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Brucella melitensis Rev1Δwzm: Placental pathogenesis studies and safety in pregnant ewes. 布鲁氏菌 Rev1Δwzm：妊娠母羊的胎盘致病机理研究和安全性。
Vaccine Pub Date : 2024-05-15 DOI: 10.1016/j.vaccine.2024.04.085
Irati Poveda-Urkixo, Sara Mena-Bueno, Gustavo A Ramírez, Ana Zabalza-Baranguá, Renee M Tsolis, María-Jesús Grilló
{"title":"Brucella melitensis Rev1Δwzm: Placental pathogenesis studies and safety in pregnant ewes.","authors":"Irati Poveda-Urkixo, Sara Mena-Bueno, Gustavo A Ramírez, Ana Zabalza-Baranguá, Renee M Tsolis, María-Jesús Grilló","doi":"10.1016/j.vaccine.2024.04.085","DOIUrl":"https://doi.org/10.1016/j.vaccine.2024.04.085","url":null,"abstract":"<p><p>One of the main causes of human brucellosis is Brucella melitensis infecting small ruminants. To date, Rev1 is the only vaccine successfully used to control ovine and caprine brucellosis. However, it is pathogenic for pregnant animals, resulting in abortions and vaginal and milk shedding, as well as being infectious for humans. Therefore, there is an urgent need to develop an effective vaccine that is safer than Rev1. In efforts to further attenuate Rev1, we recently used wzm inactivation to generate a rough mutant (Rev1Δwzm) that retains a complete antigenic O-polysaccharide in the bacterial cytoplasm. The aim of the present study was to evaluate the placental pathogenicity of Rev1Δwzm in trophoblastic cells, throughout pregnancy in mice, and in ewes inoculated in different trimesters of pregnancy. This mutant was evaluated in comparison with the homologous 16MΔwzm derived from a virulent strain of B. melitensis and the naturally rough sheep pathogen B. ovis. Our results show that both wzm mutants triggered reduced cytotoxic, pro-apoptotic, and pro-inflammatory signaling in Bewo trophoblasts, as well as reduced relative expression of apoptosis genes. In mice, both wzm mutants produced infection but were rapidly cleared from the placenta, in which only Rev1Δwzm induced a low relative expression of pro-apoptotic and pro-inflammatory genes. In the 66 inoculated ewes, Rev1Δwzm was safe and immunogenic, displaying a transient serological interference in standard RBT but not CFT S-LPS tests; this serological response was minimized by conjunctival administration. In conclusion, these results support that B. melitensis Rev1Δwzm is a promising vaccine candidate for use in pregnant ewes and its efficacy against B. melitensis and B. ovis infections in sheep warrants further study.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interchangeability of different COVID-19 vaccine platforms as booster doses: A phase 3 study mimicking real-world practice 不同 COVID-19 疫苗平台作为加强剂量的互换性：模拟真实世界实践的 3 期研究
Vaccine Pub Date : 2024-05-01 DOI: 10.1016/j.vaccine.2024.05.009
Sue Ann Costa Clemens, Lily Weckx, Eveline P. Milan, Igor Smolenov, Ralf Clemens
{"title":"Interchangeability of different COVID-19 vaccine platforms as booster doses: A phase 3 study mimicking real-world practice","authors":"Sue Ann Costa Clemens, Lily Weckx, Eveline P. Milan, Igor Smolenov, Ralf Clemens","doi":"10.1016/j.vaccine.2024.05.009","DOIUrl":"https://doi.org/10.1016/j.vaccine.2024.05.009","url":null,"abstract":"","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141029375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of mRNA booster doses in preventing infections and hospitalizations due to SARS-CoV-2 and its dominant variant over time in Valencian healthcare workers, Spain. mRNA 强化剂量在预防西班牙巴伦西亚医护人员感染 SARS-CoV-2 及其显性变种并随时间推移住院治疗方面的效果。
Vaccine Pub Date : 2024-05-01 DOI: 10.1016/j.vaccine.2024.05.011
Natali Jiménez-Sepúlveda, Paula Gras-Valenti, P. Chico-Sánchez, José Miguel Castro-García, Elena Ronda-Pérez, H. Vanaclocha, S. Peiró, J. S. Burgos, Ana Berenguer, D. Navarro, José Sánchez-Payá
{"title":"Effectiveness of mRNA booster doses in preventing infections and hospitalizations due to SARS-CoV-2 and its dominant variant over time in Valencian healthcare workers, Spain.","authors":"Natali Jiménez-Sepúlveda, Paula Gras-Valenti, P. Chico-Sánchez, José Miguel Castro-García, Elena Ronda-Pérez, H. Vanaclocha, S. Peiró, J. S. Burgos, Ana Berenguer, D. Navarro, José Sánchez-Payá","doi":"10.1016/j.vaccine.2024.05.011","DOIUrl":"https://doi.org/10.1016/j.vaccine.2024.05.011","url":null,"abstract":"","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":"42 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141043647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative analysis of cholera serum vibriocidal antibodies from Convalescent and vaccinated adults in Zambia. 赞比亚霍乱痊愈者和接种过疫苗的成年人血清中杀弧菌抗体的比较分析。
