The international journal of lower extremity wounds最新文献

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Prophylactic Negative Pressure Wound Therapy Versus Standard Wound Care Among Lower Extremity Amputations: A Meta-Analysis. 下肢截肢患者预防性负压伤口治疗与标准伤口护理:一项荟萃分析。
IF 1.5
The international journal of lower extremity wounds Pub Date : 2026-10-16 DOI: 10.1177/15347346261499135
Nikhil Pallem, Anna Johnson, Anthony A Mangino, Eleftherios Xenos
{"title":"Prophylactic Negative Pressure Wound Therapy Versus Standard Wound Care Among Lower Extremity Amputations: A Meta-Analysis.","authors":"Nikhil Pallem, Anna Johnson, Anthony A Mangino, Eleftherios Xenos","doi":"10.1177/15347346261499135","DOIUrl":"https://doi.org/10.1177/15347346261499135","url":null,"abstract":"<p><p>Prophylactic closed incisional negative pressure wound therapy (NPWT) has emerged as a promising strategy to reduce postoperative wound complications following lower extremity amputation in patients with peripheral arterial disease (PAD). We conducted a meta-analysis to evaluate whether closed incisional NPWT reduces wound complications compared with standard wound care (SWC) in this high-risk vasculopathic population. A systematic search was performed to identify studies comparing closed incisional NPWT and SWC among patients with PAD undergoing lower extremity amputation. PubMed, Embase, Web of Science, and CINAHL were searched from inception to January 2025 using predefined search strings. Six studies met eligibility criteria and were included in the analysis. Odds ratios (ORs) and 95% confidence intervals (CIs) were pooled using random-effects models as the primary analysis to account for anticipated clinical and methodological heterogeneity across studies. Leave-one-out analyses and an analysis excluding the study in which NPWT was delivered as part of a multifaceted care bundle were performed to assess robustness. A total of 893 patients were included, including 408 in the closed incisional NPWT group and 485 in the SWC group. Closed incisional NPWT was associated with lower odds of postoperative surgical site infection (SSI) (OR = 0.370; 95% CI = 0.143-0.957; <i>P</i> = .044) and wound dehiscence (OR = 0.224; 95% CI = 0.125-0.401; <i>P</i> = .008). Closed incisional NPWT was associated with lower odds of postoperative SSI and wound dehiscence following lower extremity amputation in patients with PAD. Because the evidence is predominantly observational and prediction intervals included the null value, these findings should be interpreted cautiously and confirmed in adequately powered randomized trials.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346261499135"},"PeriodicalIF":1.5,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diabetic Foot Ulcers and Curcumin. 糖尿病足溃疡和姜黄素。
IF 1.5
The international journal of lower extremity wounds Pub Date : 2026-10-12 DOI: 10.1177/15347346261498938
Nikolaos D Karakousis, Dimitrios S Karagiannakis, Nikolaos Papanas
{"title":"Diabetic Foot Ulcers and Curcumin.","authors":"Nikolaos D Karakousis, Dimitrios S Karagiannakis, Nikolaos Papanas","doi":"10.1177/15347346261498938","DOIUrl":"https://doi.org/10.1177/15347346261498938","url":null,"abstract":"","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346261498938"},"PeriodicalIF":1.5,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of a Structured Preventive Intervention on Diabetic Foot Outcomes: A Randomized Controlled Trial with Qualitative Insights. 结构化预防干预对糖尿病足结局的影响:一项具有定性见解的随机对照试验。
IF 1.5
The international journal of lower extremity wounds Pub Date : 2026-10-10 DOI: 10.1177/15347346261494692
Sol Tejeda-Ramírez, Aroa Tardáguila-García, Laura Palacios-Abril, Cristina De Benito-Morán, Esther García-Morales, José Luis Lázaro-Martínez
