Canadian Journal of Chemistry最新文献_第6页

A Beginner's Guide to 19F NMR and its Role in Drug Discovery 19F核磁共振初学者指南及其在药物发现中的作用

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-05-08 DOI: 10.1139/cjc-2023-0028

S. Prosser

引用次数: 1

Efficient protocol for the preparation of α-heteroaryl acetaldehydes α-杂芳基乙醛的高效制备工艺

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-05-05 DOI: 10.1139/cjc-2022-0275

Cohan Huxley, Callum Lucas, Juan Manuel Mesa Bruno, Matthew J Anketell, Emma K. Davison, G. Muir, Matthew B. Nodwell, Michael Meanwell, S. Silverman, Robert Britton, Louis-Charles Campeau

引用次数: 0

Generation of copper fluoroalkyl complexes (CuRFLn) from chlorotrifluoroethylene and −RF transfer to aroyl chlorides 从三氟乙烯和- RF转移到芳酰氯生成氟烷基铜配合物(CuRFLn)

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-05-05 DOI: 10.1139/cjc-2022-0240

Luana L.T.N. Porto, Moutasem Seifi, Nicole Johnson, R. Baker

引用次数: 0

Synthesis and characterization of tetraphenylethylene-functionalized N-heterocyclic carbene-stabilized gold nanoparticles with aggregation-induced emission 聚致发射四苯乙烯功能化n-杂环碳稳定金纳米粒子的合成与表征

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-05-05 DOI: 10.1139/cjc-2022-0260

Marilyne Bélanger-Bouliga, N. Kihal, Hanae Mahious, P. T. Nguyen, S. Bourgault, A. Nazemi

{"title":"Synthesis and characterization of tetraphenylethylene-functionalized N-heterocyclic carbene-stabilized gold nanoparticles with aggregation-induced emission","authors":"Marilyne Bélanger-Bouliga, N. Kihal, Hanae Mahious, P. T. Nguyen, S. Bourgault, A. Nazemi","doi":"10.1139/cjc-2022-0260","DOIUrl":"https://doi.org/10.1139/cjc-2022-0260","url":null,"abstract":"Gold nanoparticles (AuNPs) have found use in broad range of applications such as in catalysis and nanomedicine. Despite the fact that thiol-based AuNPs have been widely studied, they suffer from relative instability in various conditions, such as high and low temperatures, pH variations, and are prone to oxidation. Over the last decade, N-heterocyclic carbenes (NHCs) have been under spotlight as suitable ligands to stabilize metal nanoparticles and surfaces. Although NHC-functionalized AuNPs have been shown to outperform their thiol-based analogs in terms of stability, their applications in nanomedicine have not been realized. Hybrid nanomaterials, such as AuNPs tagged with π-conjugated molecules with aggregation-induced emission (AIE) property, are promising candidates to develop fluorescent materials for cellular imaging. The combination of NHC-stabilized AuNPs with AIE to form stable, fluorescent hybrid AuNPs is of significant interest to open the door to develop new NHC-based nanomaterials. Herein, we report the synthesis and characterization of water-soluble fluorescent NHC-decorated AuNPs for potential applications in nanomedicine. Their stability in biologically relevant conditions is investigated.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"109 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82565169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theoretical Study on Effect of Substituent on Aromaticity of Tetrazole Ring 取代基对四唑环芳香性影响的理论研究

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-04-26 DOI: 10.1139/cjc-2023-0014

Chunhai Yang, Xue Li, N. Zhou, Beihua Chen, Huilong Dong, Junxun Jin, Xiuli Hu, Tao Huang, Lei Shen, Jun Yi, Wang Quan, D. Ouyang

