{"title":"Eruptive Melanocytic Nevi Associated With Encorafenib and Cetuximab Therapy in Two Patients With BRAF V600E-Mutated Colorectal Cancer.","authors":"Takayuki Shuto, Michiko Nakajima, Etsuko Okada","doi":"10.1111/1346-8138.70488","DOIUrl":"https://doi.org/10.1111/1346-8138.70488","url":null,"abstract":"","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Local Low-Frequency Vibration Enhances Wound-Healing and Modulates Cellular Senescence in Tissues and Exudates in a Hyperglycemic Rat Model.","authors":"Daijiro Haba, Chihiro Takizawa, Qi Qin, Sanai Tomida, Ai Horinouchi, Hiromi Sanada, Gojiro Nakagami","doi":"10.1111/1346-8138.70486","DOIUrl":"https://doi.org/10.1111/1346-8138.70486","url":null,"abstract":"<p><p>Hard-to-heal wounds, such as diabetic foot ulcers and pressure injuries, pose major clinical challenges due to chronic inflammation and cellular senescence. Cellular senescence-associated mechanisms, including stress-responsive p53/p21 signaling and senescence-associated secretory phenotype-related inflammation, contribute to impaired wound repair. We investigated whether local low-frequency vibration modulates wound healing and senescence-associated markers in tissues and exudates in a hyperglycemic rat full-thickness wound model, and whether treatment frequency affects its efficacy. A full-thickness wound model was established in hyperglycemic rats and local low-frequency vibration at 52 Hz was applied once or twice daily for 40 min (n = 5). The relative wound area was monitored, and molecular and histological analyses were performed on tissue samples and exudates to evaluate cellular senescence and the senescence-associated secretory phenotype. Local low-frequency vibration application twice daily significantly accelerated wound closure compared with that observed in the control group. Molecular and histological analyses revealed a reduction in the number of PTX3-positive cells and p53 expression in the twice-daily treatment group. Senescence-associated genes related to p53/p21 signaling, including Cdkn1a and Rb1, were downregulated in tissues and exudates. The number of p53-positive cells in exudate was lower in the twice-daily treatment group. In conclusion, local low-frequency vibrations enhanced wound healing and reduced the expression of senescence-associated markers and inflammatory mediators in tissues and exudates. These findings suggest that local low-frequency vibrations may act as a noninvasive, senomorphic physical therapy that modulates senescence-related pathways and inflammation, although future studies should determine whether local low-frequency vibrations further modulate senescence pathways.</p>","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diego García Silvera, Elsa Benítez García, José González Rodríguez, Estela García Peris, José Suárez Hernández
{"title":"Nail-Patella Syndrome in an Adolescent: Importance of Nail Examination.","authors":"Diego García Silvera, Elsa Benítez García, José González Rodríguez, Estela García Peris, José Suárez Hernández","doi":"10.1111/1346-8138.70427","DOIUrl":"10.1111/1346-8138.70427","url":null,"abstract":"","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":"e735-e736"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13555101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148623590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Interpretation of a Novel AAGAB Splice-Site Variant (c.73+5G>A) of Uncertain Significance in a Clinically Typical Punctate Palmoplantar Epidermal Differentiation Disorder Phenotype.","authors":"Kengo Kinjo, Mari Minatogawa, Yoshihide Asano","doi":"10.1111/1346-8138.70398","DOIUrl":"10.1111/1346-8138.70398","url":null,"abstract":"","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":"e757-e759"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13555200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seyed Mohammad Vahabi, Mahshid Sadat Ansari, Ifa Etesami, Shamir Geller, Larisa J Geskin
{"title":"CTCL During Immunomodulatory Treatment: Diagnostic Gaps and the Importance of Distinguishing Unmasking From True Onset: Comment on \"Mycosis Fungoides Following IL-17 Inhibitor Treatment: A Case Series of Five Patients\".","authors":"Seyed Mohammad Vahabi, Mahshid Sadat Ansari, Ifa Etesami, Shamir Geller, Larisa J Geskin","doi":"10.1111/1346-8138.70361","DOIUrl":"10.1111/1346-8138.70361","url":null,"abstract":"","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":"e770-e771"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148255249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}