Vaccine最新文献

{"title":"Exploring COVID-19 vaccination behavior: A cross-country study among pregnant and postpartum women in Brazil, Ghana, Kenya, and Pakistan.","authors":"Rupali J Limaye, Berhaun Fesshaye, Emily S Miller, Prachi Singh, Saleem Jessani, Muhammad Asim, Ferdinand Okwaro, Caroline Dinam Badzi, Emefa Modey Amoah, Renato T Souza, Maria Laura Costa, Sarah Saleem, Marleen Temmerman, Kwasi Torpey, Jose G Cecatti, Vanessa Brizuela, Jessica L Schue","doi":"10.1016/j.vaccine.2025.127478","DOIUrl":"10.1016/j.vaccine.2025.127478","url":null,"abstract":"<p><p>Pregnant women infected with SARS-CoV2 are more likely to be hospitalized and require ventilation, compared to non-pregnant women. Although the development of the COVID-19 vaccine was regarded as a scientific breakthrough among many, the pace of development in combination with delayed and unclear recommendations for maternal vaccination led to slower vaccine uptake among this population. We explored the decision-making process for COVID-19 vaccination among pregnant and postpartum women in four countries: Brazil, Ghana, Kenya, and Pakistan through 201 in-depth interviews. A grounded theory approach was used for analysis, and a socio-ecological framework was used to synthesize emerging themes. Four levels of influence on vaccine-related attitudes and behaviors were identified: individual, interpersonal, community, and policy. Risk perception and beliefs about vaccines safety were the primary individual-level factors identified. Risk perception of the disease was a common reason for vaccine acceptance, whereas lower risk perception emerged as a reason to not vaccinate. Vaccine safety concerns, for the pregnant woman herself, her pregnancy, and her baby were common across all countries. At the interpersonal level, the influence of the male partner and peers emerged across all countries. While participants identified the partner or spouse was most influential, they also discussed the limited impact the male partner had on decision-making, particularly in Ghana, Kenya, and Pakistan. At the community-level, healthcare providers helped in allaying vaccine safety concerns, and women looked to them for their health expertise and recommendations. At the policy-level, the requirement - real or perceived - of vaccination to access services, travel, work, and education was an important factor in all countries. Vaccine decision-making is complex, multi-faceted, and context-specific. When promoting vaccination among pregnant and postpartum women, engaging influential individuals can support the successful uptake of maternal vaccination.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":" ","pages":"127478"},"PeriodicalIF":3.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 vaccine attitudes and behaviors among pregnant women in Nairobi, Kenya with diverse socio-economic and educational backgrounds.","authors":"Jessica L Schue, Ferdinand Okwaro, Ingrid Gichere, Daizy Cherono, Mandeep Sura, Emily S Miller, Berhaun Fesshaye, Prachi Singh, Grace Belayneh, Rupali J Limaye, Marleen Temmerman","doi":"10.1016/j.vaccine.2025.127480","DOIUrl":"https://doi.org/10.1016/j.vaccine.2025.127480","url":null,"abstract":"<p><strong>Introduction: </strong>Pregnant women are at increased risk of severe manifestations of COVID-19, resulting in ICU admission, mechanical ventilation, and death compared to non-pregnant women. COVID-19 vaccines were approved for use in pregnant women in early 2022 by the World Health Organization, but permissive policies toward vaccine women differed by country. As education has been associated with vaccine uptake, this study sought to examine the association between socio-economic or educational status and vaccination behaviors, including reasons for vaccination or non-vaccination among pregnant women seeking health care services in Nairobi, Kenya.</p><p><strong>Methods: </strong>This study administered a survey to pregnant women at the two referral hospitals in Nairobi: Aga Khan University Hospital (AKUH) and Pumwani Maternity Hospital (PMH).