{"title":"Correlation of Wound Prognosis with serum IL-6, ICAM-1 and sST2 in Patients with Diabetic Foot and Construction of a Nomogram Model.","authors":"Yali Zhou, Wenhu Zhou, Yu Guo, Changping Hu","doi":"10.1177/15347346251345262","DOIUrl":"https://doi.org/10.1177/15347346251345262","url":null,"abstract":"<p><p>Diabetes foot (DF) is one of the most serious chronic complications of diabetes. This study explored the relationship between serum interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) and soluble suppression of tumorigenicity 2 (sST2) and wound prognosis in 210 DF patients between January 2019 and January 2024. 210 DF patients were divided into the good prognosis (n = 147) and poor prognosis (n = 63) group according to the prognosis. Comparative analysis revealed that levels of serum IL-6, ICAM-1 and sST2 in the poor prognosis group were all higher than those in the good prognosis group significantly (<i>P</i> < .05). Multivariate logistic regression identified these 3 biomarkers as independent risk factors for poor wound healing (<i>P</i> < .05). Positive correlations between serum IL-6 (r = 0.269), ICAM-1 (r = 0.302), sST2 (r = 0.289) levels and poor prognosis were confirmed through Pearson's correlation analysis. A prediction model was established to analyse their predictive value. The training and validation sets ROC curves had AUCs of 0.79 (0.71-0.87) and 0.75 (0.59-0.91) respectively. Calibration curves were plotted to evaluate the consistency of the model, and the results showed that the predictive value of the nomogram model was similar to that of the actual one. Decision curves were plotted, which showed that the nomogram had higher positive net benefit in the range of 20% to 60%. This study suggest that serum IL-6, ICAM-1, and sST2 levels may serve as valuable prognostic indicators for wound healing progression in DF patients, with combined biomarker assessment showing potential clinical utility for outcome prediction. The total sample size (n = 210), with validation set (n = 63) of this study are relatively limited and the representativeness is restricted, which may affect the universality of the research conclusions.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251345262"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel Tissue-Engineered Amniotic Dressing for Chronic Wound Healing.","authors":"Pengwen Ni, Kefeng Zhang, Xin Wu, Zhaoqi Jiang, Yao Huang, Beiqian Mao, Bowen Liu, Ting Xie","doi":"10.1177/15347346241308087","DOIUrl":"https://doi.org/10.1177/15347346241308087","url":null,"abstract":"<p><p>Chronic wounds represent a worldwide challenge, often proving difficult to heal with currently available treatments. This report introduces a novel tissue-engineered amniotic dressing, AmGel, used for treating chronic wounds in two patients. Prepared by integrating amniotic membrane with natural biopolymers, AmGel demonstrates excellent biocompatibility and safety, offering a safe, efficacious, and user-friendly therapeutic solution for chronic wounds. The aim of this study was to conduct a preliminary evaluation of the safety and effectiveness of this tissue-engineered amniotic dressing. Both patients achieved over an 80% wound healing rate within six weeks of treatment with AmGel, with complete wound closure occurring after twelve weeks. No adverse events were reported during the treatment period. This study describes the details of the clinical cases and provides an overview of the current evidence on the use of AmGel dressings in clinical practice.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346241308087"},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advancements in Deep Wounds Therapies: The Synergistic Application of Laser Therapy and Nanomaterials.","authors":"Zahra Al Timimi, Diwan Mohsen","doi":"10.1177/15347346251345255","DOIUrl":"https://doi.org/10.1177/15347346251345255","url":null,"abstract":"<p><p>There have been advances in the treatment of wounds in recent years due to the innovative combination of nanomaterials and lasers. Laser therapy for wounds enhances cell proliferation at the wound site. This promotes angiogenesis, tissue healing, and anti-inflammatory effects. Because of their unique physicochemical properties, nanoparticles are also found to possess antibacterial effects, improve biocompatibility, and provide targeted drug delivery, thereby being beneficial as wound therapies. Nanomaterials and medical lasers are aimed at improving the therapeutic efficacy for the standard management of wounds with infection control and impaired healing. This research is intended to elucidate the mechanisms of the new treatment approach, clinical applications, and objectives for future research towards improving wound healing.