Vaccine Pub Date : 2024-05-01 DOI: 10.1016/j.vaccine.2024.05.027
Harriet Ng’ombe, S. Bosomprah, Bernard Phiri, Mutinta Muchimba, Fraser Liswaniso, Mwelwa Chibuye, C. C. Luchen, Kennedy Chibesa, Kalo Musukuma-Chifulo, K. Mwape, Sekayi Tigere, Suwilanji Silwamba, Annel Sinkala, M. Simuyandi, Nyuma Mbewe, Fred Kapaya, Adam F Cunningham, R. Chilengi, David Sack, C. Chisenga
{"title":"Comparative analysis of cholera serum vibriocidal antibodies from Convalescent and vaccinated adults in Zambia.","authors":"Harriet Ng’ombe, S. Bosomprah, Bernard Phiri, Mutinta Muchimba, Fraser Liswaniso, Mwelwa Chibuye, C. C. Luchen, Kennedy Chibesa, Kalo Musukuma-Chifulo, K. Mwape, Sekayi Tigere, Suwilanji Silwamba, Annel Sinkala, M. Simuyandi, Nyuma Mbewe, Fred Kapaya, Adam F Cunningham, R. Chilengi, David Sack, C. Chisenga","doi":"10.1016/j.vaccine.2024.05.027","DOIUrl":"https://doi.org/10.1016/j.vaccine.2024.05.027","url":null,"abstract":"","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":"101 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141052336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
WITHDRAWN: PIRES2-EGFP/CTB-UreI vaccination activated a mixed Th1/Th2/Th17 immune system defense towards Helicobacter pylori infection in the BALB/c mice model. 在 BALB/c 小鼠模型中，接种 PIRES2-EGFP/CTB-UreI 疫苗可激活 Th1/Th2/Th17 混合免疫系统防御幽门螺旋杆菌感染。
Vaccine Pub Date : 2024-03-07 DOI: 10.1016/j.vaccine.2024.02.050
Sana Ghasemifar, Omid Chabak, Tohid Piri-Gharaghie, Abbas Doosti
{"title":"WITHDRAWN: PIRES2-EGFP/CTB-UreI vaccination activated a mixed Th1/Th2/Th17 immune system defense towards Helicobacter pylori infection in the BALB/c mice model.","authors":"Sana Ghasemifar, Omid Chabak, Tohid Piri-Gharaghie, Abbas Doosti","doi":"10.1016/j.vaccine.2024.02.050","DOIUrl":"10.1016/j.vaccine.2024.02.050","url":null,"abstract":"<p><p>This article has been withdrawn at the request of the Editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/policies/article-withdrawal. The data presented in the manuscript was deemed severely flawed after appearing online as an Article in Press. The scientific community raised concerns about the methodology (including but not limited to major technical issues) used in the study and the subsequent conclusions drawn from the presented experiments. After careful investigation, the Vaccine editorial office concluded that the data in the publication was indeed severely flawed and that the concerns raised by the scientific community were valid. Therefore, the journal editors decided to withdraw the article and sincerely apologize for any inconvenience caused.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":" ","pages":"125733"},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140061679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
WITHDRAWN: Behavioral abnormalities in young female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil. 撤销：接种铝佐剂和人类乳头瘤病毒 (HPV) 疫苗加卫苗后，年轻雌性小鼠出现行为异常。
Vaccine Pub Date : 2016-01-09 DOI: 10.1016/j.vaccine.2015.12.067
Rotem Inbar, Ronen Weiss, Lucija Tomljenovic, Maria-Teresa Arango, Yael Deri, Christopher A Shaw, Joab Chapman, Miri Blank, Yehuda Shoenfeld
{"title":"WITHDRAWN: Behavioral abnormalities in young female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil.","authors":"Rotem Inbar, Ronen Weiss, Lucija Tomljenovic, Maria-Teresa Arango, Yael Deri, Christopher A Shaw, Joab Chapman, Miri Blank, Yehuda Shoenfeld","doi":"10.1016/j.vaccine.2015.12.067","DOIUrl":"10.1016/j.vaccine.2015.12.067","url":null,"abstract":"<p><p>This article has been withdrawn at the request of the Editor-in-Chief due to serious concerns regarding the scientific soundness of the article. Review by the Editor-in-Chief and evaluation by outside experts, confirmed that the methodology is seriously flawed, and the claims that the article makes are unjustified. As an international peer-reviewed journal we believe it is our duty to withdraw the article from further circulation, and to notify the community of this issue. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139975280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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