</p><p><strong>Results: </strong>A total of 400 women took the survey. Pregnant women with college level education were more likely to have been vaccinated for COVID-19 compared to pregnant women without a college education. Women registered or visiting for pregnancy and delivery care from AKUH Kenya were also more likely to be vaccinated compared to women receiving care from PMH. Despite this difference in COVID-19 vaccine uptake, women from both the hospitals had similar reasons for receiving or refusing a COVID-19 vaccine. a Our findings align with previous studies that have showed that education status correlates positively with COVID-19 vaccination among pregnant women.</p><p><strong>Discussion: </strong>To improve maternal vaccination acceptance, education status can be used as a way to segment audiences to inform messaging and other demand generation efforts.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":" ","pages":"127480"},"PeriodicalIF":0.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engaging rural and non-Hispanic Black persons in conversations about the COVID-19 vaccine: a process evaluation of a natural helper intervention.","authors":"Robin E McGee, D'Jata A Barrett, Robert A Bednarczyk, Marian Grant-Whitlock, Michelle C Kegler, Kimberly R Jacob Arriola","doi":"10.1016/j.vaccine.2025.127587","DOIUrl":"10.1016/j.vaccine.2025.127587","url":null,"abstract":"<p><p>The COVID-19 pandemic heightened health inequities among historically marginalized groups. Community-based and culturally responsive interventions, like the Natural Helper (NH) model, leverage trusted community members to impart health related information. The VaxUP! intervention sought to reach non-Hispanic Black and rural people living in Southwest Georgia by deploying NHs to address vaccine hesitancy and support vaccination. We recruited and trained 31 NHs to engage with their community and to make vaccine appointments. As part of the process evaluation, tracking forms that included closed- and open-ended questions were analyzed to understand NH activities. NHs reached over 1950 people and booked over 600 vaccine appointments. Most encounters occurred over the telephone and through one-on-one interactions. During the interactions, NHs discussed many COVID-19 related topics and most frequently discussed vaccination benefits and COVID-19 information. Through this intervention, NHs were able to engage their community in conversations about the COVID-19 vaccine and book appointments.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":"60 Suppl 1 ","pages":"127587"},"PeriodicalIF":3.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing attitudes toward COVID-19 vaccine decision making among pregnant women in Pakistan.","authors":"Saleem Jessani, Muhammad Asim, Sarah Saleem, Sidrah Nausheen, Haleema Yasmeen, Jessica L Schue, Prachi Singh, Sami L Gottlieb, Rupali J Limaye","doi":"10.1016/j.vaccine.2025.127479","DOIUrl":"10.1016/j.vaccine.2025.127479","url":null,"abstract":"<p><strong>Background: </strong>Lower rates of COVID-19 vaccination among pregnant women prompt an investigation into the underlying reasons. This study aims to explore the attitudes of pregnant women in Pakistan regarding COVID-19 vaccination decision-making and to identify the factors influencing their vaccine uptake.</p><p><strong>Methods: </strong>A cross-sectional survey of pregnant women was conducted at two hospitals in Karachi in February-May 2024. The survey included a four-point Likert scale to evaluate 19 attitudes toward COVID-19 vaccination during pregnancy. These attitudes were later grouped into nine categories: disease risk perception, vaccine effectiveness, vaccine safety, general hesitancy (including concerns about vaccine ingredients), self-efficacy, social norms and family norms. Multivariable logistic regression was performed to identify attitudes associated with vaccine uptake.</p><p><strong>Results: </strong>Among the 400 women surveyed, 46 % (95 %CI: 41-51) reported being vaccinated against. COVID-19. Participants with higher COVID-19 risk perception were 5.71 times more likely to be vaccinated than their counterparts (95 %CI: 2.65-12.29). Those with higher self-efficacy and those who believed their friends or family had received or would receive the vaccine, had 2.28 (95 %CI: 1.08-4.65) times and 2.19 (95 %CI: 1.03-4.65) times higher odds of being vaccinated, respectively. The adjusted odds ratio for general vaccine hesitancy was 0.37 (95 %CI: 0.18-0.78), indicating that women with higher hesitancy were 63 % less likely to be vaccinated compared to those with lower hesitancy. Furthermore, women with less support from family regarding vaccine decision-making were 69 % less likely to be vaccinated than those who received more support.