The journals of gerontology. Series A, Biological sciences and medical sciences最新文献

{"title":"Associations of periodontitis with biological aging among US adults: An exploratory mediation analysis via lactate.","authors":"Huan Zhou, Yong Li, Di Miao, Jiayu Zhang, Lisa Yang, An Li, Ruoyan Cao","doi":"10.1093/gerona/glaf061","DOIUrl":"https://doi.org/10.1093/gerona/glaf061","url":null,"abstract":"<p><strong>Background: </strong>To investigate the potential role of lactate in the relationship between periodontitis and biological aging.</p><p><strong>Methods: </strong>Cross-sectional data from 9,652 participants in the National Health and Nutrition Examination Survey 2009-2014 were analyzed. Periodontitis was categorized based on the Centers for Disease Control and Prevention and American Academy of Periodontology (CDC/AAP) classification. Biological aging was assessed based on KDM-BA acceleration and PhenoAge acceleration, while lactate levels were assessed using lactate dehydrogenase (LDH). Weighted multivariable linear regression analyses were conducted to examine the association between periodontitis and biological aging. Additionally, exploratory mediation analyses were carried out to determine the mediating effect of LDH on this association.</p><p><strong>Results: </strong>Participants with moderate/severe periodontitis showed accelerated biological aging and higher serum LDH levels. Similarly, mean attachment loss (AL) and probing pocket depth (PPD) were positively associated with biological aging and serum LDH levels. Furthermore, serum LDH was found to mediate 8.4% and 3.8% of the associations between periodontitis and KDM-BA acceleration and PhenoAge acceleration, respectively. LDH also explained 11.0% and 4.4% of the association between mean PPD and KDM-BA acceleration and PhenoAge acceleration, respectively. However, the role of LDH in the relationship between mean AL and biological aging was not observed.</p><p><strong>Conclusion: </strong>These findings indicate that LDH, an enzyme that converts pyruvate to lactate, mediates the association between periodontitis and biological aging. However, additional longitudinal or interventional studies are needed to more effectively assess causality and confirm our findings.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mito-Modulatory Medication Use and Skeletal Muscle Bioenergetics Among Older Men and Women: the Study of Muscle, Mobility and Aging.","authors":"Howard J Phang, Jaclyn Bergstrom, Rabia S Atayee, Laura A Hart, Peggy M Cawthon, Terri Blackwell, Philip A Kramer, Giovanna Distefano, Erin E Kershaw, Steven R Cummings, Anthony J A Molina","doi":"10.1093/gerona/glaf063","DOIUrl":"https://doi.org/10.1093/gerona/glaf063","url":null,"abstract":"<p><strong>Background: </strong>The potential impacts of drug-induced modulation of mitochondrial function in humans remain unclear despite the high prevalence of \"mito-modulatory\" medication use among older adults. While these medications, such as statins and metformin, have undergone extensive characterization of their effects on mitochondrial function in vitro, the effects in humans are far more complex and poorly understood.</p><p><strong>Methods: </strong>This study uses data from the Study of Muscle, Mobility and Aging (SOMMA) to evaluate how mito-modulatory medication use is related to skeletal muscle bioenergetic capacity, measured by ex vivo high-resolution respirometry and in vivo phosphorus magnetic resonance spectroscopy in healthy older adults.</p><p><strong>Results: </strong>We found that mito-modulatory medication use was related to lower maximal complex I&II supported oxidative phosphorylation (Max OXPHOS), maximal electron transfer system capacity (Max ETS), and maximal ATP production capacity (ATP Max) in men, but not in women. We also found this to be dependent on the number of medications used, in which higher mito-modulatory medication load was associated with lower Max OXPHOS, Max ETS, and ATP Max.</p><p><strong>Conclusions: </strong>Our results provide greater insight into the potential clinical effects of mito-modulatory medication use and highlight the need to test the impact of these medications on mitochondrial function in randomized trials.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-associated increase in AT1R expression in human testis and its intervention effects on Leydig cell senescence in aged rodents.","authors":"Minye Zhao, Jinhua Wei, Yao Geng, Yang Zhang, Jie Zhao, Hong Yang, Wei Hua, Wei Li","doi":"10.1093/gerona/glaf004","DOIUrl":"https://doi.org/10.1093/gerona/glaf004","url":null,"abstract":"<p><p>The active peptide hormone Ang II (angiotensin II) mediates the vast majority of the RAS (renin-angiotensin system) action, mainly through activation of AT1R (Angiotensin II type-1 receptor). AT1R expression peaks in newborn males and decreases toward the adult age, and it is shown to exhibit an inhibitory effect on hCG (human chorionic gonadotropin)-stimulated steroidogenesis in LCs (Leydig cells), as well as an promoting effect on smooth muscle