The Journal of dermatology最新文献

{"title":"Perinatal Characteristics of Japanese Children With Infantile Hemangioma: A Questionnaire-Based Case-Control Study.","authors":"Megumi Mizawa, Teruhiko Makino, Kenta Matsumura, Fumina Furukawa, Kei Hamazaki, Hidekuni Inadera, Tadamichi Shimizu","doi":"10.1111/1346-8138.70506","DOIUrl":"https://doi.org/10.1111/1346-8138.70506","url":null,"abstract":"<p><p>Infantile hemangioma (IH) is the most common vascular tumor in infants. Clinical and perinatal data from Japanese hospital-based studies are limited. We performed a questionnaire-based case-control study to describe the clinical characteristics of IH and evaluate the factors associated with IH. The study included 150 children with IH and 150 pediatric dermatological controls without IH who visited our hospital. IH was diagnosed by direct dermatological examination in all cases, and questionnaires were administered during hospital visits. The clinical characteristics of children with IH were summarized. Background factors were compared between groups, and factors associated with IH were analyzed using multivariable logistic regression after multiple imputation to calculate adjusted odds ratios (aORs) and 95% confidence intervals (CIs). Among 150 children with IH, 124 (82.7%) had a single lesion, and 26 (17.3%) had multiple lesions. The most frequent lesion sites were the head and neck (n = 64), trunk (n = 51), and upper extremities (n = 39). Children with IH had lower birth weights than controls (2904 ± 474 vs. 3007 ± 391 g; p = 0.041). However, low birth weight (< 2500 g) was not associated with IH after adjustment (aOR 1.65 [95% CI 0.69-3.94]; p = 0.263). Firstborn children were more frequent in the IH group than in the control group (82/150 [54.7%] vs. 63/149 [42.3%]; p = 0.030). In the multivariable analysis, firstborn status remained associated with IH after adjustment (aOR 1.82 [95% CI 1.03-3.20]; p = 0.039). In this Japanese hospital-based case-control study, firstborn status was associated with IH after adjusting for maternal, perinatal, and socioeconomic factors. Although children with IH had a lower mean birth weight than controls, low birth weight (< 2500 g) was not associated with IH in the adjusted model.</p>","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149003301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two Cases of Anaphylaxis Induced by Carboxymethylcellulose.","authors":"Yuka Kanamori, Noriko Kubota, Mari Okune, Junichi Furuta, Toshifumi Nomura","doi":"10.1111/1346-8138.70496","DOIUrl":"https://doi.org/10.1111/1346-8138.70496","url":null,"abstract":"","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous Toxicities of Anti-GPRC5D Bispecific Antibodies for Multiple Myeloma: Retrospective Study.","authors":"Alfonso Gotor-Rivera, Alberto Blanco-Sánchez, Belén Rodríguez-Sánchez, Joaquín Martínez-López, Pablo L Ortiz-Romero, Fátima Tous-Romero","doi":"10.1111/1346-8138.70497","DOIUrl":"https://doi.org/10.1111/1346-8138.70497","url":null,"abstract":"<p><p>Talquetamab, a bispecific antibody, has a high efficacy in multiple myeloma (MM), with common dermatologic adverse events. We aim to describe the real-world burden of cutaneous toxicities. A retrospective study of MM patients treated with talquetamab between March 2021 and February 2026. Demographic and clinical data were extracted from electronic health records. Cutaneous, nail, and mucosal toxicities attributed to talquetamab were recorded. Of 32 patients (mean age 61.4 years; 59.4% male), 28 (87.5%) developed cutaneous adverse events. A total of 87 dermatologic events were recorded. Most frequent manifestations were exanthema (37.5% of cutaneous events), xerosis (33.3%), and palmoplantar involvement (46.9% of patients). Nail toxicity affected 75% of the cohort, predominantly onychomadesis. Mucositis affected 34.4%, with a tendency to occur earlier compared with cutaneous and nail toxicities. Dermatologic evaluation was associated with therapeutic management of adverse events (95.8% vs. 69.9%, p = 0.0098). No patient required permanent talquetamab discontinuation due to mucocutaneous toxicity. Median time to resolution was 50 days. Talquetamab is associated with a high burden of mucocutaneous toxicity. Early dermatologic assessment enables accurate diagnosis and effective management. These findings expand the clinicopathological spectrum of talquetamab toxicity and highlight the importance of interdisciplinary care.