Canadian Journal of Chemistry最新文献_第7页

When is a Pyridine Not a Pyridine? Benzannulated N-Heterocyclic Ligands in Molecular Materials Chemistry 什么时候吡啶不是吡啶?分子材料化学中的苯环n -杂环配体

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-04-05 DOI: 10.1139/cjc-2022-0314

David E. Herbert

引用次数: 0

Visible-Light Photoredox-catalyzed Coupling of Alkylsulfones with α-(Trifluoromethyl)styrenes 可见光光氧化还原催化烷基砜与α-(三氟甲基)苯乙烯的偶联

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-04-05 DOI: 10.1139/cjc-2022-0271

Yasuyo Tahara, Koushik Ghosh, Masakazu Nambo

引用次数: 0

Revisiting the Coupling Reaction Between 4-Aminoantipyrine and Phenols: A Potential One-Pot Reaction Pathway to 4,11- and 5,12-Naphthoxazepine Isomers 4-氨基安替比林与苯酚的偶联反应:4,11-和5,12-萘甲西平异构体的一锅反应途径

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-04-05 DOI: 10.1139/cjc-2022-0239

O. Otim

{"title":"Revisiting the Coupling Reaction Between 4-Aminoantipyrine and Phenols: A Potential One-Pot Reaction Pathway to 4,11- and 5,12-Naphthoxazepine Isomers","authors":"O. Otim","doi":"10.1139/cjc-2022-0239","DOIUrl":"https://doi.org/10.1139/cjc-2022-0239","url":null,"abstract":"This journal (Canadian Journal of Chemistry) published a while ago a set of seminal studies revealing the underlying mechanisms supporting the then widely used analytical technique for detecting phenols at low levels in domestic water supply using 4-aminoantipyrine (4-AAP). The current paper revisits these studies with a primary focus on the dimension of this reaction that synthesizes 6- and 7-membered heterocyclic rings containing both N and O in a single step. Here we report a rather unusual outcome of the reaction in which, while the oxidative coupling of 4-AAP to 1-naphthol in aqueous solution at high pH (or condensation with 1,4-naphthoquinone in chloroform) leads to the same naphthoquinonimide product, a similar set of reactions with 2-naphthol and 1,2-naphthoquinone produces two isomeric forms of an oxazepine instead. In one isomer, the 4-AAP/naphthol C-N and the C-O linkages are at positions 1 and 2 of naphthyl ring, respectively and in the other form, these linkages are at positions 2 and 1, respectively. This unexpected difference in a one-pot reaction at ambient temperature is potentially the flexibility needed to synthesize families of pharmaceutically relevant oxazepines. Spectroscopic features useful for identifying 12 heterocyclic compounds, nine of which are new, are also provided.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"23 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72936679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benchtop 19F nuclear magnetic resonance spectroscopy enabled kinetic studies and optimization of the synthesis of carmofur 台式19F核磁共振波谱使动力学研究和优化合成卡莫弗

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-04-05 DOI: 10.1139/cjc-2022-0266

Xina Wang, Julia Vu, Charissa Luk, Edward Njoo

引用次数: 1

Investigating the Rydberg States and Photodissociation Dynamics of Kr2 using Velocity Map Imaging 利用速度图成像技术研究Kr2的Rydberg态和光解动力学

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-04-05 DOI: 10.1139/cjc-2022-0283

Cailum M K Stienstra, N. Coughlan, Alexander Haack, Patrick J. J. Carr, J. Crouse, Joshua Featherstone, Scott W. Hopkins

