Social cognitive and affective neuroscience最新文献_第5页

Differential responses to group and individual emotional voices: a behavioral and ERP study. 对群体和个人情绪声音的差异反应：行为和ERP研究。

IF 3.1

Social cognitive and affective neuroscience Pub Date : 2026-01-21 DOI: 10.1093/scan/nsag041

Shuqin Liu, Min Shao, Yudie Zhang, Lu Chen, Lu Yu, Rong Huang, Jiayi Shi, Jingyang Yu, Jing Meng

{"title":"Differential responses to group and individual emotional voices: a behavioral and ERP study.","authors":"Shuqin Liu, Min Shao, Yudie Zhang, Lu Chen, Lu Yu, Rong Huang, Jiayi Shi, Jingyang Yu, Jing Meng","doi":"10.1093/scan/nsag041","DOIUrl":"10.1093/scan/nsag041","url":null,"abstract":"Human beings live in social groups, and processing group emotions is crucial for interacting with and understanding others' behaviors and feelings. This study investigated the cognitive and neural mechanisms of processing group versus individual emotional voices within the auditory modality. We examined ERP responses of 34 participants to group and individual voices across three emotional valences (negative, neutral, positive). Behavioral results revealed a significant interaction: group voices yielded shorter reaction times for neutral and positive emotions but longer for negative ones, alongside more positive overall emotional reactions. Electrophysiologically, group voices elicited more positive N1 and larger P2 amplitudes, with shorter latencies. More specifically, for negative and positive voices, group voices elicited larger P2 amplitudes than individual voices, while no significant difference between group and individual voices emerged for neutral voices. Furthermore, P2 amplitudes elicited by group voices were negatively correlated with participants' trait cognitive empathy. These results suggest that group voices elicit stronger early neural responses driven by an interplay of acoustic and social salience. Importantly, rather than demonstrating a direct empathy-specific neural mechanism, the observed negative correlation suggests that trait empathy may play a role in modulating the early sensory detection and attentional processing of complex, emotional group empathy.","PeriodicalId":94208,"journal":{"name":"Social cognitive and affective neuroscience","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13283483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148158978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scaffolding the social mind: emotion recognition supports mentalizing but reinforces bias. 搭建社会心理：情感识别支持心理化但强化偏见。

IF 3.1

Social cognitive and affective neuroscience Pub Date : 2026-01-21 DOI: 10.1093/scan/nsag039

Carolina Biasiotti, Daniela Ruzzante, Federica Meconi, Jeroen Vaes

{"title":"Scaffolding the social mind: emotion recognition supports mentalizing but reinforces bias.","authors":"Carolina Biasiotti, Daniela Ruzzante, Federica Meconi, Jeroen Vaes","doi":"10.1093/scan/nsag039","DOIUrl":"10.1093/scan/nsag039","url":null,"abstract":"Mentalizing-inferring others' mental states-is a core social function supported by both perceptual and contextual processes. Emotion recognition similarly unfolds in two stages: early perceptual decoding of facial features followed by context-sensitive interpretation. Here, we tested whether emotion recognition scaffolds mentalizing across these stages and whether they attenuate or amplify social bias. Participants (N = 34) completed a face categorization task during EEG recording, in which mentalizing was operationalized as differential neural responses to mindful (human) versus mindless (doll-like) faces, while perceptual (neutral vs. smiling) and contextual (ingroup vs. outgroup) cues were systematically manipulated. Early neural responses differentiated human from doll-like faces, indicating rapid mind detection despite perceptual similarity. Smiling expressions enhanced early neural sensitivity across both human and doll-like faces, suggesting that emotional information is extracted at early perceptual stages independently of stimulus humanity. Later EEG components revealed an asymmetry: emotional expressions selectively boosted mental state attribution for ingroup faces, reflecting the integration of contextual social information at later stages. Implicit association tests confirmed this pattern, with mind-related concepts more strongly associated with smiling ingroup faces.","PeriodicalId":94208,"journal":{"name":"Social cognitive and affective neuroscience","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13427767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Action-effect proximity, order, and predictability differentially modulate electrophysiological responses and explicit judgements of agency. 动作效应的接近性、顺序性和可预见性差异调节电生理反应和显性代理判断。