and endothelial cell senescence. However, whether hyperactivation of the AT1R signaling exerts any effects on Leydig cell senescence, which could provide insights into hypogonadism mechanisms for aging males, remains unexplored. We herein reported that AT1R expression was significantly upregulated in aged human and rat testes. Transgenic overexpression of AT1R in LCs mimicked multiple late-onset hypogonadism phenotypes, including acceleration of Leydig cell senescence, defective steroidogenesis and spermatogenesis, and increased inflammation and oxidative stress. One of the core biochemical events underpinning AT1R action was the AT1R-induced enhancement of the interaction between MDM2 (murine double minute 2) and the p65 subunit of NF-κB (nuclear factor-kappaB), consequently augmenting polyubiquitination and activation of p65, in a p38-dependent manner. Conversely, repression of AT1R activity ameliorated Leydig cell senescence and rescued testicular steroidogenesis in old rats. Together, forced expression of AT1R within the testicular interstitium potentiates aging-related traits in LCs, thereby leading to fertility impairment with defective steroidogenesis and spermatogenesis in male rodents. Our systematic analysis also indicates that blocking the Ang II/AT1R signal might be beneficial in intervening disorders of late-onset hypogonadism in old males.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discussing the interplay of social determinants of health, aging and Alzheimer's biomarkers in U.S. Latinos.","authors":"Jairo E Martinez, Jaime Perales-Puchalt, Miriam J Rodriguez, Monica Rosselli, Christian Salazar, David X Marquez, Melissa Lamar, Clara Vila-Castelar, Katya Rascovsky, Sid O'Bryant, Raul Vintimilla, Mirella Díaz-Santos, Idaly Velez-Uribe, Yakeel T Quiroz, Jorge Llibre-Guerra","doi":"10.1093/gerona/glaf020","DOIUrl":"10.1093/gerona/glaf020","url":null,"abstract":"<p><p>This perspective examines the impact of Social Determinants of Health (SDoH) on biological age-related decline and Alzheimer's Disease and Related Dementias (ADRD) biomarker trajectories in U.S. Latino populations, emphasizing the need for comprehensive multilevel research frameworks tailored to the community. We discuss the prevailing SDoH among U.S. Latino communities, including economic, educational, and healthcare access inequities that heighten health risks. Subsequently, we examine the pronounced differences in ADRD prevalence and biomarker trajectories among Latinos, suggesting that the interplay between SDoH and biological markers contributes to ADRD risk and progression. Our perspective reflects on the existing research landscape, noting a substantial gap in studies extending beyond identifying and understanding disparities in ADRD, to research incorporating biomarkers and developing actionable interventions to address broader SDoH. This shift is essential for creating a more holistic approach to ADRD research and devising truly effective strategies to mitigate ADRD disparities and improve brain health for older U.S. Latinos.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Senolysis by GLS1 Inhibition Ameliorates Kidney Aging by Inducing Excessive mPTP Opening Through MFN1.","authors":"Yuting Chen, Nan Zhao, Yu Zhang, Xueqi Chen, Yi Chen, Yifan Wang, Jianqing Wu, Weihong Zhao","doi":"10.1093/gerona/glae294","DOIUrl":"10.1093/gerona/glae294","url":null,"abstract":"<p><p>Cellular senescence is a pivotal contributor to aging and age-related diseases. The targeted elimination of senescent cells, known as senolysis, has emerged as a promising therapeutic strategy for mitigating these conditions. Glutaminase 1 (GLS1), a key enzyme in the glutaminolysis pathway, has been implicated in various cellular senescence processes. However, its specific role in senescent renal tubular epithelial cells (TECs) remains unclear. This study investigates the role and underlying mechanisms of GLS1 in senescent TECs. Using d-galactose (d-gal)-induced senescence of HK-2 cells, we found that GLS1 inhibition eliminated senescent TECs by promoting excessive mitochondrial permeability transition pore (mPTP) opening. Mechanistically, the excessive mPTP opening is associated with the upregulation of mitofusin 1 (MFN1). Inhibition of GLS1 in d-gal-treated HK-2 cells induced a shift in mitochondrial dynamics from fission to fusion, accompanied by a significant increase in MFN1 expression. Knocking down MFN1 reduced the mPTP opening and the expression of mPTP-related genes (PPIF, VDAC, and BAX) in cells co-treated with d-gal and the GLS1 inhibitor BPTES. Moreover, treatment of aged mice with BPTES specifically eliminated senescent TECs and ameliorated age-associated kidney disease. These findings reveal that GLS1 inhibition eliminate senescent TECs by promoting excessive mPTP opening, suggesting that targeting GLS1 may be a novel senolytic strategy for alleviating aging-related kidney diseases.