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251345255"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nina L Petrova, Michael E Edmonds, Nikolaos Papanas
{"title":"Jean-Martin Charcot: 200 years after his birth, still a paragon in the diabetic foot.","authors":"Nina L Petrova, Michael E Edmonds, Nikolaos Papanas","doi":"10.1177/15347346251343915","DOIUrl":"https://doi.org/10.1177/15347346251343915","url":null,"abstract":"","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251343915"},"PeriodicalIF":0.0,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad M Elsharkawy, Eslam Mohammed Rabea, Anas Ashraf Elassal, Anan Maher Salaimeh, Adam Naji Zaro, Saad Mohamed Saad, Mohamed Eldesouki
{"title":"Efficacy of Topical Timolol in Chronic Unhealed Ulcers: A Systematic Review and Meta-Analysis.","authors":"Muhammad M Elsharkawy, Eslam Mohammed Rabea, Anas Ashraf Elassal, Anan Maher Salaimeh, Adam Naji Zaro, Saad Mohamed Saad, Mohamed Eldesouki","doi":"10.1177/15347346251345249","DOIUrl":"https://doi.org/10.1177/15347346251345249","url":null,"abstract":"<p><p>BackgroundTopical timolol appears to provide a curative effect in managing chronic ulcers. However, the pooled evidence of its effect hasn't been established yet. This is the first Meta-analysis to evaluate and assess the efficacy of topical timolol in accelerating wound healing in patients with chronic refractory ulcers.MethodsWe comprehensively searched different electronic databases; PubMed, Scopus, Web of Science, Cochrane library and ClinicalTrials.gov from their inception to November 2024. The search was conducted without imposing any restrictions on publication date or study design. The ROB-II tool was used to assess the quality of included RCTs. NIH tools were used to evaluate the quality of included cohort and single arm studies. Risk ratios (RR) and mean differences (MD), with 95% confidence intervals (CIs), were used as effect estimates.ResultsSix studies were included in this systematic review, comprising two single-arm studies and four double-arm studies (3 RCTs and 1 cohort study). Data from the four double-arm studies on venous ulcers were pooled for meta-analysis. The results showed that topical timolol significantly reduced ulcer area compared to control at 2 weeks (-23.63%; 95% CI: -29.26 to -18.00; p < 0.00001), 4 weeks (-41.40%; 95% CI: -49.57 to -33.23; p < 0.00001), and 12 weeks (-23.38%; 95% CI: -39.43 to -7.33; p = 0.004). Complete ulcer healing was observed at 4 weeks (RR: 12.00; 95% CI: 1.68 to 85.84; p = 0.01) and 12 weeks (RR: 3.79; 95% CI: 0.44 to 32.54; p = 0.22).ConclusionTopical timolol has the potential to promote healing in chronic unhealed ulcers. This meta-analysis, focusing on chronic venous ulcers, consistently showed favorable results across different time points. However, the small sample sizes, lack of blinding, and inclusion of only four studies limit the generalizability of the findings.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251345249"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hai Gao, Juanmin Yang, Zhaohui Wang, Shu Wu, Yangyan Yi