IF 3.1

Social cognitive and affective neuroscience Pub Date : 2026-01-21 DOI: 10.1093/scan/nsag061

Stefanie Sturm, Marta Blasco-Oliver, Iria SanMiguel

{"title":"Action-effect proximity, order, and predictability differentially modulate electrophysiological responses and explicit judgements of agency.","authors":"Stefanie Sturm, Marta Blasco-Oliver, Iria SanMiguel","doi":"10.1093/scan/nsag061","DOIUrl":"10.1093/scan/nsag061","url":null,"abstract":"Attenuation of neural responses to self- versus externally generated stimuli is widely considered an implicit marker of the Sense of Agency and often interpreted within predictive processing and comparator frameworks. Agency is thought to arise from the integration of multiple cues, including action-effect timing and outcome predictability. How these factors jointly shape electrophysiological correlates of agency remains unclear. In this study, we manipulated the temporal relationship and pitch congruency of sounds generated by button presses to examine their effects on explicit agency judgments and event-related potentials. Sounds were presented up to 120 ms before/after actions, allowing investigation of action-effect proximity irrespective of temporal order and electrophysiological correlates of illusory agency perception. Temporal proximity and outcome congruency strongly influenced agency judgments. While the typical order of action preceding effect was critical, participants reported illusory agency when congruent sounds preceded actions by up to 60 ms, consistent with predictive accounts. Neurally, sounds preceding actions elicited an N200 mismatch response, congruent outcomes evoked a late positive orienting response, and P2 attenuation occurred for temporally proximal events regardless of order. These findings support cue integration accounts by showing that temporal structure and predictability jointly shape agency judgments and their electrophysiological signatures.","PeriodicalId":94208,"journal":{"name":"Social cognitive and affective neuroscience","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148537756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social mind at rest: resting-state connectivity associated with social thought relates to friendship quality. 静息状态下的社会心理：与社会思维相关的静息状态连通性与友谊质量的关系。

IF 3.1

Social cognitive and affective neuroscience Pub Date : 2026-01-21 DOI: 10.1093/scan/nsag069

Yi-Sheng Wong, Junhong Yu

{"title":"Social mind at rest: resting-state connectivity associated with social thought relates to friendship quality.","authors":"Yi-Sheng Wong, Junhong Yu","doi":"10.1093/scan/nsag069","DOIUrl":"10.1093/scan/nsag069","url":null,"abstract":"Although mind wandering is often associated with adverse outcomes, certain thought content may support adaptive functions. This study investigated how latent dimensions of resting-state thought relate to adaptive functioning, mental, emotional, and behavioral problems, and resting-state connectivity patterns in 130 healthy adults. Exploratory factor analysis of the New York Cognition Questionnaire identified seven thought dimensions: five content-related factors (Social Cognition, Self-Oriented Reflection, Interpersonal Reflection, Near-Term Past/Future, and Positive & Meaningful) and two form-related factors (Specificity and Imagery). This is partially consistent with prior work, especially for the social dimension. Controlling for sex and age, partial Pearson correlations showed that Social Cognition and Interpersonal Reflection were positively associated with friendship quality. Vertex-wise analyses identified multiple cortical clusters linked to distinct thought dimensions, and network-based statistics revealed that Social Cognition was associated with resting-state functional connectivity (rsFC) primarily between the default mode and ventral attention networks. Notably, both positive and negative rsFC network strengths related to Social Cognition were associated with friendship quality. These findings collectively support the content regulation hypothesis, suggesting that specific thought dimensions engage distinct neural networks and relate to meaningful social outcomes. Overall, the results highlight the importance of integrating subjective phenomenological experience with objective neural measures.","PeriodicalId":94208,"journal":{"name":"Social cognitive and affective neuroscience","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13581425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148820660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hierarchical systems in the default mode network when reasoning about self and other mental states. 在推理自我和其他心理状态时，默认模式网络中的等级系统。

