Canadian Journal of Chemistry最新文献

Parallel Valet Parking: Selective Ion Escape over an AC Barrier During Ion/ion Reactions in a Quadrupole Linear Ion Trap. 平行代客泊车：在四极线性离子阱中离子/离子反应期间，选择性离子越过交流势垒逃逸。

IF 1 4区化学

Canadian Journal of Chemistry Pub Date : 2026-02-23 DOI: 10.1139/cjc-2025-0266

Seth A Horn, Nicolas J Pizzala, Scott A McLuckey

{"title":"Parallel Valet Parking: Selective Ion Escape over an AC Barrier During Ion/ion Reactions in a Quadrupole Linear Ion Trap.","authors":"Seth A Horn, Nicolas J Pizzala, Scott A McLuckey","doi":"10.1139/cjc-2025-0266","DOIUrl":"10.1139/cjc-2025-0266","url":null,"abstract":"Ion storage in a quadrupole linear ion trap (QLIT) in the x- and y-dimensions relies on a quadrupolar electric field that oscillates at a radio-frequency. In the z-dimension, trapping can take place either via a fixed DC electrostatic potential, via oscillatory AC voltages, or via a combination of the two applied to plates situated at the ends of the QLIT. With a combination of an AC barrier with an attractive DC potential, it is possible to effect storage in the z-dimension that is mass-to-charge (m/z) dependent. In this work, the m/z-dependent release of ions from a QLIT to an adjacent time-of-flight (TOF) mass spectrometer is demonstrated. An application of this phenomenon is demonstrated with gas-phase ion/ion proton transfer reactions in which high m/z ions generated via charge-state reduction are released to a TOF mass analyzer before a significant degree of neutralization can take place. The transfer of a product ion from a QLIT to an adjacent mass analyzer is referred to as 'valet parking'. Valet parking has been demonstrated previously using ion/molecule proton transfer reactions with the transfer of ions within a narrow band of m/z values. The selective release of ions that exceed a threshold m/z value allows for the simultaneous valet parking of ions derived from mixtures of analytes. This is referred to a 'parallel valet parking', which is demonstrated here with a three-protein mixture of cytochrome c, ubiquitin, and myoglobin.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12931820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147302588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two-step synthesis of large-π conjugated polyimides for the anode of sodium ion battery 钠离子电池负极用大π共轭聚酰亚胺的两步法合成

4区化学

Canadian Journal of Chemistry Pub Date : 2025-06-23 DOI: 10.1139/cjc-2025-0080

Jun‐Long Zhang, Mingcong Yang, Huile Jin, Jun Li, Shun Wang, Jichang Wang

{"title":"Two-step synthesis of large-π conjugated polyimides for the anode of sodium ion battery","authors":"Jun‐Long Zhang, Mingcong Yang, Huile Jin, Jun Li, Shun Wang, Jichang Wang","doi":"10.1139/cjc-2025-0080","DOIUrl":"https://doi.org/10.1139/cjc-2025-0080","url":null,"abstract":"This study explored a two-step synthesis to prepare polyimide (PI) for applications as the anode of sodium ion batteries (SIBs). Recently, organic materials, particularly π-conjugated organic polymers, have emerged as promising alternatives to hard carbons for SIBs that have garnered considerable attention in advancing energy storage technology due to the abundance of sodium resources and their cost-effectiveness. The proposed two-step synthesis took place at a moderate temperature 120 °C, which was much lower than the existing single step method, in which the elevated temperature might lead to by-product formation. This low temperature synthesis incorporated multiple carbonyl redox sites in the final products and effectively addressed the structural instability and active site loss that were typically associated with high-temperature synthesis processes. The resulting SIBs demonstrate a reversible capacity of 330.1 mAh g −1 after 1100 cycles at a current density of 1.0 A g −1 , with a capacity retention of 99.2% and a capacity maintenance rate of 98.8%. These performance metrics are comparable to those of existing hard carbon anode materials. The results suggest that the optimization of polyimide materials presents a viable strategy for improving sodium-ion battery performance.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147914393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small science and big science entanglement: the advent of a new era of synchrotron light sources for chemical research—Chemistry at the Edge 小科学与大科学的纠缠：化学研究用同步加速器光源新时代的到来——边缘化学

