Canadian Journal of Chemistry最新文献_第2页

Multiparametric cytotoxicity profiling reveals cell-line and ligand-dependent toxicity for pegylated gold nanoparticles (AuNP-PEG) 多参数细胞毒性分析揭示了聚乙二醇化金纳米粒子（AuNP-PEG）的细胞系和配体依赖性毒性

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-12-05 DOI: 10.1139/cjc-2023-0137

Hannah F Cahill, Bryn S Scott, Olaiya Peter Oni, Grace VL Stapleton, T. MacCormack, Vicki Meli, Jillian Rourke

{"title":"Multiparametric cytotoxicity profiling reveals cell-line and ligand-dependent toxicity for pegylated gold nanoparticles (AuNP-PEG)","authors":"Hannah F Cahill, Bryn S Scott, Olaiya Peter Oni, Grace VL Stapleton, T. MacCormack, Vicki Meli, Jillian Rourke","doi":"10.1139/cjc-2023-0137","DOIUrl":"https://doi.org/10.1139/cjc-2023-0137","url":null,"abstract":"The highly tunable surface chemistry of gold nanoparticles (AuNPs) make them ideal candidates for cancer treatments. Modification of AuNP surface chemistry creates linkage points for different surface coatings whose chemical structure regulates AuNP interactions with cells and thus plays a key role in AuNP cytotoxicity. This study looked at AuNPs functionalized with three polyethylene glycol (PEG) coatings, differing in end group functionality: PEG methyl terminated thiol (PEGCH3), PEG amine terminated thiol (PEGNH2), and PEG carboxylic acid terminated thiol (PEGCOOH). Cytotoxic effects were compared across three cell lines: Human embryonic kidney (HEK293T/17), prostate cancer (PC-3), and ovarian cancer (SKOV3). Biochemical assays measured the effect AuNPs elicit on the ability of single cells to form colonies, metabolize thiazolyl blue tetrazolium bromide (MTT), or produce reactive oxygen species (ROS) using 2',7’-dichlorofluorescein. Overall, AuNP-PEG particles were minimally toxic. HEK293T/17 colony formation was significantly decreased with all but PEGCOOH particle types, and PEGNH2 treatments significantly decreased colony formation for all three tested cell lines. ROS production was significantly increased when treated with 100 μg mL-1 AuNP PEGNH2 in all three cell lines, with PEGCH3 also showing increased ROS in PC-3 cells. PEGCH3 reduced metabolic function (MTT metabolism) in only SKOV3 cells, while PEGCOOH was toxic to HEK293T/17 cells at 100 μg mL-1. These results suggest that differing end group chemistry leads to modest cytotoxic profiles for each AuNP that are cell line and coating dependent. Elucidation of AuNP mechanisms of toxicity is a critical step in the evaluation of the future therapeutic potential for these particles.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"123 31","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138599360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ionic Salt Cocrystals Studied via Multinuclear Solid-State Magnetic Resonance. A Case Study of Lithium 4-Methoxybenzoate:L-Proline Polymorphs 通过多核固态磁共振研究离子盐共晶。4-甲氧基苯甲酸锂：L-脯氨酸多晶体的案例研究

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-11-30 DOI: 10.1139/cjc-2023-0176

Yishu Shi, David L. Bryce

{"title":"Ionic Salt Cocrystals Studied via Multinuclear Solid-State Magnetic Resonance. A Case Study of Lithium 4-Methoxybenzoate:L-Proline Polymorphs","authors":"Yishu Shi, David L. Bryce","doi":"10.1139/cjc-2023-0176","DOIUrl":"https://doi.org/10.1139/cjc-2023-0176","url":null,"abstract":"Lithium salts continue to find pharmaceutical applications, particularly as psychiatric medications. As with any active pharmaceutical ingredient, structural polymorphism is an important concern for lithium-based medications which can influence solubility and other physicochemical properties. Here we report a 13C, 1H, and 7Li magic-angle spinning solid-state nuclear magnetic resonance (MAS SSNMR) study of two 1:1 polymorphic ionic cocrystals of lithium 4-methoxybenzoate and L-proline (L4MPRO(α) and L4MPRO(β)). One-dimensional 13C cross-polarization magic-angle spinning and two-dimensional heteronuclear correlation NMR spectra hint at differential mobilities of the proline and benzoate moieties for the two polymorphs. Five key resonances differ in 13C chemical shift by more than 1 ppm between the two polymorphs, clearly distinguishing between them. Gauge-including projector-augmented-wave density functional theory (GIPAW DFT) calculations of 13C and 1H magnetic shielding constants correlate strongly with the experimental chemical shifts for both polymorphs. R2 and root-mean-square deviation metrics are shown to be insufficient in the case of 13C, but sufficient in the case of 1H, for differentiating between the polymorphs. 7Li satellite-transition MAS NMR of both polymorphs are identical, as are the computed lithium magnetic shielding constants, demonstrating the insensitivity of 7Li NMR to polymorphism in these samples. This work highlights the utility of solid-state NMR spectroscopy for examining ionic salt cocrystals and also highlights some caveats in this regard.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"18 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139208187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NMR characterization of novel interactions between p97 AAA+ ATPase and the p47 adapter revealing insights into substrate delivery mechanism p97 AAA+ ATPase 与 p47 适配体之间新型相互作用的核磁共振表征揭示了底物输送机制的奥秘

