The Journal of dermatology最新文献_第8页

Response to Melanoma Surgical Excision Margins Beyond Breslow Thickness: Should Histotype Matter? 黑色素瘤手术切除边缘超过乳房厚度的反应：组织类型是否重要？

IF 2.7

The Journal of dermatology Pub Date : 2026-09-27 DOI: 10.1111/1346-8138.70515

Chun-Yu Lin, Wei-Ting Liu

引用次数: 0

Fatal Disseminated Herpes Zoster With Varicella-Zoster Virus Pneumonia Despite Two-Dose Recombinant Zoster Vaccination in an Immunosuppressed Patient. 尽管免疫抑制患者接种了两剂重组带状疱疹疫苗，但致命的播散性带状疱疹伴水痘-带状疱疹病毒肺炎。

IF 2.7

The Journal of dermatology Pub Date : 2026-09-27 DOI: 10.1111/1346-8138.70510

Katsuya Konishi, Fumihito Abe, Hiroki Wakabayashi, Eisuke Tanaka, Daiki Sakai, Ai Nishida, Kaichi Kaneko, Tetsuya Higuchi

引用次数: 0

Melanoma Surgical Excision Margins Beyond Breslow Thickness: Should Histotype Matter? 黑色素瘤手术切除边缘超过乳房厚度：组织类型是否重要？

IF 2.7

The Journal of dermatology Pub Date : 2026-09-25 DOI: 10.1111/1346-8138.70514

Vincenzo De Giorgi, Gabriella Perillo, Giovanni Cecchi, Federica Fazzari, Biancamaria Zuccaro

引用次数: 0

Granulomatous Folliculotropic Non-Alopecic Secondary Syphilis Presenting With Generalized Nodular Lesions. 肉芽肿性嗜滤泡性非脱发继发性梅毒，表现为广泛性结节性病变。

IF 2.7

The Journal of dermatology Pub Date : 2026-09-22 DOI: 10.1111/1346-8138.70508

Maki Takada, Masato Ishikawa, Toshiyuki Yamamoto

引用次数: 0

Association Between Anatomical Subsite and Invasive Disease in Head and Neck Lentigo Maligna and Lentigo Maligna Melanoma. 头颈部恶性慢斑痣和恶性慢斑痣黑色素瘤解剖亚位点与侵袭性疾病的关系

IF 2.7

The Journal of dermatology Pub Date : 2026-09-21 DOI: 10.1111/1346-8138.70513

Emi Dika, Ludovica Schiavo, Elisabetta Magnaterra, Leonardo Veneziano, Elena Maria Cama, Daniela Tassone, Federico Venturi

{"title":"Association Between Anatomical Subsite and Invasive Disease in Head and Neck Lentigo Maligna and Lentigo Maligna Melanoma.","authors":"Emi Dika, Ludovica Schiavo, Elisabetta Magnaterra, Leonardo Veneziano, Elena Maria Cama, Daniela Tassone, Federico Venturi","doi":"10.1111/1346-8138.70513","DOIUrl":"https://doi.org/10.1111/1346-8138.70513","url":null,"abstract":"Lentigo maligna (LM) and LM melanoma (LMM) predominantly arise on chronically sun-damaged head and neck skin and are often considered biologically uniform across facial locations. Whether invasive potential varies by anatomical subsite remains unclear. We aimed to evaluate the association between predefined head and neck subsites and invasive phenotype in LM and LMM. In this retrospective cohort study, 134 patients with histopathologically confirmed LM and LMM were analyzed. Head and neck lesions were stratified a priori into scalp, nose, ear, periocular region, other facial areas, and neck. Multivariable linear and logistic regression models assessed associations between anatomical subsite, Breslow thickness, and invasive disease, adjusting for age and sex. Among 118 head and neck lesions, 50% were invasive. Anatomical subsite was independently associated with invasive disease (p = 0.0025), with auricular lesions demonstrating the highest frequency of invasion and nasal and periocular lesions showing significantly lower odds. Among invasive LMM, nasal lesions also demonstrated significantly lower Breslow thickness compared with auricular lesions in adjusted analysis (p = 0.026). To conclude, head and neck LM and LMM demonstrated significant anatomical differences in invasive presentation. These findings suggest that anatomical subsite may influence the likelihood of invasive disease and support greater anatomical consideration during clinical evaluation.","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tinea Incognito Caused by Trichophyton mentagrophytes With Spongiform Pustule: A Histopathological Pitfall Mimicking Pustular Psoriasis. 由带有海绵状脓疱的毛癣引起的隐蔽性癣：模拟脓疱性银屑病的组织病理学缺陷。

IF 2.7

The Journal of dermatology Pub Date : 2026-09-21 DOI: 10.1111/1346-8138.70512

Anri Morita, Yoshio Kawakami, Tomoko Miyake, Kyosuke Horikawa, Kohei Taniguchi, Kazushi Anzawa, Akira Shimizu, Shin Morizane

引用次数: 0

Tissue Olink Proteomics Analysis Reveals CCL17 as a Potential Biomarker in Patients With Pressure Ulcers. 组织链接蛋白质组学分析显示CCL17是压疮患者的潜在生物标志物。

IF 2.7

The Journal of dermatology Pub Date : 2026-09-20 DOI: 10.1111/1346-8138.70492

Linjun Wu, Shihan Zhou, Shiqin Li, Yang Chen, Ying Luo, Dan Zhang, Xuchao Cai, Chenming Wang, Lei Fan, Mingli Zhu, Longhuan Zeng, Yongke Zheng