4区化学

Canadian Journal of Chemistry Pub Date : 2025-02-20 DOI: 10.1139/cjc-2024-0096

Tsun‐Kong Sham

{"title":"Small science and big science entanglement: the advent of a new era of synchrotron light sources for chemical research—Chemistry at the Edge","authors":"Tsun‐Kong Sham","doi":"10.1139/cjc-2024-0096","DOIUrl":"https://doi.org/10.1139/cjc-2024-0096","url":null,"abstract":"Large facilities (big science) that provide advanced capabilities not available in researchers’ laboratories in universities and institutions have become increasingly indipensible to advance research and innovation. A synchrotron light source is one of such facilities crucial to chemical research. Herein, the entanglement of small science and big science in general is described with emphasis placed on the interplay of research in individuals’ laboratory (small science), and advanced tools at the synchrotron light source (big science) from the perspective of matching scientific problems with techniques at the synchrotron for solution, and the interaction of users with the staff and management of the facility (human activity). The discussion is focused on one phenomenon, X-ray absorption and related techniques, which are element specific and ideally suited for probing structure and bonding of materials and their functionality. I will describe why X-ray absorption spectroscopy is literally “Chemistry at the Edge”. The sociology of synchrotron research and its impact on science will also be presented. The evolution of synchrotron science and technology globally will be noted, especially the history of R&D of synchrotron research in Canada and the bright prospect for chemical research using future synchrotron light sources.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"103 10","pages":"537-554"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147889168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Qualitative and quantitative analysis of cresols found in maskwio'mi (birch bark extract) 桦树皮提取物中甲酚的定性和定量分析

4区化学

Canadian Journal of Chemistry Pub Date : 2024-02-28 DOI: 10.1139/cjc-2023-0166

Viktor Lyczywek, Rajendran Kaliaperumal, Volodymyra Zuieva, Sarah Titcombe, Matthias Bierenstiel

{"title":"Qualitative and quantitative analysis of cresols found in maskwio'mi (birch bark extract)","authors":"Viktor Lyczywek, Rajendran Kaliaperumal, Volodymyra Zuieva, Sarah Titcombe, Matthias Bierenstiel","doi":"10.1139/cjc-2023-0166","DOIUrl":"https://doi.org/10.1139/cjc-2023-0166","url":null,"abstract":"Maskwio'mi (Mi'kmaw language for “oil made from birch bark”) is a traditional topical skin medicine of the Mi'kmaq people of Atlantic Canada and is produced in a torrefaction process by heating birch bark ( Betula papyrifera, paper birch) inside a metal container in a fire. The resulting viscous, oily mixture is traditionally mixed with goose fat or bear grease to create a topical salve that is subsequently applied to affected skin areas. When birch bark is exposed to high temperatures, pyrolytic chemical processes produce a complex mixture of pharmacologically active compounds, including potentially harmful side products such as ortho-, meta-, and para-cresol. This study discusses the qualitative and quantitative GC-MS analysis of cresols found in maskwio'mi and the challenges of the complex organic matrix. Using caffeine as an internal standard, ortho-, meta-, and para-cresol in birch bark extract were determined to be in the approximate order of 50–1500 ppm range with 3.24 ± 0.09 × 10 2 ng mg −1 (324 ppm), 8.7 ± 1.0 × 10 2 ng mg −1 (87 ppm), and 12.4 ± 1.6 × 10 2 ng mg −1 (1240 ppm), respectively, and thus suitable by Health Canada and FDA cosmetics regulation standards when the extract is co-formulated in creams to concentrations of 0.1–5 wt.% for topical use.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"102 4","pages":"289-295"},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147903711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The occurrence of cytokinins and their biosynthesis pathways in epithelioma papulosum cyprini cells 上皮乳头状瘤细胞中细胞分裂素的出现及其生物合成途径

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-12-21 DOI: 10.1139/cjc-2023-0108

Angela Schincaglia, M. Seegobin, Craig R. Brunetti, R. J. N. Emery

{"title":"The occurrence of cytokinins and their biosynthesis pathways in epithelioma papulosum cyprini cells","authors":"Angela Schincaglia, M. Seegobin, Craig R. Brunetti, R. J. N. Emery","doi":"10.1139/cjc-2023-0108","DOIUrl":"https://doi.org/10.1139/cjc-2023-0108","url":null,"abstract":"Cytokinins are small signaling molecules present in all kingdoms of life; however, their biological relevance outside of plants is poorly characterized. Cytokinin detection across kingdoms has been shown to be inconsistent and is often organism or cell line dependent. To ensure optimal detection in epithelioma papulosum cyprini (EPC), a cold-blooded vertebrate cell line, a range of biomasses were evaluated. Cytokinins were extracted by solid-phase extraction and then detected using high performance liquid chromatography and tandem mass spectrometry. The objectives were to establish endogenous CK profiles and characterize their biosynthesis in EPC cells. Among the fourteen CKs that were scanned for, only four forms were detected overall within the samples analyzed, including, N6-(Δ2-isopentenyl) adenine-9-riboside (iPR), N6-(Δ2-isopentenyl) adenine-9-riboside-5’ (mono/di/tri)phosphate (iPNT), and cis-zeatin-9-riboside-5’ (mono/di/tri)phosphate (cZNT) and 2‐methylthio‐zeatin (2MeSZ). The total cytokinin concentrations ranged from 0.03 pmol/g to 681.025 pmol/gfwt. The results from this study provided evidence that EPC cells can produce and process cytokinins.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"31 8","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138948546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A computational study of the structures and base-pairing properties of pyrrolizidine alkaloid-derived DNA adducts 吡咯里西啶生物碱衍生 DNA 加合物结构和碱基配对特性的计算研究

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-12-21 DOI: 10.1139/cjc-2023-0177