</p>","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dermoscopic Step-Like Border in Circumscribed Hypokeratosis: A Case Involving the Finger and Literature Reappraisal Across Palmar, Plantar, and Digital Lesions.","authors":"Takuya Nagata, Yasuaki Ikuno, Masahiro Yamada, Yasuhiro Maeda, Akihiko Yamaguchi, Toshifumi Takahashi, Akiko Arakawa, Noriki Fujimoto","doi":"10.1111/1346-8138.70499","DOIUrl":"https://doi.org/10.1111/1346-8138.70499","url":null,"abstract":"<p><p>Circumscribed hypokeratosis is a rare acquired disorder characterized clinically by a sharply demarcated, slightly depressed erythematous patch and histopathologically by abrupt thinning of the stratum corneum. Although initially described on the palm, similar lesions have been reported on the sole, fingers, and other acral sites, generating site-based terms such as circumscribed palmar, plantar, acral, and digital hypokeratosis. Across these presentations, peripheral dermoscopic findings have been variously described as stair-step, step-ladder, rim-like, or geological-strata appearances; however, their consistency across acral sites and their significance relative to other dermoscopic findings have not been specifically reappraised. Here, prompted by a finger lesion with a distinct dermoscopic step-like border, we reappraised previously reported cases with dermoscopic documentation to assess the consistency of this border finding across acral sites and its significance relative to other dermoscopic features. Among 24 previously reported dermoscopy-documented cases, a step-like peripheral border was identified in 22, whereas associated dermoscopic findings varied considerably among reports. The present dorsal finger case further illustrates that this border phenomenon can occur outside classical palmoplantar presentations. These observations suggest that peripheral border architecture may represent a more consistently reported dermoscopic feature than any single associated finding and may aid recognition of circumscribed hypokeratosis.</p>","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Diagnostic Journey of Mucous Membrane Pemphigoid: Referral Pathways and Diagnostic Delay at a Regional Tertiary Dermatology Center in Japan.","authors":"Shohei Kitayama, Teruhiko Makino, Tadamichi Shimizu","doi":"10.1111/1346-8138.70503","DOIUrl":"https://doi.org/10.1111/1346-8138.70503","url":null,"abstract":"<p><p>Mucous membrane pemphigoid is a rare autoimmune blistering disease that may involve multiple mucosal sites and is often diagnosed after substantial delay. We retrospectively reviewed 23 patients with mucous membrane pemphigoid seen at Toyama University Hospital between January 2016 and January 2026 to characterize their clinical and immunopathological features, referral pathways, and diagnostic delays. Oral involvement was present in all patients, and nine (39.1%) had high-risk disease. IgA deposition on direct immunofluorescence was detected in eight patients (34.8%) and was associated with high-risk disease (75.0% vs. 20.0%; p = 0.023) and differed across severity categories (p = 0.034). Oral symptoms were the initial presentation in 17 patients (73.9%), and dentistry was the most common first specialty consulted (56.5%). Gingivitis, periodontitis, or stomatitis was recorded at the first medical institution in 12 patients (52.2%), whereas autoimmune blistering disease was suspected in only three (13.0%). Median delays from symptom onset to the first medical consultation (patient delay), from the first consultation to definitive diagnosis (professional delay), and from symptom onset to definitive diagnosis (total diagnostic delay) were 1, 7, and 10 months, respectively. Professional delay was significantly longer than patient delay (p = 0.010) and exceeded it in 17 patients (73.9%). These findings from a regional tertiary dermatology center highlight professional delay as the predominant component of diagnostic delay and identify an exploratory association between IgA deposition on direct immunofluorescence and greater disease severity.</p>","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tapinarof-Induced Folliculitis With Pathologic Analysis.","authors":"Nao Matsuyoshi, Tatsuya Ogawa, Junichi Furuta, Natsumi Kawamatsu, Noriko Takemura, Daisuke Matsubara, Toshifumi Nomura","doi":"10.1111/1346-8138.70498","DOIUrl":"https://doi.org/10.1111/1346-8138.70498","url":null,"abstract":"","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vunakizumab Treatment for Pediatric Generalized Pustular Psoriasis: Two Case Reports.","authors":"Fei Jiang, Mingfei Chen, Feifei Sun, Jianfeng Wang, Qing Yang","doi":"10.1111/1346-8138.70500","DOIUrl":"https://doi.org/10.1111/1346-8138.70500","url":null,"abstract":"","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multicenter Clinical Comparison Between Anti-NXP2 and Anti-TIF1-γ Antibody-Positive Myositis, and Analysis of the Clinical Significance of Anti-NXP2 Antibody Titers in Idiopathic Inflammatory Myopathies.","authors":"Satoshi Kamiya, Mariko Ogawa-Momohara, Yoshinao Muro, Yuta Yamashita, Satoko Yuasa, Masato