The journals of gerontology. Series A, Biological sciences and medical sciences最新文献

{"title":"Cell-based screen identifies translation state modulators that extend lifespan in Drosophila melanogaster and Caenorhabditis elegans.","authors":"Binbin Wu, Li-Jie Wang, Adwait A Godbole, Ji Heon Han, Erin S Keebaugh, Gisselle Chavez, Christine A Sedore, Anna L Coleman-Hulbert, Erik Johnson, Patrick C Phillips, Gordon J Lithgow, Monica Driscoll, Matthew S Gill, William W Ja","doi":"10.1093/gerona/glag165","DOIUrl":"10.1093/gerona/glag165","url":null,"abstract":"<p><p>Aging is associated with declining mitochondrial function and translational regulation-processes modulated by interventions such as dietary restriction (DR) and cold-induced longevity (CHIL). Both DR and CHIL inhibit global protein synthesis but selectively enhance translation of proteins that support mitochondrial efficiency, stress resistance, and lifespan extension. These translational shifts are mediated, at least in part, by the 4E-BP/eIF4E pathway, which regulates translation according to mRNA 5'-untranslated region (5'-UTR) length and structure. To identify compounds that mimic the beneficial effects of DR/CHIL, we developed a cell-based phenotypic screen that reports on mRNA translation as a function of 5'-UTR length. A pilot screen identified compounds that preferentially increased the expression of mRNAs with short 5'-UTRs relative to those with long 5'-UTRs, and these hits were enriched for known lifespan-extending agents, such as curcumin and rapamycin. Among the novel candidates, fluspirilene significantly extended life in both Drosophila melanogaster and Caenorhabditis elegans, and mitigated age-related locomotor decline in female flies. Fluspirilene-mediated longevity in C. elegans required the DAF-16/FOXO and HLH-30/TFEB transcription factors and the autophagy gene, atg-18. Fluspirilene failed to extend lifespan in two other Caenorhabditis species, as well as in flies maintained on a high-yeast diet, indicating that its pro-longevity effects are constrained by evolutionary divergence and nutrient status. Together, our findings identify fluspirilene as a novel modulator of translation that extends life and preserves healthspan via an autophagy-dependent mechanism and support the promise of drug discovery efforts that modulate translation state as a therapeutic strategy for healthy aging.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13346107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148284933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the relevance of gait speed resiliencies to different stressors: the ARIC Study.","authors":"B Gwen Windham, Hunter C Sylvester, James Henegan, Matthew McMullan, Anna Kucharska-Newton, Priya Palta, Jennifer A Schrack, Thomas H Mosley, Karen Bandeen-Roche, Michael E Griswold","doi":"10.1093/gerona/glag129","DOIUrl":"10.1093/gerona/glag129","url":null,"abstract":"<p><strong>Background: </strong>Different stressors may impact physical resilience differently (resiliencies). Objective metrics assessing different stressors' \"relevance\" on associated resiliencies are lacking. We propose an approach for defining relevance metrics and potential moderating effects of sex and mortality on gait speed resiliencies.</p><p><strong>Methods: </strong>Among 1559 ARIC participants (age 66-80 years) with \"good\" gait speed (≥1 m/s), 864 (55%) maintained good gait speed at follow-up (mean 6.5 years). Gait speed resiliencies were defined using 11 intermediary stressors (stroke, cancer, depression, etc.). Each stressor's relevance was examined using Relative Ratios (RRs, 95% CI), comparing the prevalence of maintaining good gait speed among those experiencing the stressor (resilience) against the prevalence among those without the stressor, adjusting for demographics and body mass index. Mortality effects and sex differences were examined.</p><p><strong>Results: </strong>Stressor relevance varied from greatest (self-reported poor health: RR = 0.41, [95% CI, 0.26, 0.65], 59% reduction in maintaining good gait speed), to least influential (poor social support RR = 1.02 [0.89, 1.18]), with 6/11 stressors supported as relevant. Mortality and sex-differences were present; an intermediary fall was more relevant for women, where maintaining good speed versus dying was 76% less likely after a fall, RRWomen = 0.24 (0.12, 0.50), compared to men, RRMen = 0.75 (0.39, 1.44), yielding a 67% lower chance of women having good speed versus dying after a fall than men, relevance RR-ratio = (RRWomen/RRMen) = 0.33 (0.12, 0.86).</p><p><strong>Conclusions: </strong>Studies of physical resilience should use objective metrics to examine the relevance/importance of different combinations of stressors and functional outcomes when defining physical resiliencies. The relevance of gait speed resiliencies can vary by stressors, mortality inclusion in resiliencies, and sex.