{"title":"Theoretical Study on Effect of Substituent on Aromaticity of Tetrazole Ring","authors":"Chunhai Yang, Xue Li, N. Zhou, Beihua Chen, Huilong Dong, Junxun Jin, Xiuli Hu, Tao Huang, Lei Shen, Jun Yi, Wang Quan, D. Ouyang","doi":"10.1139/cjc-2023-0014","DOIUrl":"https://doi.org/10.1139/cjc-2023-0014","url":null,"abstract":"Tetrazole compounds are a category of energetic materials with great potential. Their stability is inherently related to their aromatics. On the basis of research in DFT at b3lyp/6-311** level on three compounds interested, viz. 5-amino-1H-tetrazole, 5-Carboxyl-1H-tetrazole, 2-methyl-5-Carboxyl-tetrazole, their aromatic characters are extensively analyzed by virtue of different estimation method. Analyses show that these methods, NICS, ICSS, AdNDP, π-electrons density and LOL-pi, are efficient for substituted-tetrazole ring aromaticity estimation. Conclusion denotes that both substituent and substituted position can significantly affect the aromaticity of tetrazole ring of tetrazole compound. Among these given substituents, electro-withdrawing group -COOH significantly increases the aromaticity of the tetrazole rings due to the withdrawing to π-electrons thereof but electro-donating group -NH2 weakens the one of the tetrazole rings due to the donating to π-electrons thereof. But for 2-methyl-5-Carboxyl-tetrazole, the aromaticity increasing of -COOH imposed on π-electrons of tetrazole ring thereof is partially balanced by the existence of the electron-donating group -CH3 at asymmetric meta-position of tetrazole ring. Consequently, the aromaticity order is 5-Carboxyl-1H-tetrazole > 2-methyl-5-Carboxyl-tetrazole > 5-amino-1H-tetrazole.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"29 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77526434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A fluorescence sensor based on quantum dots for the detection of mercury ions 一种基于量子点的荧光传感器，用于检测汞离子

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-04-25 DOI: 10.1139/cjc-2022-0145

Yang Qin, Yunhan Yang, Y. Ho, Ling Zhang

{"title":"A fluorescence sensor based on quantum dots for the detection of mercury ions","authors":"Yang Qin, Yunhan Yang, Y. Ho, Ling Zhang","doi":"10.1139/cjc-2022-0145","DOIUrl":"https://doi.org/10.1139/cjc-2022-0145","url":null,"abstract":"Mercury (II) ion (Hg2+) is one of the most widespread pollutants that poses a serious threat to public health and the environment. Research efforts on selective and sensitive detection of Hg2+, have therefore drawn considerable attention in recent years. Herein, we report a facile approach to detect Hg2+ based on quantum dots (QDs)-based nanosensor. The two single-stranded DNA (ssDNA) used in this work are modified with biotin (ssDNA-biotin) and fluorescence quencher BHQ2 (ssDNA-BHQ2). These two strands are complementary but with TTT-recognized base sequences for the Hg2+ to form a T-Hg2+-T complex. The biotin-modified ssDNA (ssDNA-biotin) is first bound to the streptavidin-modified QDs, forming a QDs/ssDNA-biotin assembly, which may be further hybridized with the ssDNA-BHQ2, producing a complex of QDs/ssDNA-biotin/ssDNA-BHQ2. The BHQ2 serves as an effective quencher of QDs with the QDs and BHQ2 in a proximity within the QDs/ssDNA-biotin/ssDNA-BHQ2 complex. The decrease of fluorescence intensity therefore serves as an indication of the presence of Hg2+. The fluorescence reduction is observed linearly correlated with the concentration of Hg2+ in the range of 1.0-20.0 nM, with a detection limit at 0.87 nM. The presented QDs-based method is expected to provide a simple, rapid and sensitive method for the detection of Hg2+ in environmental water samples.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"19 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82129840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New bis(thieno[2,3-b]pyridine) hybrids linked to arene units as potential bacterial biofilm and MRSA inhibitors 与芳烃单元连接的新型双(噻吩[2,3-b]吡啶)杂合体作为潜在的细菌生物膜和MRSA抑制剂

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-04-20 DOI: 10.1139/cjc-2022-0236

