Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy最新文献

{"title":"Fear of COVID-19 and Multidimensional Health Literacy Among Patients on Hemodialysis: A Multicenter Cross-Sectional Study.","authors":"Atsuro Kawaji, Ryohei Inanaga, Mamiko Ukai, Tetsuro Aita, Yusuke Kanakubo, Takumi Toishi, Masatoshi Matsunami, Tatsunori Toida, Yu Munakata, Tadao Okada, Tomo Suzuki, Noriaki Kurita","doi":"10.1002/1744-9987.70156","DOIUrl":"10.1002/1744-9987.70156","url":null,"abstract":"<p><strong>Introduction: </strong>This multicenter cross-sectional study evaluated fear of COVID-19 after vaccination and the association between multidimensional health literacy (HL) and fear in patients undergoing hemodialysis.</p><p><strong>Methods: </strong>COVID-19 fear scores were compared with those of adults in April 2020 using an unpaired t-test. The association between multidimensional HL and COVID-19 fear scores was estimated using a multivariable-adjusted general linear model.</p><p><strong>Results: </strong>A total of 446 patients were analyzed, of whom 431 (97%) and 9 (2%) received three and two vaccination doses, respectively. Participants' COVID-19 fear scores were significantly lower than those of the general population at the beginning of the pandemic. Higher functional HL was associated with lower fear, whereas higher critical HL was associated with greater fear. Communicative HL was not associated with fear.</p><p><strong>Conclusion: </strong>Fear of COVID-19 among patients with low-functional HL could be reduced by providing health information in an easy-to-understand manner.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"613-621"},"PeriodicalIF":1.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147936688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red Blood Cell Exchange in Sickle Cell Disease Care: A Comprehensive Review.","authors":"Mahtab Mashayekhi, Mojtaba Akhtari, Akshat Jain, Nasim Salimiaghdam, Amir Abdipour","doi":"10.1002/1744-9987.70155","DOIUrl":"10.1002/1744-9987.70155","url":null,"abstract":"<p><p>Erythrocytaphoresis or RBC exchange (RBCX) is a key intervention in the management of sickle cell anemia for both chronic prophylaxis and emergent clinical care during sickle cell disease (SCD) emergencies. RBCX removes sickled RBCs while replacing them with donor RBCs and reducing hemoglobin S (HbS) levels. Unlike simple transfusion, it minimizes iron overload and avoids fluid overload, making it a mainstay for the management of acute stroke, acute chest syndrome, and other settings where fluid overload can complicate disease morbidity. Chronic RBCX has shown benefit in not only improving oxygenation and reducing hospitalization rates but also improving overall quality of life in SCD patients. Advances in apheresis technology and personalized transfusion have brought new opportunities for enhancement in safety, efficacy, and feasibility of this therapeutic modality. In this review, we explore the clinical efficacy and role of chronic RBC exchange and its long-term outcomes in managing complications of SCD.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"482-488"},"PeriodicalIF":1.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147877107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Dietary Attitudes in Hemodialysis Patients: A Mixed-Methods Study.","authors":"Serkan Budak, Yasemin Karacan, Rıdvan Bayram","doi":"10.1002/1744-9987.70203","DOIUrl":"https://doi.org/10.1002/1744-9987.70203","url":null,"abstract":"<p><strong>Background: </strong>Dietary attitudes are relevant to self-management in hemodialysis, but clinical associations alone cannot explain patients' experiences.</p><p><strong>Methods: </strong>This explanatory sequential mixed-methods study included 66 patients quantitatively and 18 purposively selected patients with lower dietary attitude scores qualitatively. Correlations were evaluated with false discovery rate correction, followed by exploratory adjusted multivariable linear regression. Qualitative data were analyzed thematically and integrated through a joint display.</p><p><strong>Results: </strong>The exploratory adjusted model accounted for 54.3% of the variance. Longer hemodialysis duration, comorbidity, higher blood urea nitrogen, and a higher triglyceride-to-high-density lipoprotein ratio were associated with lower dietary attitude scores, whereas higher ferritin was associated with higher scores. Among participants with lower ASDTHP scores, themes involved emotional, social, environmental, functional, and motivational experiences.</p><p><strong>Conclusion: </strong>Dietary attitudes were associated with clinical and psychosocial factors. The qualitative findings reflected participants with lower ASDTHP scores. Individualized multidisciplinary support may help address dietary self-management barriers.