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13403272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High frailty index scores predict mortality and changes in blood-based biomarkers in aging female mice.","authors":"Elise S Bisset, Shashi Gujar, Kenneth Rockwood, Susan E Howlett","doi":"10.1093/gerona/glag158","DOIUrl":"10.1093/gerona/glag158","url":null,"abstract":"<p><p>Variability in aging rates can be quantified with a frailty index (FI) based on the accumulation of clinically evident health deficits in aging mice. Deficit accumulation characteristics have been investigated in longitudinal studies of male but not female mice. We investigated frailty longitudinally in aging female C57BL/6N mice (n = 79; 6-29 months) and determined whether high frailty scores predicted mortality and abnormalities in blood-based biomarkers. Female mice exhibited a gradual rate of deficit accumulation (slope = 0.025) as previously observed in males. High FI scores (>0.20 at 18 months) predicted mortality during follow-up at 24 months and older (p = .015). The range of FI scores broadened with age, with a submaximal limit to frailty of 0.55, similar to values in males. Few correlations were significant between blood-based biomarkers and chronological age in female mice, with only urea (r = 0.39; p = .006) and creatinine (r = 0.35; p = .01) levels exhibiting positive correlations with age. By contrast, many biomarkers were closely graded by the degree of frailty in females. Urea (r = 0.46, p = .001), creatinine (r = 0.35; p = .01), and chloride (r = 0.49; p = .001) were all positively associated with FI scores whereas glucose (r = -0.63; p = .001), hematocrit (r = -0.53; p = .001), and hemoglobin (r = -0.45; p = .002) were negatively correlated. Interestingly, in a small cohort of aging male mice (n = 15; aged 13-27 months), no biomarkers significantly correlated with age, despite many being correlated with frailty. Characteristic features of deficit accumulation are present in female mice. High FI scores based on the accumulation of clinically evident health deficits forecast early mortality and predict abnormalities in blood-based biomarkers better than chronological age.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13342712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing matters: denture use for cognitive protection is most effective before major tooth loss.","authors":"Ruotong Zhang, Xiaochen Liu","doi":"10.1093/gerona/glag162","DOIUrl":"10.1093/gerona/glag162","url":null,"abstract":"<p><strong>Background: </strong>Tooth loss is a potential risk factor for cognitive decline, but the longitudinal evidence on the protective role of dentures and the intervention timing remains limited. This study aimed to investigate the associations of tooth loss, denture use, and their changes with distinct cognitive trajectories among older adults.</p><p><strong>Methods: </strong>We conducted a prospective cohort study of 2188 community-dwelling older adults from the Chinese Longitudinal Healthy Longevity Survey (2008-2014). Group-based trajectory modeling (GBTM) identified heterogeneous cognitive pathways. Multinomial logistic regression was used to estimate risk ratios (RRs) for the associations of baseline tooth number, denture use, and longitudinal tooth loss with cognitive trajectory membership.</p><p><strong>Results: </strong>GBTM identified 2 cognitive trajectories: maintained-high (57.4%) and low-declining (42.6%). Baseline tooth loss (0-4 vs. ≥21 teeth: RR = 1.20, 95% confidence interval [CI]: 1.02-1.41) and progression to having 0-4 teeth (RR = 1.76, 95% CI: 1.55-2.00) significantly increased the risk of the low-declining trajectory. Denture use was associated with a 13% lower risk (RR = 0.87, 95% CI: 0.78-0.96). Critically, a gradient effect was observed: the protective association was strongest in participants with ≥21 teeth (RR = 0.27, 95% CI: 0.08-0.86, corresponding to a 73% risk reduction) but attenuated with greater tooth loss.</p><p><strong>Conclusions: </strong>Tooth loss is a significant risk factor for adverse cognitive trajectories, while denture use is associated with a mitigated risk. The effectiveness of dentures is highly dependent on timing, with the greatest cognitive benefit achieved when used early, before major tooth loss occurs. These findings underscore the importance of timely prosthodontic intervention as a potential strategy for cognitive preservation in older adults.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148284931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Application of Claims-based Frailty Index to a Structured Electronic Health Record Data.","authors":"","doi":"10.1093/gerona/glag184","DOIUrl":"10.1093/gerona/glag184","url":null,"abstract":"","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":"81 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148623597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validating ICD code case definitions for condition case ascertainment in multimorbidity measurement: a retrospective chart review.","authors":"Ashley J Kang, Chi-Hong Tseng, Melissa Y Wei","doi":"10.1093/gerona/glag157","DOIUrl":"10.1093/gerona/glag157","url":null,"abstract":"<p><strong>Background: </strong>Accurate case ascertainment of chronic conditions is critical for research, clinical decision-making, and population health management, especially for older adults with high multimorbidity. However, validation of International Classification of Diseases (ICD)-based case definitions in the electronic health record (EHR) data remains limited. We sought to determine whether a single ICD code is sufficient for accurate identification of chronic conditions in the EHR, or whether multiple codes improve validity.