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home Ambient Temperature and Self-Reported Attention in Community-Dwelling Older Adults.","authors":"Amir Baniassadi, Wanting Yu, Thomas Travison, Ryan Day, Lewis Lipsitz, Brad Manor","doi":"10.1093/gerona/glae286","DOIUrl":"10.1093/gerona/glae286","url":null,"abstract":"<p><strong>Background: </strong>Climate change is expected to disrupt weather patterns across the world, exposing older adults to more intense and frequent periods of hot weather. Meanwhile, lab-based studies have established a causal relationship between ambient temperature and cognitive abilities, suggesting the expected rise in temperature may influence older adults' cognitive functioning. Nevertheless, it is not clear whether, and to what extent, the temperature variations in older adults' own homes-which unlike lab settings are under their control-influence their cognitive functioning. Our objective was to provide proof of concept that home ambient temperature influences self-reported ability to maintain attention in older adults.</p><p><strong>Methods: </strong>We conducted a longitudinal observational study, continuously monitoring the home ambient temperature and self-reported difficulty keeping attention for 12 months in 47 of community-dwelling older adults living in Boston, Massachusetts.</p><p><strong>Results: </strong>We observed a U-shaped relationship between home ambient temperature at the time of assessment and the odds ratio (OR) of reporting difficulty keeping attention such that the OR was lowest between 20°C and 24°C and doubled when moving away from this range by 4°C in either direction.</p><p><strong>Discussion: </strong>Our results suggest that even under the current climate, a considerable portion of older adults encounter indoor temperatures detrimental to their cognitive abilities. Climate change may exacerbate this problem, particularly among low-income and underserved older adults. Addressing this issue in public health and housing policy is essential to building climate resiliency in this vulnerable population.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Association of Olfactory Function with Frailty in Older Adults: The Atherosclerosis Risk in Communities Study.","authors":"Hannah Pleasants, Yaqun Yuan, Keran Chamberlin, Chenxi Li, David Couper, Srishti Shrestha, Vidyulata Kamath, Jennifer A Deal, Thomas H Mosley, Priya Palta, Jayant M Pinto, Honglei Chen, Anna Kucharska-Newton","doi":"10.1093/gerona/glaf018","DOIUrl":"10.1093/gerona/glaf018","url":null,"abstract":"<p><strong>Background: </strong>Emerging evidence suggests that olfactory dysfunction may be a marker of frailty, a key predictor of adverse health outcomes in aging populations. This study examines the association between olfactory impairment and frailty in older adults.</p><p><strong>Methods: </strong>We analyzed data from 5,231 participants (mean age: 75.3 ± 5.0 years; 59% women; 22% Black) of the Atherosclerosis Risk in Communities (ARIC) Study. Olfactory function, assessed using the 12-item Sniffin' Sticks Test at Visit 5 (2011-2013), was categorized as poor (0-8), moderate (9-10), or good (11-12). Frailty status was ascertained using both the Fried Frailty Phenotype and the Cumulative Frailty Index. Cross-sectional associations between olfactory function and frailty status were examined using logistic regression and linear regression. Logistic regression was used to examine the association between olfactory function and prefrailty or frailty occurring within five years among 1,519 participants robust at baseline.</p><p><strong>Results: </strong>In cross-sectional analyses, good olfactory function was associated with lower odds of frailty (odds ratio [OR] = 0.29, 95% confidence interval [CI]: 0.22, 0.39) and prefrailty (OR = 0.52, 95% CI: 0.45, 0.61). These associations remained robust after adjusting for covariates. Longitudinal analyses similarly showed a dose-response pattern, with improved olfaction associated with decreased odds of experiencing prefrailty (OR=0.63 95% CI [0.48, 0.83]) or frailty (OR=0.50, 95% CI [0.25, 1.02]).</p><p><strong>Conclusions: </strong>Good, as compared to poor, olfactory function is associated with lower frailty risk in older adults, suggesting that olfactory impairment may serve as an early marker of frailty. Further research is needed to elucidate the mechanisms linking olfaction and frailty and explore potential interventions.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Workshop Report-Heterogeneity and Successful Aging Part I: Heterogeneity in Aging-Challenges and Opportunities.","authors":"George A Kuchel, Andrea L Hevener, J Graham Ruby, Paola Sebastiani, Vivek Kumar","doi":"10.1093/gerona/glaf023","DOIUrl":"10.1093/gerona/glaf023","url":null,"abstract":"<p><p>Historically, aging research has focused primarily on the study of differences in means of varied measures obtained at different ages. However, growing evidence has shown that for many parameters, variability in measurements obtained both between- and within-age groups increases with aging. Moreover, growing heterogeneity may become especially apparent when examined via longitudinal as opposed to cross-sectional aging data. Efforts to deconvolute and better understand such heterogeneity present remarkable translational opportunities for developing targeted and more effective interventions into aging. Here, we present Part I, a summary of the NIA Heterogeneity and Successful Aging workshop virtually held in May 2023.