The international journal of lower extremity wounds最新文献_第2页

Jean-Martin Charcot: 200 years after his birth, still a paragon in the diabetic foot. Jean-Martin Charcot：在他出生200年后，仍然是糖尿病足的典范。

The international journal of lower extremity wounds Pub Date : 2025-05-25 DOI: 10.1177/15347346251343915

Nina L Petrova, Michael E Edmonds, Nikolaos Papanas

引用次数: 0

Efficacy of Topical Timolol in Chronic Unhealed Ulcers: A Systematic Review and Meta-Analysis. 局部替莫洛尔治疗慢性未愈合溃疡的疗效：一项系统综述和荟萃分析。

The international journal of lower extremity wounds Pub Date : 2025-05-23 DOI: 10.1177/15347346251345249

Muhammad M Elsharkawy, Eslam Mohammed Rabea, Anas Ashraf Elassal, Anan Maher Salaimeh, Adam Naji Zaro, Saad Mohamed Saad, Mohamed Eldesouki

{"title":"Efficacy of Topical Timolol in Chronic Unhealed Ulcers: A Systematic Review and Meta-Analysis.","authors":"Muhammad M Elsharkawy, Eslam Mohammed Rabea, Anas Ashraf Elassal, Anan Maher Salaimeh, Adam Naji Zaro, Saad Mohamed Saad, Mohamed Eldesouki","doi":"10.1177/15347346251345249","DOIUrl":"https://doi.org/10.1177/15347346251345249","url":null,"abstract":"BackgroundTopical timolol appears to provide a curative effect in managing chronic ulcers. However, the pooled evidence of its effect hasn't been established yet. This is the first Meta-analysis to evaluate and assess the efficacy of topical timolol in accelerating wound healing in patients with chronic refractory ulcers.MethodsWe comprehensively searched different electronic databases; PubMed, Scopus, Web of Science, Cochrane library and ClinicalTrials.gov from their inception to November 2024. The search was conducted without imposing any restrictions on publication date or study design. The ROB-II tool was used to assess the quality of included RCTs. NIH tools were used to evaluate the quality of included cohort and single arm studies. Risk ratios (RR) and mean differences (MD), with 95% confidence intervals (CIs), were used as effect estimates.ResultsSix studies were included in this systematic review, comprising two single-arm studies and four double-arm studies (3 RCTs and 1 cohort study). Data from the four double-arm studies on venous ulcers were pooled for meta-analysis. The results showed that topical timolol significantly reduced ulcer area compared to control at 2 weeks (-23.63%; 95% CI: -29.26 to -18.00; p < 0.00001), 4 weeks (-41.40%; 95% CI: -49.57 to -33.23; p < 0.00001), and 12 weeks (-23.38%; 95% CI: -39.43 to -7.33; p = 0.004). Complete ulcer healing was observed at 4 weeks (RR: 12.00; 95% CI: 1.68 to 85.84; p = 0.01) and 12 weeks (RR: 3.79; 95% CI: 0.44 to 32.54; p = 0.22).ConclusionTopical timolol has the potential to promote healing in chronic unhealed ulcers. This meta-analysis, focusing on chronic venous ulcers, consistently showed favorable results across different time points. However, the small sample sizes, lack of blinding, and inclusion of only four studies limit the generalizability of the findings.","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251345249"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic Kidney Disease as an Independent Risk Factor for Chronic Lower Extremity Ulcers: A Cross-Sectional Analysis of US Adults. 慢性肾脏疾病是慢性下肢溃疡的独立危险因素：美国成年人的横断面分析

The international journal of lower extremity wounds Pub Date : 2025-05-22 DOI: 10.1177/15347346251343707