</p><p><strong>Methods: </strong>Population-based retrospective chart review, 2013-2019, at large academic tertiary and quaternary care health system. Our sample included adults aged ≥18 years with ≥2 encounters within a 2-year period. We conducted gold-standard chart review to determine validity of using ≥1 or ≥2 ICD codes to identify 23 chronic conditions included in the validated multimorbidity-weighted index, specifically those lacking robust case definitions in EHR data. Validation statistics included positive predictive value (PPV), negative predictive value, Cohen's kappa, sensitivity, specificity, and percent sample size loss associated with stricter ≥2 ICD code case definitions.</p><p><strong>Results: </strong>The final analytic sample included 780 873 adults (mean [SD] age 47.7 [18.0] years, 56.9% female). For 22 of 23 conditions, use of ≥1 ICD code yielded a PPV ≥0.70. Requiring ≥2 ICD codes yielded minimal improvement in PPV but with substantial sample size loss that ranged from 16.8% to 64.5%.</p><p><strong>Conclusions: </strong>At least one ICD code was sufficient to accurately identify most chronic conditions with high accuracy in the EHR over a multi-year timeframe. However, condition-specific validation remains essential, as performance varies by condition.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13372667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An appropriate ASMI cutoff value enhances utilization of the CHARLS database for studying sarcopenia.","authors":"Li An, Wei Gao, Liqun Ren, Jing Wang, Yao Wang","doi":"10.1093/gerona/glag160","DOIUrl":"10.1093/gerona/glag160","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia research based on the China Health and Retirement Longitudinal Study (CHARLS) frequently employs an anthropometric equation to estimate appendicular skeletal muscle mass (ASM). Liu et al. recently questioned the reliability of this equation. We aimed to validate the equation against bioelectrical impedance analysis (BIA) measurements and to examine the impact of different cutoff values for low muscle mass used in CHARLS-based studies.</p><p><strong>Methods: </strong>We retrospectively analyzed BIA data from 548 diabetic patients (age range 23-90 years, median 62 years; 41.06% women). ASM measured by BIA (bASM) was compared with ASM calculated by the equation (cASM). Spearman correlation, intraclass correlation coefficient (ICC), and Bland‑Altman analysis were performed. Two commonly used height‑adjusted ASM (ASM/Ht2) cutoff sets were tested against the AWGS 2019 reference standard.</p><p><strong>Results: </strong>cASM correlated strongly with bASM (r = 0.94, p < .001). ICC demonstrated excellent agreement (0.933; 95% CI 0.919-0.945). Bland‑Altman plots showed acceptable limits of agreement. One cutoff set (men 7.05, women 5.63 kg/m2) showed almost perfect agreement with AWGS 2019 (Kappa = 0.909, McNemar p = 1.000), whereas the other set (men 6.79, women 4.90 kg/m2) showed only moderate agreement (Kappa = 0.492) and a significant level of discordance (McNemar p < .001).</p><p><strong>Conclusion: </strong>The ASM estimation equation remains valid for CHARLS-based sarcopenia research, including in diabetic populations. To avoid misclassification and ensure cross-study comparability, we recommend using AWGS 2019-aligned cutoffs.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148255271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of huntingtin-polyQ aggregation by glucose transporters and saccharide-binding receptors during aging in Drosophila.","authors":"Mamta Rai, Zane Coleman, Michelle Curley, Fabio Demontis","doi":"10.1093/gerona/glag153","DOIUrl":"10.1093/gerona/glag153","url":null,"abstract":"<p><p>Saccharides and responsive signaling pathways are important regulators of physiological and pathological processes. Saccharides can exert these functions via dedicated intracellular transporters and through binding to cellular sensors, such as saccharide-binding receptors. Glucose homeostasis and saccharide signaling are emerging as important regulators of neurodegeneration. Here, we utilized a Drosophila model of Huntington's disease to examine the role of Glut1 (homologous to multiple human glucose transporters) and saccharide-binding receptors. We find that Glut1 knockdown increases the amount of huntingtin-polyQ protein aggregates during aging, whereas Glut1 upregulation has converse effects. RNAi screening identifies several saccharide-binding receptors that either increase or decrease the levels of huntingtin-polyQ protein aggregates. In particular, pathogenic polyglutamine aggregates are reduced by knockdown of the lectin domain-containing G-protein coupled receptor Cirl (Calcium-independent receptor for α-latrotoxin), orthologous to human ADGRL1 and ADGRL2. These findings indicate that glucose transporters and saccharide-binding receptors regulate proteostasis and neurodegeneration during aging.