McKenzie Franz, Melanie Kebel, Pardeepak Sandhu, Denisa Moldovan, Taylor Adamitz, Rajwinder Kaur, Ye Eun Rebecca Jeong, S. Wetmore

{"title":"A computational study of the structures and base-pairing properties of pyrrolizidine alkaloid-derived DNA adducts","authors":"McKenzie Franz, Melanie Kebel, Pardeepak Sandhu, Denisa Moldovan, Taylor Adamitz, Rajwinder Kaur, Ye Eun Rebecca Jeong, S. Wetmore","doi":"10.1139/cjc-2023-0177","DOIUrl":"https://doi.org/10.1139/cjc-2023-0177","url":null,"abstract":"Pyrrolizidine alkaloids (PAs) are found in many plants worldwide, including some in Canada. PAs have been linked to losses in livestock populations and development of human PA-diseases. Four PA-derived dehydrosupinidine (DHP) adducts formed at the exocyclic amino groups of DNA purines have been found in tumor tissue and flagged as potential biomarkers for tumor formation (denoted DHP-G/A–3 and DHP-G/A–4). Four additional adducts (DHP-G/A–1 and DHP-G/A–2) have also been identified, which differ in the stereochemistry at the DHP–nucleobase linker or DHP ring carbon containing the hydroxy group, as well as the length of the DHP–nucleobase linker. Since the impact of these distinct chemical features on adduct mutagenicity is currently unclear, the present work uses density functional theory calculations to uncover the structures and base-pairing properties of these experimentally-observed DHP-derived purine adducts. Adduct Watson-Crick base pairs involving the canonical partner are energetically and structurally feasible. However, the G/A–3 and G/A–4 adducts are also highly susceptible to mispairing with G. Indeed, the longer and more flexible DHP–nucleobase linker in these adducts affords interactions between the DHP moiety and the pairing G that are not possible for the G/A–1 and G/A–2 counterparts. Our data thus rationalize the experimental identification of this subset of adducts in liver tumor tissue, and provide key insights to guide future experimental and computational studies that investigate the replication and broader biological outcomes of DHP-derived lesions.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"18 5","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138948726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of a Fluorescent Chemical Probe for Imaging of L-Type Voltage Gated Calcium Channels 合成用于 L 型电压门控钙通道成像的荧光化学探针

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-12-21 DOI: 10.1139/cjc-2023-0149

Megan Danielle Schroeder, Victor Hellgren, Frederic Menard

引用次数: 0

Synthesis of two air and moisture-stable copper(II)-N-heterocyclic carbene complexes 两种空气和湿度稳定的 N-杂环碳烯铜(II)配合物的合成

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-12-21 DOI: 10.1139/cjc-2023-0101

Jacob G Hoare, Tanner George, Jason D. Masuda, Robert Douglas Singer

引用次数: 0

Sex differences in mouse placental metabolite profiles: an NMR metabolomics study 小鼠胎盘代谢物特征的性别差异：核磁共振代谢组学研究

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-12-08 DOI: 10.1139/cjc-2023-0113

Jenna Hanrahan, Katherine L. Steeves, Grace V. Mercer, Thomas M. O'Brien, Drew P. Locke, Nikita E. Harvey, Alexandre S. Maekawa, Amy N. Stephenson, Céline M. Schneider, Lindsay S. Cahill

{"title":"Sex differences in mouse placental metabolite profiles: an NMR metabolomics study","authors":"Jenna Hanrahan, Katherine L. Steeves, Grace V. Mercer, Thomas M. O'Brien, Drew P. Locke, Nikita E. Harvey, Alexandre S. Maekawa, Amy N. Stephenson, Céline M. Schneider, Lindsay S. Cahill","doi":"10.1139/cjc-2023-0113","DOIUrl":"https://doi.org/10.1139/cjc-2023-0113","url":null,"abstract":"A proper functioning placenta is essential for normal fetal development. The placenta has a vital function as a protective barrier and is critical for nutrient and waste exchange for the developing fetus. Our group and others have reported sex differences in both placental structure and function; however, differences in the placental metabolome between female and male fetuses have been understudied. Here, placental tissue samples were collected from healthy pregnant CD-1 mice in late gestation ( n = 26 female and n = 27 male placentas from 17 dams at embryonic day 17.5). Metabolite profiles were determined using 1H magic angle spinning nuclear magnetic resonance. The relative concentration of alanine was significantly higher in male placentas whereas, threonine was higher in female placentas ( p < 0.05). This study adds to the growing literature demonstrating sex differences in healthy placental function and emphasizes the importance of examining both female and male placentas in metabolomics studies.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"13 3","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138589224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Preliminary Characterization of Two Copper(I) Chromophore-Acceptor Dyads as Potential Photoredox Catalysts 作为潜在光氧化催化剂的两种铜(I)发色团-受体二元化合物的合成与初步表征

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-12-08 DOI: 10.1139/cjc-2023-0140

Joseph Ricardo-Noordberg, Zujhar Singh, Mohammadamin Nikpayam, Jahnai Francis, Marek Majewski

引用次数: 0