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148623582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Distraction: Embedding Digital Games in Mental-Health-Informed Hemodialysis Care.","authors":"Chi-Wei Ye, Lien-Chung Wei","doi":"10.1002/1744-9987.70204","DOIUrl":"https://doi.org/10.1002/1744-9987.70204","url":null,"abstract":"","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148623550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell Damage-Like Proteomic Signatures Distinguish Cell-Free and Concentrated Ascites Reinfusion Therapy (CART) Membranes in Malignant Ascites: A Mechanistic Study.","authors":"Masaki Nojima, Goh Murayama, Moeko Inoue, Takuya Urita, Sumio Ohtsuki, Takashi Hirayama, Akira Uchiyama, Yu Yamaji, Yukitomo Hagiwara, Takumi Saito, Taiga Kuga, Tomoko Miyashita, Makio Kusaoi, Yasuhisa Terao, Atsuo Itakura, Kenichi Ikejima, Naoto Tamura, Ken Yamaji","doi":"10.1002/1744-9987.70201","DOIUrl":"https://doi.org/10.1002/1744-9987.70201","url":null,"abstract":"<p><strong>Introduction: </strong>Cell-free and concentrated ascites reinfusion therapy (CART) alleviates the symptoms of malignant ascites but may trigger inflammation. We investigated why AHF-MO filter (A-A)-processed concentrates showed weaker bioactivity than EC20W filter (A-E)-processed concentrates.</p><p><strong>Methods: </strong>Ascites from three patients with ovarian cancer were processed into untreated ascites (UA), A-A, or A-E. Whole ascites, extracellular vesicles (EVs), and EV-depleted supernatants were injected intraperitoneally into mice. Serum cytokines were measured, and label-free proteomics was used to identify inflammatory pathways.</p><p><strong>Results: </strong>A-E induced the strongest proinflammatory and Th17/type I interferon responses compared to UA. A-A produced intermediate activation. EV-depleted A-E supernatants remained highly bioactive. A-E was enriched in proteins associated with cellular damage pathways and proinflammatory signaling. A-A exhibited attenuated changes and preserved regulatory proteins.</p><p><strong>Conclusion: </strong>A-A yields a more balanced inflammatory and proteomic profile than A-E. Our findings provide a preliminary mechanistic rationale for its use in CART and offer targets for membrane optimization.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148595237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Plasma Exchange for Acute and Acute-on-Chronic Liver Failure: A Randomized Pilot Study Comparing Standard- and High-Volume Protocols in a Resource-Limited Setting.","authors":"Amany Sholkamy, Ahmed Fayed, Sanaa A Khalil, Amr Osama Elsayed, Ahmad Mohamed Shenawy, Karim M Soliman, Rasha Ahmed Darwish","doi":"10.1002/1744-9987.70199","DOIUrl":"https://doi.org/10.1002/1744-9987.70199","url":null,"abstract":"<p><strong>Background: </strong>Acute liver failure (ALF) and acute-on-chronic liver failure (ACLF) carry substantial short-term mortality. While liver transplantation is the definitive therapy, access is often delayed in settings reliant on living-donor transplantation, such as Egypt. Therapeutic plasma exchange (TPE) has emerged as a potential bridging strategy, but evidence from resource-limited health systems remains scarce.</p><p><strong>Methods: </strong>We conducted a prospective randomized pilot study including 46 adults with ALF or ACLF at a tertiary center in Egypt. Participants were assigned to standard medical therapy (SMT; n = 15), standard-volume plasma exchange (SVPE; n = 16), or high-volume plasma exchange (HVPE; n = 15). SVPE involved exchange of 1.5-2.0 plasma volumes per session, whereas HVPE delivered 8-12 L/day for 3 consecutive days. All patients received guideline-based SMT. Changes in alanine aminotransferase (ALT), total bilirubin, international normalized ratio (INR), and MELD-Na score were evaluated alongside procedure-related complications and 90-day mortality.</p><p><strong>Results: </strong>Both TPE strategies produced greater improvements in ALT, total bilirubin, INR, and MELD-Na compared with SMT alone. HVPE achieved the largest reduction in MELD-Na but was associated with higher rates of catheter-related infection and neurological complications. SVPE demonstrated a more favorable safety-effectiveness profile. Ninety-day mortality was highest with SMT and lower in both TPE groups.</p><p><strong>Conclusions: </strong>In a resource-limited tertiary setting, protocolized TPE is feasible and may improve short-term outcomes in ALF and ACLF. SVPE may represent a safer and more scalable bridging strategy when immediate access to liver transplantation is limited.