IF 3.1

Social cognitive and affective neuroscience Pub Date : 2026-01-21 DOI: 10.1093/scan/nsag047

Isaac R Christian, Samuel A Nastase

{"title":"Hierarchical systems in the default mode network when reasoning about self and other mental states.","authors":"Isaac R Christian, Samuel A Nastase","doi":"10.1093/scan/nsag047","DOIUrl":"10.1093/scan/nsag047","url":null,"abstract":"Humans spend considerable time contemplating the minds of others. But this ability is not limited to external agents-we also turn the lens for reading minds inward, reflecting on our own thoughts, emotions, and sense of self. Some processes involved in reasoning about minds may rely on shared mechanisms, while others may be specific to the agent under consideration. We developed a paradigm where participants performed either a mental state inference task or a control task targeting either another person presented onscreen or their own mind. Using functional MRI and multi-voxel pattern analysis, we replicate a well-established self-other gradient along the medial prefrontal wall: ventral regions encoded mental state inference patterns for self, but not other, whereas more dorsal regions encoded mental state inference for both self and other, compared to control conditions. Posterior cingulate cortex, on the other hand, differentiated the target of mental state inference. Using a cross-classification analysis, we also found that patterns in the dorsomedial prefrontal cortex, ventromedial prefrontal cortex, and right temporoparietal junction were sensitive to mental state reasoning, regardless of the target agent. Our findings reveal a functional hierarchy for mental state reasoning where certain areas support agent-specific reasoning and others support more abstract, agent-general reasoning.","PeriodicalId":94208,"journal":{"name":"Social cognitive and affective neuroscience","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13431780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anxiety makes time pass quicker: neural correlates. 焦虑让时间过得更快：神经相关。

IF 3.1

Social cognitive and affective neuroscience Pub Date : 2026-01-21 DOI: 10.1093/scan/nsag006

Ioannis Sarigiannidis, Karel Kieslich, Christian Grillon, Monique Ernst, Jon P Roiser, Oliver J Robinson

{"title":"Anxiety makes time pass quicker: neural correlates.","authors":"Ioannis Sarigiannidis, Karel Kieslich, Christian Grillon, Monique Ernst, Jon P Roiser, Oliver J Robinson","doi":"10.1093/scan/nsag006","DOIUrl":"10.1093/scan/nsag006","url":null,"abstract":"Anxiety can be adaptive, but at a cost. One theory suggests that whilst anxiety promotes harm-avoidant cognitive processing, it impairs concurrent (non-harm-related) processing by commandeering finite neurocognitive resources. Our previous work has shown that anxiety reliably 'speeds up time', promoting temporal underestimation, possibly due to a loss of temporal information. Whether this results from anxiety overloading neurocognitive systems involved in time processing remains unclear. Here, we examined whether anxiety and time processing overlap, particularly in regions of the cingulate cortex. Across two studies (an exploratory Study 1, N = 13, informing a pre-registered Study 2, N = 29), we combined a well-established anxiety manipulation (threat of shock) with a temporal bisection task while participants underwent fMRI. Consistent with our previous findings, time was perceived to pass more quickly under anxiety. Anxiety induction led to widespread activation in the cingulate cortex, while perceiving longer intervals was associated with more circumscribed activation in a mid-cingulate region. Importantly, conjunction analysis revealed convergence between anxiety and time processing in the insula and mid-cingulate cortex. These results tentatively support the idea that anxiety overloads already-engaged neural resources. In particular, overloading mid-cingulate capacity may drive emotion-related changes in temporal perception, consistent with its hypothesized role in mediating responses to anxiety.","PeriodicalId":94208,"journal":{"name":"Social cognitive and affective neuroscience","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13089397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Together we sync: a systematic qualitative and quantitative review of fMRI hyperscanning studies. 我们一起同步：功能磁共振成像超扫描研究的系统定性和定量回顾。

IF 3.1

Social cognitive and affective neuroscience Pub Date : 2026-01-21 DOI: 10.1093/scan/nsaf122

Tommaso Berni, Lucia Maria Sacheli, Maria Cicirello, Marco Tettamanti, Eraldo Paulesu, Laura Zapparoli