</p><p><strong>Conclusion: </strong>Attitudes associated with increased vaccination among pregnant women were higher COVID-19 risk perception, higher self-efficacy, and supportive social norms. In contrast, general vaccine hesitancy, and unsupportive family norms were significant barriers to vaccination during pregnancy. Targeted strategies are needed to address women's concerns about vaccine ingredients and promote supportive family influences, enhancing vaccine uptake in this important group.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":" ","pages":"127479"},"PeriodicalIF":3.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promotion of COVID-19 vaccination for youth and families in Worcester, Massachusetts: a Diffusion of Innovations approach.","authors":"Amy Borg, Melissa Goulding, Princilla Minkah, Domenica Perrone, Matilde Castiel, Milagros C Rosal, Stephenie C Lemon, Grace W Ryan","doi":"10.1016/j.vaccine.2025.127586","DOIUrl":"10.1016/j.vaccine.2025.127586","url":null,"abstract":"<p><strong>Introduction: </strong>Diffusion of innovations (DOI) theory can explain adoption of new technologies, like COVID-19 vaccines. We used an adapted version of DOI theory to guide efforts to adapt and implement evidence-based interventions to support COVID-19 vaccination for youth and families.</p><p><strong>Methods: </strong>Guided by community partner input, we triangulated data on infection and vaccination rates with qualitative focus group and interview data, and a synthesis of literature on evidence-based interventions for vaccine promotion to adapt interventions.</p><p><strong>Results: </strong>Implemented in three phases, we relied on trusted messengers to share vaccine narratives and tailored the degree of interaction between trusted messengers and adopters. We began broadly in the form of a community-wide communications campaign and progressively narrowed in focus towards direct engagement with trusted messengers.</p><p><strong>Discussion: </strong>DOI framework can be used to plan for and implement interventions as demonstrated by our two-year project to respond to the ever-evolving context of the COVID-19 pandemic.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":"60 Suppl 1 ","pages":"127586"},"PeriodicalIF":3.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing COVID-19 vaccine uptake among pregnant women in Greater Accra Region, Ghana.","authors":"Caroline Dinam Badzi, Emefa Modey, Amos Apreku, Chris Guure, Kwasi Torpey, Berhaun Fesshaye, Jessica Schue, Rupali Limaye","doi":"10.1016/j.vaccine.2025.127073","DOIUrl":"https://doi.org/10.1016/j.vaccine.2025.127073","url":null,"abstract":"<p><strong>Background: </strong>A number of vaccines were recommended by many countries for pregnant persons to reduce the risk associated with COVID 19 infection in pregnancy. Despite this potential of the vaccine, uptake remains challenging among pregnant women especially in low-income countries. Hence, this study assessed the influence of some factors on the uptake of COVID- 19 vaccine among pregnant women.</p><p><strong>Method: </strong>A structured tool which elicited information on participants' background, knowledge, attitude and the outcome of interest 'ever vaccinated for COVID-19' at any point in time were used to interview the pregnant women from three facilities in the Greater Accra Region, Ghana.</p><p><strong>Findings: </strong>A total of 401 pregnant women were recruited consecutively from all three facilities. Most of the women were between 25 and 34 years old (55.8 %), married (75.6 %), in their third trimester of pregnancy (41.4 %) and had attained junior or senior high school education (61.1 %). The frequency of COVID-19 vaccine uptake among participants was 41.9 %. Vaccination was higher among women with a college or university education (AOR = 3.35, 95 % CI = 1.48-7.54), older women aged 35-49 years (AOR = 1.82, 95 % CI = 0.90-3.66), and women who believed the COVID-19 vaccine in pregnancy will reduce their baby's risk (AOR = 3.02, 95 % CI = 1.37-6.63).</p><p><strong>Discussion: </strong>The study recommends the need for vaccination education campaign among pregnant women with more efforts targeted at those with low level of education and younger (below 35 years old).