{"title":"Investigating the Rydberg States and Photodissociation Dynamics of Kr2 using Velocity Map Imaging","authors":"Cailum M K Stienstra, N. Coughlan, Alexander Haack, Patrick J. J. Carr, J. Crouse, Joshua Featherstone, Scott W. Hopkins","doi":"10.1139/cjc-2022-0283","DOIUrl":"https://doi.org/10.1139/cjc-2022-0283","url":null,"abstract":"Although the krypton dimer, Kr2, is a prototypical weakly bound van der Waals complex in its ground electronic state, the excited states of Kr2 exhibit many and various interactions. Resonance enhanced multiphoton ionization and velocity map imaging provide an avenue to explore the electronic structure and photofragmentation dynamics of Kr2 in the vacuum ultraviolet region. By monitoring photofragmentation product channels and recoil anisotropy distributions, one can gain insights into excited state symmetries and lifetimes, which can aid in interpreting spectroscopy. Here, we study the spectroscopy and photodissociation dynamics of Kr2 in the 91,000 – 94,500 cm-1 region. We record and assign photofragment product channels for 32 vibronic bands corresponding to seven electronic transitions. We also identify two previously unobserved vibronic band systems, which we assign as the Kr2 5p [5/2]3 1g ← X0g+ and 5p [3/2]2 0g+ ← X0g+ transitions. Velocity map images show photofragments arising from predissociation of the neutral Rydberg states and from dissociative photoionization at the n > 2 photon level. We also observe variation in branching ratios between the predissociative and dissociative photoionization channels depending on the lifetime of the intermediate; longer lived states favour higher dissociative photoionization yields and exhibit β6 anisotropy parameters for predissociation product channels, indicating “rotational smearing” of the product angular distributions.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90290566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, anticancer evaluation and molecular docking study of some Arylidenehydrazono analogues 一些芳基二肼类似物的合成、抗癌评价及分子对接研究

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-04-05 DOI: 10.1139/cjc-2022-0276

M. Soliman, N. Mahmoud, Aml B. Mohamed, Howayda E. Khaled

{"title":"Synthesis, anticancer evaluation and molecular docking study of some Arylidenehydrazono analogues","authors":"M. Soliman, N. Mahmoud, Aml B. Mohamed, Howayda E. Khaled","doi":"10.1139/cjc-2022-0276","DOIUrl":"https://doi.org/10.1139/cjc-2022-0276","url":null,"abstract":"A series of 2-(arylidenehydrazono)-5-(2-oxo-2-arylethyl)thiazolidin-4-one derivatives were synthesized, characterized by spectral analyses and evaluated for their in vitro antitumor activity. The IC50 determination of compounds was investigated on the human breast cancer cell line MCF-7. Among the series, compounds 3, 6, 10, 16, 17 and 24 showed remarkable anticancer activity with mean IC50 values 2.34, 0.73, 2.69, 3.40, 1.18 and 1.76 μg/ml respectively, against MCF-7 cancer cells. Compound 16 enhanced the concentration of caspase-9, inhibited the concentration of KI67 and showed a profound reduction in the amount of MMP9 secreted into the medium of MCF-7 treated cells. Furthermore, compound 16 revealed anti-angiogenic activity through down-regulation the concentration of VEGF in the medium of MCF-7 treated cells. Compound 16 exerted cytotoxic effects on MCF-7 tumor cells via anti-proliferative, apoptotic, antiangiogenic and antimetastatic activities. Molecular docking methodology was performed for the most effective anticancer compounds to rationalize the possible interactions with active site of VEGFR-2 enzyme.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"25 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81589343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gathering Validity Evidence in the Development of a New Version of the Attitude Toward the Subject of Chemistry Inventory (ASCI-UE) 新版《化学清单》主题态度量表的效度证据收集

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-04-05 DOI: 10.1139/cjc-2022-0162

{"title":"Gathering Validity Evidence in the Development of a New Version of the Attitude Toward the Subject of Chemistry Inventory (ASCI-UE)","authors":"","doi":"10.1139/cjc-2022-0162","DOIUrl":"https://doi.org/10.1139/cjc-2022-0162","url":null,"abstract":"Organic chemistry is one of the most feared and failed courses due to its complex and fast-paced nature. Investigating affective metrics that relate to achievement in these courses can be worthwhile, particularly when these metrics show predictive relationships to achievement. Attitude toward chemistry has been investigated utilizing a variety of instruments. We present herein an instrument related to the well-established ASCIv2. This new instrument was developed utilizing The Standards of Psychological and Educational Measurement which describe five aspects of validity evidence that should be gathered when using instruments in research. Content validity was gathered through consultation with experts. Response process validity was gathered through student interviews. Internal structure validity was collected through confirmatory factor analysis. Relations to other variables were investigated through correlation analysis and structural equation modeling. Consequential validity was studied through measurement invariance testing before comparing scores for subgroups (high- and low-achieving students). Additionally, reliability evidence was tested with Omega coefficients for each of the factors. We showed that all tests and analyses were done with high rigor, and that this new instrument, ASCI-UE, measuring Utility and Emotional Satisfaction, can provide interesting results and implications for research and practice.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"21 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91139967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adsorption of tetracycline antibiotics to gold nanoparticles and feasibility of aptamer-based label-free colorimetric detection 四环素类抗生素在金纳米颗粒上的吸附及基于适配体的无标记比色检测的可行性