Hai Gao, Juanmin Yang, Zhaohui Wang, Shu Wu, Yangyan Yi

{"title":"Chronic Kidney Disease as an Independent Risk Factor for Chronic Lower Extremity Ulcers: A Cross-Sectional Analysis of US Adults.","authors":"Hai Gao, Juanmin Yang, Zhaohui Wang, Shu Wu, Yangyan Yi","doi":"10.1177/15347346251343707","DOIUrl":"https://doi.org/10.1177/15347346251343707","url":null,"abstract":"BackgroundChronic lower extremity ulcers (CLEU) are a significant health burden, often linked to complications such as diabetes and vascular diseases. Chronic kidney disease (CKD), a prevalent global health issue, has been increasingly associated with CLEU, though the nature of this relationship remains poorly understood. This study aimed to explore the association between CKD and CLEU in the US adult population.MethodsWe analyzed data from the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2004. The study included adults aged 20 years and older who completed interviews and examinations. CLEU was defined as self-reported ulcers or sores on the leg or foot lasting more than four weeks. CKD was diagnosed based on the 2012 KDIGO guidelines, using estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (UACR). Logistic regression models were used to assess the association between CKD and CLEU, adjusting for demographics, BMI, lifestyle factors, and comorbidities.ResultsAmong 8564 participants, individuals with CKD had a higher likelihood of developing CLEU, with an unadjusted odds ratio (OR) of 2.33 (95% CI: 1.86-2.91). After adjusting for confounders, the association remained significant, with adjusted ORs of 1.64 (95% CI: 1.26-2.12) and 1.57 (95% CI: 1.2-2.04) in Models 2 and 3, respectively. Stratified analyses showed no significant interactions across subgroups defined by age, sex, diabetes, hypertension, hyperlipidemia, and peripheral artery disease (PAD).ConclusionThis study demonstrates a robust association between CKD and CLEU in US adults, suggesting that CKD is an independent risk factor for CLEU. These findings highlight the need for integrated management strategies for CKD patients to reduce the risk of CLEU. Future longitudinal studies are needed to establish causality and inform targeted interventions.","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251343707"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Authorship Disputes: An Endemic Plague. 作者争议：一场地方性瘟疫。

The international journal of lower extremity wounds Pub Date : 2025-05-14 DOI: 10.1177/15347346251341635

Miltos K Lazarides, Nikolaos Papanas

引用次数: 0

Higher Serum Levels of Lipoprotein-Associated Phospholipase A2 are Associated with Diabetic Foot Osteomyelitis. 血清脂蛋白相关磷脂酶A2水平升高与糖尿病足骨髓炎有关

The international journal of lower extremity wounds Pub Date : 2025-05-13 DOI: 10.1177/15347346251340757

Haojie Sun, Shucai Zhang, Xuekui Liu, Houfa Geng, Jun Liang

{"title":"Higher Serum Levels of Lipoprotein-Associated Phospholipase A2 are Associated with Diabetic Foot Osteomyelitis.","authors":"Haojie Sun, Shucai Zhang, Xuekui Liu, Houfa Geng, Jun Liang","doi":"10.1177/15347346251340757","DOIUrl":"https://doi.org/10.1177/15347346251340757","url":null,"abstract":"BackgroundDiabetic foot osteomyelitis (DFO) is often difficult to detect in its early stages, making diagnosis challenging. This study is to investigate the relationship between lipoprotein-associated phospholipase A2 (Lp-PLA2) and DFO, while also evaluating the potential of Lp-PLA2 as an early diagnostic biomarker for DFO.MethodsA total of 265 patients with type 2 diabetes complicated by diabetic foot infections were selected for the study. Participants were divided into the Non-DFO group (184 cases) and the DFO group (81 cases). Serum Lp-PLA2 levels were measured. Logistic regression analysis was utilized to identify risk factors associated with DFO. Receiver Operating Characteristic curve analysis was performed to assess the diagnostic value of Lp-PLA2 in patients with DFO.ResultsLp-PLA2 in the DFO group were significantly higher than those in the Non-DFO group (P < .05). Lp-PLA2 (OR, 1.015 [95% CI, 1.011-1.019]; P < .001), lower extremity arterial disease (OR, 2.453 [95% CI, 1.147-5.247]; P < .05), and ESR (OR, 1.042 [95% CI, 1.026-1.059]; P < .001) were the independent risk factors for DFO. Lp-PLA2 and ESR were shown to be associated with DFO, with their respective areas under the curve (AUC) being 0.787 and 0.683. The sensitivity and specificity of Lp-PLA2 were 65.4% and 82.6%, respectively, while those of ESR were 48.1% and 95.1%. Combined Lp-PLA2 and ESR showed the best diagnostic performance (AUC 0.858, sensitivity 79.0%, specificity 84.2%).ConclusionAs a preliminary one, Lp-PLA2 demonstrates significant diagnostic value for DFO. The combination of Lp-PLA2 and ESR can significantly improve diagnostic accuracy of DFO.","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251340757"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LncRNA SNHG14 Drives NLRP3 Inflammasome Activation in Diabetic Foot Ulcers: Mechanistic Insights and Diagnostic Implications. LncRNA SNHG14驱动NLRP3炎性体在糖尿病足溃疡中的激活：机制见解和诊断意义