</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":" ","pages":"127073"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-year follow-up evaluation of approved Subolesin anti-tick vaccine in Uganda.","authors":"Paul D Kasaija, Fredrick Kabi, Jimmy Semakula, Ivan Kyakuwa, Marinela Contreras, Gabriela de la Fuente, Justus Rutaisire, Swidiq Mugerwa, Christian Gortázar, José de la Fuente","doi":"10.1016/j.vaccine.2024.126562","DOIUrl":"10.1016/j.vaccine.2024.126562","url":null,"abstract":"<p><p>After approval of the Subolesin-based anti-tick vaccine in Uganda, we completed a one-year follow-up evaluation study. The results showed significantly 2.1-5.0-fold higher anti-SUB IgG antibody titers in vaccinated cattle in Mbarara and Maruzi with vaccine effectiveness higher than 95 %. In Mbarara, total number of ticks were 0.8-fold lower in vaccinated cattle with a negative correlation tendency between anti-SUB antibody titers and tick counts. The CCHFV-seropositive cattle significantly decreased in 40 % in SUB-vaccinated animals with a significant positive correlation between CCHFV-seropositive cattle and the total number of ticks per animal and a negative correlation tendency between anti-SUB antibody titers and CCHFV-seropositive cattle. A boosting vaccine dose yearly after primary vaccination with three doses is sufficient to maintain protective antibody titers against ticks and tick-borne diseases affecting human and animal health. These results are relevant for implementation of anti-tick Subolesin-based vaccines in Uganda and other countries in Sub-Saharan Africa.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":"44 ","pages":"126562"},"PeriodicalIF":3.5,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 vaccine responses are influenced by distinct risk factors in naive and SARS-CoV-2 experienced hemodialysis recipients.","authors":"Nicolas Gemander, Delphine Kemlin, Stéphanie Depickère, Natasha S Kelkar, Shilpee Sharma, Pieter Pannus, Alexandra Waegemans, Véronique Olislagers, Daphnée Georges, Emilie Dhondt, Margarida Braga, Leo Heyndrickx, Johan Michiels, Anaïs Thiriard, Anne Lemy, Thomas Baudoux, Marylène Vandevenne, Maria E Goossens, André Matagne, Isabelle Desombere, Kevin K Ariën, Margaret E Ackerman, Alain Le Moine, Arnaud Marchant","doi":"10.1016/j.vaccine.2024.126544","DOIUrl":"10.1016/j.vaccine.2024.126544","url":null,"abstract":"<p><strong>Background: </strong>Clinical risk factors of deficient immune responses to COVID-19 mRNA vaccination in SARS-CoV-2 naive hemodialysis recipients (HDR) have already been identified. Clinical factors influencing hybrid immunity induced by SARS-CoV-2 infection and vaccination in HDR have not been reported.</p><p><strong>Methods: </strong>A comprehensive analysis of antibody (Ab) and T cell responses to two doses of BNT162b2 mRNA vaccination was performed in 103 HDR, including 75 SARS-CoV-2 naive and 28 experienced patients, and in 106 healthy controls (HC) not undergoing HD, including 40 SARS-CoV-2 naive and 66 experienced subjects. Clinical risk factors associated with lower humoral and cellular immunity were analyzed in SARS-CoV-2 naive and experienced HDR by univariate and multivariate analyses.</p><p><strong>Results: </strong>Naive HDR had lower neutralizing and non-neutralizing antibody responses to vaccination than naive HC; lower vaccine responses were correlated with previous transplantation, immunosuppressive treatment, corticosteroid treatment, hypoalbuminemia, older age, hypertension, and negative response to hepatitis B vaccination. In contrast, vaccine responses of SARS-CoV-2 experienced HDR were similar to those of HC and were correlated with time between infection and vaccination and with previous transplantation, but not with the other risk factors associated with lower vaccine responses in naive HDR.</p><p><strong>Conclusion: </strong>COVID-19 vaccine responses are influenced by distinct risk factors in SARS-CoV-2 naive and experienced HDR. These observations have important implications for the understanding of vaccine-induced immunity and for the management of this vulnerable patient population.