The Journal of dermatology最新文献

{"title":"When JAK Selectivity Matters: Worsening Urticaria and Recurrent Allergic Rhinitis After Switching From Baricitinib to Ritlecitinib in Alopecia Areata.","authors":"Koki Ito, Yasuaki Ikuno, Masahiro Yamada, Akihiko Yamaguchi, Toshifumi Takahashi, Akiko Arakawa, Noriki Fujimoto","doi":"10.1111/1346-8138.70559","DOIUrl":"https://doi.org/10.1111/1346-8138.70559","url":null,"abstract":"","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149291559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pendulous Arteriovenous Hemangioma Arising on the Cheek.","authors":"Hanako Miyahara, Rie Honda, Yusuke Homma, Shusaku Ito","doi":"10.1111/1346-8138.70549","DOIUrl":"https://doi.org/10.1111/1346-8138.70549","url":null,"abstract":"","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149279274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hailey-Hailey Disease Caused by a Deep Intronic ATP2C1 Variant Leading to Pseudoexon Activation.","authors":"Takumi Hashimoto, Chinatsu Shobatake, Yasuhiro Mitsui, Yuki Nakamura-Nishimura, Satoru Shinkuma","doi":"10.1111/1346-8138.70537","DOIUrl":"https://doi.org/10.1111/1346-8138.70537","url":null,"abstract":"","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149279310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Pleomorphic Dermal Sarcoma Arising in the Irradiated Field of Angiosarcoma of the Scalp.","authors":"Takahiko Abe, Kohei Horimoto, Sayuri Kishino, Toshiya Handa, Akimi Yokoyama, Ayako Gonda, Yukinori Akiyama, Hisashi Uhara","doi":"10.1111/1346-8138.70502","DOIUrl":"https://doi.org/10.1111/1346-8138.70502","url":null,"abstract":"","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149279301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Cataract and Its Association With Phototherapy Among Patients With Psoriasis.","authors":"Yan-Jie Su, Yu-Hsuan Joni Shao, Chia-Li Chang, De-Kuang Hwang, Chia-Chen Wang, Yuh-Mou Sue","doi":"10.1111/1346-8138.70552","DOIUrl":"https://doi.org/10.1111/1346-8138.70552","url":null,"abstract":"<p><p>Psoriasis is a chronic inflammatory disease associated with multiple comorbidities, but its association with cataract remains unclear. We aimed to examine the risks of cataract and cataract surgery in psoriasis patients and the associations of ultraviolet phototherapy with these outcomes. Using the Taiwan National Health Insurance Research Database (2012-2023), we conducted a retrospective cohort study of patients with newly diagnosed psoriasis who were matched to non-psoriasis controls by age, sex, and index year. Cox proportional hazards models were used to estimate hazard ratios (HRs) for cataract and cataract surgery. A nested case-control analysis was then performed among psoriasis patients who developed cataract or underwent cataract surgery, with matching to psoriasis patients without these outcomes. Conditional logistic regression was used to evaluate the associations of psoriasis-related treatments, including phototherapy and systemic treatments, with cataract and cataract surgery. A total of 61 622 psoriasis patients and 61 622 matched controls were included. Psoriasis was associated with increased risks of cataract (adjusted HR, 1.32; 95% confidence interval [CI], 1.24-1.40) and cataract surgery (adjusted HR, 1.41; 95% CI, 1.30-1.53). These associations were generally consistent across subgroups stratified by age, sex, and psoriatic arthritis status. In the nested case-control analysis, both psoralen plus ultraviolet A (PUVA) (adjusted OR, 1.88) and ultraviolet B (UVB) phototherapy (adjusted OR, 1.22) were associated with increased odds of cataract, without a clear dose-response relationship. In contrast, systemic treatments, including biologics/Janus kinase inhibitors (adjusted OR, 0.49) and conventional disease-modifying antirheumatic drugs (adjusted OR, 0.74) were associated with reduced odds of cataract. Similar findings were observed for cataract surgery. Psoriasis was associated with increased risks of cataract and cataract surgery. PUVA and UVB phototherapy were associated with higher odds of cataract and cataract surgery, whereas systemic treatments were associated with lower odds.