The international journal of lower extremity wounds Pub Date : 2025-05-07 DOI: 10.1177/15347346251339713

Xincheng Liao, Zhengying Jiang, Zhonghua Fu, Mingzhuo Liu, Guanghua Guo

{"title":"LncRNA SNHG14 Drives NLRP3 Inflammasome Activation in Diabetic Foot Ulcers: Mechanistic Insights and Diagnostic Implications.","authors":"Xincheng Liao, Zhengying Jiang, Zhonghua Fu, Mingzhuo Liu, Guanghua Guo","doi":"10.1177/15347346251339713","DOIUrl":"https://doi.org/10.1177/15347346251339713","url":null,"abstract":"BackgroundDiabetic foot (DF), a severe complication of diabetes mellitus (DM), poses significant challenges in early diagnosis and mechanistic understanding. This study investigates the expression patterns and clinical relevance of long non-coding RNA SNHG14 (lncRNA SNHG14) and the NLRP3 inflammasome in DF pathogenesis.MethodsA total of 176 DM patients (88 DF cases vs 88 Non-DF controls) admitted between September 2022 and February 2024 were enrolled. Serum SNHG14 and NLRP3 levels were quantified via qRT-PCR, while DF severity was categorized using the Wagner grading system. Pearson's correlation assessed SNHG14-NLRP3 interactions, Spearman's rank correlation evaluated their associations with Wagner grades, logistic regression identified independent risk factors, and ROC analysis determined diagnostic efficacy.ResultsDF patients exhibited significantly prolonged diabetes duration, elevated HbA1c%, FPG, and upregulated SNHG14/NLRP3 expression compared to Non-DF controls (P < 0.05). A robust positive correlation was observed between SNHG14 and NLRP3 (r = 0.7006, P < 0.0001). Multivariate logistic regression revealed diabetes duration (OR = 7.423, P < 0.0001), HbA1c (OR = 19.478, P = 0.002), SNHG14 overexpression (OR = 5941.653, P < 0.001), and NLRP3 upregulation (OR = 529.864, P = 0.036) as independent DF risk factors. Both SNHG14 (r = 0.5953) and NLRP3 (r = 0.5554) positively correlated with Wagner grades (P < 0.0001). ROC analysis demonstrated high diagnostic accuracy for SNHG14 (AUC = 0.8688) and NLRP3 (AUC = 0.8074), with combined detection further improving performance (AUC = 0.8773, sensitivity = 77.27%, specificity = 93.18%).ConclusionOverexpression of SNHG14 and NLRP3 is intricately linked to DF progression, metabolic dysregulation, and ulcer severity. Their combined use synergistically enhances diagnostic precision, highlighting transformative potential in DF management.","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251339713"},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcutaneous Application of Gaseous CO₂ Improves Diabetic Distal Symmetrical Polyneuropathy in Patients with and Without Chronic Wounds. 经皮应用气态CO2改善有或无慢性伤口的糖尿病远端对称性多神经病变。

The international journal of lower extremity wounds Pub Date : 2025-05-06 DOI: 10.1177/15347346251338680