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148595276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on \"Clinical Value of Serum Procalcitonin in the Early Diagnosis of Peritoneal Dialysis-Associated Gram-Negative Bacterial Peritonitis\".","authors":"Mohammad Barary, Mehran Shokri, Soheil Ebrahimpour","doi":"10.1002/1744-9987.70202","DOIUrl":"https://doi.org/10.1002/1744-9987.70202","url":null,"abstract":"","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthopedic Surgery as a Risk Factor for Extracorporeal Circuit Coagulation in Patients on Hemodialysis: A Retrospective Observational Study.","authors":"Yuki Nakamura, Arata Osanami, Keitaro Nishizawa, Yuzuki Okada, Shun Tsugawa, Satoru Enami, Makoto Terasawa, Kota Endo, Yufu Gocho, Shingo Muratsubaki, Marenao Tanaka, Masato Furuhashi","doi":"10.1002/1744-9987.70195","DOIUrl":"https://doi.org/10.1002/1744-9987.70195","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to investigate the clinical background associated with extracorporeal circuit coagulation (ECC) with a specific focus on the impact of orthopedic surgery.</p><p><strong>Methods: </strong>A single-center retrospective observational study of 290 hospitalized adult hemodialysis patients (men/women: 204/86, median age: 70 years) was included. Univariate and multivariate negative binomial regression analyses were performed to identify factors associated with ECC.</p><p><strong>Results: </strong>Twenty-five ECC events were observed in a total of 20 (6.8%) patients (men/women: 14/6). In univariate negative binomial regression analysis, orthopedic surgery was significantly associated with ECC (incidence rate ratio, 4.16; 95% confidence interval, 1.68-10.0, p = 0.001). In multivariate analysis, the performance of orthopedic surgery emerged as a potent and independent factor for an increased frequency of ECC.</p><p><strong>Conclusion: </strong>Orthopedic surgery is significantly associated with an increased frequency of ECC. This finding highlights the importance of considering orthopedic surgery as a potential clinical factor for ECC in perioperative hemodialysis management.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148551958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross-Sectional Study.","authors":"Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito","doi":"10.1002/1744-9987.70196","DOIUrl":"https://doi.org/10.1002/1744-9987.70196","url":null,"abstract":"<p><strong>Introduction: </strong>Peritoneal dialysis (PD) is an established home-based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.</p><p><strong>Methods: </strong>In this retrospective cross-sectional study, 175 patients who initiated maintenance hemodialysis or PD between April 2021 and September 2024 were classified by attendance at a dedicated KRT modality selection clinic. Logistic regression and propensity score matching were performed.</p><p><strong>Results: </strong>Among 175 patients, 40 attended the clinic. PD was initiated in 35.0% of attendees compared with 10.4% of nonattendees. Clinic attendance was independently associated with PD initiation (adjusted odds ratio, 4.51; 95% confidence interval, 1.89-10.77; p < 0.001), and this association remained significant after matching.</p><p><strong>Conclusions: </strong>Individualized education in a dedicated outpatient clinic was associated with a higher likelihood of PD initiation.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148475139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intradialytic Exercise Training Versus Cognitive Training to Reduce Sedentary Behavior in Patients Undergoing Hemodialysis: A Pilot Study.","authors":"Kohji Iwai, Tomoharu Okubo, Takahiro Okumura, Wataru Hachiya","doi":"10.1002/1744-9987.70193","DOIUrl":"https://doi.org/10.1002/1744-9987.70193","url":null,"abstract":"<p><strong>Introduction: </strong>Reduced physical activity and prolonged sedentary behavior (SB) are associated with poor prognosis in patients undergoing hemodialysis. Although intradialytic exercise training (IET) is increasingly implemented, its effect on SB remains unclear. This study compared the effects of IET and cognitive training on SB.</p><p><strong>Methods: </strong>In this multicenter pilot crossover study, patients aged 70-80 years undergoing maintenance hemodialysis completed 12 weeks of IET and 12 weeks of intradialytic cognitive training, separated by a 2-week washout period. Sedentary time (≤ 1.5 METs) and step counts were assessed using an accelerometer before and after each intervention.</p><p><strong>Results: </strong>Nine participants completed the study. IET significantly reduced SB on all days and non-dialysis days (p = 0.02), whereas cognitive training showed no significant change. Reductions were significantly greater following IET. Step counts did not change.</p><p><strong>Conclusion: </strong>IET reduced SB, whereas cognitive training did not, suggesting its clinical relevance in dialysis care.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148458268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}