{"title":"Tissue Olink Proteomics Analysis Reveals CCL17 as a Potential Biomarker in Patients With Pressure Ulcers.","authors":"Linjun Wu, Shihan Zhou, Shiqin Li, Yang Chen, Ying Luo, Dan Zhang, Xuchao Cai, Chenming Wang, Lei Fan, Mingli Zhu, Longhuan Zeng, Yongke Zheng","doi":"10.1111/1346-8138.70492","DOIUrl":"https://doi.org/10.1111/1346-8138.70492","url":null,"abstract":"Pressure ulcer (PU) typically arises as a chronic cutaneous ulcer stemming from a complex interplay of factors. However, the underlying mechanisms of this condition remain unclear. The aim of this study was to identify inflammatory biomarkers in patients with PU. In this study, PU and normal tissues were collected from 24 patients with PU. An exploratory Olink Inflammation Panel analysis was performed to identify candidate differentially expressed proteins (DEPs) between PU and normal tissue samples from 16 of the 24 patients with PU. A total of 16 candidate DEPs were identified using an unadjusted p < 0.05 threshold between the two groups. Among them, CCL17 had the largest fold change and diagnostic potential with an optimal AUC value (0.75). In addition, CCL17, ANGPT1, FASLG, and VEGFA demonstrated high clinical relevance in the patients with PU. Immunohistochemistry and western blotting using PU tissues obtained from the remaining 8 patients confirmed the decreased expression of CCL17 in PU tissues. In conclusion, CCL17 is a novel potential biomarker for PU pathogenesis and prognosis.","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149013467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refractory Epidermolysis Bullosa Acquisita Treated With Apremilast. 阿普米司特治疗顽固性大疱性表皮松解症。

IF 2.7

The Journal of dermatology Pub Date : 2026-09-20 DOI: 10.1111/1346-8138.70511

Taisuke Yukawa, Yukinobu Nakagawa, Yutaka Matsumura, Kyoko Tonomura, Mako Mine, Chiharu Tateishi, Daisuke Tsuruta, Manabu Fujimoto

引用次数: 0

Pembrolizumab-Induced Palmoplantar Keratoderma With Nail Involvement. 派姆单抗诱导的掌跖角化病伴指甲受累。

IF 2.7

The Journal of dermatology Pub Date : 2026-09-20 DOI: 10.1111/1346-8138.70509

Maho Matsuo, Akihiro Tsukamoto, Naoya Masuda, Hiroaki Iwata

引用次数: 0

Association of Oxidative Stress Index With Disease Control During Omalizumab-Based Treatment in Antihistamine-Refractory Chronic Spontaneous Urticaria: A Prospective Observational Study. 奥玛珠单抗治疗抗组胺难治性慢性自发性荨麻疹期间氧化应激指数与疾病控制的关联：一项前瞻性观察研究

IF 2.7

The Journal of dermatology Pub Date : 2026-09-18 DOI: 10.1111/1346-8138.70504

Kübra Aşık-Cansız, Nurhan Aliye Sayaca, Eylem Yıldırım, Beyhan Cengiz Özyurt, Ece Onur, Serkan Erdal, Talat Ecemiş, Cengiz Kırmaz

{"title":"Association of Oxidative Stress Index With Disease Control During Omalizumab-Based Treatment in Antihistamine-Refractory Chronic Spontaneous Urticaria: A Prospective Observational Study.","authors":"Kübra Aşık-Cansız, Nurhan Aliye Sayaca, Eylem Yıldırım, Beyhan Cengiz Özyurt, Ece Onur, Serkan Erdal, Talat Ecemiş, Cengiz Kırmaz","doi":"10.1111/1346-8138.70504","DOIUrl":"https://doi.org/10.1111/1346-8138.70504","url":null,"abstract":"Chronic spontaneous urticaria (CSU) is monitored mainly with patient-reported outcomes, whereas objective biomarkers that reflect disease status remain limited. This prospective observational cohort study included 55 adults with antihistamine-refractory CSU who initiated omalizumab as part of routine clinical care and 30 healthy controls for baseline oxidative stress comparisons. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were measured at baseline and month 6, and at month 12 in patients requiring treatment escalation. Disease control, disease activity, and quality of life were assessed using validated instruments. Unadjusted baseline TOS and OSI were lower in patients than in controls, but these differences were attenuated and were no longer statistically significant after adjustment for age, sex, and BMI (log-TOS: β = -0.297, p = 0.115; log-OSI: β = -0.310, p = 0.102). Month-6 OSI was higher in uncontrolled than controlled patients [0.274 (0.162-0.382) vs. 0.135 (0.100-0.245) AU, p = 0.010] and remained associated with uncontrolled disease after adjustment for baseline OSI, BMI, CRP, total IgE, and angioedema presence (β = 0.572, p = 0.030). Within-person change in OSI correlated inversely with change in UCT (rho = -0.596, p < 0.001), whereas its association with change in CU-Q2oL did not reach statistical significance (rho = 0.264, p = 0.053). In the 15-patient escalation subgroup, OSI did not change significantly over time (Friedman p = 0.074). These exploratory findings indicate that on-treatment OSI was associated with concurrent disease control and that within-person OSI change paralleled change in UCT. Incremental value beyond validated patient-reported outcomes, predictive performance, and treatment-guiding value was not established.","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149003254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0