Synthesis of a Fluorescent Chemical Probe for Imaging of L-Type Voltage Gated Calcium Channels

IF 1.1 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Canadian Journal of Chemistry Pub Date : 2023-12-21 DOI:10.1139/cjc-2023-0149

Megan Danielle Schroeder, Victor Hellgren, Frederic Menard

引用次数: 0

Abstract

Herein, we report the synthesis of a chemical probe for real-time visualization of L-type voltage-gated calcium channels (LTCCs) using fluorescence microscopy. The probe, FluoBar2, is based on a barbiturate ligand selective for LTCCs. FluoBar2 contains the organic fluorophore 5-carboxyfluorescein and was synthesized in seven total steps with a 22% overall yield.

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合成用于 L 型电压门控钙通道成像的荧光化学探针

在此，我们报告了利用荧光显微镜实时观察 L 型电压门控钙通道（LTCC）的化学探针的合成过程。该探针名为 FluoBar2，是基于对 LTCCs 有选择性的巴比妥配体。FluoBar2 含有有机荧光团 5-羧基荧光素，共分七步合成，总产率为 22%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Canadian Journal of Chemistry 化学-化学综合

CiteScore

1.90

自引率

9.10%

发文量

审稿时长

1 months

期刊介绍： Published since 1929, the Canadian Journal of Chemistry reports current research findings in all branches of chemistry. It includes the traditional areas of analytical, inorganic, organic, and physical-theoretical chemistry and newer interdisciplinary areas such as materials science, spectroscopy, chemical physics, and biological, medicinal and environmental chemistry. Articles describing original research are welcomed.