The international journal of lower extremity wounds最新文献

Reliability of Microwave Radiometry for the Assessment of Charcot Foot. 微波辐射测量法评定夏科足的可靠性。

The international journal of lower extremity wounds Pub Date : 2025-06-12 DOI: 10.1177/15347346251329733

Ioanna Eleftheriadou, Anastasios Tentolouris, Ourania Kosta, Paraskevi Kontrafouri, Maria Tektonidou, Petros P Sfikakis, Nikolaos Tentolouris

{"title":"Reliability of Microwave Radiometry for the Assessment of Charcot Foot.","authors":"Ioanna Eleftheriadou, Anastasios Tentolouris, Ourania Kosta, Paraskevi Kontrafouri, Maria Tektonidou, Petros P Sfikakis, Nikolaos Tentolouris","doi":"10.1177/15347346251329733","DOIUrl":"https://doi.org/10.1177/15347346251329733","url":null,"abstract":"Applying infrared thermometry for temperature measurement is recommended for Charcot neuro-osteoarthropathy (CNO) diagnosis and monitoring of its course. Microwave radiometry (MWR) is used for the detection of temperature changes in human tissues. This study evaluates the agreement between these two methods in CNO assessment. Individuals with diabetes mellitus (DM) with and without active CNO were included. MWR measurements were performed by a microwave computer-based system that detects microwave radiation from the area under investigation and temperatures of the internal tissues. Sensors with diameters of 0.8 cm (MWR 0.8), 2 cm (MWR 2), and 5 cm (MWR 5) were used, with larger diameters enabling deeper tissue assessment. Nine individuals (mean age: 54.6 ± 15.7, 2 females) with active CNO and 5 people with DM without CNO were included in the study. The agreement between temperatures measured by infrared thermometry and by MWR 0.8 was high and the average temperature discrepancy between the two methods was 0.034 °C (P = .676). The average temperature discrepancy between infrared thermometry and MWR 2 was -0.323 °C (P < .001) and between infrared thermometry and MWR 5 was -0.315 °C (P = .002). Participants with active CNO were followed-up for a median period of 67 [39, 79] weeks. During follow up, the difference in skin temperature between the affected and the contralateral foot was lower than 2 °C in 7 (77.8%) participants. Three out of 5 individuals had re-activation of CNO in 21, 22 and 65 weeks after the removal of the offloading device, respectively. The decision to gradually start loading would be different only for one person if we had used MWR instead of infrared thermometry for the measurement of temperature difference between the affected and the contralateral foot. In conclusion, infrared thermometry showed high agreement with MWR 0.8 but not with MWR 2 or MWR 5.","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251329733"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pig's Toenail Egg Yolk Ointment Promotes Pressure Ulcer Healing via the PI3K-Akt Pathway: A Randomized Controlled Trial. 猪脚趾甲蛋黄膏通过PI3K-Akt通路促进压疮愈合：一项随机对照试验

The international journal of lower extremity wounds Pub Date : 2025-06-09 DOI: 10.1177/15347346251348798

Jiansheng Shao, Hui Zhang, Xiamei Zhang, Ying Xu, Jianhua Gu, Li Su

{"title":"Pig's Toenail Egg Yolk Ointment Promotes Pressure Ulcer Healing via the PI3K-Akt Pathway: A Randomized Controlled Trial.","authors":"Jiansheng Shao, Hui Zhang, Xiamei Zhang, Ying Xu, Jianhua Gu, Li Su","doi":"10.1177/15347346251348798","DOIUrl":"https://doi.org/10.1177/15347346251348798","url":null,"abstract":"Objective: To investigate the efficacy and mechanism of pig's toenail egg yolk ointment in treating pressure ulcers. Methods: Eighty patients with Stage III-IV pressure ulcers were randomized into an experimental group (n = 50) receiving pig's toenail egg yolk ointment and a control group (n = 30) receiving conventional dressing. Clinical outcomes included Pressure Ulcer Scale for Healing(PUSH) score, wound healing rate, healing rate, and dressing costs. Additionally, a rat pressure ulcer model was used to assess healing rates, histopathology, and expression of VEGF, TNF-α, IL-1β, PI3 K, p-PI3 K, AKT, and p-AKT. Results: Clinical research: The experimental group showed significantly lower PUSH scores, higher wound healing rates, and reduced dressing costs compared to the control group (P < 0.05). Animal experiments: In rats, the ointment group demonstrated faster wound healing, neovascularization, and reduced inflammatory cell infiltration. ELISA results showed increased VEGF and decreased TNF-α and IL-1β levels. Western blot analysis indicated elevated p-PI3 K and p-AKT expression in the ointment group (P < 0.05). Conclusion: Pig's toenail egg yolk ointment promotes pressure ulcer healing by enhancing angiogenesis and modulating inflammatory factors through activation of the PI3K-Akt pathway.","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251348798"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effectiveness of Pentoxifylline 10% Topical Gel on the Pressure Ulcer Healing: A Randomized Controlled Clinical Trial. 10%己酮茶碱外用凝胶治疗压疮的疗效：一项随机对照临床试验。

