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Potential thioflavin T false positives in lipomembranous changes in adipocytes during systemic amyloidosis diagnosis. 系统性淀粉样变性诊断过程中脂肪细胞脂膜变化中潜在的硫黄素 T 假阳性。
The Journal of dermatology Pub Date : 2024-09-24 DOI: 10.1111/1346-8138.17476
Mari Kishibe, Kaori Umekage, Hiroyoshi Nozaki, Tomoe Nakagawa, Kyoko Kanno, Akira Manabe, Akemi Ishida-Yamamoto
{"title":"Potential thioflavin T false positives in lipomembranous changes in adipocytes during systemic amyloidosis diagnosis.","authors":"Mari Kishibe, Kaori Umekage, Hiroyoshi Nozaki, Tomoe Nakagawa, Kyoko Kanno, Akira Manabe, Akemi Ishida-Yamamoto","doi":"10.1111/1346-8138.17476","DOIUrl":"10.1111/1346-8138.17476","url":null,"abstract":"<p><p>The diagnosis of systemic amyloidosis relies on the detection of amyloid deposition in the tissue, often utilizing biopsy specimens from the abdominal skin owing to their minimal invasiveness. Several amyloid staining methods, including Congo Red, Direct Fast Scarlet (DFS), and Thioflavin T (ThT), have been employed for visualization. Lipomembranous fat necrosis (LFN) is a non-specific reaction pattern of adipose tissue to injury, typically derived from blood insufficiency across a wide range of clinical conditions or diseases. It is characterized by the presence of eosinophilic, crenulated, and/or serpiginous membranes in fat lobules. We encountered a patient in whom ThT yielded suspiciously positive results in amyloidosis screening tests. Furthermore, our retrospective observations suggested that ThT staining was positive for LFN, whereas DFS and Congo red staining yielded negative results. The awareness that LFN can result in false-positive ThT staining during amyloid screening is crucial to avoiding the misdiagnosis of systemic amyloidosis. Furthermore, skin samples should not be collected from areas prone to developing lipomembranous changes. The use of more than two different stains for skin biopsy specimens is recommended.</p>","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of Darier's disease with a missense mutation in exon 8 of ATP2A2. 一例 ATP2A2 第 8 号外显子发生错义突变的达里尔病病例。
The Journal of dermatology Pub Date : 2024-09-24 DOI: 10.1111/1346-8138.17477
Akiko Hasegawa, Kazuki M Matsuda, Masato Ogishi, Shunsuke Miura, Ayumi Yoshizaki, Matthieu Chaldebas, Baptiste Milisavljevic, Peng Zhang, Jean-Laurent Casanova, Shinichi Sato
{"title":"A case of Darier's disease with a missense mutation in exon 8 of ATP2A2.","authors":"Akiko Hasegawa, Kazuki M Matsuda, Masato Ogishi, Shunsuke Miura, Ayumi Yoshizaki, Matthieu Chaldebas, Baptiste Milisavljevic, Peng Zhang, Jean-Laurent Casanova, Shinichi Sato","doi":"10.1111/1346-8138.17477","DOIUrl":"https://doi.org/10.1111/1346-8138.17477","url":null,"abstract":"","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A challenging case of pityriasis versicolor with clinical resistance to Itraconazole. 一例对伊曲康唑产生临床耐药性的红斑狼疮疑难病例。
The Journal of dermatology Pub Date : 2024-09-24 DOI: 10.1111/1346-8138.17466
Joe Khodeir, Paul Ohanian
{"title":"A challenging case of pityriasis versicolor with clinical resistance to Itraconazole.","authors":"Joe Khodeir, Paul Ohanian","doi":"10.1111/1346-8138.17466","DOIUrl":"https://doi.org/10.1111/1346-8138.17466","url":null,"abstract":"","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bimekizumab-induced acral pustulovesicular eruption in a patient with psoriatic arthritis. 一名银屑病关节炎患者因比美单抗诱发的尖丘疹性脓疱疹。