{"title":"Effect of a Structured Preventive Intervention on Diabetic Foot Outcomes: A Randomized Controlled Trial with Qualitative Insights.","authors":"Sol Tejeda-Ramírez, Aroa Tardáguila-García, Laura Palacios-Abril, Cristina De Benito-Morán, Esther García-Morales, José Luis Lázaro-Martínez","doi":"10.1177/15347346261494692","DOIUrl":"https://doi.org/10.1177/15347346261494692","url":null,"abstract":"<p><p>To evaluate the effectiveness of a specialist-led structured preventive educational intervention on diabetic foot outcomes in adults at risk of diabetic foot complications.Study designParallel-group randomized controlled trial with an embedded qualitative component.SettingSpecialised diabetic foot unit within a public healthcare setting.ParticipantsAdults with diabetes classified at any ulceration risk level according to the International Working Group on the Diabetic Foot were randomly assigned to the intervention or control group. Forty-two participants completed the 6-month follow-up.InterventionsThe intervention group received a specialist-led structured preventive educational programme comprising two structured group sessions in addition to standard podiatric care. The control group received standard podiatric care alone.ResultsForty-two participants completed the study. No diabetic foot ulceration occurred during the 6-month follow-up. Participants receiving the educational intervention improved disease-related knowledge, preventive self-care behaviours, and foot skin quality. Qualitative findings indicated greater confidence, emotional support, and engagement in preventive self-care.ConclusionsA specialist-led structured preventive educational intervention improved disease-related knowledge, preventive self-care behaviours, and foot skin quality in adults at risk of diabetic foot complications. These findings support the integration of structured education into routine preventive diabetic foot care.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346261494692"},"PeriodicalIF":1.5,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is "No-Option Critical Limb Threatening Ischaemia" a Right Definition? A Paradigm Shift Driven by Autologous Cell Therapy for Diabetic Foot Disease. “无选择的危重肢体威胁性缺血”是一个正确的定义吗?由自体细胞治疗糖尿病足病驱动的范式转变。
IF 1.5
The international journal of lower extremity wounds Pub Date : 2026-10-09 DOI: 10.1177/15347346261496150
Marco Meloni, Roberto Da Ros, Luigi Uccioli, Alessia Scatena, Laura Giurato
{"title":"Is \"No-Option Critical Limb Threatening Ischaemia\" a Right Definition? A Paradigm Shift Driven by Autologous Cell Therapy for Diabetic Foot Disease.","authors":"Marco Meloni, Roberto Da Ros, Luigi Uccioli, Alessia Scatena, Laura Giurato","doi":"10.1177/15347346261496150","DOIUrl":"https://doi.org/10.1177/15347346261496150","url":null,"abstract":"<p><p>Diabetic foot ulcers (DFUs) complicated by chronic limb threatening ischemia (CLTI) is one of the most severe pattern of diabetic foot disease (DFD). Although significant improvements in the management of CLTI by the availability of advanced devices and the use of extreme revascularization techniques, there is still a group of patients with unreconstructable vascular disease. These patients have a high risk of major amputation and are commonly defined as no-option CLTI subjects. Nonetheless, by the recent availability of autologous cell therapy (ACT), mainly mononuclear cell therapy, the natural history of no-option CLTI seems to change by a significant improvement in the rate of wound healing and limb salvage. Therefore, authors suggest that the term \"no-option CLTI\" may no longer be appropriate, as these patients could still have a second chance to achieve limb salvage even after failed revascularization procedures. This editorial highlights the practical implications of ACT for diabetic foot patients with unreconstructable vascular disease, suggesting a new definition and future perspectives.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346261496150"},"PeriodicalIF":1.5,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Offloading Matters: A Meta-Research Audit of Mechanical Validity in Trials Supporting the 2023 IWGDF Recommendations on Interventions to Enhance Healing of Foot Ulcers in People with DM. 卸载事项:支持2023年IWGDF关于加强糖尿病患者足部溃疡愈合干预措施建议的试验机械效度的荟萃研究审计。
IF 1.5
The international journal of lower extremity wounds Pub Date : 2026-10-09 DOI: 10.1177/15347346261493802
Mariana Alves Bandeira, Yolanda Garcia Alvarez, Mateo López Moral, Sebastián Flores Escobar, José Luis Lázaro Martinez, Vera Lucia Conceição De Gouveia Santos