The international journal of lower extremity wounds Pub Date : 2025-06-03 DOI: 10.1177/15347346251345244

Atefeh Alsadat Tayyebi, Rasool Soltani, Morteza Pourahmad, Erfaneh Ghassami, Mehdi Shahbazi Azad, Mohammad Mehdi Ahmadi, Mohammadreza Tabatabaei

{"title":"The Effectiveness of Pentoxifylline 10% Topical Gel on the Pressure Ulcer Healing: A Randomized Controlled Clinical Trial.","authors":"Atefeh Alsadat Tayyebi, Rasool Soltani, Morteza Pourahmad, Erfaneh Ghassami, Mehdi Shahbazi Azad, Mohammad Mehdi Ahmadi, Mohammadreza Tabatabaei","doi":"10.1177/15347346251345244","DOIUrl":"https://doi.org/10.1177/15347346251345244","url":null,"abstract":"Background and aimsRecent studies have shown wound-healing properties of systemic pentoxifylline (PTX). This study aimed to investigate the effectiveness of PTX 10% topical gel in the healing of pressure ulcer (PU).MethodsThe patients with stages 2 or 3 PU were randomly divided to PTX and control groups (n = 35 in each). For the first group, 10% PTX gel was used topically, along with common treatments, once a day for two weeks, while for the control group, a novel dressing along with the common wound care were applied. At the end of the first and second weeks, the wound size change and healing rate were compared between the groups.ResultsThere was a significant decrease in wound size at the first and second weeks in PTX group compared to the control (P < 0.05). Furthermore, the number of cases showing complete wound healing in PTX group (n = 16; 45.71%) was more than control group (n = 9; 25.71%); however, the difference was not statistically significant (P = 0.081).ConclusionThis study demonstrated that PTX 10% topical gel can be a promising treatment option to accelerate wound healing in patients with PU.","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251345244"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive Management of Venous Leg Ulcers: Evidence-Based Strategies and Treatment Options. 下肢静脉性溃疡的综合管理：循证策略和治疗选择。

The international journal of lower extremity wounds Pub Date : 2025-06-01 Epub Date: 2025-04-15 DOI: 10.1177/15347346251333202

Myo Zin Oo, Boonying Siribumrungwong, Saritphat Orrapin, Nuttawut Sermsathanasawadi, Nikolaos Papanas, Kittipan Rerkasem

引用次数: 0

Diabetic Foot Ulcer in Malaysia: Consensus on Treatment Patterns, Health Care Utilization and Cost. 马来西亚的糖尿病足溃疡：关于治疗模式、医疗保健利用率和成本的共识》（Consensus on Treatment Patterns, Health Care Utilization and Cost.

The international journal of lower extremity wounds Pub Date : 2025-06-01 Epub Date: 2022-03-29 DOI: 10.1177/15347346221090096

Harikrishna K R Nair, P Norlizah, M N Mariam, Syed A L Alsagoff, Kam Ming Long, K R Anantha, Ngoh Chin Liew, Nizam Ali Husien