{"title":"Chronic Kidney Disease as an Independent Risk Factor for Chronic Lower Extremity Ulcers: A Cross-Sectional Analysis of US Adults.","authors":"Hai Gao, Juanmin Yang, Zhaohui Wang, Shu Wu, Yangyan Yi","doi":"10.1177/15347346251343707","DOIUrl":"https://doi.org/10.1177/15347346251343707","url":null,"abstract":"<p><p>BackgroundChronic lower extremity ulcers (CLEU) are a significant health burden, often linked to complications such as diabetes and vascular diseases. Chronic kidney disease (CKD), a prevalent global health issue, has been increasingly associated with CLEU, though the nature of this relationship remains poorly understood. This study aimed to explore the association between CKD and CLEU in the US adult population.MethodsWe analyzed data from the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2004. The study included adults aged 20 years and older who completed interviews and examinations. CLEU was defined as self-reported ulcers or sores on the leg or foot lasting more than four weeks. CKD was diagnosed based on the 2012 KDIGO guidelines, using estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (UACR). Logistic regression models were used to assess the association between CKD and CLEU, adjusting for demographics, BMI, lifestyle factors, and comorbidities.ResultsAmong 8564 participants, individuals with CKD had a higher likelihood of developing CLEU, with an unadjusted odds ratio (OR) of 2.33 (95% CI: 1.86-2.91). After adjusting for confounders, the association remained significant, with adjusted ORs of 1.64 (95% CI: 1.26-2.12) and 1.57 (95% CI: 1.2-2.04) in Models 2 and 3, respectively. Stratified analyses showed no significant interactions across subgroups defined by age, sex, diabetes, hypertension, hyperlipidemia, and peripheral artery disease (PAD).ConclusionThis study demonstrates a robust association between CKD and CLEU in US adults, suggesting that CKD is an independent risk factor for CLEU. These findings highlight the need for integrated management strategies for CKD patients to reduce the risk of CLEU. Future longitudinal studies are needed to establish causality and inform targeted interventions.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251343707"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Authorship Disputes: An Endemic Plague.","authors":"Miltos K Lazarides, Nikolaos Papanas","doi":"10.1177/15347346251341635","DOIUrl":"https://doi.org/10.1177/15347346251341635","url":null,"abstract":"","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251341635"},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haojie Sun, Shucai Zhang, Xuekui Liu, Houfa Geng, Jun Liang
{"title":"Higher Serum Levels of Lipoprotein-Associated Phospholipase A2 are Associated with Diabetic Foot Osteomyelitis.","authors":"Haojie Sun, Shucai Zhang, Xuekui Liu, Houfa Geng, Jun Liang","doi":"10.1177/15347346251340757","DOIUrl":"https://doi.org/10.1177/15347346251340757","url":null,"abstract":"<p><p>BackgroundDiabetic foot osteomyelitis (DFO) is often difficult to detect in its early stages, making diagnosis challenging. This study is to investigate the relationship between lipoprotein-associated phospholipase A2 (Lp-PLA2) and DFO, while also evaluating the potential of Lp-PLA2 as an early diagnostic biomarker for DFO.MethodsA total of 265 patients with type 2 diabetes complicated by diabetic foot infections were selected for the study. Participants were divided into the Non-DFO group (184 cases) and the DFO group (81 cases). Serum Lp-PLA2 levels were measured. Logistic regression analysis was utilized to identify risk factors associated with DFO. Receiver Operating Characteristic curve analysis was performed to assess the diagnostic value of Lp-PLA2 in patients with DFO.ResultsLp-PLA2 in the DFO group were significantly higher than those in the Non-DFO group (<i>P</i> < .05). Lp-PLA2 (OR, 1.015 [95% CI, 1.011-1.019]; <i>P</i> < .001), lower extremity arterial disease (OR, 2.453 [95% CI, 1.147-5.247]; <i>P</i> < .05), and ESR (OR, 1.042 [95% CI, 1.026-1.059]; <i>P</i> < .001) were the independent risk factors for DFO. Lp-PLA2 and ESR were shown to be associated with DFO, with their respective areas under the curve (AUC) being 0.787 and 0.683. The sensitivity and specificity of Lp-PLA2 were 65.4% and 82.6%, respectively, while those of ESR were 48.1% and 95.1%. Combined Lp-PLA2 and ESR showed the best diagnostic performance (AUC 0.858, sensitivity 79.0%, specificity 84.2%).ConclusionAs a preliminary one, Lp-PLA2 demonstrates significant diagnostic value for DFO. The combination of Lp-PLA2 and ESR can significantly improve diagnostic accuracy of DFO.