{"title":"Offloading Matters: A Meta-Research Audit of Mechanical Validity in Trials Supporting the 2023 IWGDF Recommendations on Interventions to Enhance Healing of Foot Ulcers in People with DM.","authors":"Mariana Alves Bandeira, Yolanda Garcia Alvarez, Mateo López Moral, Sebastián Flores Escobar, José Luis Lázaro Martinez, Vera Lucia Conceição De Gouveia Santos","doi":"10.1177/15347346261493802","DOIUrl":"https://doi.org/10.1177/15347346261493802","url":null,"abstract":"<p><p>AimThis study aimed to evaluate and quantify the mechanical offloading methodological robustness of RCTs cited in the 2023 IWGDF interventions to enhance healing recommendations.MethodsA meta-research audit was conducted on 43 RCTs referenced in IWGDF guideline. A predefined framework assessed study characteristics, offloading system, adherence and activity monitoring, protocol implementation and symmetry, and mechanical offloading confounding risks. Trials were evaluated using a 10-point Offloading Quality Score (OQS), scale. Descriptive analyses and exploratory statistical tests) were performed.ResultsThe mean OQS was 2.07 (SD ± 2.83), with a median of 0 (IQR 0-4). Twenty-seven trials (62.79%) scored ≤2/10, while only three (7%) achieved scores ≥8/10. Offloading strategies were insufficiently described in 81.4% of studies, and adherence monitoring was absent in 88.4% of trials. Non-removable offloading devices were used in 7% of studies and were positively associated with higher OQS in regression analysis (β = 0.82, p < 0.001).ConclusionsMost RCTs underpinning the 2023 IWGDF recommendations demonstrate limited reporting and standardization of mechanical offloading. This may introduce unmeasured variability in mechanical exposure and could affect the interpretation of treatment effects. Future trials should standardize offloading protocols to improve internal validity and DFU research interpretation.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346261493802"},"PeriodicalIF":1.5,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Discrimination to Decision: External Validation and Clinical Utility of a Diabetic Foot Ulcer Prediction Model. 从鉴别到决策:糖尿病足溃疡预测模型的外部验证和临床应用。
IF 1.5
The international journal of lower extremity wounds Pub Date : 2026-09-11 DOI: 10.1177/15347346261485157
Shuning Li, Shi Wang, Peiwen Yu
{"title":"From Discrimination to Decision: External Validation and Clinical Utility of a Diabetic Foot Ulcer Prediction Model.","authors":"Shuning Li, Shi Wang, Peiwen Yu","doi":"10.1177/15347346261485157","DOIUrl":"https://doi.org/10.1177/15347346261485157","url":null,"abstract":"","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346261485157"},"PeriodicalIF":1.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148946550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the Association Between GLP-1 Receptor Agonists and Diabetic Foot Complications Using Real-World Pharmacovigilance Database and Mendelian Randomization. 使用真实世界药物警戒数据库和孟德尔随机化评估GLP-1受体激动剂与糖尿病足并发症之间的关系
IF 1.5
The international journal of lower extremity wounds Pub Date : 2026-09-11 DOI: 10.1177/15347346261487722
Tianqiao Zhang, Xifan Luo, Canyu Chen, Yong Zhang, Bo Xu, Zunbo He, Jiecan Zhou
{"title":"Assessing the Association Between GLP-1 Receptor Agonists and Diabetic Foot Complications Using Real-World Pharmacovigilance Database and Mendelian Randomization.","authors":"Tianqiao Zhang, Xifan Luo, Canyu Chen, Yong Zhang, Bo Xu, Zunbo He, Jiecan Zhou","doi":"10.1177/15347346261487722","DOIUrl":"https://doi.org/10.1177/15347346261487722","url":null,"abstract":"<p><p>BackgroundLimited studies to date have yielded inconsistent results regarding the association between glucagon-like peptide-1 receptor agonist (GLP-1RA) use and diabetic foot complications. We conducted a comprehensive analysis of the FDA Adverse Event Reporting System (FAERS) database and performed drug target Mendelian randomization (MR) studies to explore the association between GLP-1RAs and diabetic foot complications.MethodsWe mined the FAERS database from 2005q2 to 2024q2 using AERSMine. Additionally, a two-sample MR analysis was conducted to investigate the causal relationship between GLP-1R agonism and diabetic foot complications.ResultsA total of 1819 adverse event reports were recorded for GLP-1RAs, compared to 17,206 reports for other ATC-A10 class drugs. The frequency of diabetic foot reports in the GLP-1RA group was significantly lower than