Kakeda, Kimiko Nakajima, Hiroyuki Morita, Mitsuyo Kinjo, Takako Hashimoto, Ken Yoshida, Takuya Takeichi, Haruka Koizumi, Norika Akashi, Eori Noda, Masashi Akiyama","doi":"10.1111/1346-8138.70490","DOIUrl":"10.1111/1346-8138.70490","url":null,"abstract":"<p><p>We aimed to measure anti-nuclear matrix protein 2 antibody (anti-NXP2) titers in patients with anti-NXP2-positive idiopathic inflammatory myopathies, investigate whether these titers are associated with clinical manifestations, malignancy risk, and treatment response, and compare the clinical and serological features between anti-NXP2-positive and anti-transcriptional intermediary factor 1-γ antibody (anti-TIF1-γ)-positive dermatomyositis in order to identify practical indicators for differentiating the two subsets. We established a newly optimized in-house enzyme-linked immunosorbent assay for the quantitative measurement of anti-NXP2. After excluding two of the 34 initially identified patients with anti-NXP2 antibody reactivity, we used the assay to analyse sera from 32 patients with anti-NXP2-positive idiopathic inflammatory myopathy. Clinical correlations between anti-NXP2 titers and inflammatory indices, cardiothoracic ratio, malignancy status, and longitudinal changes after immunosuppressive therapy were examined. We developed a novel clinical scoring system to differentiate between anti-NXP2-positive and anti-TIF1-γ-positive myositis. The anti-TIF1-γ-positive patients showed a higher frequency of classic dermatomyositis skin manifestations, whereas the anti-NXP2-positive patients had significantly higher creatine kinase, aldolase, and lactate dehydrogenase levels, indicating more prominent muscle involvement. Anti-NXP2 titers correlated with erythrocyte sedimentation rate and cardiothoracic ratio and were significantly higher in patients with malignancy in the anti-NXP2-positive idiopathic inflammatory myopathy patients. Longitudinal analyses demonstrated declines in antibody titers after immunosuppressive treatment. Our scoring system, incorporating age at onset, Gottron's sign, creatine kinase, lactate dehydrogenase, and malignancy status, highly accurately distinguished between anti-NXP2-positive and anti-TIF1-γ-positive myositis. Anti-NXP2 titers reflect systemic inflammation, cardiac involvement, and malignancy risk in anti-NXP2-positive idiopathic inflammatory myopathy. The observed decline in anti-NXP2 titers after therapy suggests the potential utility of these titers as biomarkers for longitudinal disease assessment and stratifying malignancy risk.</p>","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resolution of Secukinumab/Guselkumab-Induced Long-Term Paradoxical Eczematous Eruptions After Switching to Tildrakizumab Treatment.","authors":"Fumi Miyagawa, Yuki Minami","doi":"10.1111/1346-8138.70494","DOIUrl":"https://doi.org/10.1111/1346-8138.70494","url":null,"abstract":"","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three Cases of Merkel Cell Carcinoma Treated With Lutetium-177 Oxodotreotide.","authors":"Michitoshi Kurisaki, Eiji Nakano, Yoshiki Sakai, Misaki Kase, Harutaka Seshimo, Yuta Kage, Dai Ogata, Naoya Yamazaki, Kimiteru Ito, Kenjiro Namikawa","doi":"10.1111/1346-8138.70495","DOIUrl":"https://doi.org/10.1111/1346-8138.70495","url":null,"abstract":"<p><p>Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer associated with early metastasis and poor outcomes in the advanced stages. Immune checkpoint inhibitors (ICIs), particularly avelumab, represent the first-line therapy for metastatic MCC. However, effective treatment options after progression or intolerance remain limited. Peptide receptor radionuclide therapy (PRRT) using radiolabeled somatostatin analogs has emerged as a potential therapeutic option for tumors expressing somatostatin receptors (SSTRs). We present three patients with advanced MCC (aged 73, 45, and 77 years, respectively) treated with ¹⁷⁷Lu-oxodotreotide after failure or intolerance of ICI therapy and cytotoxic chemotherapy. ¹¹¹In pentetreotide single photon emission computed tomography/computed tomography demonstrated SSTR uptake in all patients, supporting the rationale for PRRT. All patients ultimately experienced disease progression; however, one achieved transient disease stabilization with tumor reduction. The times from the first PRRT administration to death were 3.4, 4.2, and 1.4 months, respectively. No serious treatment-related adverse events were observed. These findings suggest that ¹⁷⁷Lu-oxodotreotide may represent a feasible and relatively safe option for patients with treatment-refractory MCC, although its antitumor efficacy is limited. However, further prospective studies are required to elucidate its clinical role.</p>","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}