S. Sanad, Ahmed E. M. Mekky

{"title":"New bis(thieno[2,3-b]pyridine) hybrids linked to arene units as potential bacterial biofilm and MRSA inhibitors","authors":"S. Sanad, Ahmed E. M. Mekky","doi":"10.1139/cjc-2022-0236","DOIUrl":"https://doi.org/10.1139/cjc-2022-0236","url":null,"abstract":"Using sonication and mediated by piperazine, new arene-linked bis(thieno[2,3-b]pyridine) hybrids were efficiently prepared in this study. The target hybrids were prepared by reacting bis(α-haloketone) with two equivalents of the appropriate pyridine-2(1H)-thiones in the presence of 1.4 equivalents of piperazine. The reaction mixture was subjected to sonication at 60 °C for 30-40 min to produce the desired products in 88-95% yields. When tested against six different ATCC bacterial strains, the new products demonstrated a wide range of antibacterial activity. The 4-(4-methoxyphenyl)-linked hybrids 1i, and 1j, attached to 6-(4-methoxyphenyl) and 6-(p-tolyl) units, respectively, had the best efficacy against S. aureus, E. faecalis, E. coli, and P. aeruginosa strains. Both hybrids showed more effective potency than the reference ciprofloxacin with MIC and MBC values in the ranges from 2.0-2.1, and 4.1-4.2 μM, respectively. Additionally, hybrids 1i, and 1j demonstrated stronger efficacy than linezolid with MIC values ranging from 2.0-4.2 µM, and MBC values ranging from 8.2-8.5 µM, respectively, against the MRSA ATCC:33591, and ATCC:43300 strains. Furthermore, hybrids 1i, and 1j showed inhibitory antibacterial biofilm activity comparable to the standard ciprofloxacin. They had IC50 values ranging from 3.8-4.6 μM against S. aureus, E. faecalis, E. coli, and P. aeruginosa strains. The cytotoxicity of hybrids 1i, and 1j against the human breast epithelial cell line MCF-10A lends credence to both hybrids' potential as safe antibacterial agents.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"23 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73168988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Solubility and Solvation Thermodynamics of L-tryptophan in Aqueous Methanol Solvent mixtures l -色氨酸在甲醇水溶液混合物中的溶解度和溶剂化热力学

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-04-20 DOI: 10.1139/cjc-2022-0308

Avishek Saha, K. Mahali, Sanjay Dhar Roy

引用次数: 1

Synthesis of Novel 2- and 8-Substituted 4-Amino-7-chloroquinolines and their N-Alkylated Coupling Products 新型2-和8-取代4-氨基-7-氯喹啉及其n -烷基化偶联产物的合成

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-04-20 DOI: 10.1139/cjc-2023-0005

Dion B. Nemez, Baldeep K. Sidhu, Kevin Carlin, A. Friesen, David E. Herbert

引用次数: 0

Novel CoMnFeO4-MWCNT nanocomposite based on a green synthesized method for supercapacitor applications 基于绿色合成方法的新型CoMnFeO4-MWCNT纳米复合材料应用于超级电容器

IF 1.1 4区化学

Canadian Journal of Chemistry Pub Date : 2023-04-11 DOI: 10.1139/cjc-2022-0117

A. Babapoor, B. Mirzayi, Laleh Salehghadimi, Raha Hadi, S. Farhoudian, Meysam Paar

{"title":"Novel CoMnFeO4-MWCNT nanocomposite based on a green synthesized method for supercapacitor applications","authors":"A. Babapoor, B. Mirzayi, Laleh Salehghadimi, Raha Hadi, S. Farhoudian, Meysam Paar","doi":"10.1139/cjc-2022-0117","DOIUrl":"https://doi.org/10.1139/cjc-2022-0117","url":null,"abstract":"A novel nanocomposite of CoMnFeO4-MWCNT has been synthesized via green and simple hydrothermal method and the structure characterization has been done through FT-IR, X-ray diffraction, scanning electron microscopy, EDX, and high-resolution transmission electron microscopy analysis in this research. Cyclic voltammetry and galvanostatic charge–discharge methods are picked as the strategies to compare their supercapacitor behavior. The specific capacitance of about 1310 F g−1 (at 1 A g−1) in 3 mol L−1 KOH has been recorded for CoMnFeO4-MWCNT nanocomposite when the working voltage is 1.2 V. Moreover, this nanocomposite retains 89% of its initial capacitance after 10 000 charge–discharge cycles. Also, some initial mechanistic studies are performed to achieve a deeper insight into the electrochemical behavior of the nanocomposite implying that the oxidation-reduction process of CoMnFeO4-MWCNT nanocomposite is generally quasi-reversible and diffusion-controlled. From the view of time, coat, and environment, the hydrothermal process is much more reliable and beneficial regarding higher performance.","PeriodicalId":9420,"journal":{"name":"Canadian Journal of Chemistry","volume":"17 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91097748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0