in the control group (6.38 vs 11.31/1000 reports), with a proportional reporting ratio (PRR) of 0.56 (95% confidence interval [CI], 0.54 to 0.59; <i>P</i> < 0.001). This trend was consistently observed across individual GLP-1RA molecules, including semaglutide (PRR, 0.45; 95% CI, 0.39 to 0.51), dulaglutide (PRR, 0.49; 95% CI, 0.45 to 0.54), and liraglutide (PRR, 0.30; 95% CI, 0.26 to 0.35). These results remained robust after conducting secondary and sensitivity analyses, further supporting their consistency and reliability. MR results generally corroborated the findings from the retrospective analyses of the AE records in the FAERS database.ConclusionsPharmacovigilance and drug target MR suggested a potential association between GLP-1RA use and diabetic foot complications, but the evidence is preliminary and requires further real-world prospective validation.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346261487722"},"PeriodicalIF":1.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148946557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Peripheral Artery Disease by Ankle-Brachial and Toe-Brachial Indices and Factors Associated with Toe-Brachial Index-Defined Disease in Maintenance Hemodialysis Patients. 维持性血液透析患者踝肱指数和趾肱指数外周动脉疾病的患病率以及与趾肱指数定义疾病相关的因素
IF 1.5
The international journal of lower extremity wounds Pub Date : 2026-09-11 DOI: 10.1177/15347346261487727
Kochaphan Phirom, Amaraporn Rerkasem, Pak Thaichana, Prit Kusirisin, Suwinai Saengyo, Sasinat Pongtam, Puntapong Taruangsri, Supapong Arwon, Saranat Orapin, Termpong Reanpang, Poon Apichartpiyakul, Chayathon Chansakaow, Kittipan Rerkasem
{"title":"Prevalence of Peripheral Artery Disease by Ankle-Brachial and Toe-Brachial Indices and Factors Associated with Toe-Brachial Index-Defined Disease in Maintenance Hemodialysis Patients.","authors":"Kochaphan Phirom, Amaraporn Rerkasem, Pak Thaichana, Prit Kusirisin, Suwinai Saengyo, Sasinat Pongtam, Puntapong Taruangsri, Supapong Arwon, Saranat Orapin, Termpong Reanpang, Poon Apichartpiyakul, Chayathon Chansakaow, Kittipan Rerkasem","doi":"10.1177/15347346261487727","DOIUrl":"https://doi.org/10.1177/15347346261487727","url":null,"abstract":"<p><p>BackgroundPeripheral artery disease (PAD) is common in maintenance hemodialysis patients, and ankle-brachial index (ABI) may underestimate disease because arterial calcification can yield falsely normal or elevated values. Toe-brachial index (TBI) may better detect distal ischemia. This study compared PAD detection by ABI and TBI and identified factors associated with TBI-defined PAD.MethodsIn this multicenter cross-sectional study, 211 maintenance hemodialysis patients underwent ABI and TBI assessment. PAD was defined separately as ABI <0.90 and TBI <0.70 using guideline-supported thresholds. Intermittent claudication, chronic wounds and burning toe pain were recorded. Detection rates were compared using McNemar's test, and associated factors were evaluated using multivariable Poisson regression with robust variance.ResultsPAD prevalence was 13.3% by ABI and 76.3% by TBI. TBI identified more patients with PAD than ABI (p < 0.001), with 133 patients (63.0%) showing normal ABI but abnormal TBI. Among these, 9.2% had at least one clinical ischemic feature. Diabetes mellitus, older age, and longer renal replacement therapy duration were independently associated with TBI-defined PAD.ConclusionTBI identified substantially more PAD than ABI and may provide complementary information when ABI alone could miss clinically relevant ischemia. Diabetes mellitus, older age, and longer RRT duration were independent correlates of TBI-defined PAD.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346261487727"},"PeriodicalIF":1.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148946543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Statins in Diabetic Foot Ulcer Healing: From Biological Mechanisms to Clinical Evidence. A Comprehensive Literature Review. 他汀类药物治疗糖尿病足溃疡:从生物学机制到临床证据。综合文献综述。
IF 1.5
The international journal of lower extremity wounds Pub Date : 2026-09-08 DOI: 10.1177/15347346261486484
Dimitrios Pantazopoulos, Dimitri P Mikhailidis, Nikolaos Papanas