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251340757"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"LncRNA SNHG14 Drives NLRP3 Inflammasome Activation in Diabetic Foot Ulcers: Mechanistic Insights and Diagnostic Implications.","authors":"Xincheng Liao, Zhengying Jiang, Zhonghua Fu, Mingzhuo Liu, Guanghua Guo","doi":"10.1177/15347346251339713","DOIUrl":"10.1177/15347346251339713","url":null,"abstract":"<p><p>BackgroundDiabetic foot (DF), a severe complication of diabetes mellitus (DM), poses significant challenges in early diagnosis and mechanistic understanding. This study investigates the expression patterns and clinical relevance of long non-coding RNA SNHG14 (lncRNA SNHG14) and the NLRP3 inflammasome in DF pathogenesis.MethodsA total of 176 DM patients (88 DF cases vs 88 Non-DF controls) admitted between September 2022 and February 2024 were enrolled. Serum SNHG14 and NLRP3 levels were quantified via qRT-PCR, while DF severity was categorized using the Wagner grading system. Pearson's correlation assessed SNHG14-NLRP3 interactions, Spearman's rank correlation evaluated their associations with Wagner grades, logistic regression identified independent risk factors, and ROC analysis determined diagnostic efficacy.ResultsDF patients exhibited significantly prolonged diabetes duration, elevated HbA1c%, FPG, and upregulated SNHG14/NLRP3 expression compared to Non-DF controls (P < 0.05). A robust positive correlation was observed between SNHG14 and NLRP3 (r = 0.7006, P < 0.0001). Multivariate logistic regression revealed diabetes duration (OR = 7.423, P < 0.0001), HbA1c (OR = 19.478, P = 0.002), SNHG14 overexpression (OR = 5941.653, P < 0.001), and NLRP3 upregulation (OR = 529.864, P = 0.036) as independent DF risk factors. Both SNHG14 (r = 0.5953) and NLRP3 (r = 0.5554) positively correlated with Wagner grades (P < 0.0001). ROC analysis demonstrated high diagnostic accuracy for SNHG14 (AUC = 0.8688) and NLRP3 (AUC = 0.8074), with combined detection further improving performance (AUC = 0.8773, sensitivity = 77.27%, specificity = 93.18%).ConclusionOverexpression of SNHG14 and NLRP3 is intricately linked to DF progression, metabolic dysregulation, and ulcer severity. Their combined use synergistically enhances diagnostic precision, highlighting transformative potential in DF management.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251339713"},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Igor Frangež, Nikolaos Papanas, Vesna Đermanović Dobrota, Helena Ban Frangež, Vesna Lukinović-Škudar
{"title":"Transcutaneous Application of Gaseous CO<sub>2</sub> Improves Diabetic Distal Symmetrical Polyneuropathy in Patients with and Without Chronic Wounds.","authors":"Igor Frangež, Nikolaos Papanas, Vesna Đermanović Dobrota, Helena Ban Frangež, Vesna Lukinović-Škudar","doi":"10.1177/15347346251338680","DOIUrl":"https://doi.org/10.1177/15347346251338680","url":null,"abstract":"<p><p>The study explores the effects of non-invasive transcutaneous CO<sub>2</sub> therapy on diabetic symmetrical peripheral polyneuropathy (DSPN). Overall, we included 120 patients with diabetes: 40 patients with DSPN (group A) and 40 patients with DSPN and diabetic foot ulceration (DFU) (group B), both receiving 20 sessions of CO<sub>2</sub> therapy; 40 DSPN patients not receiving treatment (group C). Outcomes were assessed using the Semmes-Weinstein monofilament test, 128 Hz tuning fork vibration sensation, hallux temperature, wound dimensions, and adverse effects. There was a significant improvement in protective sensation for the CO<sub>2</sub>-treated groups. Group A exhibited a 53% improvement, while Group B improved by 34% (p = .002). In Groups A, B vibration sensation improvement was 30% and 23%, respectively. Hallux temperature increased more in Group A (5.10 °C) compared with Group B (3.89 °C). Improvement in monofilament sensation was observed in both CO<sub>2</sub> treated groups, regardless of ankle-brachial index (ABI), with best results in patients having borderline ABI (67.5% in Group A and 53.1% in Group B). In conclusion, CO<sub>2</sub> therapy effectively alleviated DSPN symptoms in patients with/without DFUs, with normal or insufficient circulation, and it was well-tolerated without adverse effects.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251338680"},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}