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-11-21 DOI: 10.1139/cjc-2023-0160

Peter Kim, Megan Black, Felipe Perez, Rui Huang

{"title":"NMR characterization of novel interactions between p97 AAA+ ATPase and the p47 adapter revealing insights into substrate delivery mechanism","authors":"Peter Kim, Megan Black, Felipe Perez, Rui Huang","doi":"10.1139/cjc-2023-0160","DOIUrl":"https://doi.org/10.1139/cjc-2023-0160","url":null,"abstract":"p97/VCP is an essential AAA+ ATPase involved in diverse cellular activities by interacting with an array of protein adapters that recruit p97 for specific tasks. p47 is one of the adapters that targets p97 for membrane remodeling by forming a stable complex with p97 through multivalent interactions. Here we report a pair of previously unidentified interactions between the N-terminal part of p47 (residue 1-94) and the N-terminal domain (NTD) of p97. Using NMR spectroscopy, we identify two binding sites on p47, one located on the UBA domain and the other on the intrinsically disordered linker, that interact with the same basic patch on p97 NTD, driven by electrostatic forces. Reciprocal NMR titration experiments between p47 (residue 1-94) and p97 NTD reveal that these interactions are relatively weak in nature with dissociation constants on the order of hundreds of micromolar to millimolar in trans. Structural models of the two interactions are developed based on NMR chemical shift perturbations, which reveal details of the tentative binding interfaces. Our findings provide new insights into the mechanism by which ubiquitinated substrates are delivered from p47 to p97 for unfolding.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"29 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139253429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interactional Behaviour of analgesic drugs in Aqueous Solution of Caffeine at different temperatures using multi-technique Approach 采用多技术方法分析咖啡因水溶液中镇痛药物在不同温度下的相互作用行为

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-11-20 DOI: 10.1139/cjc-2023-0097

Aashima Beri, R. Kant, T. S. Banipal

{"title":"Interactional Behaviour of analgesic drugs in Aqueous Solution of Caffeine at different temperatures using multi-technique Approach","authors":"Aashima Beri, R. Kant, T. S. Banipal","doi":"10.1139/cjc-2023-0097","DOIUrl":"https://doi.org/10.1139/cjc-2023-0097","url":null,"abstract":"Drug combination therapies have been a promising strategy to overcome drug resistance. However, unexpected Drug-Drug interaction may cause adverse reactions, which puts patients in danger. Keeping this in mind, the interactions between pain killers, paracetamol (PCM) and ibuprofen sodium (IBU) with caffeine (CAF) have been studied. Apparent molar volumes (V2,ϕ) and apparent molar isentropic compression (Ks,2,ϕ)for analgesic drugs in aqueous (1, 2, 5 and 10 mmol·kg-1) caffeine (CAF) solutions have been determined from measured densities, ρ and speeds of sound, u, respectively at T = (288.15 to 318.15) K and at pressure p = 101.3 kPa. The results have also been interpreted in terms of various interactions occurring in the mixed solution. Calorimetrically determined negative values of ΔtrΔdilH0, indicate the exothermicity and thus the occurrence of energetically more favorable process. The hyperchromic shift (UV-absorption) in the spectra of PCM in aqueous solution of CAF suggest the dominance of solute-cosolute interactions through the hydrophobic-hydrophobic/hydrophilic groups (1H NMR) of PCM + CAF system.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"66 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139255427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A synthesis of L-(+)-quinic acid from D-(–)-quinic acid 从 D-(-)-奎宁酸合成 L-(+)-奎宁酸

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-11-17 DOI: 10.1139/cjc-2023-0139

Johnny Nguyen, Sandeep Bhosale, Andrew J. Bennet

引用次数: 0

Comparison of Seasonality of Urban Grime in Three Southern Ontario Cities 安大略省南部三个城市城市尘螨季节性比较

4区化学

Canadian Journal of Chemistry Pub Date : 2023-11-14 DOI: 10.1139/cjc-2023-0143

Yao Yan Huang, Emma M. McLay, James Donaldson

{"title":"Comparison of Seasonality of Urban Grime in Three Southern Ontario Cities","authors":"Yao Yan Huang, Emma M. McLay, James Donaldson","doi":"10.1139/cjc-2023-0143","DOIUrl":"https://doi.org/10.1139/cjc-2023-0143","url":null,"abstract":"Urban grime refers to films made of a complex chemical mixture of organics and inorganics deposited on outdoor surfaces. The specific chemical composition of such films can vary considerably due to geographic and seasonal influences. We compared the seasonal change of grime’s water-soluble inorganic ion content in a rural (Thamesford), suburban (Oshawa), and urban city (Toronto) in southern Ontario, Canada. Sodium, calcium, chloride, nitrate and sulphate amounts in grime was collected and quantified over four seasons in Oshawa, ON and Thamesford, ON and compared with results from a previous study in Toronto to elucidate differences. We found that all three regions displayed a clear seasonality in sodium and chloride consistent with winter road salt inputs and chloride loss in summer. Mole fractions of sulphate were consistently the lowest of the measured ions and NO3-/SO42- ratios showed a winter-spring minimum and summer-fall maximum. Urban – rural differences in the seasonal changes of ionic mole ratios suggests that additional chloride displacement by nitrate occurs within grime in Toronto that is not present in the two other rural/suburban cities in the same region.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"30 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134957424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benzimidazolium Ionic Liquid Functionalized Star-polycaprolactone Stationary Phase for Capillary Gas Chromatography 苯并咪唑离子液体功能化星型聚己内酯毛细管气相色谱固定相