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-03-10 DOI: 10.1139/cjc-2022-0253

Yuheng Song, Derek H. G. von Eppinghoven, Yang Zhou, Hanxiao Zhang, Juewen Liu

{"title":"Adsorption of tetracycline antibiotics to gold nanoparticles and feasibility of aptamer-based label-free colorimetric detection","authors":"Yuheng Song, Derek H. G. von Eppinghoven, Yang Zhou, Hanxiao Zhang, Juewen Liu","doi":"10.1139/cjc-2022-0253","DOIUrl":"https://doi.org/10.1139/cjc-2022-0253","url":null,"abstract":"Tetracyclines are a group of very important antibiotics that are still in use to date. To extract, detect and remove tetracyclines from the environment, various nanomaterials have been employed. Although gold nanoparticles (AuNPs) are a commonly cited material for these purposes, fundamental understanding of these tetracycline-AuNP systems are still limited. In this work, the adsorption of tetracycline, oxytetracycline and doxycycline to AuNPs was studied. The effect on the colloidal stability of AuNPs, adsorption kinetics, and the resulting adsorption isotherms were measured. While millimolar concentrations of the tetracyclines can cause aggregation of AuNPs, saturated monolayer adsorption was achieved with low micromolar concentrations of the tetracyclines. Adsorption was instantaneous, and adsorption to AuNPs enhanced their intrinsic fluorescence instead of quenching. With the assumption of aptamer/target complexes cannot be easily adsorbed by AuNPs compared to free aptamers, a label-free colorimetric detection method was tested. While the label-free sensor showed target-dependent aggregation of AuNPs, a non-binding mutant aptamer showed the same trend, suggesting that the color change did not reflect aptamer adsorption but other events such as target adsorption. This study indicates the importance of fundamental understanding of target/AuNP interactions to correctly design aptamer and AuNP-based label-free biosensors.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"67 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83162831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Celebrating the life of Suning Wang 纪念王苏宁的一生

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-03-01 DOI: 10.1139/cjc-2023-0024

Z. Hudson, B. Blight

引用次数: 0

Stable, π-conjugated radical anions of boron–nitrogen dihydroindeno[1,2-b]fluorenes 硼氮二氢茚[1,2-b]芴的稳定π共轭自由基阴离子

4区化学

Canadian Journal of Chemistry Pub Date : 2023-03-01 DOI: 10.1139/cjc-2022-0039

Tony Nguyen, Tyler Hannah, Warren E. Piers, Benjamin Gelfand

{"title":"Stable, π-conjugated radical anions of boron–nitrogen dihydroindeno[1,2-b]fluorenes","authors":"Tony Nguyen, Tyler Hannah, Warren E. Piers, Benjamin Gelfand","doi":"10.1139/cjc-2022-0039","DOIUrl":"https://doi.org/10.1139/cjc-2022-0039","url":null,"abstract":"We have recently reported the synthesis and application of boron–nitrogen dihydroindeno[1,2-b]fluorene derivatives as acceptors in organic photovoltaic devices. Their modest observed efficiencies may be related to the properties of their reduced congeners. In this work, we report two new members of this family of compounds prepared via the electrophilic borylation of 2,5-di- p-tolylpyrazine followed by an arylation of the boron center with ZnAr 2 reagents. Two derivatives, 1 (Ar = 2,4,6-F 3 C 6 H 2 ) and 2 (Ar = C 6 F 5 ) were synthesized, and their radical anions, 1 •− and 2 •− , were formed via chemical reductions with CoCp* 2 and CoCp 2 , respectively. Through comparison of structural parameters, as well as spectroscopic and computational data, the unpaired electron in the radical anions is localized in the planar core of the molecule, and dimerization is disfavored as a result. However, unlike the neutral starting materials, 1 •− and 2 •− are reactive toward ambient atmosphere. These observations suggest that the reduced compounds are stable toward intrinsic degradation pathways but subject to extrinsic degradation in device operation.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135742783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2