Igor Frangež, Nikolaos Papanas, Vesna Đermanović Dobrota, Helena Ban Frangež, Vesna Lukinović-Škudar

{"title":"Transcutaneous Application of Gaseous CO2 Improves Diabetic Distal Symmetrical Polyneuropathy in Patients with and Without Chronic Wounds.","authors":"Igor Frangež, Nikolaos Papanas, Vesna Đermanović Dobrota, Helena Ban Frangež, Vesna Lukinović-Škudar","doi":"10.1177/15347346251338680","DOIUrl":"https://doi.org/10.1177/15347346251338680","url":null,"abstract":"The study explores the effects of non-invasive transcutaneous CO2 therapy on diabetic symmetrical peripheral polyneuropathy (DSPN). Overall, we included 120 patients with diabetes: 40 patients with DSPN (group A) and 40 patients with DSPN and diabetic foot ulceration (DFU) (group B), both receiving 20 sessions of CO2 therapy; 40 DSPN patients not receiving treatment (group C). Outcomes were assessed using the Semmes-Weinstein monofilament test, 128 Hz tuning fork vibration sensation, hallux temperature, wound dimensions, and adverse effects. There was a significant improvement in protective sensation for the CO2-treated groups. Group A exhibited a 53% improvement, while Group B improved by 34% (p = .002). In Groups A, B vibration sensation improvement was 30% and 23%, respectively. Hallux temperature increased more in Group A (5.10 °C) compared with Group B (3.89 °C). Improvement in monofilament sensation was observed in both CO2 treated groups, regardless of ankle-brachial index (ABI), with best results in patients having borderline ABI (67.5% in Group A and 53.1% in Group B). In conclusion, CO2 therapy effectively alleviated DSPN symptoms in patients with/without DFUs, with normal or insufficient circulation, and it was well-tolerated without adverse effects.","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251338680"},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Efficacy of Ischemia Modified Albumin (IMA) as a Predictor for Postoperative Healing among People with Diabetic Foot Ulcer. 缺血修饰白蛋白（IMA）对糖尿病足溃疡患者术后愈合的预测作用

The international journal of lower extremity wounds Pub Date : 2025-05-04 DOI: 10.1177/15347346251332708

Udyama Juttada, Satyavani Kumpatla, Rabeka Manikandan, Vijay Viswanathan

{"title":"The Efficacy of Ischemia Modified Albumin (IMA) as a Predictor for Postoperative Healing among People with Diabetic Foot Ulcer.","authors":"Udyama Juttada, Satyavani Kumpatla, Rabeka Manikandan, Vijay Viswanathan","doi":"10.1177/15347346251332708","DOIUrl":"https://doi.org/10.1177/15347346251332708","url":null,"abstract":"The aim of the study is to determine the efficacy of ischemia-modified albumin (IMA) among diabetic foot ulcers (DFU) individuals as a predictor for wound healing based on IMA values at different stages of treatment. In this hospital based cross-sectional follow up study a total of 71 (41 males and 30 females) individuals were recruited and divided into three groups: Group-I- Control without T2DM (n = 20). Group-II -T2DM without any complication (n = 15), Group-III T2DM with DFU (n = 36) DFU group is further subdivided into two with and without peripheral artery disease as PAD and nonPAD. Demographic and Biochemical characteristics were recorded. Serum IMA levels were measured using Human IMA ELISA kit at 4 regular intervals during treatment of ulcer ie Pre and Post Debridement or angiogram/angioplasty, after HBOT therapy and after healing. Mean age of the study participant was 51.6 ± 12.8 years. The clinical parameters were not associated with age, lipid profile, urea, creatinine, eGFR whereas positive association was observed in glucose level, ESR, Total albumin, WBC, HbA1c among the study groups. Serum IMA levels at baseline in the DFU groups were significantly higher than in the T2DM and control groups (P < .001). Whereas IMA levels when compared at 4 regular intervals showed drastic decline in IMA levels at each interval (P = .0059). IMA levels remained constant after HBOT therapy. In conclusion IMA is a highly sensitive marker and has a high predictive value, which might prove the usefulness of this as a biomarker for early detection of wound healing.","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251332708"},"PeriodicalIF":0.0,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging Knowledge Gaps: Enhancing Burn Wound Management Through Evidence-Based Educational Interventions in Outpatient Settings. 弥合知识差距：通过门诊设置的循证教育干预加强烧伤创面管理。

