-9 and MMP-13 play an important and independent role in OSCC progression and invasiveness. Intense expression of MMP-9 and MMP-13, irrespective of histological grade of OSCC, correlates well with TNM stage. Consequently, it is evident that MMP-9 and MMP-13 are important for the invasiveness and progression of tumors. The findings may facilitate the development of new approaches for evaluating lymph node metastases and interventional therapy techniques, hence enhancing the prognosis of patients diagnosed with OSCC.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"15 2","pages":"94514"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing bone marrow harvesting sites for enhanced mesenchymal stem cell yield and efficacy in knee osteoarthritis treatment.","authors":"Arulkumar Nallakumarasamy, Sandeep Shrivastava, Ravi Velamoor Rangarajan, Naveen Jeyaraman, Avinash Gandi Devadas, Swaminathan Ramasubramanian, Madhan Jeyaraman","doi":"10.5662/wjm.v15.i2.101458","DOIUrl":"10.5662/wjm.v15.i2.101458","url":null,"abstract":"<p><p>Knee osteoarthritis (OA) is a debilitating condition with limited long-term treatment options. The therapeutic potential of mesenchymal stem cells (MSCs), particularly those derived from bone marrow aspirate concentrate, has garnered attention for cartilage repair in OA. While the iliac crest is the traditional site for bone marrow harvesting (BMH), associated morbidity has prompted the exploration of alternative sites such as the proximal tibia, distal femur, and proximal humerus. This paper reviews the impact of different harvesting sites on mesenchymal stem cell (MSC) yield, viability, and regenerative potential, emphasizing their relevance in knee OA treatment. The iliac crest consistently offers the highest MSC yield, but alternative sites within the surgical field of knee procedures offer comparable MSC characteristics with reduced morbidity. The integration of harvesting techniques into existing knee surgeries, such as total knee arthroplasty, provides a less invasive approach while maintaining therapeutic efficacy. However, variability in MSC yield from these alternative sites underscores the need for further research to standardize techniques and optimize clinical outcomes. Future directions include large-scale comparative studies, advanced characterization of MSCs, and the development of personalized harvesting strategies. Ultimately, the findings suggest that optimizing the site of BMH can significantly influence the quality of MSC-based therapies for knee OA, enhancing their clinical utility and patient outcomes.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"15 2","pages":"101458"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}