{"title":"Together we sync: a systematic qualitative and quantitative review of fMRI hyperscanning studies.","authors":"Tommaso Berni, Lucia Maria Sacheli, Maria Cicirello, Marco Tettamanti, Eraldo Paulesu, Laura Zapparoli","doi":"10.1093/scan/nsaf122","DOIUrl":"10.1093/scan/nsaf122","url":null,"abstract":"Social interaction relies on neurocognitive processes that support mutual prediction and coordination. Traditional neuroimaging investigates brain activity at the individual level, limiting insight into the reciprocal nature of social exchange. Hyperscanning overcomes this by simultaneously recording brain activity from interacting individuals. We conducted a systematic review of 28 functional magnetic resonance imaging (fMRI) hyperscanning studies examining inter-brain coupling during interactive tasks. We assessed study features and examined whether paradigms included four key properties that make the use of hyperscanning particularly valuable over single-brain designs: real-time reciprocity, mutual information flow, unpredictability, and irreproducibility. Substantial methodological heterogeneity was observed, and only a few studies incorporated all four theoretically relevant features. To identify consistent spatial neural patterns of inter-brain coupling, we performed coordinate-based hierarchical clustering on residual (task-independent) and task-evoked coupling data. The latter was further analysed in relation to the complexity of the interaction. Residual coupling consistently involved the right posterior superior temporal gyrus, overlapping with the anterior temporo-parietal junction (TPJ), suggesting a role in spontaneous alignment. Task-evoked coupling differed by interactional complexity, with posterior temporal regions involved in low-complexity tasks, and medial frontal, mid-cingulate, and insular areas in high-complexity ones. These findings support the relevance of fMRI hyperscanning for studying inter-brain dynamics and inform future methodological development.","PeriodicalId":94208,"journal":{"name":"Social cognitive and affective neuroscience","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12863086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From lab to concert hall: effects of live performance on neural-acoustic phase-locking and engagement. 从实验室到音乐厅：现场表演对神经声学锁相和接合的影响。

IF 3.1

Social cognitive and affective neuroscience Pub Date : 2026-01-21 DOI: 10.1093/scan/nsag021

Arun Asthagiri, Psyche Loui

{"title":"From lab to concert hall: effects of live performance on neural-acoustic phase-locking and engagement.","authors":"Arun Asthagiri, Psyche Loui","doi":"10.1093/scan/nsag021","DOIUrl":"10.1093/scan/nsag021","url":null,"abstract":"Live music performances continue to captivate audiences despite widespread availability of high-quality recordings, yet the neural mechanisms underlying the experience of live music remain poorly understood. This study investigates the effect of live versus recorded music on neural-acoustic phase-locking, an index of neural coupling with acoustic rhythms. Twenty-one participants listened to two live and two recorded performances of fast and slow movements of J.S. Bach's works for the solo violin in a concert hall setting, while their EEG data were collected. Participants made behavioral ratings of engagement, spontaneity, pleasure, investment, focus, and distraction after each trial. Live performances were rated higher than recorded performances on a pleasure-engagement dimension. Live trials showed significantly higher neural-acoustic phase-locking than recorded trials in frequencies corresponding to rhythmic timescales within the excerpts. A follow-up analysis linked the effects of liveness on phase-locking to the increases in pleasure and engagement reported for live over recorded trials. Altogether, results demonstrate that live music strengthens dynamical responses to musical rhythm within the brain, which provides a candidate neural basis for the widespread appeal of live music and theories of social bonding through music.","PeriodicalId":94208,"journal":{"name":"Social cognitive and affective neuroscience","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13166874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lonelier people feel less empathic despite intact neural empathy responses after meditation training. 尽管冥想训练后的神经移情反应完好无损，但孤独的人的移情能力较差。

IF 3.1

Social cognitive and affective neuroscience Pub Date : 2026-01-21 DOI: 10.1093/scan/nsag015

Marla Dressel, Naomi Nero, Paige Freeburg, Melinda C Somers, Joseph S Venticinque, Ashley S VanMeter, Shawn A Rhoads, Abigail A Marsh