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of inactivation of the USP19 deubiquitinase gene in mice on important phenotypes of aging.","authors":"Kai Sheng, Erin S Coyne, Nathalie Bédard, Emilie Lu, David Goltzman, Lisbet Haglund, Simon S Wing","doi":"10.1093/gerona/glag138","DOIUrl":"10.1093/gerona/glag138","url":null,"abstract":"<p><p>Aging is associated with many chronic conditions that increase morbidity and mortality. These include obesity, diabetes, sarcopenia, osteoporosis, and neurodegeneration. The deubiquitinase USP19 is involved in many of these disorders suggesting that it may modulate common mechanism(s) that impact the aging process. Inactivation of USP19 is protective against muscle atrophy, obesity, and diabetes in young adult mice. Whether such protection persists in older adult mice remains unknown. In addition, the potential role of USP19 in osteoporosis remains unexplored. Here, we demonstrate that loss of USP19 is protective against loss of muscle mass and obesity in mice aged 22-24 months. Glucose tolerance was also improved in these older adult USP19 KO mice, but only in females. Bone mineral content was decreased in the USP19 KO bone, more evidently in cortical bone than in trabecular bone and only in males. This was associated with a reduced work-to-failure in the KO femurs. Osteoblasts derived from USP19 KO bone marrow cells demonstrated decreased ex-vivo mineralization compared to WT cells and the KO marrow cells showed enhanced differentiation into TRAP-positive multinucleated osteoclasts. These findings identify important potential benefits as well as risks of therapeutic targeting of USP19 for the prevention or treatment of key aging related disorders.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13341015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148145761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MedADL: high-throughput information extraction of functional status from electronic health records to advance frailty assessment in older adults.","authors":"Sunyang Fu, Zhiyi Yue, Jennyly T Nguyen, Huipeng Liu, Jaerong Ahn, Vanessa Ramirez, Jude Des Bordes, Hongfang Liu, Min Ji Kwak, Nahid J Rianon","doi":"10.1093/gerona/glag154","DOIUrl":"10.1093/gerona/glag154","url":null,"abstract":"<p><strong>Background: </strong>Functional status is essential for assessing frailty and planning care in older adults but is often under-documented in the structured fields of electronic health records. Manual chart review can capture functional status information but is labor-intensive and time-consuming. In this study, we developed and validated a scalable natural language processing (NLP) model to extract functional status information from unstructured electronic health record (EHR) notes.</p><p><strong>Methods: </strong>This retrospective cohort study included 110 older adults seen at a geriatric osteoporosis clinic. A large language model-augmented symbolic NLP pipeline (MedADL) was developed to extract activities of daily living (ADL) and instrumental activities of daily living (IADL) impairments from 13 182 clinical notes and derive the Cumulative Functional Burden Index (CFBI), validated against grip strength, walking speed, balance score, and frailty status using ordinal logistic regression with 10-fold cross-validation.</p><p><strong>Results: </strong>The NLP model demonstrated moderate to strong performance across 16 ADL and IADL categories, with an average precision of 0.868, sensitivity of 0.828, specificity of 0.937, and F1 score of 0.816. CFBI was significantly associated with frailty status (odds ratio [OR] = 0.799, reciprocal OR = 1.25, p = .049, AUC (Area Under the Curve) = 0.66), indicating that each additional functional deficit was associated with approximately 25% higher odds of being classified in a less robust frailty category. CFBI was correlated with walking speed (r = 0.43, p < .001), balance (r = -0.42, p < .001), grip strength (r = -0.24, p = .019), and fall history (r = 0.21, p = .040).</p><p><strong>Conclusion: </strong>MedADL demonstrated moderate-to-strong performance across 16 bADL and iADL categories, and the derived CFBI was significantly associated with frailty status and correlated with 4 objective physical performance measures. Future studies will prospectively evaluate long-term outcomes and integrate the model into the EHR to enable real-time clinical decision support.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13354602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148214174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}