The Journal of dermatology Pub Date : 2024-09-24 DOI: 10.1111/1346-8138.17468
Ryuto Mukaiyama, Toshiyuki Yamamoto
{"title":"Bimekizumab-induced acral pustulovesicular eruption in a patient with psoriatic arthritis.","authors":"Ryuto Mukaiyama, Toshiyuki Yamamoto","doi":"10.1111/1346-8138.17468","DOIUrl":"https://doi.org/10.1111/1346-8138.17468","url":null,"abstract":"","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generalized pustular psoriasis patient with a heterozygous hypomorphic MPO variant refractory to intravenous spesolimab. 泛发性脓疱型银屑病患者伴有对静脉注射斯贝单抗无效的杂合子低表型 MPO 变异。
The Journal of dermatology Pub Date : 2024-09-20 DOI: 10.1111/1346-8138.17464
Youichi Ogawa, Eri Maejima, Takuya Takeichi, Takashi Okamoto, Hiroshi Mitsui, Shinji Shimada, Masashi Akiyama, Tatsuyoshi Kawamura
{"title":"Generalized pustular psoriasis patient with a heterozygous hypomorphic MPO variant refractory to intravenous spesolimab.","authors":"Youichi Ogawa, Eri Maejima, Takuya Takeichi, Takashi Okamoto, Hiroshi Mitsui, Shinji Shimada, Masashi Akiyama, Tatsuyoshi Kawamura","doi":"10.1111/1346-8138.17464","DOIUrl":"https://doi.org/10.1111/1346-8138.17464","url":null,"abstract":"<p><p>Generalized pustular psoriasis (GPP) is a recurrent and sometimes life-threatening sterile pustular disease. Because interleukin (IL)-36 is the central cytokine in disease formation, spesolimab, which interferes with IL-36 receptor signaling, is highly effective. Here, we report a patient with GPP with a heterozygous hypomorphic MPO variant refractory to intravenous spesolimab. Although spesolimab showed excellent clinical efficacy in resolving pre-existing pustules and erythema, it did not suppress the emergence of new pustules and erythema, which did not decrease the peripheral blood neutrophil count, therefore bimekizumab, an anti-IL-17A/IL-17F antibody, was administered after the second spesolimab infusion, which resolved the pustules and erythema. We discuss the possible reasons for the resistance mechanism to spesolimab.</p>","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrent eosinophilic cellulitis (Wells syndrome) after vaccination in a child. 一名儿童接种疫苗后复发嗜酸性细胞性蜂窝织炎（韦尔斯综合征）。
The Journal of dermatology Pub Date : 2024-09-20 DOI: 10.1111/1346-8138.17417
Ilaria Praturlon, Lisa Sant, Lorenzo D'Alì, Stefanny Andrade, Enzo Errichetti, Paola Cogo, Giorgia Martini
{"title":"Recurrent eosinophilic cellulitis (Wells syndrome) after vaccination in a child.","authors":"Ilaria Praturlon, Lisa Sant, Lorenzo D'Alì, Stefanny Andrade, Enzo Errichetti, Paola Cogo, Giorgia Martini","doi":"10.1111/1346-8138.17417","DOIUrl":"https://doi.org/10.1111/1346-8138.17417","url":null,"abstract":"","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of Stevens-Johnson syndrome after influenza a virus infection. 一例感染甲型流感病毒后出现史蒂文斯-约翰逊综合征的病例。
The Journal of dermatology Pub Date : 2024-09-20 DOI: 10.1111/1346-8138.17467
Chiaki Sakashita, Kento Mizutani, Mai Nishimura, Hiroshi Kitagawa, Koji Habe, Keiichi Yamanaka
{"title":"A case of Stevens-Johnson syndrome after influenza a virus infection.","authors":"Chiaki Sakashita, Kento Mizutani, Mai Nishimura, Hiroshi Kitagawa, Koji Habe, Keiichi Yamanaka","doi":"10.1111/1346-8138.17467","DOIUrl":"https://doi.org/10.1111/1346-8138.17467","url":null,"abstract":"","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What is "eczema"? 什么是 "湿疹"？