The international journal of lower extremity wounds Pub Date : 2025-04-29 DOI: 10.1177/15347346251337852

Abdul-Monim Batiha

{"title":"Bridging Knowledge Gaps: Enhancing Burn Wound Management Through Evidence-Based Educational Interventions in Outpatient Settings.","authors":"Abdul-Monim Batiha","doi":"10.1177/15347346251337852","DOIUrl":"https://doi.org/10.1177/15347346251337852","url":null,"abstract":"BackgroundKnowledge deficits in burn wound management among healthcare providers often lead to inconsistent practices and adverse patient outcomes. This study assessed how well a brief, evidence-based educational module affected the confidence and knowledge of Jordanian healthcare professionals.MethodsA pre-post intervention was conducted with 22 healthcare providers across two hospitals in Jordan. Participants attended a 25-min educational session focusing on evidence-based burn care practices. Knowledge and confidence were assessed before and immediately after the session, with follow-up testing conducted 5 weeks later. Paired Student's t-tests were used in the statistical analysis to assess score changes.ResultsThe mean knowledge score significantly increased from 3.8 ± 1.2 at baseline to 6.4 ± 1.1 immediately post-intervention (p = 0.001), with sustained improvement at 5 weeks (mean score: 6.2 ± 1.0, p = 0.001). Confidence levels also showed significant gains, rising from 2.3 ± 0.7 to 3.6 ± 0.6 (p = 0.001) post-intervention. These findings demonstrate the effectiveness of targeted education in addressing critical knowledge gaps and improving provider confidence.ConclusionThe results strongly support the need for integrating structured, evidence-based training modules in burn wound management to standardize practices, improve outcomes, and foster sustained learning among healthcare providers.","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251337852"},"PeriodicalIF":0.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Local Use of Insulin on Wound-Ulcer in Diabetic or Non-Diabetic Patients: A Scoping Review. 局部使用胰岛素对糖尿病或非糖尿病患者伤口溃疡的影响：一项范围综述。

The international journal of lower extremity wounds Pub Date : 2025-04-29 DOI: 10.1177/15347346251338182

Anastasia Stergioti, Vassiliki Karra, Maria Chatzopoulou, Maria Kalafati

{"title":"The Effect of Local Use of Insulin on Wound-Ulcer in Diabetic or Non-Diabetic Patients: A Scoping Review.","authors":"Anastasia Stergioti, Vassiliki Karra, Maria Chatzopoulou, Maria Kalafati","doi":"10.1177/15347346251338182","DOIUrl":"https://doi.org/10.1177/15347346251338182","url":null,"abstract":"Insulin regulates numerous metabolic functions and plays a pivotal role in the regulation of cellular growth. This scoping review was conducted due to insufficient evidence regarding the effects of topical insulin administration on ulcer-wound healing in adults, both with and without Diabetes Mellitus (DM). The main objective of this review was to investigate whether the local application of insulin to ulcers-wounds could be used safely to promote faster healing of ulcers. We conducted a comprehensive search of PubMed, Cochrane, and EBSCO databases for primary studies, with no date restrictions. Clinical trials, both randomized and non-randomized, involving adults (> 19 years) with wounds-ulcers, regardless of DM status, were included. A total number of 173 articles were initially identified. Following the application of the PICOS criteria, 14 articles were included in the study. The analysis revealed that topical insulin, via injection or dressing, accelerates ulcer healing, indicating its role beyond blood glucose regulation. The majority of studies reported better wound size reduction and closure with insulin than alternative treatments, with local injection being most effective. In most cases, applying insulin to wounds did not cause adverse effects. The review concluded that insulin may be a valuable addition to standard ulcer care treatments.","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251338182"},"PeriodicalIF":0.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0