</p>","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149279295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypogammaglobulinemia and Infection After Rituximab in Pemphigus, With Divergent Desmoglein Antibody and Immunoglobulin Kinetics: A Retrospective Cohort Study.","authors":"Ece Gökyayla, Mert Bardak, Hakan Koçer, Nezahat Nehir Mızraklı, İdil Ünal, İlgen Ertam Sağduyu, Işıl Karaarslan, Nilay Duman, Ayda Acar","doi":"10.1111/1346-8138.70550","DOIUrl":"https://doi.org/10.1111/1346-8138.70550","url":null,"abstract":"<p><p>Pemphigus is a rare autoimmune blistering disease for which rituximab is a first-line treatment, yet most safety data derive from lymphoma and rheumatoid arthritis cohorts. This study assessed hypogammaglobulinemia and infection during rituximab treatment, the baseline predictors of new-onset hypogammaglobulinemia, and whether desmoglein antibody titers and total immunoglobulin levels fall together. In this single-center retrospective cohort study, the records of 97 patients given rituximab for pemphigus between January 2015 and June 2026 were reviewed. Patients who received intravenous immunoglobulin were excluded, leaving 69 patients for outcome analyses. Among 51 patients with a normal baseline immunoglobulin G level, new-onset hypogammaglobulinemia, defined as a fall below 700 mg/dL after treatment, occurred in 5 (10%), and no patient reached the severe threshold of 400 mg/dL. Seven further patients were already below 700 mg/dL before treatment. Patients who developed new-onset hypogammaglobulinemia were older and had lower baseline immunoglobulin G and immunoglobulin M levels (areas under the curve 0.85, 0.83, and 0.81). Patients with hypogammaglobulinemia had received more corticosteroid per cycle, so a contribution of corticosteroids cannot be excluded. Late-onset neutropenia was not detected (0 of 69). Infection occurred in 5 of 69 patients (7%) and severe infection in 2 of 69 (3%). 6 months after induction, desmoglein 1 and desmoglein 3 antibody titers had fallen to 16% and 19% of baseline (p < 0.001), whereas immunoglobulin G remained at 97% (p = 0.46), independently of hypogammaglobulinemia. Hypogammaglobulinemia remained mild and the serologic response was not mirrored in total immunoglobulin levels. Advanced age and low baseline immunoglobulin levels are candidate markers of risk. These findings come from a retrospective single-center cohort and require confirmation in larger series.</p>","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149279271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"En Bloc Excision of a Temporal Atypical Lipomatous Tumor Extending Beneath the Zygomatic Arch Through a Temporal Approach Alone.","authors":"Natsumi Abe, Takaya Komori, Sadao Inoue, Mao Ikari, Motoaki Sou, Junya Hasegawa, Yasuhiro Nakamura","doi":"10.1111/1346-8138.70547","DOIUrl":"https://doi.org/10.1111/1346-8138.70547","url":null,"abstract":"","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149248172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secukinumab for Refractory Psoriasiform Cutaneous Manifestations in CTSC-Syndromic Epidermal Differentiation Disorder: A Pediatric Case Report.","authors":"Ke Zheng, Hao-Jie Chu, Meng-Yao Zhang, Zheng Qin, Jian-Guo Li, Shuai Zhang, Jian-Bo Wang","doi":"10.1111/1346-8138.70546","DOIUrl":"https://doi.org/10.1111/1346-8138.70546","url":null,"abstract":"<p><p>CTSC-syndromic epidermal differentiation disorder is a rare autosomal recessive genodermatosis caused by loss-of-function mutations in the cathepsin C gene. It is characterized by palmoplantar keratoderma and early-onset periodontal destruction, and no standardized disease-specific therapy has been established. We report a 3-year-old boy with disease onset in infancy, presenting with palmoplantar and generalized erythematous scaly lesions, severe pruritus, sleep disturbance, and nail roughness. Whole-exome sequencing followed by Sanger sequencing identified compound heterozygous variants in the cathepsin C gene: c.774C>G inherited from his father and c.328G>T inherited from his mother. Treatment with cyclosporine combined with systemic retinoids failed to prevent disease progression. After pretreatment evaluation and written informed consent from his guardian, secukinumab was administered subcutaneously at a dose of 75 mg at weeks 0, 1, 2, 3, and 4, followed by once every 4 weeks thereafter. After 12 weeks of treatment, the patient showed marked improvement in clinical manifestations, quality-of-life scores, and disease severity scores, with no infectious complications during treatment at our institution. After secukinumab was continued locally, an infection involving the right foot and ankle led to treatment discontinuation, and a pulmonary infection was reported during later follow-up.