The Journal of dermatology Pub Date : 2024-09-20 DOI: 10.1111/1346-8138.17439
Yoshiki Tokura, Marina Yunoki, Shumpei Kondo, Masaki Otsuka
{"title":"What is \"eczema\"?","authors":"Yoshiki Tokura, Marina Yunoki, Shumpei Kondo, Masaki Otsuka","doi":"10.1111/1346-8138.17439","DOIUrl":"https://doi.org/10.1111/1346-8138.17439","url":null,"abstract":"<p><p>Eczema is the most common category of inflammatory skin disorders as dermatologists see many patients with eczematous diseases in daily practice. It is characterized by the three major morphological features: multiple-pinpoint condition, polymorphism, and itch. To describe polymorphism, \"eczema triangle\" has been used in German/Japanese dermatology. The multiple pinpoints correspond to numerous tiny foci from which individual papules/vesicles arise. The polymorphism betrays composition of erythema, papule, seropapule, vesicle, pustule, scale, and crust, which are seen in acute eczema. Meanwhile, chronic eczema is represented by lichenification and hyperpigmentation, and possibly by hypopigmentation. In acute eczema, spongiosis is associated with overproduction of hyaluronic acid, secretion of self-protective galectin-7, and decreased expression of E-cadherin. In the upper dermis, Th1/Tc1 or Th2/Tc2, and additional Th17, Th22, and/or Tc22 infiltrate, depending on each eczematous disease. Innate lymphoid cells are also involved in the formation of eczema. In chronic eczema, periostin contributes to remodeling of inflammatory skin with dermal fibrosis, and epidermal melanogenesis and dermal pigment deposition result in hyperpigmentation. Finally, eczematous diseases are potentially associated with increased risk of comorbidities, including not only other allergic diseases but also coronary heart disease and mental problems such as depression. Although the original word for eczema is derived from old Greek \"ekzein,\" eczema remains a major target of modern science and novel therapies.</p>","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upadacitinib shows efficacy in Netherton syndrome with poor response to Dupilumab. 乌达帕替尼对尼瑟顿综合征中对杜匹单抗反应不佳的患者有疗效。
The Journal of dermatology Pub Date : 2024-09-20 DOI: 10.1111/1346-8138.17461
Hui Li, Jianbo Wang
{"title":"Upadacitinib shows efficacy in Netherton syndrome with poor response to Dupilumab.","authors":"Hui Li, Jianbo Wang","doi":"10.1111/1346-8138.17461","DOIUrl":"https://doi.org/10.1111/1346-8138.17461","url":null,"abstract":"","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Grade 3 acute kidney injury caused anti‐glomerular basement membrane nephritis during immune checkpoint inhibitor treatment for melanoma 黑色素瘤免疫检查点抑制剂治疗期间抗肾小球基底膜肾炎引起的三级急性肾损伤
The Journal of dermatology Pub Date : 2024-09-13 DOI: 10.1111/1346-8138.17460
Akemi Fukuda, Dai Ogata, Yoichi Oshima, Eiji Nakano, Kenjiro Namikawa, Motoaki Komatsu, Akira Nakamura, Kohei Sugiura, Naoya Yamazaki
{"title":"Grade 3 acute kidney injury caused anti‐glomerular basement membrane nephritis during immune checkpoint inhibitor treatment for melanoma","authors":"Akemi Fukuda, Dai Ogata, Yoichi Oshima, Eiji Nakano, Kenjiro Namikawa, Motoaki Komatsu, Akira Nakamura, Kohei Sugiura, Naoya Yamazaki","doi":"10.1111/1346-8138.17460","DOIUrl":"https://doi.org/10.1111/1346-8138.17460","url":null,"abstract":"","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":"189 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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