{"title":"Diabetic Foot Ulcer in Malaysia: Consensus on Treatment Patterns, Health Care Utilization and Cost.","authors":"Harikrishna K R Nair, P Norlizah, M N Mariam, Syed A L Alsagoff, Kam Ming Long, K R Anantha, Ngoh Chin Liew, Nizam Ali Husien","doi":"10.1177/15347346221090096","DOIUrl":"10.1177/15347346221090096","url":null,"abstract":"Healthcare resource utilization for Diabetic foot ulcers (DFUs) in Malaysia needs to be clarified. This modified Delphi panel study aimed to describe the clinical pathways for diabetic foot ulcer in Malaysia and to define the healthcare resources used and their costs. A systematic review of the literature was carried out on the management of diabetic foot ulcer in Malaysia. A modified Delphi panel involving 7 local experts was organized to validate the statements, in order to arrive at a consensus on the resources used for the treatment of DFU patients in Malaysia and their costs. A Markov model was then used to estimate the financial burden of DFU patients in Malaysia.The total cost per patient per annum was MYR 5981 in public and MYR 8581 in private setting. In the public setting, outpatient visits costs represent 50% of the overall cost, followed by medical devices which represent 38% of total costs. In the private setting, as in the public, outpatient visits and devices contribute the most to overall costs with 51% and 21%, respectively. However, hospital inpatient costs are higher in private setting and represent 14% of the total costs versus 5% in public setting.These findings may prove useful for clinicians and decision makers in understanding the economic implications of managing DFUs in Malaysia and the need for innovative therapies to reduce the burden for patients but also for the society.","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":"1 1","pages":"312-319"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84960267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studying Microbial Ecology of Diabetic Foot Infections: Significance of PCR Analysis for Prudent Antimicrobial Stewardship. 研究糖尿病足感染的微生物生态：PCR 分析对谨慎使用抗菌药物的意义。

The international journal of lower extremity wounds Pub Date : 2025-06-01 Epub Date: 2024-02-19 DOI: 10.1177/15347346241230288

Deema Jaber, Nidal Younes, Enam Khalil, Abla Albsoul-Younes, Mohammed Zawiah, Amal G Al-Bakri

{"title":"Studying Microbial Ecology of Diabetic Foot Infections: Significance of PCR Analysis for Prudent Antimicrobial Stewardship.","authors":"Deema Jaber, Nidal Younes, Enam Khalil, Abla Albsoul-Younes, Mohammed Zawiah, Amal G Al-Bakri","doi":"10.1177/15347346241230288","DOIUrl":"10.1177/15347346241230288","url":null,"abstract":"This study presents a comprehensive investigation into the microbial ecology of diabetic foot infections (DFIs), using molecular-polymerase chain reaction (PCR) analysis to accurately identify the causative agents. One hundred DFI patients were recruited and classified using the Depth Extent Phase and Associated Etiology (DEPA) score according to their severity. Results revealed polymicrobial infections in 75% of cases, predominantly featuring Staphylococcus epidermidis (83%) and Staphylococcus aureus (63%). Importantly, 20% of samples exhibited facultative anaerobes Bacteroides fragilis or Clostridium perfringens, exclusively in high DEPA score ulcers. Candida albicans coinfection was identified in 19.2% of cases, underscoring the need for mycological evaluation. Empirical antimicrobial therapy regimens were tailored to DEPA severity, yet our findings highlighted a potential gap in methicillin-resistant Staphylococcus aureus (MRSA) coverage. Despite an 88% prevalence of methicillin-resistant Staphylococci, vancomycin usage was suboptimal. This raises concerns about the underestimation of MRSA risk and the need for tailored antibiotic guidelines. Our study demonstrates the efficacy of molecular-PCR analysis in identifying diverse microbial communities in DFIs, influencing targeted antibiotic choices. The results advocate for refined antimicrobial guidelines, considering regional variations in microbial patterns and judiciously addressing multidrug-resistant strains. This research contributes crucial insights for optimizing DFIs management and helps the physicians to have a fast decision in selection the suitable antibiotic for each patient and to decrease the risk of bacterial resistance from the improper use of broad-spectrum empirical therapies.","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"497-505"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139907188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial Peptide Buforin-I Facilitates the Healing of Foot Wounds in Diabetic Mice. 抗菌肽buforin - 1促进糖尿病小鼠足部伤口愈合。

The international journal of lower extremity wounds Pub Date : 2025-05-30 DOI: 10.1177/15347346251336569