</p>","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149248256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten-Year Longitudinal Changes in Nailfold Videocapillaroscopy Findings and Clinical Features in Systemic Sclerosis.","authors":"Naoki Mugii, Yasuhito Hamaguchi, Yuya Sato, Kanako Hattori, Akane Takayama, Kenta Kudo, Jiro Nishio, Motoki Horii, Natsumi Fushida, Kie Mizumaki, Kyosuke Oishi, Sho Horie, Goro Sakurai, Takashi Matsushita","doi":"10.1111/1346-8138.70531","DOIUrl":"https://doi.org/10.1111/1346-8138.70531","url":null,"abstract":"<p><p>To investigate whether 10-year changes in nailfold videocapillaroscopy (NVC) findings are associated with changes in clinical characteristics in systemic sclerosis (SSc). This retrospective single-center study included 84 patients with SSc who underwent NVC assessment at baseline and after 10 years. NVC patterns were classified as normal, non-specific, early, active, or late. Patients were categorized by longitudinal NVC changes. Associations of NVC-change groups with changes in clinical characteristics including modified Rodnan skin score (mRSS), digital ulcers, interstitial lung disease, percent predicted vital capacity (%VC), and percent predicted diffusing capacity for carbon monoxide (%DLco) were examined. Over 10 years, NVC findings improved in 19 patients, remained unchanged in 41, and worsened in 24. Change in mRSS differed significantly among the groups, with greater improvement in the improved group than in the unchanged group (p = 0.0140) and the worsened group (p = 0.0161). Changes in digital ulcers were not associated with NVC-change groups. Among 47 patients with longitudinal %DLco data, Δ%DLco differed significantly among the groups, with the greatest decline in the worsened group (p = 0.0067), whereas Δ%VC did not differ significantly. NVC-change group was significantly associated with mRSS at 10 years after adjustment for baseline mRSS and disease duration (p = 0.0291), but not with Δ%DLco after adjustment for interstitial lung disease and pulmonary hypertension at 10 years (p = 0.0684). In conclusion, long-term NVC changes may occur in both directions may reflect the long-term course of skin sclerosis.</p>","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149279317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Responses Associated With Nephritis-Associated Plasmin Receptor in IgA Vasculitis.","authors":"Suguru Yoshida, Ryujin Miyata, Tamaki Matsumoto, Yoshishige Miyabe, Takashi Oda, Kazuo Yudoh, Naoko Ishiguro, Jun Yamagami, Chie Miyabe","doi":"10.1111/1346-8138.70548","DOIUrl":"https://doi.org/10.1111/1346-8138.70548","url":null,"abstract":"<p><p>IgA vasculitis (IgAV), formerly known as Henoch-Schönlein purpura, is a small-vessel vasculitis characterized by IgA-dominant immune deposits in the skin, kidney, gastrointestinal tract, and joints, often following infections, particularly β-hemolytic streptococci. Nephritis-associated plasmin receptor (NAPlr), a streptococcal glyceraldehyde-3-phosphate dehydrogenase, has been identified as a nephritogenic protein in post-streptococcal acute glomerulonephritis, binding plasmin and maintaining its proteolytic activity, thereby promoting tissue injury. However, the role of NAPlr in IgAV pathophysiology remains unclear. In this study, we investigated histological staining for NAPlr and plasmin activity in IgAV cutaneous lesions and evaluated circulating anti-NAPlr antibodies. Skin specimens from patients with IgAV were analyzed by immunofluorescence and in situ zymography, and serum anti-NAPlr antibodies (IgG, IgM, and IgA) were measured by enzyme-linked immunosorbent assay in 21 patients with IgAV and 18 healthy donors. Positive staining for NAPlr and plasmin activity was observed in dermal lesions in 7 of 11 patients with IgAV, but was minimal in control skin. Patients with IgAV showed significantly elevated serum levels of anti-NAPlr IgG and IgA antibodies compared with healthy donors. Anti-NAPlr IgG levels positively correlated with serum creatinine and negatively correlated with CH50, with a nonsignificant inverse association with estimated glomerular filtration rate (eGFR). Serum galactose-deficient IgA1 levels were also significantly increased in patients with IgAV, and were positively correlated with anti-NAPlr IgA levels but negatively correlated with C4. These findings demonstrate the presence of a protein that is stained by anti-NAPlr antibody in IgAV cutaneous lesions alongside elevated circulating anti-NAPlr antibodies, suggesting that immune responses to NAPlr may contribute to IgA-mediated vascular inflammation, potentially through complement activation.</p>","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149241021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}