{"title":"Statins in Diabetic Foot Ulcer Healing: From Biological Mechanisms to Clinical Evidence. A Comprehensive Literature Review.","authors":"Dimitrios Pantazopoulos, Dimitri P Mikhailidis, Nikolaos Papanas","doi":"10.1177/15347346261486484","DOIUrl":"https://doi.org/10.1177/15347346261486484","url":null,"abstract":"<p><p>Diabetic foot ulcers (DFUs) are a serious complication of diabetes mellitus. Statins are widely used for treatment of dyslipidaemia and prevention of cardiovascular events. They also exert multiple pleiotropic effects, including improvement of endothelial function, and promotion of angiogenesis and tissue repair. Accumulating evidence suggests that these properties may be beneficial in diabetic wound healing. The aim of this comprehensive review was to summarise preclinical and clinical data regarding the potential role of statins in DFUs management. Experimental studies consistently demonstrated that statins promote wound healing through several mechanisms, including increased nitric oxide bioavailability, vascular endothelial growth factor (VEGF)-mediated angiogenesis, improved endothelial function, and increased collagen synthesis and deposition. Emerging drug-delivery strategies, including topical formulations and tissue-engineered scaffolds, further improved therapeutic efficacy. Clinical evidence remains limited but encouraging. Observational studies have reported inconsistent findings, whereas randomised controlled trials suggest that statins may reduce ulcer recurrence and accelerate wound healing without significant safety concerns. Overall, the evidence supports a strong biological rationale for the use of statins as adjunctive therapy in DFUs. However, further research is required to establish their clinical efficacy, dosage, route of administration and treatment duration.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346261486484"},"PeriodicalIF":1.5,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomarker Insights into Diabetic Foot Ulcers: Evaluating Pentraxin-3 and Netrin-1 for Diagnosis and Clinical Associations. 生物标志物洞察糖尿病足溃疡:评估戊traxin-3和Netrin-1的诊断和临床关联。
IF 1.5
The international journal of lower extremity wounds Pub Date : 2026-09-07 DOI: 10.1177/15347346261484298
Pankila Yadav, Palani Selvam Mohanraj, Akash Bansal, Shailendra Dwivedi, Ravi Gupta, Kanishka Kumar, Aroop Mohanty
{"title":"Biomarker Insights into Diabetic Foot Ulcers: Evaluating Pentraxin-3 and Netrin-1 for Diagnosis and Clinical Associations.","authors":"Pankila Yadav, Palani Selvam Mohanraj, Akash Bansal, Shailendra Dwivedi, Ravi Gupta, Kanishka Kumar, Aroop Mohanty","doi":"10.1177/15347346261484298","DOIUrl":"https://doi.org/10.1177/15347346261484298","url":null,"abstract":"<p><p>AimTo measure serum levels of Pentraxin-3 (PTX-3) and Netrin-1 in diabetic patients with and without foot ulcers and determine how these levels relate to clinical features, glycemic control, and ulcer status.MethodsIn this cross-sectional study, 80 patients were divided into three groups: infected diabetic foot ulcer (IDFU, n = 27), non-infected diabetic foot ulcer (NIDFU, n = 27), and diabetes control (n = 26). Biochemical, demographic, and clinical data were gathered. PTX-3 and Netrin-1 levels in serum were measured using ELISA. ANOVA, regression, and correlation analyses were used to assess biomarker relationships and group comparisons.ResultsAcross all groups, there was a significant increase in fasting blood glucose, HbA1c, and diabetes duration. There was no significant difference in PTX-3 levels. Netrin-1 levels were linked with HbA1c (r = 0.37) and fasting blood glucose (r = 0.41) and were higher in both ulcer groups (p < 0.001). While PTX3 performed poorly (AUC = 0.518-0.576), Netrin-1 exhibited good diagnostic accuracy for differentiating IDFU and NIDFU from DM (AUC = 0.891 and 0.855, respectively). Netrin-1 did not, however, distinguish infected from non-infected ulcers (AUC = 0.510).ConclusionElevated serum Netrin-1 levels and their positive association with glycemic indices suggest a potential role for Netrin-1 in diabetic foot ulceration, whereas PTX-3 showed no significant associations.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346261484298"},"PeriodicalIF":1.5,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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