Huang Hu, Hong Zhang, Meixian He, Jingjing Tai

{"title":"Antimicrobial Peptide Buforin-I Facilitates the Healing of Foot Wounds in Diabetic Mice.","authors":"Huang Hu, Hong Zhang, Meixian He, Jingjing Tai","doi":"10.1177/15347346251336569","DOIUrl":"https://doi.org/10.1177/15347346251336569","url":null,"abstract":"BackgroundDiabetic wounds are difficult to heal due to long-term chronic ulcers, thus lacking effective treatment methods. Some antimicrobial peptides are known to have biological functions that promote wound healing, but the effects of the antimicrobial peptide Buforin-I on diabetic wound healing and the mechanisms underlying these effects are not yet elucidated.MethodsThis project investigated the effects of Buforin-I on the healing rate of foot wounds in streptozotocin (STZ)-induced diabetic mice and the antioxidant reactions in wound tissues. Histological staining with HE and Masson, as well as biochemical assays with immunohistochemistry (IHC), were applied to assess tissue chemistry markers. The activity levels of SOD, GSH, and reactive oxygen species (ROS) were measured to evaluate oxidative stress levels. TUNEL analysis was carried out to detect the apoptosis rate. The levels of VEGF, TGF-β1, and Nrf2 were measured by enzyme-linked immunosorbent assay (ELISA) and western blot (WB). In addition, the in vitro effects of Buforin-I on cell proliferation, apoptosis, migration, and oxidative stress levels under high glucose conditions were analyzed on HaCaT cells. Cell viability was measured using an MTT assay, and cell migration was assessed through the wound healing experiment.ResultsBuforin-I treatment accelerated the healing of foot wounds in STZ-induced diabetic mice, with increased fibroblast proliferation and collagen deposition in the wound tissue and decreased Nrf2-mediated oxidative stress levels. Furthermore, Buforin-I facilitated the proliferation and migration as well as reduced apoptosis of HaCaT cells under high glucose conditions, thus enhancing the antioxidant capacity of HaCaT cells.ConclusionIn conclusion, this study confirmed the promoting effect of Buforin-I on diabetic wound healing through the regulation of oxidative stress, highlighting the potential application of Buforin-I in diabetic wound healing.","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251336569"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of Wound Prognosis with serum IL-6, ICAM-1 and sST2 in Patients with Diabetic Foot and Construction of a Nomogram Model. 糖尿病足患者伤口预后与血清IL-6、ICAM-1、sST2的相关性及Nomogram模型的建立

The international journal of lower extremity wounds Pub Date : 2025-05-30 DOI: 10.1177/15347346251345262

Yali Zhou, Wenhu Zhou, Yu Guo, Changping Hu

{"title":"Correlation of Wound Prognosis with serum IL-6, ICAM-1 and sST2 in Patients with Diabetic Foot and Construction of a Nomogram Model.","authors":"Yali Zhou, Wenhu Zhou, Yu Guo, Changping Hu","doi":"10.1177/15347346251345262","DOIUrl":"https://doi.org/10.1177/15347346251345262","url":null,"abstract":"Diabetes foot (DF) is one of the most serious chronic complications of diabetes. This study explored the relationship between serum interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) and soluble suppression of tumorigenicity 2 (sST2) and wound prognosis in 210 DF patients between January 2019 and January 2024. 210 DF patients were divided into the good prognosis (n = 147) and poor prognosis (n = 63) group according to the prognosis. Comparative analysis revealed that levels of serum IL-6, ICAM-1 and sST2 in the poor prognosis group were all higher than those in the good prognosis group significantly (P < .05). Multivariate logistic regression identified these 3 biomarkers as independent risk factors for poor wound healing (P < .05). Positive correlations between serum IL-6 (r = 0.269), ICAM-1 (r = 0.302), sST2 (r = 0.289) levels and poor prognosis were confirmed through Pearson's correlation analysis. A prediction model was established to analyse their predictive value. The training and validation sets ROC curves had AUCs of 0.79 (0.71-0.87) and 0.75 (0.59-0.91) respectively. Calibration curves were plotted to evaluate the consistency of the model, and the results showed that the predictive value of the nomogram model was similar to that of the actual one. Decision curves were plotted, which showed that the nomogram had higher positive net benefit in the range of 20% to 60%. This study suggest that serum IL-6, ICAM-1, and sST2 levels may serve as valuable prognostic indicators for wound healing progression in DF patients, with combined biomarker assessment showing potential clinical utility for outcome prediction. The total sample size (n = 210), with validation set (n = 63) of this study are relatively limited and the representativeness is restricted, which may affect the universality of the research conclusions.","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251345262"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Tissue-Engineered Amniotic Dressing for Chronic Wound Healing. 用于慢性伤口愈合的新型组织工程羊膜敷料。

The international journal of lower extremity wounds Pub Date : 2025-05-29 DOI: 10.1177/15347346241308087

Pengwen Ni, Kefeng Zhang, Xin Wu, Zhaoqi Jiang, Yao Huang, Beiqian Mao, Bowen Liu, Ting Xie

引用次数: 0

Advancements in Deep Wounds Therapies: The Synergistic Application of Laser Therapy and Nanomaterials. 深度伤口治疗的进展：激光治疗和纳米材料的协同应用。

The international journal of lower extremity wounds Pub Date : 2025-05-27 DOI: 10.1177/15347346251345255

Zahra Al Timimi, Diwan Mohsen

引用次数: 0