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":"80 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationships Between Subjective Well-Being and Frailty: Staying With a Positive Mind, Stepping Away From Accelerated Aging.","authors":"Yuchen Liu, Wenjie Cai, Eve Wittenberg, Dae Hyun Kim, David E Bloom, Laura D Kubzansky, Benjamin J Seligman","doi":"10.1093/gerona/glaf001","DOIUrl":"10.1093/gerona/glaf001","url":null,"abstract":"<p><strong>Background: </strong>Subjective well-being (SWB) is a crucial measure of life quality in older adults. Understanding its relationship with frailty may inform strategies to promote healthy aging.</p><p><strong>Methods: </strong>We analyzed data for older adults aged ≥60 years old from Waves 3 and 4 of the China Health and Retirement Longitudinal Study. SWB was measured based on participants' self-reported overall satisfaction with life. A frailty index was developed using the deficit accumulation approach. We conducted a cross-sectional Poisson regression to investigate the relationship between SWB and counts of frailty deficits. Additionally, we conducted a longitudinal analysis to determine the 3-year relative risk of clinically significant frailty progression or mortality for different levels of SWB. The analyses were adjusted for individual weights, including adjustments for household nonresponse.</p><p><strong>Results: </strong>The cross-sectional analysis included 9 702 individuals. After adjusting for covariates, lower baseline life satisfaction was associated with higher counts of frailty deficits (mean deficit counts ratio [95% confidence interval]: 1.66 [1.54, 1.78] for \"not satisfied\" and 1.06 [1.02, 1.10] for \"somewhat satisfied\" relative to the reference \"very satisfied\"). The longitudinal analysis included 8 599 individuals. Participants who were \"not satisfied\" with life at baseline were at a greater risk of frailty progression compared with those who were \"very satisfied\" (risk ratio: 1.16 [1.00, 1.35]).</p><p><strong>Conclusions: </strong>Our study finds that a lower level of SWB is associated with more severe frailty. It is also associated with frailty progression or death. These results emphasize that both psychological well-being and physical health are essential components of healthy aging.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142981146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Apple Watches to Monitor Health and Behaviors of Individuals With Cognitive Impairment: A Case Series Study.","authors":"Colby T Ford, Jake A Galler, Yingnan He, Cathrine Young, Beata Gabriela K Simpson, Chao-Yi Wu, Jake Pfaffenroth, Eh So Wah, Steven E Arnold, Hiroko H Dodge, Jon A Corkey, Sudeshna Das","doi":"10.1093/gerona/glae250","DOIUrl":"10.1093/gerona/glae250","url":null,"abstract":"<p><strong>Background: </strong>This study explores the potential of developing digital biomarkers from wearables for monitoring individuals with Alzheimer's Disease and Related Dementias, focusing on the feasibility of using Apple Watches for tracking health and behaviors in older adults with cognitive impairment.</p><p><strong>Methods: </strong>Data collection used the Amissa Health technology stack, which passively collects time-series data from smartwatches and provides a high-frequency cloud database for secure data storage, query, and visualization by clinicians and researchers. The platform consists of (i) AmissaWear, a software app that runs on smartwatches and sends information to a cloud database using a secure API; and (ii) AmissaOrbis, a centralized cloud portal for the collected data. Each participant was provided an Apple Watch configured to collect steps, calories burned, accelerometer and gyroscope readings, heart rate, and sleep information.</p><p><strong>Results: </strong>Seven participants, with cognitive impairment diagnosed by a neurologist, were enrolled in the study from December 2023 through June 2024. The watches successfully collected more than 700 000 observations during the study. Each observation contains data recorded from over a dozen sensors (eg, heart rate, pedometer, gyroscope, and accelerometer). The participants wore Apple Watches for an average of 11.48 hours/day for 84.91% of days during a 6-month period without a decrease in usage over time. Overall, the technology yielded high wear adherence and participation within this pilot.</p><p><strong>Conclusions: </strong>This study demonstrates the feasibility of using widely available Apple Watches for continuous monitoring of individuals with cognitive impairment and provides insights into their daily health and activity patterns, which could aid in future development of digital biomarkers.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}