4区化学

Canadian Journal of Chemistry Pub Date : 2023-11-08 DOI: 10.1139/cjc-2023-0068

Ruonan Chen, Hongbing Yang, Qiuchen Huang, Mengyi Ba, Wen Li, Yanli Song, Zhiqiang Cai, Tao Sun, Qiaoqiao Feng, Shuai Li

{"title":"Benzimidazolium Ionic Liquid Functionalized Star-polycaprolactone Stationary Phase for Capillary Gas Chromatography","authors":"Ruonan Chen, Hongbing Yang, Qiuchen Huang, Mengyi Ba, Wen Li, Yanli Song, Zhiqiang Cai, Tao Sun, Qiaoqiao Feng, Shuai Li","doi":"10.1139/cjc-2023-0068","DOIUrl":"https://doi.org/10.1139/cjc-2023-0068","url":null,"abstract":"In this work, an innovative ionic liquid functionalized star-shape-polymer is synthesized by coupling star-polycaprolactone with benzimidazolium (star-PCL-Bim), and statically coated into a capillary column for gas chromatographic (GC) separations. The fabricated star-PCL-Bim capillary column with moderate-polar nature reveals a high column efficiency of 3598 plates/m for n-dodecane at 120°C, and advantageous distinguishing ability (R > 1.5) for 9 aromatic isomer mixtures and 12 cis-/trans-isomers. Its excellent resolving capacity can be credit to the architecture of star-PCL-Bim, the PCL arms and π-electron-rich benzimidazolium cations, and it results in a quite different retention behavior of star-PCL-Bim from that of star-PCL and commercial HP-35 columns, with “dual-nature” selectivity in separating a mixture including 29 compounds. These favorable chromatographic characteristics demonstrate the great application potential of this material in GC, and provide a prospective strategy to obtain high-performance stationary phases.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"13 s4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135341162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple Verdazyl Radicals Appended to a Triarylamine Scaffold 附加在三芳胺支架上的多个硫酰基自由基

4区化学

Canadian Journal of Chemistry Pub Date : 2023-10-31 DOI: 10.1139/cjc-2023-0148

Sydney Reiber, Bennett Templeman-Vivian, Michelle Mills, Chris Tremblay, David Leitch, Erin Chernick

引用次数: 0

High temperature Raman spectroscopic analysis of the crystal growth of Bi2ZnOB2O6 Bi2ZnOB2O6晶体生长的高温拉曼光谱分析

4区化学

Canadian Journal of Chemistry Pub Date : 2023-10-31 DOI: 10.1139/cjc-2023-0098

Ji Zhang, Daojun Liu

引用次数: 0

Copper crosslinked silicone elastomers in RGB colors: Degradable on Demand RGB颜色的铜交联有机硅弹性体:按需降解

4区化学

Canadian Journal of Chemistry Pub Date : 2023-10-16 DOI: 10.1139/cjc-2023-0118

Daniel Hrabowyj, Liam A. Wittenberg, Erin M. Donahue-Boyle, Yang Chen, Michael A. Brook

{"title":"Copper crosslinked silicone elastomers in RGB colors: Degradable on Demand","authors":"Daniel Hrabowyj, Liam A. Wittenberg, Erin M. Donahue-Boyle, Yang Chen, Michael A. Brook","doi":"10.1139/cjc-2023-0118","DOIUrl":"https://doi.org/10.1139/cjc-2023-0118","url":null,"abstract":"Increasing demand for fully recyclable polymers has prompted an interest in materials crosslinked via non-covalent interactions. Aggressive depolymerization can cleave backbone SiO bonds to generate linear oils or cyclic monomers from silicone rubbers, but one would rather recover the starting material oils simply by selectively breaking crosslinks. We demonstrate that ligand binding to metals can be used to reversibly crosslink silicone chains. Aminopropylsilicones were crosslinked via complexation with copper (II) acetate to form blue silicone oils. These oils slowly cured in air at room temperature to form soft, green elastomers over a month, or overnight at 50-55 °C in air to give robust, hard red elastomers. Potential explanations for the observed color changes are discussed. Elastomers prepared by either pathway underwent ready degradation by removal of the copper ions via competitive ligand binding using ethylenediamine, allowing for recovery of the unmodified silicone oil; the recovered amine could be reused with more copper to form a (softer) elastomer. This process provides a method for the synthesis of stable elastomeric silicones that are degradable on demand. ","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136078833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1