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":"44 ","pages":"126544"},"PeriodicalIF":3.5,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating parental perceptions of respiratory syncytial virus (RSV) and attitudes to RSV vaccine in Jiangsu, China: Insights from a cross-section study.","authors":"Qiang Wang, Liuqing Yang, Lan Li, Shixin Xiu, Min Yang, Xuwen Wang, Yuan Shen, Weibing Wang, Leesa Lin","doi":"10.1016/j.vaccine.2024.126570","DOIUrl":"10.1016/j.vaccine.2024.126570","url":null,"abstract":"<p><strong>Introduction: </strong>Our study aimed to assess parents' perceptions of respiratory syncytial virus (RSV) and their attitudes towards the RSV vaccine in China.</p><p><strong>Method: </strong>The cross-section study was performed between August 21 and November 15, 2023, in Jiangsu province, eastern China. We collected socio-demographics, awareness, knowledge, perceptions of susceptibility and severity of RSV, and attitudes towards RSV vaccine using online survey questionnaire from parents of child aged ≤14 years old. The chi-square test and logistic regression model to explore the associated factors.</p><p><strong>Results: </strong>A total of 2135 participants were included. About 26.0 % indicated that they had never heard of RSV (556/2135) and were unaware that infants and young children are at a high risk of contracting RSV (557/2135). The proportion of parents with a child under 1 year of age who were unaware of RSV was notably higher than that of parents with children in other age groups. 42.9 % of parents (916/2135) showed low level of perceived susceptibility of contacting RSV infection for their child. 70.6 % of parents (1508/2135) expressed their willingness to vaccinate their child against RSV. The most common reason for refusing the RSV vaccine was \"Concern about vaccine's safety or side effects.\" 60.8 % of participants (1299/2135) considered a price of the RSV vaccine below 200 CNY (28 USD) as acceptable.</p><p><strong>Conclusion: </strong>The parents, particularly those with younger children, exhibited limited awareness and knowledge regarding RSV infection. Our study also showed the potential role of vaccine price as a barrier to the future use of RSV vaccine in China.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":"44 ","pages":"126570"},"PeriodicalIF":3.5,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudomonas aeruginosa elongation factor-Tu (EF-Tu) is an immunogenic protective protein antigen.","authors":"Dina A Moustafa, Emma Lou, Morgan E Schafer-Kestenman, Margalida Mateu-Borrás, Antonio Doménech-Sanchez, Sebastián Albertí, Joanna B Goldberg","doi":"10.1016/j.vaccine.2024.126476","DOIUrl":"10.1016/j.vaccine.2024.126476","url":null,"abstract":"<p><p>Pseudomonas aeruginosa is a Gram-negative, opportunistic pathogen that infects immunocompromised individuals, especially in the hospital setting. This bacterium is an important pathogen in people with weakened immune systems, injuries, and other underlying physiologic dysfunctions. P. aeruginosa is responsible for up to 20 % of all hospital-acquired pneumonias. It is one of the major causes of nosocomial infections and has been noted to be one of the most common bacteria co-infecting patients with COVID-19 or causing super-infections following COVID-19 infections. Despite improvements in antimicrobial therapy and hospital care, P. aeruginosa bacteremia and pneumonia remain fatal in about 30 % of cases. P. aeruginosa is also the leading cause of chronic life-threatening lung infections in cystic fibrosis patients. This bacterium is naturally antibiotic resistant, and infections are notoriously difficult to treat once established, with no vaccine available. We have previously shown that elongation factor-Tu (EF-Tu), a protein best known for its role in protein synthesis, is surface exposed on P. aeruginosa. As this protein is highly expressed, evolutionally conserved, and essential, we hypothesized it would make a good vaccine target. In this study, we found that P. aeruginosa EF-Tu is immunogenic in people, and that mice can develop an immune response following immunization with recombinant P. aeruginosa EF-Tu. Furthermore, immunized mice were protected from subsequent P. aeruginosa pneumonia and transfer of this vaccine antisera to naïve mice resulted in decreased colonization. Altogether these findings support the consideration of EF-Tu as a new vaccine candidate against P. aeruginosa.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":"42 26","pages":"126476"},"PeriodicalIF":3.5,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}