{"title":"Lonelier people feel less empathic despite intact neural empathy responses after meditation training.","authors":"Marla Dressel, Naomi Nero, Paige Freeburg, Melinda C Somers, Joseph S Venticinque, Ashley S VanMeter, Shawn A Rhoads, Abigail A Marsh","doi":"10.1093/scan/nsag015","DOIUrl":"10.1093/scan/nsag015","url":null,"abstract":"Loneliness, which has reached an all-time high in the United States, has been linked to reduced self-reported empathy. Loving kindness meditation (LKM) is aimed at extending love and kindness to others and has been shown to increase empathy. But whether LKM can reduce loneliness, and whether this corresponds to higher levels of trait empathy, state empathy, and/or neural empathic responding, has not been assessed. In this pre-registered mixed-design randomized controlled trial, 108 participants completed LKM or active control training. Loneliness and trait empathy were assessed pre- and post-intervention. Neural empathic responding was measured in 54 participants during functional MRI by computing the multi-voxel pattern similarity between experiencing and observing both pain and fearful anticipation of pain. Both interventions reduced loneliness, but not trait empathy, which failed to support the hypothesis that LKM is effective in reducing loneliness by increasing empathy. Furthermore, we found no credible evidence that loneliness is associated with differences in neural empathic responding. However, loneliness was associated with lower self-reported empathy. Together, these results suggest that lonelier individuals simulate others' experiences but may not subjectively perceive themselves as empathetic, emphasizing the potential of interventions that address maladaptive social cognition in loneliness.","PeriodicalId":94208,"journal":{"name":"Social cognitive and affective neuroscience","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13282970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fear, anxiety, and the extended amygdala-absence of evidence for strict functional segregation. 恐惧、焦虑和扩展的杏仁核——缺乏严格功能分离的证据。

IF 3.1

Social cognitive and affective neuroscience Pub Date : 2026-01-21 DOI: 10.1093/scan/nsag040

Paige R Didier, Shannon E Grogans, Claire M Kaplan, Hyung Cho Kim, Samiha Islam, Allegra S Anderson, Rachael M Tillman, Manuel Kuhn, Juyoen Hur, Andrew S Fox, Kathryn A DeYoung, Jason F Smith, Alexander J Shackman

{"title":"Fear, anxiety, and the extended amygdala-absence of evidence for strict functional segregation.","authors":"Paige R Didier, Shannon E Grogans, Claire M Kaplan, Hyung Cho Kim, Samiha Islam, Allegra S Anderson, Rachael M Tillman, Manuel Kuhn, Juyoen Hur, Andrew S Fox, Kathryn A DeYoung, Jason F Smith, Alexander J Shackman","doi":"10.1093/scan/nsag040","DOIUrl":"10.1093/scan/nsag040","url":null,"abstract":"Since the time of Freud, the distinction between fear and anxiety has been a hallmark of influential models of emotion and emotional illness, including the Diagnostic and Statistical Manual of Mental Disorders and Research Domain Criteria. Fear and anxiety disorders are common, debilitating, and challenging to treat, underscoring the importance of developing accurate models of the underlying neurobiology. Although there is consensus that the extended amygdala (EA) plays a central role in orchestrating responses to threat, the respective contributions of its two major subdivisions-the central nucleus of the amygdala (Ce) and bed nucleus of the stria terminalis (BST)-remain contentious. To help adjudicate this debate, we performed a harmonized mega-analysis of fMRI data acquired from 295 adults as they completed a well-established threat-anticipation paradigm. Contrary to popular double-dissociation models, results demonstrated that the Ce responds to temporally uncertain threat and the BST responds to certain threat. In direct comparisons, the two regions showed statistically indistinguishable responses, with strong Bayesian evidence of regional equivalence. In contrast, frontocortical regions responded preferentially to uncertain-threat anticipation. Together, these observations underscore the need to reformulate conceptual models that posit a strict segregation of temporally certain and uncertain threat processing in the EA.","PeriodicalId":94208,"journal":{"name":"Social cognitive and affective neuroscience","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13322395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0